SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
A retractor for exposure and dissection of the internal mammary artery incorporating a fiber-optic transillumination system is presented. The device, which can be converted to a standard sternal retractor, has also proved valuable in improving illumination during procedures on the mitral valve and in facilitating dissection of fibrous adhesions from the anterior surface of the heart at reoperation.
Electromagnetic tracking systems have the potential to track instruments inside the body because they are not limited by the line of sight constraints that characterize optical tracking systems. To integrate an electromagnetic tracking device into a surgical navigation system, accurate registration is required. We present a two-stage registration mechanism designed to be more accurate than the widely used global fiducial-based registration method. The first stage uses a hybrid Iterative Closest Point (ICP) registration method and the Simulated Annealing (SA) optimization algorithm, to increase the initial registration accuracy. The second stage exploits multiple implanted tracking needles that are used to calculate the affine transform based on the initial transform information, and thereby to compensate for the deformation in real time. Phantom and swine studies have demonstrated the utility of this technique.
In vivo measurement of blood pressure is critical in many settings, including patient care, medical research, and control of cardiovascular assist and replacement devices. This article describes a pressure sensor based on fiber optic, white light interferometry. An optical interference filter formed between the end face of an optical fiber and the sensing diaphragm selectively reflects a wavelength component. A low cost, thin film optical wedge interferometer placed at the output end detects the wavelength of the reflected signal, which represents a unique cavity length of the interference filter directly related to the diaphragm deflection and, therefore, pressure. Several key features of this sensing scheme include low drift, high accuracy, and insensitivity to light loss factors along the length of the optical fiber. This fiber optic pressure sensor promises significant advances as a medical monitoring tool, a research instrument, and a component of cardiovascular assist and replacement devices. A prototype pressure gauge has been built, and the feasibility of the optical approach verified. Experimental results of the prototype gauge for resolution, repeatability, and drift and a preliminary design for a high resolution, low drift, miniature fiber optic pressure probe are presented herein.
Optical fibers guide light between separate locations and enable new types of fluorescence imaging. Fiber-optic fluorescence imaging systems include portable handheld microscopes, flexible endoscopes well suited for imaging within hollow tissue cavities and microendoscopes that allow minimally invasive high-resolution imaging deep within tissue. A challenge in the creation of such devices is the design and integration of miniaturized optical and mechanical components. Until recently, fiber-based fluorescence imaging was mainly limited to epifluorescence and scanning confocal modalities. Two new classes of photonic crystal fiber facilitate ultrashort pulse delivery for fiber-optic two-photon fluorescence imaging. An upcoming generation of fluorescence imaging devices will be based on microfabricated device components.
Polarized infrared optical emission was observed from a carbon nanotube ambipolar field-effect transistor (FET). An effective forward-biased p-n junction, without chemical dopants, was created in the nanotube by appropriately biasing the nanotube device. Electrical measurements show that the observed optical emission originates from radiative recombination of electrons and holes that are simultaneously injected into the undoped nanotube. These observations are consistent with a nanotube FET model in which thin Schottky barriers form at the source and drain contacts. This arrangement is a novel optical recombination radiation source in which the electrons and holes are injected into a nearly field-free region. Sucha source may form the basis for ultrasmall integrated photonic devices.
We have designed and had manufactured a custom surface acoustic wavefront sensor, using a standard CMOS process. Ultrasound propagating along the surface of an object perturbs the reflection of incident laser light, which has been focused onto the object using a cylindrical lens. These high-frequency angular perturbations of reflected light relate to the amplitude and phase of the ultrasound along a line on the surface of the object, and thus correspond to the acoustic wavefront. The reflected light is imaged onto a custom linear array of split photodiodes; these simultaneously detect the high-frequency perturbations at several discrete points along the line, forming an acoustic wavefront sensor. As well as a description of the device, its role within an adaptive optical scanning acoustic microscope is discussed. The sensor detects the distortions to the acoustic wavefront after it has propagated through an aberrating medium, such as a metal containing grains of random orientation. The information attained may then be used to alter the generation profile of the optical generation source of the acoustic waves, thus reducing the distortion caused by the aberration and increasing the resolution and accuracy of the system as a whole.
We have constructed a simple device by which the optimal delay time between optical measurement of a cell and the application of the droplet charging pulse can be determined directly in a flow sorter. The device consists of a stainless steel chamber in which the sorted droplets are collected. In the collection chamber the collected droplets run through a capillary where a continuous fluorescence measurement is made. With a sample of fluorescent particles, the delay time is optimal when the measured fluorescence is maximal. The measuring volume is always filled with the last droplets sorted (about 3,000). With this device, the setting of the delay time can be done in a few seconds without the need for microscopical verification. The fluorescence in the collection chamber is excited and detected via optical fibers using about 10% of the light of the existing laser from the flow cytometer and an extra photomultiplier.
The ASORI stereoroentgenometric complex includes a stereoroentgenographic unit, a kit of testometric devices and a measuring stereoscope. The above unit is designed on the basis of the PYM-20 roentgenodiagnostic apparatus and provides for automatic photography. The testometric devices have inclined contrast scales and are photographed. The stereo pairs are analysed on the measuring stereoscope. The structural elements of the investigated object are measured by the unit optical marker in relation to the testometric device image. The testometric method provides for operative and accurate measuring the anatomic structures in health and disease.
