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Biomedical subjects

A Helgeland

Publications and source records attributed to A Helgeland.

At least 55 records · Page 3Linked to original sources
PubMed1980

Effect of propranolol and prazosin on blood lipids. The Oslo Study.

In 23 hypertensive men, aged 47-55, propranolol reduced serum high-density-lipoprotein (HDL) cholesterol by 13% reduced the ratio of HDL to low-density-lipoprotein (LDL)+very-low-density-lipoprotein (VLDL) cholesterol by 15%, increased total triglycerides by 24%, and increased serum uric acid by 10%. Prazosin reduced total serum cholesterol by 9%, LDL+VLDL cholesterol by 10%, and total triglycerides by 16%. These changes are statistically highly significant. On combined treatment with propranolol and prazosin HDL cholesterol was still significantly reduced but changes in other blood lipids were small and insignificant. Uric acid remained elevated. When decisions about long-term therapy are made, such metabolic effects might be of special importance.

Cerebrovascular Disorders↗
PubMed1980

Treatment of mild hypertension: a five year controlled drug trial. The Oslo study.

In 1972--1973, 785 symptom-free men, aged 40 to 49 years, without target organ damage, with systolic blood pressures between 150 and 179 mm Hg and diastolic blood pressure below 110 mm Hg, were assigned at random to one of two groups: (406 to a drug treatment group and 379 to a control group) for a five-year controlled drug treatment trial to evaluate the effect of therapy on cardiovascular complications. Drug treatment started with hydrochlorothiazide. If systolic blood pressure remained above 140 mm Hg and/or diastolic blood pressure above 90 mm Hg, alphamethyldopa was added. If there were side effects, methyldopa was replaced with propranolol. The control group was not given a placebo. The mean observation time was 66 months (range 60 to 78 months). A difference in blood pressure between groups of about 17 mm Hg systolic and 10 mm Hg diastolic was maintained throughout the study. The study protocol had a rather low "ethical" blood pressure roof, 180 mm Hg systolic and/or 110 mm Hg diastolic. Seventeen percent of the control group had an increase in blood pressure above this level during the trial, and drug treatment was started. There was no effect on major cardiovascular morbidity comparing groups as established by randomization, with 18 events in the treatment group and 20 events in the control group. There was no difference between the groups in total mortality and mortality from cardiovascular events. However, in the subgroups with diastolic blood pressure greater than or equal to 100 mm Hg before randomization, there was a probable reduction in total morbidity from cardiovascular events in favor or the group receiving drug therapy, 7.6 and 16.4 percent events in the treated and control groups, respectively. Cerebrovascular events occurred only in the control group, 7 versus 0. Two cases of fatal aortic aneurysms also occurred in the control group. Other "pressure" complications, such as marked left ventricular hypertrophy in the electrocardiogram and left ventricular failure, occurred only in the control group. However, regarding coronary heart disease, including sudden death, the incidence tended to be higher in the treated group, although it was not statistically significant. Only 13 men (1.7 percent) failed to meet for regular examinations. At the end of the study these men were also followed up with regard to possible cardiovascular events.

Adult↗
PubMed1980

Four and two-thirds years incidence of coronary heart disease in middle-aged men: the Oslo study.

The association between four and two-thirds years incidence of coronary heart disease (CHD) and serum cholesterol, blood pressure (BP), height, body weight, cigarette smoking and physical activity at work and at leisure, was studied in 14,816 Oslo men, aged 40-49 years at entry to the study and free of cardiovascular disease and diabetes. Serum cholesterol is a stronger predictor for CHD than the other continuous factors studied in this cohort. The predictive power was only moderately increased by combining cholesterol, systolic BP and cigarette smoking. The risk ratio between men physically active and sedentary at leisure was 1:3. Only 35% of this difference could be explained by the other risk factors. The epidemiology of CHD in Oslo in relation to serum cholesterol and BP was found to be unchanged from that found in a previous study in Oslo.

Adult↗
PubMed1980

Patient reaction to information and motivation factors in long-term treatment with antihypertensive drugs.

