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Biomedical subjects

A F Frolov

Publications and source records attributed to A F Frolov.

At least 55 records · Page 3Linked to original sources
PubMed1986

[New principles and criteria in assessing pathogenic and opportunistic microorganisms].

Using the ecological and natural-science approaches, the authors have come to the conclusion that microorganisms, pathogenic for humans (animals), are their parasites for whom the disease of their biological host is the necessary condition of their existence as a biological species. And accordingly, microorganisms, opportunistic in humans (animals) are their parasites and commensals, as well as saprophytes, for whom the disease of their host is not the necessary condition of their existence in nature. The biological host is a symbion necessary for the existence of pathogenic and most opportunistic microorganisms, but for a pathogenic microorganism the disease of the host is the result of symbiotic relationships, while for an opportunistic microorganism the disease of the host is the consequence of disturbances in symbiotic relationships. Such view of pathogenicity is important for creating a scientifically grounded theory of the liquidation of human infectious diseases.

Animals↗
PubMed1985

[Circulating immune complexes in the pathogenesis of recurrent erysipelas].

The dynamics of circulating immune complexes (CIC) in comparison with the level of SH-groups of serum deproteinate and other characteristics of cell-mediated and humoral immunity (the reaction of the inhibition of antibodies, the levels of T-cells and their main subpopulations) was studied in 103 erysipelas patients and in 46 persons having had the disease at the acute period of this infection and at the periods between relapses. The elevated levels of CIC and SH-groups of serum deproteinate were found to be directly correlated with the inhibition index. The study showed that, as a rule, in patients with the elevated level of CIC the frequently relapsing form of erysipelas, accompanied by the formation of relative hypersuppressor-type secondary immunodeficiency and by a decrease in the functional activity of dermal macrophages, was observed.

Acute Disease↗
PubMed1985

[Sensitivity of Proteus mirabilis to drugs in the presence of human blood serum].

For rational antibiotic therapy of patients with persisting bacterial infections, the routine determination of antibiotic resistance in the microorganisms may be insufficient. In this case estimation of the total bactericidal activity of the antibacterial drugs and sera against the causative agents is required. It was shown experimentally that in the presence of human blood sera sensitivity of the P. mirabilis strains to benzylpenicillin, ampicillin, gentamicin, kanamycin and cephaloridin increased, the sensitivity to rifampicin varied and the sensitivity to chloramphenicol and nalidixic acid lowered. The quantitative indices of the sensitivity depended on the biological properties of the strains. The bactericidal activity of the human blood sera lowered under the action of nalidixic acid, chloramphenicol and rifampicin, with the concentrations of the antibacterial drugs being equal to those attained in the blood of patients during chemotherapy. A method for determination of the bactericidal activity of human blood sera in the presence of the antibacterial drugs with the use of P. mirabilis is described. The method is relatively simple and provides satisfactory coincidence of the results indicative of the nonspecific resistance of the blood. This allows the physician to choose the rational antibiotic therapy.

Anti-Bacterial Agents↗
PubMed1984

[Use of interferon inducers in treating viral diseases].

The results obtained in the experimental and clinical study of the preparations of mephenamine acid and levamisole with respect to their interferonogenic and interferon-stimulating action and their therapeutic effectiveness in influenza and virus hepatitis are presented. The study has revealed that mephenamine acid, along with its capacity for stimulating the processes of interferon formation in the body, produces a pronounced curative effect, prevents the development of postinfluenza complications much more effectively than levamisole and remantadin and accelerates the processes of reparation in virus hepatitis.

Adolescent↗
PubMed1984

[Significance of bacteremia in the development of immunological memory suppression in Shigella sonnei infection in mice].

Experiments on mice infected intraperitoneally with S. sonnei have revealed that the level of bacteriemia is directly related to the duration of the blocking of immunological memory constituting the basis of secondary humoral and cell-mediated immune response. The transfer of syngeneic splenocytes from immunized mice has demonstrated that virulent S. sonnei directly affect the immunological memory cells.

Animals↗
PubMed1984

Peculiarities of influenza infection caused by highly and poorly immunogenic strains of influenza virus.

The authors studied the peculiarities of the course of experimental influenza infection induced by the administration of highly and poorly immunogenic strains of influenza virus to mice. Influenza viruses with varying immunogenic activity were obtained from the vaccine strain A/Victoria/35/72/50 (H3N2) by immunoselection modelling the process of natural selection. The administration of strains with high and poor immunogenicity to mice of the F1 (CBA X C57B1) line led to the development of acute influenza infection accompanied by reproduction of viruses in the tissue of the lungs and other internal organs. The poorly immunogenic strain 5/II-Victoria, unlike the initial virus A/Victoria/35 and its highly immunogenic variant 2/I-Victoria, is able to circulate for a long time in the organism of the infected animal causing development of chronic inflammatory processes and stimulating the formation of neoplasms. Immunogenicity is thus one of the factors determining the character of the course of experimental influenza infection. A conclusion was drawn concerning the epidemiological and aetiological importance of viruses with reduced immunogenicity and their role in the evolution of influenza virus. It is presumed that reduced immunogenicity is one of the adaptation mechanisms of aggression permitting the population of influenza virus to escape control by specific humoral immunity.

Animals↗