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At least 1,495 records · Page 83Linked to original sources
PubMed2004

Near-field second-harmonic generation.

Near-field microscopy of second-harmonic generation combines high surface sensitivity of the nonlinear optical process and high spatial resolution of the near-field optics. It enables investigation of nonlinear optical phenomena at the nanoscale and provides an opportunity to develop a highly sensitive optical technique for materials characterization. In this paper we overview apertured and apertureless near-field approaches for local studies of second-harmonic generation. Near-field second-harmonic generation at metal surfaces and nanostructures and related electromagnetic field enhancement and confinement effects are considered. The latter demonstrates the feasibility of achieving nanoscale light sources using second-harmonic generation. Applications of second-harmonic near-field microscopy for characterization of magnetic and ferroelectric materials are also discussed. Nonlinear nano-optics can lead to the development of novel photonic devices on the sub-wavelength-scale as well as new tools for imaging and local optical studies of materials, chemical and biological species.

Journal Article↗
PubMed2000

Semiconductor devices "from inside"

Operation of any semiconductor device can be presented by unique configuration of the electrical field (potential) and charge (doping) distribution within the device. More specifically, the status of operation is described by the quasi-Fermi energy (QFE) profile across the device. Visualization of the dynamic operation of the device and quantitative measurements of the QFE profile is provided by differential voltage contrast (DVC), which is a modification of the secondary electron imaging in a scanning electron microscope (SEM). The DVC consists of storing two images of a tested semiconductor device. Exposed to the electron beam is a cross section, for example, of a field effect transistor (FET). The first image, covering the entire inside of the FET from source to drain, is taken when the device is not biased. The second image of the same area is taken when the transistor is biased. The secondary electron signal is enhanced or retarded by actual distribution of a potential across the tested device. Subtraction pixel by pixel of the two carefully aligned images removes morphologic contrast from the screen, takes away surface features and contamination of the sample, and reveals the contribution of the electrical field to the changes of contrast. The calibration procedure allows measurement of the potential distribution with a precision of 0.05 V. The first derivative of a potential profile provides for distribution of the electrical field and the second derivative gives the doping profile across the tested device. A variety of semiconductor devices such as p-n junctions, Zener diodes, MOSFET's, MESFET's, solar cells and optical detectors, quantum well lasers, etc., were tested. Videotaping of the tested devices allows us to observe the changes in the electrical field and charge distribution as the device operates in a wide range of electrical or optical signals.

Journal Article↗
PubMed2004

All-optical switching on a silicon chip.

We present an experimental demonstration of fast all-optical switching on a silicon photonic integrated device by employing a strong light-confinement structure to enhance sensitivity to small changes in the refractive index. By use of a control light pulse with energy as low as 40 pJ, the optical transmission of the structure is modulated by more than 97% with a time response of 450 ps.

Journal Article↗
PubMed2000

Multiple sclerosis, acute disseminated encephalomyelitis, and related conditions.

Multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) are conditions whose closely related pathology suggests shared pathophysiological elements, but whose clinical courses are usually, but not always quite dissimilar. The former is largely a disease of adulthood, the latter of childhood. Optic neuritis, demyelinative transverse myelitis, and Devic's syndrome are neurological syndromes that may occur as manifestations of either MS or ADEM. Patients with Miller-Fisher syndrome and encephalomyelradiculoneuropathy usually have features suggesting ADEM in combination with acute demyelinative polyneuropathy. These various conditions and other forms of ADEM share an indistinct border with encephalitides, granulomatous, and vasculitic conditions. MS, ADEM, and the pertinent syndromic subtypes, their differential diagnosis, treatment, and prognosis are considered in this review. Acute cerebellar ataxia is a syndrome that is likely to be pathophysiologically distinct from ADEM, although its occurrence as a postinfectious illness suggests a distant kinship. It is also reviewed.

Acute Disease↗
PubMed2006

Anisotropic optical properties in electroluminescent conjugated polymers based on grazing angle photoluminescence measurements.

