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Biomedical subjects

A Beck

Publications and source records attributed to A Beck.

At least 253 records · Page 14Linked to original sources
PubMed1989

Diagnostic potential of cardiotocography (CTG) for silent uterine rupture.

We report on 3 patients with silent rupture of previous uterine scars. Despite continuous monitoring by cardiotocography, diagnosis was not made until the time of surgery. The cesarean section was indicated by the obstetrical-clinical examination, while CTG offered no evidence of uterine rupture.

Adult↗
PubMed1989

[Stent implantation as a palliative measure in an inoperable bronchial tumor. Initial experiences with an endoscopically implanted stent].

Imminent asphyxia due to tracheal or bronchial compression by inoperable tumors in the mediastinum and the central bronchi is serious, particularly if alternative treatments, i.e., radiation or chemotherapy, have been exhausted. For that reason, stents of different diameters and lengths were developed that could be dilated. With the patient under general anesthesia these stents can be introduced into the stenotic bronchus or trachea through a rigid bronchoscope. The appropriate stent is mounted on a 3-mm balloon catheter, which is inflated after the stent is in the correct position. Positioning is done under direct bronchoscopic and fluoroscopic control. After deflation of the balloon, the stent maintains its cross-sectional shape and keeps the airway open. The first clinical application was in a 53-year-old patient with end-stage small-cell carcinoma. The patient had had a relapse after combined chemo- and radiotherapy and had severe stridor. Stent insertion led to a significant relief of symptoms. The second patient, a 53-year-old woman who suffered from collapse of the bronchus caused by a radionecrosis, was treated by the same method. Nine months later, ventilation is excellent in the left lung, and the patient can tolerate the stent without any clinical symptoms. A 69-year-old woman suffered from a tracheal carcinoma with severe tracheal stenosis. It was possible to maintain the stability of the collapsed tracheal wall by insertion of a tracheal stent. This new technique can provide good palliative treatment and is sometimes even the main therapy in such cases.

Aged↗
PubMed1989

[Choledocho-gastric fistula. A rare complication of a cholangiocarcinoma].

A case of choledocho-gastric fistula resulting from a cholangio-carcinoma is reported. The final diagnosis was obtained by ERCP, whereas CT, barium examination, and gastroscopy initially did not allow a conclusive diagnosis. The only clinical finding was epigastric pain. Choledocho-gastric fistula is extremely rare.

Adenoma, Bile Duct↗
PubMed1989

Fentanyl inhibits the canine carotid chemoreceptor reflex.

To investigate the impact of fentanyl on the carotid chemoreceptor reflex, nine mongrel dogs were permanently monitored with electromagnetic flow transducers around the right common iliac artery and with heparin-filled catheters in the descending aorta and in one of the main carotid arteries with the tip just proximal to the carotid sinus. Carotid chemoreceptor activation (CCRA) produced by consecutive injections of nicotine (0.2-0.4 micrograms/kg) through the carotid catheter elicited bradycardia, expressed as an increase in cardiac cycle length by 140% +/- 18%, and a 252% +/- 16% increase in mean iliac arterial vascular resistance. These responses were markedly attenuated by fentanyl in a dose-dependent fashion: cardiac cycle length increased only by 50% +/- 7% (P less than 0.01) with 4 micrograms/kg and by 19% +/- 6% (P less than 0.01) with 8 micrograms/kg of intravenous fentanyl. These changes were paralleled by significantly (P less than 0.01) lesser increases in mean iliac arterial resistance (122% +/- 9% and 50% +/- 5%). It is concluded that fentanyl impairs the integrity of the carotid chemoreceptor reflex.

Animals↗
PubMed1989

[Ultrasound versus abdominal visualization of a problem abdomen in a young patient? An unusual cause of epigastric pain].

The case of a 24-year-old woman with epigastric pain is reported. A past history of slight abdominal pain for 4 weeks was recorded in the patient's history; no other illnesses were reported. Sonography revealed an unrecognizable longitudinal structure and extraenteric fluid. In view of the patient's age and the possibility of a pregnancy an abdominal X-ray examination was performed 3 h after admission, revealing a foreign body in the duodenum. A 15-cm-long pencil was removed by surgical operation; it had penetrated the duodenum with its hard end.

Abdomen↗
PubMed1989

[Thoracic calcification in the elderly--frequency and clinical value].

Chest X-ray films of 200 patients, aged between 90 and 102 years, were analysed for frequency of distribution and varying degrees of thoracic calcification. Calcification was found within the aortic wall in 89%, costal cartilage 79%, lung parenchyma 65%, lung hilum and/or mediastinum 64%, and tracheobronchial cartilages 55%. The degree of calcification was dependent on the tissue and sex involved (significant p less than 0.001). Calcification is of clinical value more often in younger patients than in the elderly. The classification, pathogenesis and differential diagnosis of thoracic calcifications are discussed.

Aged↗
PubMed1989

[Imaging and measurement of global and regional airflow in the lung using a radioactive gas].

