Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “apricot”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

9 recordsLinked to original sources
PubMed2025

Indel mutation in transcription factor PabHLH2 regulates amygdalin accumulation and kernel bitterness in apricot.

Amygdalin, the phytochemical responsible for the characteristic bitterness of apricot (Prunus armeniaca L.) kernels, also exhibits significant bioactive properties and therapeutic potential. Genetic regulation of amygdalin content is therefore a key objective in apricot breeding programs aimed at quality improvement. In this study, we conducted quantitative trait loci (QTL) mapping to uncover the genetic basis of sweet-bitter differentiation in apricot kernels. We identified a 15-bp insertion/deletion (indel) polymorphism strongly related to kernel bitterness, with marker validation achieving 100% concordance across 601 apricot germplasm accessions. Notably, this polymorphic site is located within the helix-loop-helix (HLH) domain of the basic HLH (bHLH) transcription factor PabHLH2. Protein interaction analyses revealed that the 15-bp deletion variant impaired dimerization capacity, reducing transcriptional activation of downstream targets. Using yeast one-hybrid screening and dual-luciferase reporter assays, we identified PaCYP71AN24 and PaCYP79D16 as direct transcriptional targets of PabHLH2. Functional characterization further indicated that the PabHLH2a variant (harboring the 15-bp insertion) significantly enhanced the promoter activity of these cytochrome P450 genes compared with the deletion variant. Transient overexpression and silencing experiments in apricot kernels further confirmed that the 15-bp insertion positively regulates both PaCYP71AN24/PaCYP79D16 expression and prunasin accumulation, the immediate biosynthetic precursor of amygdalin. Overall, these findings provide mechanistic insights into the allelic variation underlying kernel bitterness and delineate the molecular cascade of amygdalin biosynthesis. The identified molecular markers and functional characterization establish a basis for marker-assisted breeding of low-amygdalin apricot cultivars, supporting the dual-purpose utilization of kernels in food and pharmaceutical industries.

Amygdalin↗
PubMed2025

Comprehensive analysis of DNA methylome and transcriptome reveals the epigenetic regulation of nitric oxide treatment in delaying apricot fruit senescence.

Apricot produces climacteric fruit, which are perishable after harvest. To elucidate the regulatory role of NO treatment through DNA methylation in post-harvest senescence, apricot fruits were treated with 0.2 mmol/L sodium nitroprusside (SNP) solution for 10 min, with distilled water treatment serving as the control. Treated fruits were then stored at 25°C and 80% relative humidity. Changes in appearance quality, physiological parameters, metabolome profiles, transcriptome dynamics, and DNA methylation patterns were analyzed before and after storage. Results showed that NO treatment delayed apricot softening, increased flavonoid metabolite accumulation, and reduced lipid and abscisic acid accumulation, with these effects correlated to the expression of specific genes and transcription factors. This work reveals the epigenetic regulatory mechanism underlying NO treatment delaying ripening and senescence. Further analysis revealed that the transcription levels of ACO, PAL, UFGT-like, NCED1, PP2C, MYB21, CCoAOMT-like, CYP707A, and ZNF7-like were all correlated with DNA methylation. This indicates that SNP treatment can lead to large changes in DNA methylation levels in apricot fruits, and that the differences in gene transcription levels are associated with the occurrence of hypomethylation and hypermethylation. Collectively, these findings establish an epigenetic framework for post-harvest regulation of apricot fruit, revealing DNA methylation-mediated freshness preservation mechanisms.

DNA Methylation↗
PubMed1979

Aflatoxigenic potential of dried figs, apricots, pineapples, and raisins.

Spores from 3 aflatoxigenic strains were applied to the surface of dried figs, pineapple slices, apricots, and raisins. Half of the samples of each foodstuff was autoclaved (cooked) before inoculation. All 3 strains produced some toxin but not in all of the foodstuffs. No aflatoxins were found in any of the raisin cultures. The overall potential for toxin production in the dried fruit was apricot greater than fig greater than pineapple greater than raisin. Among the cooked substrates, the order was apricot greater than pineapple greater than fig=raisin. For the raw dried fruits, the ranking was fig greater than pineapple greater than apricot greater than or equal to raisin. Pineapple was considered the best broad spectrum substrate of the foodstuffs evaluated in the study.

Aflatoxins↗
PubMed1975

X-ray- and TEM-induced mitotic recombination in Drosophila melanogaster: unequal and sister-strand recombination.

Twin mosaic spots of dark-apricot and light-apricot ommatidia were found in the eyes of wa/wa females, of wa males, of females homozygous for In(1)sc4, wa and of attached-X females homozygous for wa. The flies were raised from larvae which had been treated with 1630 R of X-rays at the age of 48-52 hours. An additional group of wa/wa females and wa males came from larvae that had been fed with triethylene melamine (TEM) at the age of 22-24 hours. The twin spots apparently were the result of induced unequal mitotic recombination, i.e. from unequal sister-strand recombination in the males and from unequal sister-strand recombination as well as, possibly, unequal recombination between homologous strands in the females. That is, a duplication resulted in waDp wa/wa dark-apricot ommatidia and the corresponding deficiency in an adjacent area of wa/Df wa light-apricot ommatidia. In an additional experiment sister-strand mitotic recombination in the ring-X chromosome of ring-X/rod-X females heterozygous for w and wco is believed to be the cause for X-ray induced single mosaic spots that show the phenotype of the rod-X marker.

Drosophila melanogaster↗
PubMed1979

Choroid plexus carcinoma. Case report.

Plexus-chorioideus carcinomata or malignant plexus papillomas are very rare; only few cases have been described in the literature. A further observation is added now. In a 13-year-old girl, signs of brain pressure occured two weeks before admission to a hospital. Scintigraphy and vertebral angiography showed a process in the atrium of the right lateral ventricle which was removed by temporo-parietal trephination. The tumour had the size of an apricot and a reddish colouration, it proceeded from the plexus. After-irradiation with 5 000 rad. Six years after the operation, signs of brain pressure appeared again. Neuroradiologically the process was located in the right cerebellar hemisphere. After trephination of the cerebellum, the largely vascularised tumour, which appeared to originate from the tela choroidea of the 4th ventricle, could be removed. The further course was without pathological findings. Histologically, the typical criteria were found: Invasion of surrounding brain structures, loss of the regular papillary structure, malignisation of the cells and originating from the plexus choroideus.

Adolescent↗
PubMed1977

Occurrence of patulin in fruit and vegetables.

In different varieties of apples and pears suffering from brown rot, patulin was found in about 50 p. 100 of samples investigated (about 120). Patulin levels as high as 1 g/kg rotten material were found 2-3 days after the fruit was removed from the cold store where it had been stored for 5 months. A significant diffusion into the healthy plant tissue was not observed in apples, but in peaches, tomatoes and pears. Vegetable products with natural patulin content: apples, pears, peaches, apricots, bananas, pine apples, grapes. After inoculation with Penicillium expansum, P. urticae or Byssochlamys nivea, patulin was also found in greengages, strawberries, honeydew melons, red and green paprika, tomatoes, cucumbers and carrots. The artificial infection failed in celeriac, kohlrabi, cauliflower, red cabbage, radish, horseradish, onions, squash (zuccini), potatoes and egg plants. The author further investigated the patulin synthesis as a function of the temperature as well as its oxygen requirement in various mold species and strains.

Food Microbiology↗