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Biomedical subjects

A Agnoli

Publications and source records attributed to A Agnoli.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

[Changes in the nigrostriatal dopamine receptor compartment after continuous dopaminergic infusions in Parkinson disease].

Motor fluctuations often complicate chronic levodopa treatment of Parkinson's disease. Pharmacologically, these phenomena are characterized by a progressive shortening of the duration of action of levodopa and a gradual narrowing of the range of "optimally effective" doses, able to improve parkinsonian akinesia without inducing abnormal involuntary movements. The effects of a continuous intravenous infusion of levodopa lasting 9 +/- 0.3 days on these clinical-pharmacological indices have been studied in 12 parkinsonian patients. Continuous infusion therapy gradually ameliorated motor fluctuations by more than 40%, and this improvement lasted for at least 6 days after resuming standard oral therapy. Moreover, levodopa duration of action was prolonged by about 30%, and the range of "optimally effective" dose was widened by about 50%. The above data suggest the possibility of plastic modifications of the pathogenetic mechanisms underlying motor fluctuations in Parkinson's disease, and a potential deleterious effect of intermittent oral therapy. Consequently, continuous dopaminergic stimulation, when used in the early stages of the disease, might theoretically have a prophylactic role on the development or worsening of motor fluctuations.

Aged↗
PubMedDate not supplied

Parkinsonian tremor: a neuropharmacological study.

In the Parkinsonian syndrome tremor is the symptom which still eludes pharmacological therapy. The authors report the results of nine cases of Parkinsonian tremor in which agonist and antagonist drugs acting on the receptors were employed. These were dopaminergics, acetylcholinergics, serotoninergics, histaminics, and alpha- and beta-adrenergics. The data obtained demonstrate the involvement of all the neurotransmitters studied, some directly through quantitative modifications, others indirectly through their involvement in reciprocal functional equilibria. A sytem of equilibria is hypothesized in which the histamine: serotonin ratio is given greater emphasis. (Acta neurol belg., 1977, 77, 213-229).

Acetylcholine↗
PubMedDate not supplied

Classification and diagnostic criteria for primary headache disorders (Ad Hoc Committee IHS, 1988).

Clinical features and pathophysiological mechanisms of primary (idiopathic) headaches are revisited in the light of the new classification of headache, recently proposed by the Ad Hoc Committee of the International Headache Society. This computer-based classification is hierarchically constructed and offers operational diagnostic criteria for all headache disorders. However, further investigations are required in some cases (e.g. in case of tension-type headache) to better define the clinical form.

Cluster Headache↗
PubMedDate not supplied

Spasmophilia: a clinical neurophysiopathological and biochemical study.

Spasmophilia is a problem much debated as regards its nosographic location. Its paroxysmal onset in a "neurotic" patient has confined spasmophilia within a psychiatric syndromic complex for many years. In the present study, strict clinical criteria used in selecting a population of spasmophilic patients included clinical, neurophysiological, biohumoral and psychological evaluations, providing further information about the real organic features of this syndrome. Moreover, on the basis of an organic pathogenetic hypothesis, all patients were administered medical therapy which resulted in clinical amelioration in a significant number of cases.

Adolescent↗
PubMedDate not supplied

[Double-blind clinical study: flunarizine versus pizotifen in a single nightly dose in hemicrania patients].

In this double-blind clinical trial we compared the prophylactic efficacy of the calcium-entry blocker flunarizine (15 mg nocte) with that of pizotifen (1,5 mg nocte). In 30 patients affected by classical and common migraine. During a two months treatment both drugs showed a good efficacy. Flunarizine tended to more markedly suppress severity of pain and duration of attacks than pizotifen. Daytime drowsiness and weight gain occurred with both drugs; the first side effect was more evident in the group treated with flunarizine, the second one in the group treated with pizotifen.

Adult↗