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PubMed · 6250293

[Allergy as a typical pathological process].

A D Ado·I S Gushchin
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Abstract

Allergic reactivity has features of a typical pathologic process and can not be regarded as a "mistake" in the function of the immune system. The sensitivity of the allergic reactivity indicating the entrance of antigenic material into the organism is essentially greater than the sensitivity of all other known reactions of immunity. Reactions on the membrane of target cells after antigen-antibody-reaction are not followed by cell damage. Cellular changes after release of allergic mediators are the same ones as in other secretory cells. The mediator liberation is not a result of alteration but of an activation of target cell functions. Allergy developed in the evolution after formation and on the base of immunity and inflammation. Allergy is the combination of specifity of immunologic reaction and more general effects of inflammation. Insufficiency of tissue barriers may be caused by genetic or environmental factors. This insufficiency is possibly the main factor "to be or not to be" of allergy. The allergic reactivity is not an exception but the rule, if an antigen enters into the organism.

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Antigen-Antibody ReactionsChemotactic Factors, EosinophilCyclic AMPHumansHypersensitivityHypersensitivity, ImmediateImmunoglobulin EImmunoglobulin GInflammationReceptors, ImmunologicEnglish AbstractJournal ArticleReview

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A D Ado, I S Gushchin. 1980-01-15. [Allergy as a typical pathological process].. https://pubmed.ncbi.nlm.nih.gov/6250293/

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