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Biomedical subjects

A Fazekas

Publications and source records attributed to A Fazekas.

At least 109 records · Page 6Linked to original sources
PubMed1980

Circulatory effects of intraduodenal acidification in the rat.

The effect of intraduodenal administration of 0.3 ml/100 g 0.1 N hydrochloric acid and of the i.v. injection of 0.3 U/100 g secretin on the regional circulation was investigated in rats with the radioactive microsphere method. Intraduodenal acid produced a threefold increase in duodenal blood flow, jejunal perfusion was doubled, the perfusion of pancreas increased significantly. There were no significant changes in cardiac output, renal, myocardial, gastric and ileal blood flow. Secretin administration was without effect on the circulation. The same hormone dose produced a tenfold increase in pancreas secretion but was without effect on bile output. It is concluded that in the rat low doses of secretion do not elicit mesenteric flow changes similar to those observed after duodenal acidification.

Animals↗
PubMed1980

Measurement of regional blood flow with sulfanilamide (4-amino benzene sulfonamide).

A new technique utilising sulfanilamide (4-amino benzene sulfonamide) as a diffusible indicator is described for the measurement of organ blood flows in the rat. After a bolus injection the indicator is rapidly distributed in the tissue water and in most organs its tissue-blood partition coefficient corresponds to the relative water content of the organ. Sulfanilamide is, however, rapidly secreted by the renal tubules and slowly acetylated in the liver. This difficulty can be eliminated by the introduction of appropriate partition coefficients. The organ blood flows estimated with sulfanilamide were in the same animals compared with flows obtained by the 8Rb-uptake and by the radioactive microsphere techniques, and a high correlation was found between the flow values obtained by the different methods [sulfanilamide-86Rb; r = 0.992; sulfanilamide-MS: r = 0.995]. The merits and disadvantages of the individual methods are discussed.

Animals↗
PubMed1980

Immunogenicity studies of foot and mouth disease vaccines at different concentrations of antigen and saponin.

Frenkel-type monovalent O1 and C vaccines were tested for immunogenicity under field conditions, in a large cattle farm. Both vaccines were applied in four dilutions, to furnish different concentrations of antigen, and each dilution was tested with 4 and 8 mg/dose levels of saponin, and without adjuvant. In adult multivaccinated already one eight of the standard bovine dose of both preparations developed a satisfactory booster effect, and presence or absence of the adjuvant played little role. In the growing (5-7 months old) primary vaccinated immune response to vaccination depended on the applied dose of antigen; the higher the latter, the firmer immunity was developed. The immunogenicity-enhancing effect of saponin, too, was more pronounced in the young than in the adult vaccinated. The result of the immunization was significantly improved by the use of 8 mg saponin per dose, compared to that found with 4 mg or no adjuvant in the vaccine. The best vaccination results were obtained on combination on the highest antigen conentrations with 8 mg saponin/dose. The type O1 antigen proved to be about half as strong, as the type C one, having elicited the same degree of immunity as C in a roughly double dose.

Animals↗
PubMed1979

Evaluation of 133Xe clearance curves in the study of lingual blood flow in dogs.

Lingual blood flow was studied in dogs by the 133Xe clearance technique under control conditions, during epinephrine infusion in response to the combined treatment with Regitin and epinephrine. The composite washout curves recorded during control conditions could be resolved into three monoesponential components. It is suggested that the steep initial slope (component I)is caused by the fraction of blood that perfuses the A-V anastomoses of the tongue. Component II and III appear to the effect of epinephrine infusion might indicate the closure of arterio-venous anastomoses containing alpha receptors. Regitin pretreatment could prevent the closure of the arterio-venous anastomoses elicited by epinephrine infusion. The beta receptor stimulating activity of epinephrine migh account for the augmentation of blood flow to lingual musculature.

Animals↗
PubMed1979

[Not Available].

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History, Ancient↗
PubMed1979

Effect of renal vasodilatation on intrarenal blood flow distribution.

Total renal blood flow (TRBF) and its intrarenal and intracortical distribution were measured before and during renal vasodilatation induced by acetylcholine infusion using the 133Xe washout, 86Rb uptake and radioactive microspheres distribution techniques. A good agreement was observed between TRBF calculated from 133Xe washout and measured with the electromagnetic flowmeter (FM). 86Rb-TRBF was lower than FM-TRBF and, due to the progressive reduction of renal 86Rb uptake, the difference increased with the increase of flow. With the alteration of TRBF the intrarenal distribution of 86Rb uptake did, however, not change significantly and, accordingly there was no redistribution of RBF either between the cortex and medulla, or among the individual cortical zones. The intracortical distribution of labelled microspheres showed, however, moderate flow dependent changes: with the rise of TRBF, due probably to the reduction of the steric hindrance, the estimated fractional perfusion of the inner cortical zones increased. The sum of the per cent 86Rb content of the innermost cortical zone (C4) and of the medulla exceeded the per cent microsphere content of zone C4. It is concluded that the medulla is perfused not exclusively with blood flowing from the juxtamedullar glomeruli. The regional flow values obtained from the 133Xe curves are not comparable with the results obtained by other methods and cannot be attributed to well defined areas of the kidney.

Acetylcholine↗
PubMed1978

[Not Available].

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General Surgery↗
PubMed1978

[Not Available].

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History of Pharmacy↗