The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron. In Hodgkin's disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release. Increased concentrations of circulating ferritin have also been observed in a few cases of chronic leukaemia and myelomatosis.

Acute Disease↗

PubMed1973

The metabolism of intravenously administered iron-dextran.

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Chromatography, DEAE-Cellulose↗

PubMed1973

Serum ferritin as a measure of body iron in primary idiopathic haemochromatosis.

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Ferritins↗

PubMed1973

Immunological abnormalities in iron deficiency anaemia.

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Anemia, Hypochromic↗

PubMed1972

Defect of cell-mediated immunity in patients with iron-deficiency anaemia.

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Anemia, Hypochromic↗

PubMed1972

Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload.

The concentration of ferritin in serum gives a quantitative measure of the amount of storage iron in normal subjects and those with iron deficiency or overload. The mean level in normal men is 69 ng/ml, compared with 35 ng/ml in normal women. A concentration below 10 ng/ml is associated with a low transferrin saturation and iron-deficient erythropoiesis.

Adolescent↗

PubMed1972

Activity pattern of iron-deficient rats.

Iron-deficient rats appear to have a decrease in total activity and a disorder of diurnal rhythm. These are reversed by the administration of iron. The results may be relevant to the symptomatology of patients with iron deficiency anaemia.

Anemia, Hypochromic↗

PubMed1972

Iron metabolism in Hodgkin's disease.

An evaluation of iron metabolism has been carried out in 23 untreated patients with Hodgkin's disease and 6 patients with other lymphomata. The reduction in red cell life span is related to the stage of the disease. There is an almost universal impairment of iron release from the reticuloendothelial system with a consequent sideropenia and failure of iron delivery to the bone marrow for erythropoiesis. This defect is found in all stages of the disease and is not related to systemic symptoms.

Bone Marrow↗

PubMed1972