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At least 19 recordsLinked to original sources

Survival after liver resection for secondary tumors.

The results achieved by liver resection for metastatic cancer in more than 400 patients have been studied in a collected review. Certain conclusions seem justified: The liver is no longer the surgeon's "no-man's-land," and local excision of metastatic tumor can achieve clinical cure in some patients. The risk-benefit ratio for hepatic resection for secondaries seems to be shifting in favor of benefit for selected patients with primary colorectal tumors. At present liver resection for tumors metastatic from pancreas, breast, lung, stomach, kidney, reproductive organs, and skin (melanoma) cannot be recommended. Liver resection may play an important part in the multi-modal therapy of children with extensive malignant disease.

Colonic Neoplasms

[Ambiguous and obscure problems of liver resection (author's transl)].

On the basis of the authors personal experience of 155 liver resections, including 79 anatomical and 76 atypical ones, the paper presents various aspects of indications, choice of procedure and of various technical measures. The author demonstrates the indisputable advantages of anatomic liver resections over the atypic ones, since they permitted to increase the range of surgical aid to the liver patients.

Hepatectomy

[Clinical and operative aspects of liver resection (author's transl)].

On the basis of our experience in 57 liver resections (hydatid cyst in the liver 22 times, 7 hepatic cysts, 5 liver abscesses, 7 benign and 16 malignant hepatic tumors) a few tentative conclusions are drawn: A reliable diagnosis and assessment of operability is only possible on laparotomy. Echinococcus alveolaris should be operated as radically as possible. Primary hepatic tumors should be removed as well as malignant hepatomas and their metastases. Simultaneous extirpation of the primary tumor and metastases has given encouraging results so far, especially in easily resectable carcinomata of the colon and rectum. Cytostatic followup therapy is absolutely essential in all cases of malignancy.

Adult

[Liver resection in benign and malignant tumors].

Benign tumors of the liver, circumscribed hepatomas and solitary hepatic metastases from colonic cancer are treated by partial liver resection. In case of colonic cancer the hepatic metastasis is resected in a second operation. 20 cases of hepatic resections are reported. 10 right hepatic lobectomies, 1 left hepatic lobectomy and 9 minor resections were performed. Of the 11 patients treated by hepatic lobectomy, one (or 9%) died in the postoperative period (within 30 days after operation). Of the other 9 patients undergoing minor resections there was no death.

Carcinoma, Hepatocellular

Comparison of long-term outcomes between liver transplantation and liver resection for intrahepatic cholangiocarcinoma: An updated systematic review and meta-analysis.

BACKGROUND: Liver resection (LR) has been the standard treatment for intrahepatic cholangiocarcinoma (ICC), but is associated with high recurrence rates and poor prognosis. Recently, outcomes for liver transplantation (LT) in highly selected ICC patients have significantly improved. This review compares the long-term prognosis of LT versus LR for ICC. METHODS: A systematic review of databases including Web of Science, MEDLINE, Scopus, and Cochrane CENTRAL for comparative studies on the long-term outcomes of LT versus LR for ICC was completed. The primary outcome was 5-year overall survival (OS). Meta-analysis was performed using random-effects models. RESULTS: A total of 7 retrospective comparative studies were included. A total of 5478 patients were analyzed (LT group: 346 patients; LR group: 5132 patients). Pooled analysis showed significantly improved long-term prognosis in the LT group compared to the LR group. Five-year OS was higher in the LT group (OR 0.59, 95% CI 0.37- 0.93, p = 0.02) and 5-year recurrence-free survival (RFS) was also higher in the LT group (OR 0.44, 95% CI 0.22- 0.89, p = 0.02), although the comparison of 1-year OS (p = 0.52) and 3-year OS (p = 0.88) between the LT and LR groups showed no significant difference. However, sensitivity analysis revealed that excluding one study resulted in changes to the statistical significance of both 5-year OS and 5-year RFS. This suggests that individual studies have some influence. CONCLUSIONS: LT may be associated with improved long-term survival and recurrence outcomes compared with LR for ICC; however, the evidence is limited and should be interpreted with caution. These findings suggest a potential benefit of LT in carefully selected patients, but further prospective studies are needed to confirm these results.

