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Biomedical subjects

A Frigerio

Publications and source records attributed to A Frigerio.

At least 37 records · Page 2Linked to original sources
PubMed1988

Inter-observer variability in the interpretation of mammograms.

Inter-observer agreement was tested in the interpretation by 8 radiologists of mammograms from 45 women (for a total of 180 films per radiologist). The radiologists were representative of the whole range of those involved in mammography in the town of Torino, with a number of films read per year ranging from 100 to 4000. Out of the 45, 9 women were affected by breast cancer (histologically proved), 25 had benign disease (diagnosed with fine-needle aspiration) and 11 had normal breasts. Weighted kappa values were in the range 0.27-0.82 (median 0.60) for parenchymal patterns; 0.33-0.67 (0.48) for diagnosis in five categories; and 0.22-0.57 (0.38) for indications for further diagnostic tests. These values are comparable with those reported from other investigations.

Breast Neoplasms↗
PubMed1988

[Echo-guided adrenal needle biopsy in the staging of lung tumors. Preliminary evaluation].

In patients with lung tumors adrenal masses can represent metastases, hyperplasia, adenoma or other benign lesions, most of which can be asymptomatic. Although the sensibility of US and CT in the diagnosis of adrenal metastases is very high, their specificity is somehow less satisfactory. The risk of overstaging operable pulmonary tumors is therefore present. US-guided FNB can yield material enough for cytologic and, in some cases, histologic evaluation, thus offering a reliable solution to the clinical problem in selected cases. Our experience with US-guided percutaneous mono or bilateral FNB of adrenal masses with Chiba and/or Otto needles in 14 patients with pulmonary neoplasms is reported. The use of Otto needle is suggested in the largest adrenal masses or when histology of the primary neoplasm is unknown. Bilateral cytological FNB is suggested in borderline lesions.

Adrenal Gland Neoplasms↗
PubMed1986

Cimetropium bromide as a relaxant for the radiological examination of the stomach and duodenum.

A study was carried out to evaluate the efficacy of two different doses of a new hypotonizing agent, cimetropium bromide, as a premedication for X-ray of the stomach and duodenum. Forty consecutive patients were allocated at random to two groups and treated intravenously in double-blind fashion with 5 mg or 10 mg cimetropium bromide. The drug was administered immediately after the first phase of an upper gastro-intestinal series had been completed. Duration of the drug-induced hypokinesia was recorded fluoroscopically. The hypotonizing effect was evaluated by measuring the diameters of the gastric antrum, duodenal bulb and loop on the pre-injection and post-injection radiographs. In both groups, the relaxant effect started promptly (within 1 minute of injection) and lasted for an average of 10 minutes, which was considered adequate for the study. There were no statistically significant differences between the two groups in relaxant activity. The treatments were scored arbitrarily as 'excellent' in 75% of the examinations after the 10 mg dose and in 60% after the 5 mg dose. The difference between the two groups was not significant. Side-effects were few, of mild entity and not dose-related.

Adult↗
PubMed1986

[Mammography using stationary grids. Qualitative and dosimetric considerations].

The authors report their experience with ultra-high-strip-density (UHSD) stationary grids in mammography, based upon dosimetric measurements carried out in a phantom and mammographic examination of 62 patients. Utilization of UHSD grids made it necessary an increase in radiation exposure by a factor 3.5 in a breast 5 cm thick 50% water and 50% fat by weight. Improvement in image-quality is apparent with voltages not exceeding 30 kV, particularly in cases of questionable masses within areas of locally increased breast density. The authors believe that UHSD grids may be useful in selected cases, such as in the performance of adjunctive whole-breast or locally aimed radiograms and in the radiological examination of surgical specimens.

Female↗
PubMed1985

Liquid chromatography with pre-column dansyl derivatisation and fluorimetric detection applied to the assay of morphine in biological samples.

A simple method employing pre-column dansylation and liquid chromatography is proposed for a very sensitive and specific assay of morphine in biological samples. Nalorphine is used as an internal standard. The detection limit is 0.2 picomol of injected morphine. In the assay of human sera spiked with 150 nmol/l, the intra- and inter-assay coefficients of variation were 3.7% (n = 10) and 4.5% (n = 10), respectively. No interferences were observed from more than 70 opiate and non-opiate drugs. Urine, plasma and total blood were assayed, using different extraction methods, with negligible interference from coextractives.

Chromatography, High Pressure Liquid↗
PubMed1979

In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine.

Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule. Its in vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified: dibenzo [c,f] - [1,2]diazepine-1-N-oxide and a monohydroxyderivative in the aromatic ring.

Animals↗
PubMed1979

In vivo studied on the metabolism of dibenzo [c,f]-[1,2] diazepine.

The in vivo metabolism of dibenzo [c,f]-[1,2] diazepine (I) was studied after i.p. administration to rats, in order to observe the influence of the heteroatom on the metabolic pathway. Metabolites were separated by chromatography and their structures elucidated by mass spectrometry, by both gas chromatography coupled with mass spectrometry and the direct inlet system. Six metabolites were identified, some of them by direct comparison with authentic samples.

Animals↗
PubMed1978

[Reaction of ortho-ortho-dimethylphenacyl-halides with formamide. Formation of 4(5)-(ortho-ortho-dimethylbenzoyl)imidazoles].

Reaction of 2,3,5,6-tetramethylphenacyl halides with formamide did not produce the expected 4(5)-(2,3,5,6-tetramethylphenyl)imidazole, but 4(5)-(2,3,5,6-tetramethylbenzoyl)imidazole (VII) was isolated as the major product together with 5-(2,3,5,6-tetramethylphenyl)oxazole (III), alpha-formylamino-2,3,5,6-tetramethylacetophenone (IV) and alpha-chloro-beta-amino-vinyl 2,3,5,6-tetramethylphenyl ketone (IX) as by-products. The corresponding mesitylene derivatives gave analogous results, whereas 4(5)-(2-methylphenyl)imidazole was obtained from 2-methylphenacyl bromide as expected according to the Bredereck's reaction. The structure of the isolated compounds were elucidated by element analysis, mass, I.R., U.V. and N.M.R. spectra, and by chemical reactivity.

Acetophenones↗