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Biomedical subjects

A Cole

Publications and source records attributed to A Cole.

At least 91 records · Page 5Linked to original sources
PubMed1985

Flexible benefits contain costs, are competitive, meet employee needs.

Healthcare organizations, like other businesses, are concerned with the costs of their employee benefit programs. They want to reduce their costs and yet remain competitive in the employee marketplace. One solution is the flexible benefits program. This program allows an element of choice in benefit coverage by permitting employees to choose one benefit over another, to trade one benefit for another, or perhaps to receive cash. Such flexibility allows the organization to contain costs by not paying for benefits employees do not want; remain competitive by offering an innovative benefit plan; and meet employee needs by offering benefits the employee wants or requires.

Community Participation↗
PubMed1985

Cell surface antigens of Bordetella pertussis.

Cell surface-specific radiolabelling techniques, monoclonal antibody analyses, and chemical and physical isolation of cell fractions were used to study the surface of B. pertussis cells. Four surface specific proteins were identified by radioiodination and monoclonal antibody techniques. These included the filamentous hemagglutinin (FHA), and three outer membrane proteins-OMP91, OMP18 and OMP15. Membrane blebs were isolated from culture supernatants and shown to contain LPSII, pertussis toxin (PT), FHA, OMP91, and OMP18, but not OMP15. The level of LPS I in blebs appeared to be reduced from the level in cell envelopes. Bleb fractions contained enzymatically active adenylate cyclase (AC), and biologically active dermonecrotic toxin (DNT) and PT. Blebs were also toxic for mice, even when heated to 80 degrees C for 30 minutes. To explain these data, we propose that membrane blebs comprise an effective toxin delivery system, and that the cell surface of B. pertussis is composed of at least two domains.

Adenylate Cyclase Toxin↗
PubMed1985

Evaluation of the opportunities for and contraindications to immunization in a tropical paediatric clinic.

The immunization status and frequency of contraindications to immunization were studied in 446 children attending the paediatric clinic of a teaching hospital in south India. In all, 27% of the children were up to date in their immunizations, 19% had a contraindication, and 57% required and could safely be given immunizations. A policy of offering immunizations in paediatric clinics to all who require them and who do not have a contraindication would result in protection of a significant number of unimmunized children.

Child↗
PubMed1984

Conversion reaction presenting as acute spinal cord injury.

A conversion reaction, presenting as an acute spinal-cord injury, was diagnosed in 9.8% of new patients admitted to a spinal injury unit during the period from November 1982 to November 1983. There were eight men and one woman (mean age, 23 +/- 8 years). A history of previous episodes of conversion reaction was common in this group. Some patients had evidence of previous vertebral damage. Diagnosis of this condition is difficult, even for those who are familiar with patterns of spinal-cord injuries. All patients were walking independently and had no sensory deficits at the time of discharge from hospital.

Acute Disease↗
PubMed1984

Spinal fluid kinetics of morphine and heroin.

Nine patients undergoing cardiopulmonary bypass surgery were given either 2 mg diamorphine or 2.5 mg morphine by intrathecal injection. Spinal fluid (sf) samples were collected over 25 min and drug concentrations measured by HPLC. Concentrations in sf were about 4000 times as great as after 1 mg/kg IV morphine. The kinetic properties of morphine and heroin in sf differed; diamorphine was removed from sf much more rapidly than morphine. Lipophilic opiates may be safer for intrathecal use because of the shorter life of substantial drug concentrations in the mobile sf phase.

Chromatography, High Pressure Liquid↗
PubMed1983

Metal binding by pharmaceuticals. Part 3. Copper (II) and zinc (II) interactions with isoniazid.

Formation constants for copper(II) and zinc(II) complexes of isonicotinoylhydrazine (isoniazid) and guanosine-5'-monophosphate have been measured potentiometrically at 37 degrees C, I = 150 mmol dm-3 [NaCl]. These constants have been used in computer models to assess the extent of complex formation by the drug in vivo. The simulations indicate that the predominant complexes existing in blood plasma are ternary species formed with histidinate. However, at clinical levels of isoniazid, it seems unlikely that these complexes are physiologically significant. On the other hand, ternary complex formation with nucleosides may be involved in the binding of isoniazid to viral RNA.

Copper↗
PubMed1981

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration.

Formation constants for copper(II) and zinc(II) complexes of dextro-2,2'-(ethylenediimino)-di-1-butanol (ethambutol) and its metabolic oxidation product, 2,2'-(ethylenediimino)-dibutyric acid (EDBA) have been measured potentiometrically at 37 degrees C, I = 0.15 mol dm-3 [NaCl]. The constants are used in computer models to assess the extent of the formation of these complexes in vivo. These simulations indicate that whereas ethambutol forms metal complexes only to a limited extent in vivo, EDBA competes effectively under physiological conditions for copper(II) and zinc(II). This study suggests that zinc(II) binding by EDBA may account for a number of side effects of ethambutol treatment.

Chelating Agents↗
PubMed1980

The refurbished pulse generator.

With the advent of long-life lithium pulse generators, normally functioning pulse generators with a potential life of more than five years have been removed from patients and become available for re-implantation. Although pulse generator refurbishing is widely employed, the practice has not been accepted in the United States. At The Royal Melbourne Hospital, all lithium pulse generators removed because of patient death or other causes were washed in a quaternary ammonium compound and soaked in formaldehyde. Pulse generators were than electronically tested and, if within specification, were made available for re-implantation. Pulse generators were then washed under sterile conditions in distilled water and gas-sterilized with ethylene oxide. Between 1975 and 1978 (48 months), 600 pulse generators were implanted and 93 pulse generators removed. There were 56 deaths, 22 cases of pre-erosion, erosion, or infection and 15 elective removals either due to lead problems or impending power source depletion. Eight-three (89%) pulse generators were refurbished (14% of total implants). This included 12 pulse generators refurbished on two occasions. Ten pulse generators were returned to manufacturers, seven because of impending power source depletion, two with suspected electronic faults, and one with a damaged case. Two complications occurred in patients with refurbished pulse generators. An infective process present with the previous pulse generator spread to a new pocket. The other pulse generator was removed 35 months post second implantation because of impending power source depletion. Primary infection or unusual tissue reactions did not occur. Pulse generator refurbishing as described was found to be a safe and economic procedure.

Electric Power Supplies↗
PubMed1980

A new iridovirus of two species of terrestrial isopods, Armadillidium vulgare and Porcellio scaber.

A new iridovirus, herein named isopod iridescent virus (IIV), was isolated from two species of terrestrial isopods in Berkeley, Calif. Infected individuals of Armadillidium vulgare and Porcellio scaber (Crustacea:Isopoda) appeared purple in color; in thin sections, hemocytes, nerve cells, and fat body cells contained cytoplasmic aggregations of virions. Isolated particles, 135 nm in diameter in negative stain, contained DNA had included at least 19 polypeptide components. The virus was transmitted per os and by injection to healthy isopods, and by injection to larvae of a coleopteran. IIV from the isopod hosts differed from Tipula iridescent virus (TIV) in buoyant density, molecular weights of major polypeptides, and serological reactions with antisera to IIV and TIV.

Antigens, Viral↗