In order to learn more about the patient-physician relationship, various aspects of information and communication, patient desires and complaints, a questionnaire form was mailed to three groups of male hypertensive patients. Group A consisted of 264 patients, response rate 61% (160 patients), originating from the employees' health service at two factories in Norway, and groups B (drug-treated) and C (not drug-treated) comprised 441 patients, response rate 82% (362 patients), and 328 patients, response rate 81% (265 patients), respectively, from the hypertension trial of the Oslo Study. Information and/or communication failure was observed in all groups, more in group A than in groups B and C. More information was wanted by 50--75% of the patients, especially in written form. More than one half of the patients expressed complaints which might have been misinterpreted as being due to drug treatment. With the exception of asthenia/drowsiness, impotence and podagra, which occurred more frequently in group B than in group C, the pattern of complaints was similar in these two groups.

Adult↗
PubMed1980

Four-year mortality by some socioeconomic indicators: the Oslo study.

The association between four-year mortality and some socioeconomic indicators has been studied in al Oslo men aged 40--49, invited to a screening programme for cardiovascular disease, and in a 'healthy' subgroup of participating men free of cardiovascular disease and diabetes at screening. The lowest social class exhibited a much higher total mortality than the other classes. This was pronounced for a variety of causes of death, such as cancer of the lung, accidents and homicide, and coronary heart disease. The negative mortality gradient by increasing socioeconomic status can to a certain degree be 'explained' by the coronary risk factor pattern.

Achievement↗
PubMed1980

Serum insulin response to oral glucose load during a dietary intervention trial in healthy coronary high risk men: the Oslo study.

The effect of an ordinary lipid-lowering diet on serum insulin response to oral glucose load was investigated in a randomized, primary preventive trial of the Oslo Study of coronary heart disease in healthy high risk middle aged men. After 3 years intervention the treated group showed a significantly lower insulin response curve, a lower serum total cholesterol, a higher cholesterol ratio (defined as the ratio between high density lipoprotein cholesterol and low density + very low density lipoprotein cholesterol), lower fasting triglycerides and lower relative body weight than the control group. Increased levels of serum insulin and elevated insulin response to oral glucose load has been shown in earlier studies to be associated with increased susceptibility for atherosclerotic diseases. Therefore, it might be of importance, that lipid-lowering diet induce a lowering of serum insulin response in healthy, coronary prone men. As a contrast to the two high risk groups, the very low response curve of serum insulin and glucose in a group of coronary low risk men is also presented, and it is suggested that serum insulin levels should be added to the coronary prone syndrome of hyperlipidemia, obesity and physical inactivity.

Adult↗
PubMed1979

High density lipoprotein cholesterol and myocardial infarction or sudden coronary death: a prospective case-control study in middle-aged men of the Oslo study.

The high density lipoprotein (HDL) cholesterol concentrations of frozen specimen obtained in 1972-73 are reported from 93 men aged 40-49 years who later developed coronary heart disease (CHD), and for 186 controls. Mean HDL cholesterol of CHD-patients was 7.9% lower than that of controls matched for smoking habits and serum concentrations of triglycerides and total cholesterol (p 0.05 for 82 men who had myocardial infarction, n.s. difference for 11 with sudden coronary death), and 10.2% lower (p 0.05) than that of controls who were not matched for the parameters mentioned. The present prospective study confirms that HDL cholesterol is inversely associated with the risk of developing CHD in middle-aged men.

Adult↗
PubMed1978

Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study.

Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension. The results come from 300 men after three years of follow up; 150 men in the treatment group and 150 men in the control group. The treatment has been standardized starting with hydrochlorothiazide alone and adding alpha methyldopa when necessary. In case of side effects, alpha methyldopa was replaced with propranolol. Pretreatment results demonstrated a strong covariation among body weight, uric acid and triglycerides. In the entire treatment group, there was no significant change in triglycerides after three years (increase from 1.85 to 2.02 mM/liter, P greater than 0.05). Cholesterol was also unchanged. Further analysis showed that certain patients reacted with an increase in triglycerides during treatment: those prone to a distinct increase in uric acid and those gaining weight. Those who needed combination therapy (having the highest pretreatment blood pressure) showed most of the increase in triglyceride and uric acid. In the group treated with hydrochlorothiazide alone, the triglycerides were unchanged. However, those selected from this group with a distinct increase in uric acid also showed an increase in triglycerides. The treatment increased the pretreatment positive correlation between uric acid and triglycerides.

Adult↗