Biomedical subjects
Publications and source records attributed to A Dietz.
This report of a case of acute transverse myelitis, after otherwise uneventful varicella, further stresses the importance that the possibility of this relatively rare complication should be kept in mind in patients developing a paraplegic syndrome late in the course of the disease.
Simultaneous observational recordings were made in vivo, via an observation mirror, and via closed circuit television. Three of nine observers had extensive experience recording behavior in vivo; three had extensive experience recording behavior via mirror; and three had extensive experience recording via television. Observers recorded nine categories of disruptive behavior for children in a special class setting. Frequencies of behavior recorded in vivo, via mirror, and via television differed significantly for only one category, vocalization. There were no significant main effects or interactions involving the observers' previous experience. Occurrence reliability coefficients computed within and between media demonstrated the similarity of observer agreement in all three media. Data collection procedures using an observational mirror or closed circuit television appear to be reasonable alternatives to in vivo observation in circumstances similar to those in the present study.
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Since introduction of the new image intensifier generation coronary calcification has become a common finding during fluoroscopy. Nearly one quarter of all patients over 40 years have calcified coronary vessels, men twice as often as women. More than two thirds of all these patients have coronary heart disease. Patients with coronary calcification suffer more often than those without from risk diseases of atherosclerosis, especially of coronary heart disease. The calcification means in most cases a lumen reduction of the vessel and is predominantly located in the left coronary artery. Other uncalcified stenoses exist very often, i.e. multiple vessel disease is a very common finding in these patients. The x-ray sign confirms the diagnosis "coronary heart disease" if there are other suspicious findings but it has not rarely its own value in comparison with other non-invasive examination methods in the diagnosis of coronary heart disease.
515 women and 372 men from a rural community of 2862 inhabitants over 14 years volunteered to participate in a screening test for risk factors. We found an exceptionally high percentage of hypertension and hypercholesterolaemia as well as overweight. Women were more frequently affected than men except for smoking, which occurred 3,6 times more often in men than in women. Since the life expectancy of men in this community was clearly lower than that of women, smoking seems to have the most weight as a risk factor for cardiovascular diseases.
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A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp.n. The antibiotic is biologically active at extremely low concentrations. At 40 pg/ml, it inhibited 90% of the growth of L1210 cells in culture in tube dilution assays. The minimal inhibitory concentrations against Gram-positive bacteria is between 1 approximately 10 ng/ml, while these values for Gram-negative bacteria and fungi are mostly under 1 microgram/ml. A microbiological assay with Bacillus subtilis can detect concentrations of 1 approximately 2 ng/ml.
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We performed coronary angiography in eighty subjects with radiographically diagnosed coronary calcification. Radiographically proven coronary calcification is highly specific for coronary heart disease. Within certain limitations it helps in locating stenoses and is present more frequently in multiple vessel disease. It sometimes detects coronary artery disease missed by other non-invasive methods.
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There has, up to now, not been general acceptance in the German literature of a definite relationship between radiologically visible coronary calcification and coronary heart disease. Anglo-American authors in general agree with our coronographic findings, which show a significantly increased incidence of such coronary changes in stenosing coronary artery disease. In a random sample of patients over 40 years of age, coronary calcification was found radiographically in 25%. Two-thirds of these patients were more than 60 years, but one quarter of the 50 to 60 year age group, and 15% of the 40 to 5-year age group showed these findings. In one group of 150 patients with coronary calcification, 68.9% suffered from coronary heart disease, 7.9% were suspicious and 23.2% had no symptoms. Conversely, in 100 patients with coronary heart disease, coronary calcification was present in 42. Calcification in several vessels was confined almost entirely to patients with advanced coronary disease. Coronary angiography in patients with normal E.C.G.'s, both at rest and after exercise, usually showed some reduction in the lumen corresponding to the area of calcification. In these patients the prognostic significance of the calcification in terms of further development of atherosclerosis must be considered. The localisation of the calcification in these cases is of significance. The clinical features, histology, localisation and investigation of the calcification by radiography is discussed. In our view this has considerable significance in the screening of coronary heart disease.
IBR virus was found to replicate in WI-38 cells. At a high input multiplicity the virus yield was comparable to that obtained in bovine cells, but comparable degree of CPE took longer to achieve. At a low input multiplicity of IBR virus, such as may be encountered in virus contaminated bovine serum, virus yield was only about 1% of that in bovine cells, with 50% of the cells showing CPE, followed by cell regrowth. Infectious virus was not recoverable from the regrown cells by 5 weeks after initial infection, and these regrown cells were susceptible to reinfection with IBR virus. Aging of WI-38 cells in cultures for as little as 1 week reduced IBR virus yield to 90% less than the yield from the same lot of cells inoculated 7 days earlier.
A new variety of Streptomyces hygroscopicus was isolated from a Kalamazoo soil. This isolate is described and identified as var. geldanus. When fermented in preferential media it produces geldanamycin, nigericin, nocardamine, and a libanamycin-like activity. Fermentation conditions, chromatographic separation, and antimicrobial spectra of the antibiotics are given.
A new antitumor antibiotic, U-43,120 was discovered. It is produced by fermentation of a new species of Streptomyces, designated Streptomyces paulus DIETZ sp. n. Its antimicrobial activity is limited to bacteria. A microbiological assay with Bacillus subtilis was developed that can be detect concentrations of 1 approximately 2 mug/ml of the drug in fermentation liquors. U-43,120 was active in vivo against P-388 leukemia in mice.