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Biomedical subjects

A Jacobs

Publications and source records attributed to A Jacobs.

At least 415 records · Page 23Linked to original sources
PubMed1972

An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload.

An immunoradiometric assay for human ferritin has been developed. Concentrations of ferritin in the serum of male and female controls and patients with iron deficiency and iron overload were measured.Male controls were found to have a significantly higher mean concentration of serum ferritin than females. Patients with iron deficiency had significantly lower levels than normals of either sex and patients with iron overload had greatly elevated serum ferritin concentrations. It is thought that the serum ferritin concentration may reflect the iron stores of the body.

Anemia, Hypochromic↗
PubMed1971

Utilization of iron dextran.

The utilization of iron dextran was investigated in normal subjects, in patients with iron-deficiency anaemia, and in anaemias associated with rheumatoid arthritis, reticulosis, and uraemia. Utilization of iron for haemoglobin formation at 14 days was found to be depressed in patients with rheumatoid arthritis, reticulosis, and uraemia, but when a concomitant iron-deficiency anaemia was present utilization was significantly increased. When iron dextran is used to treat anaemias in such conditions an optimum therapeutic response will be obtained only when bone marrow iron stores are absent.

Anemia↗
PubMed1971

Observations on iron in the jejunal lumen after a standard meal.

For two hours after the ingestion of a standard meal with an iron content of 3.45 mg there is a rise in iron concentration in the jejunal lumen. Initially this is in a high molecular weight form but there is a steady increase in the concentration of low molecular weight compounds. This is consistent with the gradual intraluminal transfer of iron from a mucopolysaccharide carrier to low molecular weight ligands before absorption.

Adult↗
PubMed1971

Ascorbic acid status in iron-deficiency anaemia.

Leucocyte ascorbic acid concentration declines with age. Patients with iron-deficiency anaemia have higher concentrations than normal while those with iron overload have a reduced concentration. It is suggested that these phenomena may be a result of reduced ascorbate catabolism in iron-deficiency anaemia and they provide support for the suggestion that the amount of iron in the tissues may be an important factor in determining ascorbic acid utilization.

Adolescent↗