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Biomedical subjects

A Agnoli

Publications and source records attributed to A Agnoli.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Circadian rhythmicity of prolactin secretion in elderly subjects: changes during bromocriptine treatment.

Prolactin has been taken as an index of neuroendocrine function in aging, where dopaminergic neurotransmission in considered to be impared. The mean concentration of the hormone in the 24 h is higher in the aged men than in the adult controls. A sleep entrained periodicity is present in both aged subjects and controls, but a harmonic analysis of rhythmicity shows that secretory episodes have in aged men a slower periodicity than in adults. In aged men bromocriptine decreases the mean PRL values in the 24 h and the periodicity analysis shows the occurrence of harmonics with shorter period.

Adult↗
PubMedDate not supplied

[Correlations between E.E.G. spectral and plasma prolactin levels in elderly subjects (author's transl)].

Measurement of plasma prolactin levels in elderly subjects demonstrated the presence of a hyperprolactinemia with loss of normal circadian rhythm, regressing after bromocriptine treatment. The administration of bromocriptine to elderly subjects in a normal state of health provokes marked changes in the E.E.G. spectrum (slowing of delta activity, increase in alpha and decrease in beta rhythms). These findings show that there is an alteration in central dopaminergic systems during aging.

Aged↗
PubMedDate not supplied

Effect of phenobarbital on cerebral energy state and metabolism. Enzymatic activities.

The changes induced by phenobarbital in cerebral enzymatic activities of the Krebs' cycle (citrate synthase, malate dehydrogenase) and electron transfer chain (total NADH-cytochrome c reductase and cytochrome oxidase) were studied. In addition, the activity of lactate dehydrogenase of acetylcholine esterase and of glutamate dehydrogenase was also studied. These enzymatic activities were evaluated in the homogenate in toto and in a crude mitochondrial fraction from rat brain. The modifications in some of these activities indicate that several new metabolic situations occur in brain tissue after phenobarbital treatment.

Animals↗
PubMedDate not supplied

CT contrast enhancement on brain scans and blood-CSF barrier disturbances in cerebral ischemic infarction.

CT contrast enhancement of the ischemic infarction, blood-CSF barrier function for albumin, and severity of neurological symptoms were evaluated at predefined intervals in 41 patients with supratentorial ischemic infarctions. Contrast enhancement was most frequently observed in the 2nd and 3rd week after the stroke. This late CT enhancement was not related to infarction size and severity of blood-CSF barrier disturbance. The rare appearance of CT enhancement in the 1st week was usually associated with extensive infarctions and accompanied by blood-CSF barrier disturbances. These barrier disturbances, which occurred with higher frequency and greater severity in extensive infarctions (peak 3rd day), generally persisted for several weeks. We suggest that contrast enhancement in the 1st week after an ischemic stroke is due to diapedesis from necrotic capillaries; the more frequently observed late enhancement might be the result of a blood-brain barrier disturbance which in turn is hypothetically attributed to increased pinocytotic activity of regenerated endothelial cells.

Adult↗
PubMedDate not supplied

[The definition of a reference protocol for the clinical study of vertigo drugs].

The aim of this paper is to define the problems that arise in the clinical evaluation of drugs for the treatment of vertigo. Among these are the objective criteria used in defining vertigo and those used in evaluating efficacy of the drugs. The resulting protocol for a clinical study of vestibular drugs is a document that clarifies the debated points in the field, and above all furnishes guidelines for establishing uniformity in clinical studies. This, therefore, may become the reference protocol in Italy for clinical evaluations of drugs for the treatment of vertigo.

Clinical Protocols↗
PubMedDate not supplied

Alterations of thermoregulation in Parkinson's disease.

Sweating and superficial vasodilator responses were studied in 22 patients suffering from Parkinson's disease in order to evaluate the thermoregulatory function. Sweating was evaluated on different areas of the body with a colorimetric method (Minor's method). The superficial vasodilatation at the level of the face was assessed after oral intake of nitroglycerin by means of telethermography. Sweating and superficial vasodilatation were reduced in parkinsonian patients compared with control subjects. Asymmetries in sweating and superficial vasodilator responses were also observed between the left and right sides of the body in the patients. The decreased heat elimination was more apparent on the symptomatic side in patients with hemiparkinsonism. No relationship was found between the alterations of the thermoregulation and the other clinical features of Parkinson's disease.

Aged↗