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Biomedical subjects

A Denys

Publications and source records attributed to A Denys.

At least 127 records · Page 7Linked to original sources
PubMed1985

Phagocytic and bactericidal activities of neutrophils in duodenal ulcer patients during cimetidine treatment.

Phagocytic and bactericidal activities of neutrophils relative to Staphylococcus aureus 209 P strain were studied in 16 duodenal ulcer patients who were intravenously administered cimetidine in doses of 4 X 200 mg for 8 days and in a group of untreated healthy subjects. The investigations were made before the treatment on the last day of cimetidine administration, and one week after drug withdrawal. The bactericidal activity of neutrophils was found to be higher in duodenal ulcer patients than in the healthy controls. Cimetidine does not have a significant effect on the phagocytic activity of neutrophils and it has a moderately inhibitory effect (p less than 0.05) on the bactericidal activity relative to the ingested intracellular bacteria. This shows that cimetidine may modify some of the neutrophil functions in duodenal ulcer patients.

Adult↗
PubMed1982

Phagocytic and bactericidal activity of granulocytes in diabetic children.

Phagocytic and bactericidal activity of granulocytes were estimated in granulocytes of normal and diabetic children. The influence of candidal, tuberculin antigens, and staphylococcal antitoxin on these parameters was also tested. Thirty diabetic and forty healthy children made up the study group. Their ages were 6-18 yr. The disease duration was from 1 to 12 yr. Granulocytes from diabetic children demonstrated a normal ability to absorb staphylococcus. On the other hand, the capacity for intercellular killing of bacteria by granulocytes of diabetic children was decreased.

Adolescent↗
PubMed1982

Complex studies of the influence of the working conditions in the Plock Petrochemical Plant on the behaviour of some parameters of cell immunity.

Complex evaluations of the function of peripheral blood granulocytes in the Phenol Plant workers were made. Only precise examinations of the bactericidal and ingestive functions as well as the metabolism of those cells may lead to the discovery of a clinically unnoticeable insufficiency of the system as has been confirmed by other authors and by our own previous studies. Routine methods of separating granulocytes of heparinized peripheral blood were used. Phagocytic activity of cells after contact with three antigens was studied. Bactericidal activity of granulocytes in the presence of Staph. aureus and antibactericidal activity of lysosomal proteins of granulocytes were evaluated. According to the general assessment, no permanent disturbances of the granulocyte function were observed in the phenol plant workers. However, disturbances of the phagocytic and bactericidal abilities were detected in some individual cases. In general evaluation no disturbances of function of granulocytes concerning all some cases phagocytary and bactericidal abilities did not occur simultaneously.

Acid Phosphatase↗
PubMed1980

Bactericidal properties of lysosomal proteins obtained from human polymorphonuclear leucocytes (PMNL) examined in vitro. I. Characteristics of obtained fractions of lysosomal proteins.

In the present investigation the fractions obtained from lysosomal proteins of human peripheral blood granulocytes were analysed morphologically. In the analysis a column with DEAE-cellulose and ultracentrifugation in stepwise saccharose were employed. Electro-microscopic examinations of every fraction of lysosomes pointed to their morphological differences; the highest contents of lysosomal bags was noted in fraction number III. Correlations between activity of "indicatory" enzymes and content of protein and bactericidal activity in four studied fractions were discovered.

Acid Phosphatase↗
PubMed1980

Bactericidal properties of lysosomal proteins obtained from human polymorphonuclear leucocytes (PMNL) examined in vitro. II. Morphological estimation of cells treated with lysosomal proteins.

The present paper is concerned with the action of lysosomal proteins isolated from granulocytes of human peripheral blood on Gram-plus and Gram-minus bacteria. Differences in bacterial sensitivity to these proteins were found. The highest bactericidal activity was observed while bacteria from Staphylococcus and Escherichia were treated with lysosomal proteins. No structural changes in cells of bacteria from Streptococcus and Mycobacterium tuberculosis were observed. The sensitive bacteria cell walls underwent destruction mainly but changes also concerned cytoplasma which was destroyed.

Bacteria↗