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Biomedical subjects

A D Ado

Publications and source records attributed to A D Ado.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Allergy as a typical pathological process].

Allergic reactivity has features of a typical pathologic process and can not be regarded as a "mistake" in the function of the immune system. The sensitivity of the allergic reactivity indicating the entrance of antigenic material into the organism is essentially greater than the sensitivity of all other known reactions of immunity. Reactions on the membrane of target cells after antigen-antibody-reaction are not followed by cell damage. Cellular changes after release of allergic mediators are the same ones as in other secretory cells. The mediator liberation is not a result of alteration but of an activation of target cell functions. Allergy developed in the evolution after formation and on the base of immunity and inflammation. Allergy is the combination of specifity of immunologic reaction and more general effects of inflammation. Insufficiency of tissue barriers may be caused by genetic or environmental factors. This insufficiency is possibly the main factor "to be or not to be" of allergy. The allergic reactivity is not an exception but the rule, if an antigen enters into the organism.

Antigen-Antibody Reactions↗
PubMed1979

[Immunofluorescence studies of the immunoglobulin receptors of B-lymphocytes].

The surface membrane Ig receptors of B lymphocytes in patients with atopic pollen asthma were studied by the direct immunofluorescence method. Use was made of labelled sera against human IgE, and IgG. It was shown that on the average 2.1 +/- 0.33% lymphocytes had IgE receptors, 8.4 +/- 0.63% IgG receptors and 18.7 +/- 1.16% human globulin receptors. A specific nature of B lymphocytes is suggested.

Asthma↗
PubMed1977

[Allergic reactions of pulsating cardiac cells in culture].

The authors describe a method of cultivation and growth peculiarities in a culture of beating cells of the human embryo heart. The influence of homologous anticardiac antibodies and of the ambrosia allergen antiambrosia antibody complex on the contracting cells of the heart of chick and duck embryos was studied in a culture. Pulsation of the cardiac cells was delayed and weakened under the effect of these factors; their vacuolization developed.

Animals↗
PubMed1977

[Modeling experimental pollinosis].

Experimental pollinosis was modelled on guinea pigs. The animals were placed in a cell in which an allergen-water-dialyzed extract of ambrosia pollen was dispersed by means of coaxial pulveriser. Homocytotropic antibodies serving as indices of animal sensitization to the specific allergen formed in guinea pigs as a result of aerosol sensitization. Sensitization of the animals to the ambrosia allergen was accompanied by an increase of sensitivity of the broncho-pulmonary apparatus and was characterized by the bronchospastic reaction in resolving inhalation or inrtavenous injection of a specific allergen.

Aerosols↗