Humans

[Effectiveness of cryogenic action in experimental liver resection].

The traditional ligature methods were added with freezing of the left hepatic lobe resection line in order to block up parenchymatous bleeding and cholerhagia in atypical resection of the liver. Alterations in the enzymatic activity (alaninic and asparaginic transaminases alkaline phosphotase, lactate dehydrogenase and ribonuclease) in the blood serum and liver of the rabbits allowed to judge about the character of inflammatory and destructive changes in the liver following the use of the abovementioned methods. The rise of the activity of the enzymes under study within the first days after operation and its normalization by the 7th to 14th days in all the studied variants of hemo- an cholestasis have been established.

Animals

Postoperative treatment of patients after liver resection for trauma: a follow-up study.

In the last ten years, 89 hepatic resections were performed for trauma. Thirty-three patients survived and were followed up for one month to seven years: 15 patients had right lobectomy, nine left lobectomy, and nine left lateral segmentectomy. Complications were primarily pulmonary. All patients had transient derangement of liver function tests, but only three patients had liver dysfunction. Long-term follow-up showed no ill effects from the liver resection. Important postoperative treatment includes (1) adequate dependent drainage, (2) maintenance of blood volume, (3) intravenous albumin and glucose, (4) adequate nutritional support, and (5) selective use of intravenous glucagon.

Adolescent

Liver resection in children with hepatic neoplasms.

In the past ten years, 28 patients with primary tumors of the liver have been treated. There were 11 benign tumors, including four hamartomas, three patients with focal nodular hyperplasia, and two each with congenital cysts and hemangioma. Hamartomas and masses of focal nodular hyperplasia should be excised when possible, but both are benign lesions; therefore life threatening excisions at the porta hepatis should be avoided. Cysts are often resectable, but when occupying all lobes of the liver, they can be successfully managed by marsupialization into the free peritoneal cavity. If resectable, hemangiomas should be removed; when occupying most of the liver as they often do, patients may be subject to platelet trapping or to cardiac failure. In some instances these lesions have been controlled by steroids, radiation therapy or hepatic artery ligation. Of 17 malignant tumors seen, 12 proved to be hepatoblastomas. Nine of the 12 patients underwent liver resection, of whom four are cured, (33%). There were three children with hepatocellular carcinomas and two with embryonal rhabdomyosarcoma. One child from each of these groups is cured by surgical excision. At present the only known cures in children with primary malignant liver neoplasms have been achieved by operative removal.

Carcinoma, Hepatocellular

[Possibilities of controlling blood less in liver resection].

The methods are described by which blood loss can be reduced during hepatic surgery. This requires the proper surgical techniques (control method of hepatic lobectomy and occasionally the atypical resection with the use of a clamp- "crush" method). In additions clamping of the liver hilus and resection under hypothermia, the resection of the isolated bloodless organ under hypothermia, the application of an internal caval shunt, intraoperative autotransfusion, and acute preoperative hemodilution should be performed. The internal caval shunt can be successfully used in the case of emergency as well as during excision of large tumors which have involved the liver tissue adjacent to the vena cava. In these cases the method of complete vascular isolation and hypothermic perfusion should be performed additionally. Acute preoperative hemodilution should be widely applied with hepatic surgery; blood clotting is not impaired by this method.

Blood Transfusion, Autologous

[Anatomo-functional basis of the liver resection technique in the treatment of hepatic echinococcosis].

Hepatic resection of segments or lobes in same cases the hydatid desease of liver is necessary surgical therapy. The articl presents anatomy's bases for major hepatic resection. It's also present preoperativne care, technic of surgical therapy and postoperativ therapy. The standard liver functional testes should always be performed, in case functional insuffitiency we recomended different metods of temporary support.

Alanine Transaminase

Alopecia, ascites, and incomplete regeneration after 85 to 90 per cent liver resection.

A nineteen year old female underwent 85 to 90 per cent partial hepatectomy to treat a minimal deviation hepatoma. Observations afterwards suggested that the limit of resection compatible with survival had been reached. She recovered perfect health after many months, although liver regeneration was not complete. Severe but eventually reversible alopecia and ascites developed postoperatively, undoubtedly as a complication of the massive hepatic resection.

Adult