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Results for “Biomedical Engineering”

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At least 1,657 records · Page 92Linked to original sources
PubMed1999

[A study on guided tissue regeneration and tissue engineering-transplantation of collagen membrane seeded with cultured hyaline chondrocytes].

OBJECTIVE: Lack of transplant material is a main problem in the repair and reconstruction of tissue or organ defects. To seek the succedaneum of transplants, we studied and used tissue-engineered growth hyaline cartilage. METHODS: The articular hyaline cartilage obtained from newborn calf within 6 hours of sacrifice was enzymatically dissolved. The chondrocytes were then seeded onto the medical collagen membrane of guided tissue regeneration in a 24 well plate in RPMI1640 medium. One week later, the chondrocyte medical collagen membrane of guided tissue regeneration complex was implanted subcutaneously into the back of nude mice. Eight weeks after implantation, the animals were sacrificed. RESULTS: The present study seems to demonstrate that the cartilage-like tissue was strong enough to be transferred after being implanted for 8 weeks. The cartilage-like tissue was proved to be tissue-engineered hyaline cartilage by HE stain. The chondrocytes could secrete chondroitin sulfate as proved by Lev-Spicer stain. CONCLUSION: Tissue engineering technique was used to make tissue-engineered cartilage in vitro. It will provide a new transplant material for the repair of tissue or organ defects.

Animals↗
PubMed1979

In-house medical device maintenance.

The establishment of a medical engineering department in this 600-bed institution has proved to be cost-effective and has improved the hospital's environment.

Biomedical Engineering↗
PubMed1997

[An overview on research and application of intelligent materials in modern medicine].

The research on intelligent materials is a new advanced technology, which is much interested by many scientists and engineers in recent years. Some research results have been achieved and used in aeronautics, mecahanics, civil engineering, medicine and other associated fields. In this paper, we present the properties, functions and status of intelligent materials in modern medicine.

Biomedical Engineering↗
PubMed2026

Copper-Containing Surface Engineering for Soft-Tissue Biomedical Devices: Structure-Function Relationships and Ion Release-Driven Biological Performance, A Systematic Review.

Copper and copper-based materials have gained increasing attention for the functional modification of implantable medical devices intended for prolonged soft-tissue contact, including vascular stents, catheters, and intrauterine devices. Owing to their broad-spectrum antimicrobial activity, redox reactivity, and involvement in angiogenesis and cellular signaling, copper-based systems offer significant potential for multifunctional surface engineering. However, achieving a balance between antibacterial efficacy, corrosion behavior, controlled ion release, and cytocompatibility remains a critical challenge. This PRISMA-compliant systematic review analyzes copper-containing materials and surface modification strategies for soft-tissue biomedical applications. A structured search of Scopus, Web of Science, and PubMed (2015-2025) identified 65 eligible studies. The review encompasses bulk copper-containing alloys, electrochemical and chemical surface modification techniques, physical vapor deposition approaches, and advanced hybrid systems integrating copper with polymers, hydrogels, or metal-phenolic networks. Across the reviewed literature, antibacterial performance was strongly dependent on copper concentration, microstructural distribution, and spatiotemporal ion release profiles. Moderate, well-controlled copper incorporation frequently improved antibacterial efficacy while maintaining acceptable hemocompatibility and cytocompatibility, particularly in vascular and blood-contacting devices. In contrast, excessive copper loading often accelerated corrosion and induced adverse cellular responses. Emerging multifunctional architectures demonstrated improved regulation of biological interactions, enabling simultaneous antibacterial, antithrombotic, and proendothelial effects. Overall, copper-based surface technologies represent a versatile platform for soft-tissue implant modification. Future translational progress will require precise control of copper release kinetics and comprehensive long-term in vivo validation to ensure safety and sustained therapeutic performance. From the authors' perspective, the most promising future direction involves multifunctional copper-based hybrid coatings capable of dynamically regulating ion release, host tissue integration, and antibacterial performance simultaneously. Strategies integrating hierarchical architectures, stimulus-responsive release systems, and clinically scalable fabrication methods are expected to play a key role in translating copper-containing surfaces from experimental concepts toward commercially viable soft-tissue biomedical devices.

Copper↗
PubMedDate not supplied

Technology's implications for health care quality. A clinical engineering perspective.

Bill Gates states in Business @ The Speed of Thought that "the 2000s will be about velocity." This "decade of velocity" is driven by the flow of digital information. Health care organizations should develop a "digital nervous system" that is distinguished from a network of computers by the accuracy, immediacy, and richness of the information it brings to health care workers and by the insight and collaboration made possible by this information. This article provides a clinical engineering perspective on technology in health care in an era of rapid change. It discusses how clinical engineers work with health care professionals to manage and adapt to technological, economic, social, and regulatory forces that are redefining our approach to health care delivery.

Biomedical Engineering↗
PubMedDate not supplied

Are productivity and cost-effectiveness comparisons between in-house clinical engineering departments possible or useful?

Inter-institutional comparisons of productivity and cost-effectiveness can be a valuable source of feedback to the in-house biomedical or clinical engineering services manager. But for such comparisons to be valid, all institutions must use the same criteria. As yet, there are no standard definitions for such criteria and, in most cases, the necessary data are not kept. Therefore, reliable comparisons are not possible. It is possible, however, to keep data on the variety of tasks common to all clinical engineering departments that can then be compared inter-institutionally. As task comparisons become more common, "norms" will evolve that can become standards for the profession. From there, it is a realizable step to standards that permit comparison of productivity and cost-effectiveness. A national organization, like the American Hospital Association could help by including clinical engineering data as part of their annual hospitals survey.

