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At least 19 recordsLinked to original sources

[Interdisciplinary communication in breast-preserving therapy of early infiltrating ductal breast carcinoma].

The goal in breast-maintaining treatment of early mammary cancer means control of the tumor in a cosmetically acceptable breast worthy to be left in place. To this intent, a staged approach with agreement between therapists (surgeon, radiotherapist, oncologist) and pathologist should be used. Morphologic and histopathologic findings are relevant and are age-dependent indicators for risk of local recurrence. The cosmetic result as well as local tumor control depend on clinical findings and techniques of resection. The interdisciplinary communication weighs clinical and morphological criteria for counselling and selection of patients. In the presence of unfavourable prerequisites for cosmetically satisfactory results and increased probability of local recurrence (greater than 20%/5 years), breast-maintaining therapy should not be recommended; however, prognostic criteria do not depend on operative techniques.

Age Factors

[Computerized graphic techniques in the interdisciplinary information communication in geriatrics].

Geriatric research shows that multidimensional assessment (MA) is the best method of approaching the complex functional problems of elderly subjects which are characterized by a close interdependence of clinical, social and mental factors. A correct and standardized communication of the results and the indications deriving from this complex interdisciplinary system is essential to enable the operators, despite their different professional backgrounds, to become involved in ensuring the health and welfare of their patients using integration and coordination criteria which are appropriate to the patient's individual situation. In this context, a computerized MA programme, known as "Senior", has been designed. The programme provides two communication sheets of data with different professional orientations: I) geriatric assessment sheet for doctors and other medical staff; II) graphic geriatric assessment sheet for non-medical operators. In practice, these assessment sheets are a useful backup in providing continuity between in- and out-patient programmes.

Aged

Factors influencing ethical decision making in the home setting.

The process of ethical decision making does not differ according to the patient care setting. However, various factors in home care affect the way in which decisions are made. The factors to consider are the amount of time needed to make a decision, the involvement of the patient and family, the need for support systems, the difficulties with interdisciplinary communication, and the lack of an ethics committee. Recognizing the ways in which these variables affect the decision making can help home healthcare nurses resolve the ethical dilemmas they face. In addition, staff education programs, the use of consultants, and the development of ethics committees are possible strategies to facilitate ethical decision making.

Aged

Training in developmental pediatrics. How practitioners perceive the gap.

Ninety-seven randomly selected, board-certified pediatricians in five New England states were interviewed by two physicians to explore attitudes toward previous training and current sources of knowledge in developmental pediatrics. Formal training in development was rated as inadequate by 79%, of residency experience was viewed as highly valuable by only 30%, and 47% rated medical school as having no value. Although clinical experience was reported as a valuable source of knowledge by 99% of the sample, almost two thirds did not regard it as an adequate substitute for formal training. Frequent interdisciplinary communication was reported, and professional contacts were described as a highly valuable ongoing source of knowledge. Social class and size of practice did not correlate with differences in consultation patterns. A part-time longitudinal clinical experience for further education was preferred by 97%. Improved training with greater interdisciplinary content is needed.

Child

The National Large Bowel Cancer Project. Its goals and objectives.

The National Large Bowel Cancer Project, therefore, through the combined efforts of the Directorate, Working Cadre, and Subcommittees, has planned and activated a multidisciplinary approach to large bowel cancer aimed at reducing the incidence, mortality, and morbidity of this disease. Every effort is being made to improve interdisciplinary communications among biomedical scientists and clinical investigators involved in studies related to large bowel cancer. Early application of well-established biologic concepts of large bowel cancer to the study and management of patients with this disease, or to individuals at risk for the development of this form of cancer, hopefully will result in improved methods of controlling large bowel cancer.

Colonic Neoplasms

Preoperative combined chemotherapy and radiation therapy plus radical surgery in advanced head and neck cancer. Five-year results with impressive complete response rates and high survival.

