[Soviet allergology on the 60th anniversary of the Great October Socialist Revolution].
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Biomedical subjects
Publications and source records attributed to A D Ado.
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In experiments conducted on guinea pigs the sensitizing activity of Neisseria perflava isolated from the mucous membranes of the bronchi of patients with infectious asthma was studied. A possibility of reproducing active skin anaphylaxis after Ovary and of the contraction-test of the tracheal-chain by the neisseria antigens was shown. Neisseria perflava was found to possess a greater sensitizing activity than Staphylococcus aureus and Klebsiella pneumoniae inhabiting the bronchi of patients with infectious asthma.
The action of some dipeptides (Lalpha-alanyl-histidine, Lbeta-alanyl-histidine, histidyl-leicine and glycyl-histidine), and histidine on passive cutaneous anaphylaxis of guinea pigs was studied. Lbeta-alanyl-histidine (karnosine) and Lalpha-alanyl-histidine proved to inhibit the passive cutaneous anaphylaxis. Histidyl-leicine, glycyl-histidine, and histidine failed to produce any inhibitory effect on passive cutaneous anaphylaxis.
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An attempt was made of detecting antigenic similarity beyween the fraction of microsomes of the tissues of human broncho-pulmonary apparatus and the cells of microbes of human respiratory tract. Cross reactions of antimocrosomal sera were studied in the complement fixation test with Neisseria perflava and Klebsiella pneumoniae. Fixation of antibacterial antibodies and antibodies against the microsomal fraction of the lung tissues was studied on the sections of the lung tissues ahd human bronchi. The presence in the microsomal fraction of tissues of human bronchopulmonary apparatus of the antigens cross reacting with antimicrobial sera was demonstrated.
A study was made of localization in the cells of Neisseria perflava and Klebsiella pneumoniae of antigens common with the tissues of the human broncho-pulmonary apparatus. A study was made of cross reactions of some structures of Neisseria perflava and Klebsiella pneumoniae cells (capsule, walls, cytoplasmic structure fraction, hyaloplasm) in the complement fixation test with antilung sera. Antigens cross reacting with the antilung sera were localized not only in the surface structures (walls) of bacterial cells, but also in the "deep" components (cytoplasm fraction rich in ribonucleoproteids) of the microbe.
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