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Biomedical subjects

A Busuttil

Publications and source records attributed to A Busuttil.

At least 217 records · Page 12Linked to original sources
PubMed1978

Adenocarcinoma of the oesophagus and of the oesophagogastric junction.

The clinical and pathological features of 52 adenocarcinomas invading the oesophagus and the oesophagogastric junction are reviewed. The relationship of these tumours to the presence of a concomitant hiatal hernia and the histogenesis of primary oesophageal adenocarcinomas are discussed. Adenocarcinomas of the cardio-oesophageal junction appear to have distinctive prognostic and pathological features and there may be a case for their classification into a separate category of alimentary neoplasms.

Adenocarcinoma↗
PubMed1978

Splenic lipofuscinosis in mice.

Autopsy examination of young adult mice revealed a characteristic pigmentation of the anterior splenic pole occurring in a high proportion (8-34 per cent) of three mouse strains and two sublines. Histological studies identified the pigment as lipofuscin and electron microscopy provided supporting evidence. Preliminary results are consistent with the hypothesis that lipofuscin may represent non metabolisable debris from cellular breakdown associated with lysosomal activity.

Animals↗
PubMed1978

Simple nasal polyps and allergic manifestations.

A series of 74 consecutive patients with simple nasal polyps were interviewed with regards to features of allergy. Skin testing with a variety of antigenic extracts and estimations of peripheral blood immunoglobulins including total serum IgE were also carried out. The simple tests performed in this study have not been able to delineate a specific subgroup of atopic patients with nasal polyps. Positive skin testing with house dust mite extract may form the basis of a clinical evaluation of hyposensitization.

Adult↗
PubMed1978

Chondrosarcoma of the thyroid cartilage.

A TUMOUR which had been present for nine years in the thyroid cartilage of a 45-year-old man, was shown on microscopy to be a chondrosarcoma. This tumour probably took its origin in a pre-existing benign tumour at this site. The literature on similar previously documented tumours is reviewed, and the classification, diagnosis and management of these rare tumours is briefly discussed. Primary cartilaginous laryngeal tumours are uncommon (Hyams and Rubuzzi, 1970; Zizmor et al., 1975). A tumour of the thyroid cartilage which had been present for about nine years was shown histologically to be a low-grade chondrosarcoma probably arising from a pre-existing chondroma at this site. The clinical and pathological features of this case are presented and discussed in the light of the available literature.

Chondrosarcoma↗
PubMed1978

Pathology of salivary glandular tumours.

The incidence and pathological features of the various tumours arising from salivary glandular tissues are described in the light of the World Health Organization classification of these tumours. The modern concepts relating to their histogenesis are outlined and some of the difficulties which may be encountered in their histological diagnosis are also discussed.

Adenolymphoma↗
PubMed1977

Irradiation-induced changes in human salivary glands.

Salivary tissue shows inflammatory changes, atrophy, replacement fibrosis, marked pleomorphism and atypia of the acinar epithelium and oncocytic metaplasia in the months following irradiation. The ductular epithelium undergoes squamous changes and within the ductular lumina, secretions become inspissated. The underlying pathogenetic mechanisms for these late irradiation induced changes may be the combination of a direct irradiation effect on acinar epithelium in association with post-obstructive inflammation and ischaemia, secondary to irradiation-induced endarteritis; however, these morphological changes observed may only be the result of an unusual repair phenomenon that salivary tissue is known to go through after any form of noxious stimulation. These histological alterations may lead to a possible misdiagnosis of malignancy in surgical specimens.

Atrophy↗
PubMed1977

A reappraisal of the ultrastructure of the human respiratory nasal mucosa.

A study of the ultrastructure of human respiratory nasal mucosa using specimens of simple mucous polyps showed features essentially identical to those described in the lower respiratory tract. Minor forms of epithelial specialization seen in the nasal lining of the other mammalian species are not demonstrable in man. Inflammatory cells, especially lymphocytes, form an integral constituent of the epithelium, and are in close apposition to the epithelial cells. A marked increase in the epithelial surface area is achieved through ridging and clefting, irregularity of the cell's surface and the presence of microvilli. Branching microvilli are admixed with more conventional structures.

Basement Membrane↗
PubMed1976

Dendritic pigmented cells within human laryngeal mucosa.

Melanocytes were seen within the basal layer of the laryngeal squamous epithelium in a biopsy specimen of the vocal cord. No dendritic pigmented cells were visualized in several sections of the entire mucosa of 15 autopsy specimens of the larynx, but clear, Langerhans-like cells were seen, suggesting that melanocytes in this location may possibly become effete. This may account for the infrequent occurrence of primary malignant melanotic lesions of the larynx.

Aged↗
PubMed1976

Ultrastructure of the stroma of nasal polyps: cilia in stromal fibroblasts.

Ultrastructural examination of the stroma of simple nasal polyps was shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intracellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.

Basement Membrane↗
PubMed1976

Amyloid deposits in the trachea and esophagus ultrastructural confirmation.

The clinical details of two patients suffering from amyloid infiltration of the trachea and esophagus respectively are presented. The "amyloid tumor" in the trachea presented with dysphonia and a swelling in the lower subglottic region. Attempts at complete surgical excision of it were unsuccessful. The patient with esophageal amyloid presented acutely with dysphagia and features of dehydration and malnutrition. Systematized amyloidosis was discovered at autopsy, but no primary initiating cause for it was found. In both cases it was possible to confirm the diagnosis by electron microscopy. The current views on the composition, structure, causation and treatment of amyloid disease are reviewed.

Aged↗
PubMed1975

A clinicopathological review of 68 carcinomas of the gallbladder.

A clinical and pathological review of 68 patients with a primary carcinoma of the gallbladder was undertaken. A prolonged preceding history of biliary disease was noted. Preoperative radiological and biochemical investigations were not helpful, but an isolated elevation in serum alkaline phosphatase level in the absence of any biliary obstruction or hepatic dysfunction was noticed in some patients. The significance of stones in relation to pathogenesis is discussed. A more radical surgical approach involving a partial hepatectomy appears to be the only possible treatement in veiw of the mode of spread of this tumour and the bad overall prognosis.

Adenocarcinoma↗
PubMed1975

Granulomas in nasal polyps.

Three specimens of simple nasal polyps which were examined in a routine histopathology laboratory contained tubereuloid granulomas. One of these patients was found to have systemic sarcoidosis. The other two continue to be asymptomatic and in one of these rupture of cystic nasal mucous glands with the liberation of epithelial mucin into the stroma appears to have excited the granulomatous reaction. The causation, investigation and significance of granulomas at this site are discussed.

Adult↗