Grazing angle photoluminescence (GPL) originates from a waveguided light emitted at grazing angle to the substrate due to the total internal reflections, and the light emission is polarized with enhanced intensity at selective mode wavelength. GPL measurements reveal the optical anisotropy of luminescent conjugated polymers, in particular, the alignment of emitting dipoles from which emission occurs, in contrast to spectroscopic ellipsometry measurements that give the anisotropy in the absorption. Based on the GPL emission intensities and spectra, we investigate the anisotropic optical properties in electroluminescent poly(9,9'-di-n-octylfluorene-alt-benzothiadiazole) (F8BT) conjugated polymer thin films of different molecular weights (M(n) = 9-255 kg/mol), both in the pristine and annealed states. The optical anisotropy in F8BT films generally increases with molecular weight, suggesting that higher molecular weight polymers with longer chains are more likely to lie in-plane to the substrate. Upon annealing, high molecular weight F8BT films show even a higher degree of anisotropy, in contrast to low molecular weight F8BT films that become more isotropic. Annealing causes the polymer chains to rearrange and adopt a configuration in which the interchain exciton migration to better ordered low energy (LE) emissive states is strongly suppressed. We observe that the emissive states in F8BT are strongly affected by the local polymer chain arrangement, producing the less ordered high energy (HE) emissive states near the substrate interface where there is a higher degree of chain disorder and the LE states in the bulk of the film. When spin coated onto a quartz substrate precoated with a poly(styrenesulfonate)-doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) layer, films of F8BT show severe luminescence quenching near the PEDOT:PSS interface for both the LE and HE emissive states, but a selective quenching of the LE states in the bulk of the film. These observations have important implications for fabricating efficient electronic devices using conjugated polymers as an active material, since the performance of these devices will strongly depend on anisotropic optical properties of electroluminescent conjugated polymers.

Journal Article↗
PubMed2006

Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice.

Multiple sclerosis (MS) is a clinically and pathologically heterogeneous inflammatory/demyelinating disease of the CNS. In the MS variant Devic disease, lesions are predominantly found in the optic nerves and spinal cord but not the brain. The immunological bases of the different forms of MS are unknown. We previously generated myelin oligodendrocyte glycoprotein-specific (MOG-specific) TCR transgenic mice (TCRMOG mice; also referred to as 2D2 mice) and reported that a large proportion of these mice develop spontaneous isolated optic neuritis. We have now crossed the TCRMOG mice with MOG-specific Ig heavy-chain knock-in mice (IgHMOG mice; also referred to as Th mice), in which one-third of the B cells are specific for MOG. In these mice, MOG-specific B cells are very efficient in presenting MOG to the transgenic T cells and undergo class switching to IgG1 in the presence of the transgenic T cells. Sixty percent of TCRMOG x IgHMOG mice spontaneously developed a severe form of experimental autoimmune encephalomyelitis (EAE). Histological examination of the CNS revealed a selective distribution of meningeal and parenchymal inflammatory lesions in the spinal cord and optic nerves. Thus, CNS antigen-specific T and B cells cooperate to induce a distinct clinicopathologic EAE pattern that closely replicates human Devic disease.

Animals↗
PubMed2006

Dissecting and reducing the heterogeneity of excited-state energy transport in DNA-based photonic wires.

Molecular photonic wires are one-dimensional representatives of a family of nanoscale molecular devices that transport excited-state energy over considerable distances in analogy to optical waveguides in the far-field. In particular, the design and synthesis of such complex supramolecular devices is challenging concerning the desired homogeneity of energy transport. On the other hand, novel optical techniques are available that permit direct investigation of heterogeneity by studying one device at a time. In this article, we describe our efforts to synthesize and study DNA-based molecular photonic wires that carry several chromophores arranged in an energetic downhill cascade and exploit fluorescence resonance energy transfer to convey excited-state energy. The focus of this work is to understand and control the heterogeneity of such complex systems, applying single-molecule fluorescence spectroscopy (SMFS) to dissect the different sources of heterogeneity, i.e., chemical heterogeneity and inhomogeneous broadening induced by the nanoenvironment. We demonstrate that the homogeneity of excited-state energy transport in DNA-based photonic wires is dramatically improved by immobilizing photonic wires in aqueous solution without perturbation by the surface. In addition, our study shows that the in situ construction of wire molecules, i.e., the stepwise hybridization of differently labeled oligonucleotides on glass cover slides, further decreases the observed heterogeneity in overall energy-transfer efficiency. The developed strategy enables efficient energy transfer between up to five chromophores in the majority of molecules investigated along a distance of approximately 14 nm. Finally, we used multiparameter SMFS to analyze the energy flow in photonic wires in more detail and to assign residual heterogeneity under optimized conditions in solution to different leakages and competing energy-transfer processes.

DNA↗
PubMed2003

Axial and peripheral eye length measured with optical low coherence reflectometry.

