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Biomedical subjects

A Fazekas

Publications and source records attributed to A Fazekas.

At least 127 records · Page 7Linked to original sources

The effect of haemorrhage on renal blood flow and intrarenal flow distribution.

Bleeding of dogs to constant arterial pressure of 90 mm/g and 60 mmHg respectively decreased renal blood flow in proportion to pressure reduction. There was no evidence of autoregulation of renal blood flow or of selective renal vasoconstriction. With the radioactive microsphere technique a moderate shift of blood flow from the outer to the inner cortex was observed. In the renal 133Xe wash-out curves exponent 1(attributed to the elimination of the indicator from the cortex) was more reduced than exponents 2 and 3 (medulla). These findings may not indicate a redistribution of renal blood flow through resistance changes in specific parts of the renal vasculature but may represent the consequences of focal cortical ischaemia, most prominent in the outer cortex.

Animals↗

[Not Available].

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History of Pharmacy↗

Renal blood flow during ureteral obstruction measured with 133Xe wash out, 86Rb uptake techniques and with an electromagnetic flowmeter.

In moderate mannitol diuresis in the dog the ratio RBF-86Rb uptake/RBF-electromagnetic flowmeter decreased during ureteral obstruction from 0.923 - 0.705. In the same animals the ratio RBF-133Xe wash-out/RBF-electromagnetic flowmeter increased from 0.932 - 1.365. With the rubidium technique a significant redistribution of intrarenal blood flow was observed. No similar flow changes were seen with the 133Xe wash-out technique. The two methods do not measure during ureteral obstruction the true RBF. The change of 86Rb uptake by the individual segments of renal tissue is not an unequivocal proof for the intrarenal redistribution of blood flow, but this possibility cannot be definitely excluded.

Animals↗

[Not Available].

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Cholera↗

Efficiency testing of foot--and--mouth disease vaccines prepared from strain "C" with different adjuvants.

Various oil adjuvants were tested for immunogenicity enhancing action in "C" type FMD monovaccine preparations. The following composition proved to be optimal in mouse tests: Bayl F 85%, Arlacel A 14% Tween 80 1%. As to the quantitative relations of antigen adjuvant, 40% oil to 60% antigen was the best among all proportions tested. Oil-adjuvanted vaccines failed to evoke an immune response in calves, but proved to be the preparation of choice for adult cattle. Oil containing and DEAE-dextran-containing vaccines had an equal efficiency in pigs; both conferred full protection on one in three pigs treated with 2.5-fold bovine doses. The number of vaccinated pigs was too small to permit definitive conclusions, but it seems clear that only oil dextran are efficient adjuvants of FMD vaccines for pigs, and that the antigen component of such vaccines should be increased considerably in order to obtain a greater potency.

Adjuvants, Immunologic↗

[Not Available].

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History, Modern 1601-↗

[Not Available].

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History, Modern 1601-↗