Biomedical Engineering↗
PubMed2000

Tissue engineering: challenges and opportunities.

This article reviews the key developments in the tissue engineering field over the past several years. The issues related to the development of the components of tissue-engineered products including cells, biomaterials, and biomolecules, and their integration into safe and effective products are presented. Moreover, the article outlines the challenges to the commercialization of tissue-engineered products, and highlights the ongoing efforts by the American Society for Testing and Materials (ASTM) in developing standards for tissue-engineered medical products. Furthermore, funding opportunities at the Advanced Technology Program at NIST are presented. Published 2000 John Wiley & Sons, Inc.

Animals↗
PubMedDate not supplied

Osseous tissue engineering in oncologic surgery.

Tissue engineering is an interdisciplinary field that will yield new sources of tissue for clinical and research purposes in oncology. Bone is under intense investigation by this field. Relevant areas of progress are in advanced computing, biomaterials, cell technology, growth factor fabrication and delivery, and gene manipulation. Clinical techniques will emerge from continued investigation in each of these areas. Techniques that are developed must be scaled up to industry with products cleared by regulatory agencies and acceptable to clinicians and patients. The goals of tissue engineering in oncology are improved tissue models for basic cancer research and a change in clinical practice. Semin. Surg. Oncol. 19:294-301, 2000.

Biomedical Engineering↗
PubMed2001

Tissue engineering in plastic reconstructive surgery.

Tissue engineering (TE) is a new interdisciplinary field of applied research combining engineering and biosciences together with clinical application, mainly in surgical specialities, to develop living substitutes for tissues and organs. Tissue engineering approaches can be categorized into substitutive approaches, where the aim is the ex vivo construction of a living tissue or organ similar to a transplant, vs. histioconductive or histioinductive concepts in vivo. The main successful approaches in developing tissue substitutes to date have been progresses in the understanding of cell-cell interactions, the selection of appropriate matrices (cell-matrix interaction) and chemical signalling (cytokines, growth factors) for stimulation of cell proliferation and migration within a tissue-engineered construct. So far virtually all mammalian cells can be cultured under specific culture conditions and in tissue specific matrices. Future progress in cell biology may permit the use of pluripotent stem cells for TE. The blueprint for tissue differentiation is the genome: for this it is reasonable to combine tissue engineering with gene therapy. The key to the progress of tissue engineering is an understanding between basic scientists, biochemical engineers, clinicians, and industry.

Animals↗
PubMed2002

Future direction of the treatment of ACL ruptures.

The future of treatment of the ACL rupture is changing as our understanding of the biology surrounding the ACL continues to increase. It is our expectation that clinically applicable treatments, including the repair of the ACL and the development of a biologically engineered ACL, will occur in the next decade.

Animals↗
PubMed2004

Therapeutic cloning and tissue engineering.

A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.

Animals↗
PubMedDate not supplied

Clinical engineering practicum: a new approach in clinical engineering education.

The emerging concept of a clinical engineer is that of a practitioner of engineering science as it applies to hospital medical devices and the technology of health care delivery. Therefore, in addition to the theoretical and scientific aspects of the clinical engineer's education, there must also be some form of experiential education under proper guidance. For most university-based clinical engineering programs, this takes the form of a hospital internship. The transition between the academic environment to the hospital environment is not always a smooth one, as there is a type of "culture shock" brought on by the new and extremely demanding situation encountered in the hospital. In an effort to improve the transition from university to hospital and allow the student to focus more sharply on his or her professional goals, the concept of the clinical engineering practicum was developed. Its function is to be an introductory learning experience and half-way point between the hospital and the university.

Biomedical Engineering↗
PubMedDate not supplied

A shocking experience: Ohm's Law and the nurse.

The Clinical Engineering Center of the Northern New England/University of New Hampshire has developed a seminar on electrical safety for members of the nursing profession. This program provides an understanding of basic circuit theory, grounding problems, wiring systems, and electrical safety. Examples are drawn from actual clinical situations. Portions of the seminar are devoted to equipment demonstrations and to a panel discussion which provides the participants with an opportunity to ask questions. Through this experience, the nurses begin to view the function of a Clinical Engineer in a different light, their awareness of the role of the Clinical Engineering Center is expanded, and they become a second line of defense for electrical safety in the hospital.

Biomedical Engineering↗
PubMedDate not supplied

Technical note: preventive maintenance quality assurance.

Performance improvements in healthcare and, specifically, in clinical engineering are required by the Joint Commission on the Accreditation of Healthcare Organizations' Plant Technology and Safety Management (PTSM) documents. The goals of healthcare service quality assurance are to establish performance requirements and improve patient outcomes. It is important that these goals be kept in the forefront of the design of clinical engineering quality assurance planning. Indicator/threshold pairs must be carefully chosen on the basis of some logical relation to the desired goals of the overall program.

Biomedical Engineering↗
PubMed2001

Traditional engineering in the biological century: the biotraditional engineer.

The increasing importance of life science in all engineering is prompting departments in the traditional engineering disciplines to offer life science as part of their curricula. Students who take advantage of this opportunity--"biotraditional engineers"--will be well positioned for careers in their discipline and in related areas of bioengineering. The founder engineering societies, such as the Bioengineering Division of ASME, are responding to this trend by broadening their scope and working increasingly across interdisciplinary borders.

Biomedical Engineering↗