An optical low-coherence reflectometer (OLCR device) is described that allows the precise and noncontact measurement of eye length. The device measures eye length both on-axis and off-axis, thus enabling the determination of eye shape, an ocular parameter thought to be important in the development of refractive error. It is essential for several applications in ophthalmology and vision science. This improved OLCR device operates using a single-beam interferometer with a beam deflection mechanism that allows the precise measurement of eye length along the visual axis and within 15 deg horizontally and vertically from the fovea. The validity of this instrument and its revised software is evaluated by measuring the reproducibility of axial length results in an adult eye and an artificial eye, and by correlating axial eye length measured in a group of ten adult eyes with axial eye length obtained with A-scan ultrasound in the same eyes. The precision obtained with adult subjects is compared with that obtained with children.

Adult↗
PubMed2003

Retinal and optic nerve diseases.

A variety of disease processes can affect the retina and/or the optic nerve, including vascular or ischemic disease, inflammatory or infectious disease, and degenerative disease. These disease processes may selectively damage certain parts of the retina or optic nerve, and the specific areas that are damaged may have implications for the design of potential therapeutic visual prosthetic devices. Outer retinal diseases include age-related macular degeneration, pathologic myopia, and retinitis pigmentosa. Although the retinal photoreceptors may be lost, the inner retina is relatively well-preserved in these diseases and may be a target for retinal prosthetic devices. Inner retinal diseases include retinal vascular diseases such as diabetic retinopathy, retinal venous occlusive disease, and retinopathy of prematurity. Other retinal diseases such as ocular infections (retinitis, endophthalmitis) may affect all retinal layers. Because the inner retinal cells, including the retinal ganglion cells, may be destroyed in these diseases (inner retinal or whole retinal), prosthetic devices that stimulate the inner retina may not be effective. Common optic nerve diseases include glaucoma, optic neuritis, and ischemic optic neuropathy. Because the ganglion cell nerve fibers themselves are damaged, visual prosthetics for these diseases will need to target more distal portions of the visual pathway, such as the visual cortex. Clearly, a sound understanding of retinal and optic nerve disease pathophysiology is critical for designing and choosing the optimal visual prosthetic device.

Diabetic Retinopathy↗
PubMed2003

Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner.

Magnetic resonance (MR) imaging and spectroscopy provide important information in patients with acute head injury. However, optimal patient management requires intracranial pressure (ICP) monitoring. There are few reports on the use of ICP sensors in an MR environment. We tested the Ventrix parenchymal intracranial pressure monitoring probe and monitor (Integra Neurosciences, USA), modified by the use of a fibre-optic extension cable, within a 3 Tesla MR system. The device performed well in the MR environment, but one element within the fibre-optic extension was significantly ferromagnetic. The ICP probe produced a small susceptibility artefact on spin echo images, and a larger artefact on gradient echo images. The MR safety of the integrated system is probably acceptable, but could be easily improved with minor modifications. Although the system is MR compatible and produces generally acceptable imaging even at 3 Tesla, there is significant degradation of image quality during gradient echo sequences.

Artifacts↗
PubMed1998

Present Status of SPring-8 Insertion Devices.

According to the general policy, namely, the pursuit of pure radiation without any unreasonable heat load, the construction of various insertion devices has been scheduled at SPring-8. Most of them are of the in-vacuum type, which makes it possible to realize short-period devices, so that the fundamental of undulator radiation may be obtained in the hard X-ray region. In addition, undulator radiation in the soft X-ray range down to 100 eV is available by introducing helical or figure-8 devices having low on-axis power density, which is very beneficial for the optics, gratings or mirrors. A brief overview of the insertion devices at SPring-8 is presented with the initial commissioning results.

Journal Article↗
PubMedDate not supplied

Determination of optical properties in semi-infinite turbid media using imaging measurements of frequency-domain photon migration obtained with an intensified charge-coupled device.

Frequency-domain photon migration measurements across the surface of a tissue-mimicking, semi-infinite phantom are acquired via an intensified charge-coupled device (ICCD) detection system and used in conjunction with the diffusion approximation to determine the optical properties. The absorption and reduced scattering coefficients are determined least accurately when relative measurements of average light intensity I(rel)dc are employed either alone or in a combination with relative modulation amplitude data I(rel)ac and/or relative phase shift data theta(rel). The absorption and reduced scattering coefficients are found accurate to within 15 and 11%, respectively, of the values obtained from standard single-pixel measurements when theta(rel) measurements are employed alone or in combination with I(rel)ac data.

Algorithms↗
PubMed1989

Solid-state imagers for microscopy.