Radiation therapy combined with cisplatin as a chemoradiation sensitizer (CT/RT) has been reported to enhance tumor response in squamous cell carcinoma of the head and neck. In the present study, CT/RT was used preoperatively in advanced Stage III and IV head and neck cancer. Fifty-three patients were entered prospectively into a Phase II study. Treatment consisted of 4500 cGy of radiation therapy in 5 weeks combined with cisplatin 20 mg/m2 for 4 days during weeks 1 and 4 of radiation therapy. This was followed 4 to 8 weeks later by curative surgery. Pretherapy dental care; long-term nutritional support; individualized skin, mouth, and wound care; and continuous interdisciplinary communication were integral parts of this regimen. In four patients, CT/RT toxicity was seen (8%); three episodes of skin reaction or stomatitis and three episodes of leukopenia (less than 2500/microliters), causing a delay in CT/RT treatment in one patient. Three patients died of other causes during the preoperative interval, without clinical evidence of toxicity. Fifty patients (94%) had a complete (CR) or partial response (PR) to CT/RT. Clinical CR was seen in 38 of 51 (75%) primary tumors and 21 of 27 (78%) cervical nodes. Forty-one patients (77%) underwent curative surgery. In 27 of 32 (84%) resected CR primary tumors and 16 of 18 (89%) CR metastatic nodes, the surgical specimen was microscopically free of tumor. Postoperative morbidity was 32%. Five patients (12%) required additional surgery for their complications. Perioperative mortality was 5%. Five patients had tumor recurrence: three postoperatively after clinical PR to CT/RT and two in clinical CR patients who refused further treatment after CT/RT, then had a recurrence and were salvaged surgically. No patient with a CR in both the tumor and nodes who underwent surgery had a tumor recurrence. With a follow-up of 8 years (median, 40 months), the median survival for all patients was 45 months. The 5-year actuarial survival rate was 43% for all patients and 55% for patients who had CT/RT and surgery. This multimodality treatment of advanced head and neck cancer has low toxicity and impressive survival. It renders a significant number of patients tumor-free before surgery. These patients may be candidates for additional study triaging additional CT/RT for complete CR only and surgery for PR and biopsy-proved residual disease.

Adult

Animating insights into the biosynthesis of glycopeptide antibiotics.

The realm of natural product (NP) research is constantly expanding, with diverse applications in both medicine and industry. In this interdisciplinary field, scientists collaborate to investigate various aspects of NPs, including understanding the mode of action of these compounds, unraveling their biosynthetic pathways, studying evolutionary aspects, and biochemically characterizing the enzymes involved. However, this collaboration can be challenging as all parties involved come from very different backgrounds (such as microbiology, synthetic chemistry, biochemistry, or bioinformatics) and may not use the same terminology. Fortunately, contemporary technologies, such as videos, provide novel avenues for effective engagement. Recognizing the potency of visual stimuli in explaining complex processes, we envision a future where animations become more and more common in interdisciplinary communication, accompanying perspectives, and reviews. To demonstrate how such approaches can enhance the understanding of complex processes, we have animated the biosynthesis of the glycopeptide antibiotic vancomycin (https://youtu.be/TGAgC4c8hvo).

Anti-Bacterial Agents

Case histories in the great power of steady misrepresentation.

The widespread misrepresentation of behaviorism in the scientific and popular literature has caused its contributions to the understanding of behavior to be systematically ignored or denied. This misrepresentation is manifested, in large part, as a form of academic folklore that codifies erroneous accounts of behaviorism's assumptions, findings, and goals. This article examines three representative "case histories" of the academic folklore about behaviorism: its alleged environmentalism, totalitarian aims, and intellectual intolerance. Because academic folklore has been highly resistant to the corrective efforts of behaviorists, explicit strategies are suggested for identifying and correcting folklore and for promoting more effective interdisciplinary communication.

Behaviorism

Application of qualifying variants for genomic analysis.

MOTIVATION: Qualifying variants (QVs) are genomic alterations selected by defined criteria within analysis pipelines. Although crucial for both research and clinical diagnostics, QVs are often seen as simple filters rather than dynamic elements that influence the entire workflow. In practice these rules are embedded within pipelines, which hinders transparency, audit, and reuse across tools. A unified, portable specification for QV criteria is needed. RESULTS: Our aim is to embed the concept of a "QV" into the genomic analysis vernacular, moving beyond its treatment as a single filtering step. By decoupling QV criteria from pipeline variables and code, the framework enables clearer discussion, application, and reuse. It provides a flexible reference model for integrating QVs into analysis pipelines, improving reproducibility, interpretability, and interdisciplinary communication. Validation across diverse applications confirmed that QV based workflows match conventional methods while offering greater clarity and scalability. AVAILABILITY AND IMPLEMENTATION: The source code and data are accessible at the Zenodo repository https://doi.org/10.5281/zenodo.17414191. Manuscript files are available at https://github.com/DylanLawless/qvApp2025lawless. The QV framework is available under the MIT licence, and the dataset will be maintained for at least two years following publication.

Genomics

Interdisciplinary education in child abuse and neglect.

The increased need for professionals working with children and their families to understand, identify, and in some cases treat and follow up situations of child abuse and neglect has led to the offering of a structured graduate interdisciplinary course to students in various types of professional training. This initial effort represents an attempt not only to aid students in gaining insight into the dynamics of child abuse but also to encourage interdisciplinary communication among students from law, medicine, social work, education, and other fields which will hopefully continue into their professional life. Based on the experience accumulated from two offerings, a description is presented of the objectives, content, methodology, problems, and short-term evaluation of this course.

Child

Theory and methods for research on ethical issues in dementia care.

