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Comparison of long-term outcomes between liver transplantation and liver resection for intrahepatic cholangiocarcinoma: An updated systematic review and meta-analysis.

Jiro Kimura·Ayham Asassfeh·Toshihide Tomosugi·Siavash Raigani·Matthew Cooper·Kondragunta Rajendra Prasad
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Abstract

BACKGROUND: Liver resection (LR) has been the standard treatment for intrahepatic cholangiocarcinoma (ICC), but is associated with high recurrence rates and poor prognosis. Recently, outcomes for liver transplantation (LT) in highly selected ICC patients have significantly improved. This review compares the long-term prognosis of LT versus LR for ICC. METHODS: A systematic review of databases including Web of Science, MEDLINE, Scopus, and Cochrane CENTRAL for comparative studies on the long-term outcomes of LT versus LR for ICC was completed. The primary outcome was 5-year overall survival (OS). Meta-analysis was performed using random-effects models. RESULTS: A total of 7 retrospective comparative studies were included. A total of 5478 patients were analyzed (LT group: 346 patients; LR group: 5132 patients). Pooled analysis showed significantly improved long-term prognosis in the LT group compared to the LR group. Five-year OS was higher in the LT group (OR 0.59, 95% CI 0.37- 0.93, p = 0.02) and 5-year recurrence-free survival (RFS) was also higher in the LT group (OR 0.44, 95% CI 0.22- 0.89, p = 0.02), although the comparison of 1-year OS (p = 0.52) and 3-year OS (p = 0.88) between the LT and LR groups showed no significant difference. However, sensitivity analysis revealed that excluding one study resulted in changes to the statistical significance of both 5-year OS and 5-year RFS. This suggests that individual studies have some influence. CONCLUSIONS: LT may be associated with improved long-term survival and recurrence outcomes compared with LR for ICC; however, the evidence is limited and should be interpreted with caution. These findings suggest a potential benefit of LT in carefully selected patients, but further prospective studies are needed to confirm these results.

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HumansCholangiocarcinomaLiver TransplantationBile Duct NeoplasmsPrognosisHepatectomySurvival RateIntrahepatic cholangiocarcinomaLiver transplantationMeta-analysisSurvivalSystematic reviewJournal ArticleSystematic ReviewMeta-AnalysisComparative StudyReview

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Jiro Kimura, Ayham Asassfeh, Toshihide Tomosugi, Siavash Raigani, Matthew Cooper, Kondragunta Rajendra Prasad. 2026-07-16. Comparison of long-term outcomes between liver transplantation and liver resection for intrahepatic cholangiocarcinoma: An updated systematic review and meta-analysis.. https://doi.org/10.1016/j.suronc.2026.102504

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Comparative Study subjectHumans subjectJournal Article subjectJournal Article; Systematic Review; Meta-Analysis; Comparative Study; Review resourceMeta-Analysis subjectSystematic reviews study

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