In this paper it is shown how "circumscribed" movements of air within the lungs, such as those occurring during respiration, can be visualized and measured with the aid of the radio-active gas krypton 81 m. With this new examination technique, the previously employed procedures used for investigating the lungs have been expanded: In the imaging procedures sector, function patterns of regional ventilation can now be recognized, while the diagnostic evaluation of pulmonary function is complemented by the regional identification of disturbed and undisturbed ventilation. The equipment required for the examination is available in any nuclear medical department, and the methodology is relatively simple. The use of such studies is described on the basis of two clinical cases: The findings obtained with this new procedure clearly demonstrate the expansion of the diagnostic evaluation, and already point to the indications. Since 1982, we have carried out some 1,500 investigations of pulmonary ventilation. On the basis of the experience thus gained, a spectrum of indications can be established, and this is represented in the "Discussion". The inert gas, krypton, which is both odourless and chemically inert and has optimal physical properties for nuclear medical studies, has been shown by our investigations to be highly suitable for sophisticated analyses of pulmonary function, also in the severe-ill patient. Properly and rationally employed, the procedure is economical, and the radiation exposure low.

Aged↗
PubMed1989

[A rare case of an epigastric fistula].

The authors report on a 75-year-old man who had been operated on 50 years before because of a gastric perforation. Since then he had had no symptoms. Two weeks before visiting the doctor he had noticed a 2-mm fistula in the epigastric region. Symptomatic therapy prescribed by the general practitioner had no result. On fistulography a complete gastric fistula was diagnosed. X-ray examination of the stomach showed an area highly suggestive of gastric cancer in the antrum region. Surgical examination revealed a 6-cm-long thread with concomitant, enormously extensive granuloma.

Aged↗
PubMed1988

High-sensitivity isoelectric focusing of biotinylated peptides: a new method.

A novel technique to selectively analyze prelabeled peptides by isoelectric focusing (IEF) is presented. The conditions are described for biotinylation of peptides, their separation in polyacrylamide gels by IEF, and their fixation to the gel matrix with glutaraldehyde. The gels are developed by a color reaction catalyzed by an avidin-coupled enzyme. The technique is suitable for peptides with at least one free amino group or guanidino group after N-terminal biotinylation. The presence of other peptides or proteins does not interfere with the detection. The sensitivity is below 10 pmol, representing a 1000-fold improvement over existing techniques for analyzing low molecular weight peptides by IEF.

Biotin↗
PubMed1988

[Castleman's lymphoma. Differential diagnosis of mediastinal tumors].

This report describes two cases of Castleman's disease (male 48 yrs, female 33 yrs). Two intrathoracic lymphomas were accidentally discovered during routine x-ray examination. Histologically, follicular hyperplasia, prominent interfollicular vascularity and sheets of mature plasma cells (intermediate variant) were seen. The etiology of this benign lymphoma remains unknown. Its significance lies in its differential diagnosis from malignant tumours.

Adult↗
PubMed1988

Detection of genomic variation in Providencia stuartii clinical isolates by analysis of DNA restriction fragment length polymorphisms containing rRNA cistrons.

Chromosomal DNA from 26 strains of Providencia stuartii isolated mainly in hospitals in the United Kingdom and reference strains of P. stuartii, P. rustigianii, and Proteus vulgaris were digested with the restriction endonucleases EcoRI and HindIII. After electrophoresis in agarose gels, the fragments were subjected to Southern blot hybridization analysis with a biotin-labeled cDNA probe transcribed from a mixture of 16S and 23S rRNA from P. stuartii NCTC 11800T. The pattern of bands (the rDNA fingerprint), which depended on restriction fragment length polymorphisms containing rRNA genes, was used as a measure of minor genomic variation within and between species. The P. stuartii clinical isolates had similar total digest patterns, but the rDNA fingerprints revealed some heterogeneity between strains, with EcoRI digests providing better strain discrimination than HindIII. Such rDNA fingerprints comprised between five and seven bands with sizes in the range of 5 to 28 kilobases. The 11 different EcoRI patterns were compared by numerical analysis, and several groups or subgroups of strains were identified. Over half (15 of 26) of the urease-negative isolates (subgroups Aa and Ab) had patterns that differed only by the presence or absence of a 25-kilobase band. Urease-negative strains from other clinical material were more heterogeneous in their patterns. No correlation was apparent between strain pattern group and urease production or geographic location of isolate. The P. stuartii rDNA fingerprints were quite distinct from those of allied Providencia and Proteus species and provided a more sensitive measure of minor genomic differences than total DNA digests did.

DNA Probes↗
PubMed1988

Clinical application of percutaneous transluminal angioscopy. Comparison of findings in percutaneous transluminal angioplasty, thrombolysis, thrombus-extraction and stent-application.

Since the introduction of ultrathin angioendoscopes into clinical application, it has been possible to subject the findings of conventional or digital angiography to objective verification. In dogs and in patients, this new angioscopic method for visualization of arteries without surgical intervention has been carried out. The approach is transfemoral. Endoscopy is combined with angiography and, when indicated, percutaneous transluminal angioplasty (PTA), thrombolysis, thrombus extraction and insertion of a new type of stent. An ultrathin endoscope with an outer diameter of 1.6 mm and a working channel of 0.35 mm is used. Guidewires, contrast media and drugs for local thrombolysis can be employed through this channel. The endoscope is placed in the region of interest under fluoroscopy and direct visualization is obtained by using 0.9% NaCl for decreasing blood flow. Image recording is achieved by video or high-speed camera. With this method, the intraluminal events of dilatation, recanalization, local lysis, stent application and thrombus extraction can be visualized.

Angioplasty, Balloon↗