Solid-state imagers offer a variety of options to the modern optical microscopist. Photodiode arrays, charge injection devices, and charge-coupled devices are the three basic types of solid-state imagers available for research imaging. The charge-coupled device (CCD) is the solid-state imager of choice, because of its superior characteristics and its widespread acceptance in the research environment. The performance characteristics of the CCD are well documented and understood, having been quantified by many experimenters, especially in the physical sciences. CCDs exhibit dynamic ranges up to 50,000:1, very high quantum efficiency, and ultralow noise. The camera system in which a device is used, however, dictates the overall performance which can be achieved. The CCD imaging system as it applies to cell biology is discussed in detail in Hiraoka et al. (1987). A video camera operating at 30 frames/second does not provide the resolution, low noise, dynamic range, and linearity of a slow scan, cooled camera operating at 1 frame/second. Conversely, a slow scan camera does not offer the user the facility to resolve rapidly changing events in real time. The analogy between an 8-mm movie camera (video camera) and a 35-mm snapshot camera (slow scan cooled camera) is a useful one to emphasize the different character of these two electronic imaging systems. These two basic camera systems both employ CCD imagers, and each has very different, but complementary, characteristics. No one camera system can address the wide variety of imaging problems which face the modern microscopist. The user of this new generation of instrumentation must decide which system best fits the problem at hand.

Calibration↗
PubMed1984

Anterograde urethrotomy, a new method for internal urethrotomy.

The authors elaborated a new device permitting to perform internal urethrotomy for urethral stricture in an anterograde way, even in cases where optical retrograde urethrotomy could not be applied. The new device is similar to a bladder biopsy forceps with a diameter of Ch 5. Its cutting knife is movable. It can be used with Sachse's urethrotome, inserting it in its guide channel with closed knife and passing it through the stricture. By opening the knife, anterograde urethrotomy can be performed. Out of 145 urethrotomies, this method was utilized in only 3 cases.

Humans↗
PubMed2005

Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity.

OBJECTIVE: Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal cells becomes lower, the ability to detect these cells diminishes. We describe a device designed to augment intraoperative identification of both solid tumor and infiltrating tumor margins. METHODS: A novel, intraoperative, optical spectroscopic tool, using both white light reflectance and 337-nm excitation fluorescence spectroscopy, is described. Discrimination algorithms have been developed to segregate neoplastic tissues from normal glial and neuronal elements. The spectroscopy device was used to measure 5 to 10 locations during glioma resection. Beneath the tool, a biopsy sample was obtained and the pathological results were reviewed in a blinded fashion. Samples were classified as solid tumor, infiltrating tumor, or normal gray or white matter. Comparisons were made between the optical spectra and the histopathological results of sampled areas in evaluating the sensitivity and specificity of the tool for tissue discrimination. RESULTS: Spectral data were obtained from 24 patients with glioma and from 11 patients with temporal lobe epilepsy. A sensitivity of 80% and a specificity of 89% in discriminating solid tumor from normal tissues were obtained. In addition, infiltrating tumor margins were distinguished from normal tissues with a sensitivity of 94% and a specificity of 93%. CONCLUSION: We have developed a handheld, optical spectroscopic device that may be used rapidly and in near real time with high sensitivity and reproducibility as an optical tissue discrimination tool in glioma surgery.

Adult↗
PubMed2006

Photoconductive optically driven deformable membrane under high-frequency bias: fabrication, characterization, and modeling.

The fabrication and characterization of an optically addressable deformable mirror for a spatial light modulator are described. Device operation utilizes an electrostatically driven pixelated aluminized polymeric membrane mirror supported above an optically controlled photoconductive GaAs substrate. A 5 mum thick grid of patterned photoresist supports the 2 mum thick aluminized Mylar membrane. A conductive ZnO layer is placed on the backside of the GaAs wafer. Similar devices were also fabricated with InP. A standard Michelson interferometer is used to measure mirror deformation data as a function of illumination, applied voltage, and frequency. The device operates as an impedance distribution between two cascaded impedances of deformable membrane substrate, substrate, and electrode. An analysis of device's operation under several bias conditions, which relates membrane deformation to operating parameters, is presented.

Journal Article↗
PubMed2006

Double-pass rotary mirror array for fast scanning optical delay line.

We have developed a fast scanning optical delay line based on a rotary mirror array. A double-pass configuration is adopted to optimize the fiber-optical coupling and thus minimize the amplitude modulation in the reflected light. The achieved scanning range is extended to over 3 mm. An additional Michelson interferometer is incorporated into the reference arm to achieve high delay repeatability. Such a device is ideal for real-time optical coherence tomography, optical Doppler tomography, and spectroscopic optical coherence tomography.

Computer-Aided Design↗