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Biomedical subjects

A Cole

Publications and source records attributed to A Cole.

At least 109 records · Page 6Linked to original sources
PubMed1980

Replication of an Iridovirus in a nematode (Mermithidae).

An iridovirus was observed with the electron microscope in the tissues of a mermithid nematode parasitic in the isopods Porcellio scaber and Armadillidium vulgare. Virus particles were seen associated with virogenic areas in the cytoplasm along with viral stages suggestive of particle maturation. Extracts of portions of the same nematodes used for transmission electron microscopy appeared positive in serologically specific electron microscopy with antisera prepared against iridescent virus from the isopod hosts. These same extracts in 21 of 40 isopods produced infections when fed to P. scaber. This is the first report of a known virus replicating in a nematode and extends the host range of iridoviruses to the phylum Nematoda.

Animals↗
PubMed1979

The use of balloon-tipped electrodes for permanent cardiac pacing.

A new balloon-tipped ventricular endocardial electrode for permanent artificial cardiac pacing is described. Following transvenous insertion of the electrode to the right ventricular apex, the distal balloon is inflated with contrast material in order to wedge the electrode tip between or beneath trabeculae and prevent displacement. fifty-nine electrodes were implanted, including a second generation type incorporating a wedge tip as well as the balloon. The incidence of displacement was 17% with 10% of cases being early, and 7% late. Early in the series, 50% Urografin was used to inflate the balloon and this resulted in premature deflation and early electrode displacement in two of the nine patients. When the concentration of Urografin was reduced, the balloon remained inflated for a longer period and the incidence of early displacement was reduced to 8%. However, there was still a late displacement of 8%. Only one wedge-tipped balloon electrode displaced. This electrode had a faulty sealing mechanism and the balloon could not be adequately inflated. There was a 3% incidence of early and a 3% incidence of late threshold problems with the electrode. However, name of the wedge-tipped balloon electrodes exhibited this problem. It was concluded that this new electrode did not fulfill its objectives. The total electrode failure rate, including displacements and episodes of high threshold was approximately 24%.

Aged↗
PubMed1976

A metallurgical examination of fractured stainless-steel ASIF tibial plates.

Between 1970 and 1973 99 tibial fractures were treated by rigid internal fixation with ASIF plates. The fractures were all regarded as sufficiently stable for exercise without weight bearing, thus needing no additional external support during the healing period. Four of the plates broke late in the healing period, after the onset of weight bearing. These fractures had some degree of delayed union with slight resorption of the bone ends, resulting in cyclical bending of the plate. Examination of 2 of the fractured plates by scanning electron microscopy, electron microprobe analysis and optical metallography revealed that the primary cause of plate fracture was fatigue. There was no evidence that corrosion fatigue or inclusion content were factors leading to plate fracture.

Adult↗
PubMed1975

CHO cell repair of single-strand and double-strand DNA breaks induced by gamma- and alpha-radiations.

Neutral and alkaline sucrose gradient sedimentation analysis was used to measure double- and single-strand breaks in the DNA of Chinese hamster ovary (CHO) cells exposed to either gamma- or alpha-radiation. After irradiation, cells were incubated for 15-180 min to test the ability of the cell to rejoin the DNA breaks. Essentially complete rejoining was observed for single-strand breaks induced by gamma- or alpha-doses below 20 krad and for double-strand breaks induced by gamma doses below 60 krad. Approximately 80% rejoining was observed for double-strand breaks induced by alpha doses below 40 krad. At higher doses, the repair system appeared to saturate in such a way that essentially no additional breaks were rejoined.

Alpha Particles↗