Swedish research on ethical issues in dementia care is almost exclusively done by nursing scientists. Many of these studies are rightfully acclaimed as exemplary research. But the strong focusing on the nurse and her relation to the patient tends to bias the ethical issues--the attitudes of other persons involved or affected are also in need of investigation. Further, there is a predilection for content analysis at the expense of causal analysis. In this paper an eclectic approach to the study of ethical issues in dementia care is advocated. More interdisciplinary communication and co-operation is also needed--especially between nursing scientists and moral philosophers. To facilitate such communication and co-operation a model for analysis of ethical issues is presented and discussed. To illustrate my ideas I use three articles by researchers from the department of advanced nursing in Umeå: Ekman & Norberg (1988), Norberg & Asplund (1990) and Akerlund & Norberg (1989-90).

Behavioral Research

Stimulant drugs for hyperactivity: some additional disturbing questions.

Continued professional recognition and concern are urged in regard to increased use of stimulant drugs for treatment of hyperactivity, unaccompanied by 1) adequate interdisciplinary communication about specific behaviors leading to referral and treatment, or 2) adequate assessment of the behavioral and educational consequences of the medication. Some pertinent questions are posed.

Attention

Biomarkers in epidemiology: scientific issues and ethical implications.

The current generation of biologic markers have three characteristics that differentiate them from previous ones. These include the ability to detect xenobiotics at concentrations at the cellular and molecular level, to detect earlier biologic changes presumptive of disease or disease risk, and to identify a detailed continuum of events between an exposure and resultant disease. If biomarkers are to enhance cancer epidemiology, they must be valid, reliable, and practical. When these characteristics have not been previously demonstrated, pilot studies should be conducted prior to the primary study. Interdisciplinary communication and collaboration is required so that useful markers are selected and that collection and handling, assay, and interpretation are appropriate. The status of many biomarkers is that they have been developed in the laboratory but lack validation for field use. Validation of a marker for use in a population requires attention to issues of background prevalence, sample size, natural history, persistence, variability, confounding factors, and predictive value. Additionally, practical features such as subject preparation, access to specimens, specimen storage aspects, and costs must be clarified. Ultimately, the use of biologic markers in epidemiologic studies will depend on how well the markers increase ability to reduce misclassification, provide for better interpretation of exposure-disease associations, and increase opportunities for prevention. Validation studies and general research using biomarkers also have clinical, ethical, and legal implications. These range from communicating uncertainty about the meaning of a marker to the kinds of societal response that result when groups or individuals are identified as having an "abnormal" marker frequency.

Biomarkers, Tumor

Mental health intervention with children and adolescents with end-stage renal disease.

The increasing number of pediatric patients with end-stage renal disease who undergo dialysis and transplantation have necessitated the development of psychological interventions to lessen the emotional impact of these procedures. This report describes the dilemmas involved in mental health interventions and consultation in a treatment program for end-stage renal disease. Case illustrations of a young child's severe anxiety reaction to dialysis, an adolescent's depression, and a family's withdarwal document the varied patterns of adaptation to treatment for renal failure. Psychotherapeutic approaches are presented to illustrate the flexible use of a number of treatment modalities including brief crisis-oriented intervention which emphasized the patient's cognitive mastery of procedures. The development of viable mechanisms of professional collaboration improves the quality of patient adaptation by lessening the fragmentation of care and problems of interdisciplinary communication often associated with the medical care of children and adolescents with end-stage renal failure.

Affective Symptoms

[Pharmacokinetics--questions of terminology and problems].

Pharmacokinetics have become one indispensable tool in drug evaluation, clinical pharmacology and diagnostics. Therefore the basic principles of pharmacokinetics are outlined and pertinent definitions are given. Some scientific terms in this field are explained in order to facilitate interdisciplinary communication. The theoretical background of some practicable algorithms for obtaining pharmacokinetical parameters is described with the attempt of relying solely on the understanding usually induced by basic courses in biology, medicine and chemistry. It is demonstrated that the evaluation of pharmacokinetical analyses may only be interpreted in a context of any or all of these disciplines. Without this context pharmacokinetical results may remain mere mathematical descriptions of unknown mechanisms.

Animals

Ethical challenge in community health nursing.

Community health nurses frequently face situations involving ethical conflicts, but little research has been carried out in this area. This paper, based on a study of dilemmas defined by 30 practising community health nurses in urban and rural British Columbia, Canada, presents an analysis of the situations that contain the most serious ethical conflicts for nurses working in the community. Although issues related to client's rights, nurses' interactions with colleagues and the system, and nurses' rights were explored, nurses in the study reported that situations involving high-risk parenting provided the most serious ethical challenges. Strategies to help nurses caring for such vulnerable clients are described. As well, this paper offers some discussion on implications for community health nursing practice and education in light of current changes and challenges.

Beneficence