A high-resolution digital dosimetric system has been developed for the spatial characterization of radiation fields. The system comprises the following: 0.5-mm-thick, 25-mm-diam CaF2:Dy thermoluminescent crystal; intensified charge coupled device video camera; video cassette recorder; and a computerized image processing subsystem. The optically flat single crystal is used as a radiation imaging device and the subsequent thermally stimulated phosphorescence is viewed by the intensified camera for further processing and analysis. Parameters governing the performance characteristics of the system were measured. A spatial resolution limit of 31 +/- 2 microns (1 sigma) corresponding to 16 +/- 1 line pairs/mm measured at the 4% level of the modulation transfer function has been achieved. The full width at half maximum of the line spread function measured independently by the slit method or derived from the edge response function was found to be 69 +/- 4 microns (1 sigma). The high resolving power, speed of readout, good precision, wide dynamic range, and the large image storage capacity make the system suitable for the digital mapping of the relative distribution of absorbed doses for various small radiation fields and the edges of larger fields.
We carry out a detailed analysis of angle-sensitive devices based on the critical-angle effect. We consider their use in measuring small angular deflections of a laser beam. We establish the diffraction limit to the sensitivity for optical-angle sensors based on reflection and transmission of a laser beam. We find that this limit is identical to that of the triangulation scheme when using a position-sensitive detector or the autocollimation scheme. We analyze the main proposals to date of optical-angle sensors based on the critical-angle effect, focusing on their maximum sensitivity and their polarization dependence in practical conditions. We propose and analyze theoretically a novel and simple angle-sensitive device for sensing optical-beam deflections with very low polarization dependence and a maximum sensitivity close to the diffraction limit when used with typical laser beams. We discuss the basic principles for designing this type of device, provide numerical results, and point out a convenient fabrication procedure.
Noninvasive imaging of reporter gene expression using various imaging modalitiesis playing an increasingly important role in defining molecular events in the field of cancer biology, cell biology, and gene therapy. In this study, a novel reporter vector was constructed encoding a fusion protein comprised of a mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk) (tk), a positron emission tomography (PET) reporter gene, and renilla luciferase (rl), a bioluminescence optical reporter gene joined by a 20 amino acid long spacer sequence. We validated the activity of the two enzymes encoded by the fusion protein (tk(20)rl) in cell culture. Then, tumors stably expressing the tk(20)rl fusion gene were imaged both by microPET and optically using a cooled charge coupled device camera in xenograft-bearing living mice. Using a single fusion reporter (PET/optical) gene should accelerate the validation of reporter gene approaches developed in cell culture for translation into preclinical and clinical models.
By adoption of double-device systems, integral imaging can be enhanced in image depth, viewing angle, or image size. Theoretical analyses are done for the double-image-plane integral imaging systems. Both ray optics analysis and wave optics analysis confirm that the double-device integral imaging systems can pick up and display images at two separate image planes. The analysis results are also valuable in the understanding of the conventional integral imaging systems for image positions off the central depth plane.
Blazed diffractive optical elements (DOEs) were studied for the violet wavelength by electron-beam lithography. By optimizing electron-beam writing parameters and electron-dose distributions, we fabricated eight kinds of grating (period A = 10-0.54 microgm) with excellent blazed structure. It has been demonstrated that the measured diffraction efficiency values agreed well with the rigorous theoretical ones. For the fine period of 0.54 microm, we confirmed a peak appearance of 75.6% (TE) experimentally. A wave aberration as small as approximately 0.01 lambda (rms) was obtained for the first-order diffracted wave from the fabricated DOEs. Blazed DOEs for the violet wavelength could be used as key devices in a high-density optical disk pickup of the next generation.
An impulse train method to control aliasing was used to measure the modulation transfer function of a digital dental x-ray system (RVG 32000 ZHR, Trophy Radiologie, Vincennes, France). The detector of this system is composed of an intensifying screen, a fiber optics taper, and a charged couple device chip. The modulation transfer function could not be measured by impulse method such as the line spread function or edge response function because of aliasing from undersampling of the digital system. The system modulation transfer function was difficult to recover at the spatial frequencies smaller than the Nyquist frequency. The modulation transfer function beyond the Nyquist frequencies was impossible to recover in this study.
Elastic scattering is a cheap and simple-to-use tool that holds the promise of rapid and accurate diagnosis in many applications,including dysplasia arising in Barrett's esophagus. It is being developed as an optical biopsy technique, but preliminary work shows that it may be possible to use this approach as a field detection device. Even as a point measurement technique or optical biopsy, the technique may become an invaluable tool to endoscopists. This article focuses on elastic scattering spectroscopy (also known as diffuse reflectance spectroscopy).
Evaluation of the spectral distribution of the electromagnetic emissions from a system composed of a hydrogen-oxygen torch and a glass tube, used in the manufacturing of glass rods from which optical fibers are drawn, indicated levels in the visible and infrared portion of the electromagnetic spectrum that necessitated a specific type of eye protection to be worn by employees operating this equipment. Specific eye wear which provided qualities of both being lightweight and reducing transmission of all three major regions of the electromagnetic spectrum (ultra-violet, visible, infrared) were specified.
Critical frequency of fusion of flashes (CFFF) was measured in children by CFFF-D device recommended for clinical trials by the Ministry of Health and Medical Industry of the Russian Federation (Protocol No. 4 of June 13, 1996). A total of 213 children with central and peripheral retinal abiotrophy, partial atrophy of the optic nerve, refraction and dysbinocular amblyopia, and healthy children were examined. The most expressed changes of CFFF were observed in children with optic nerve atrophy. The CFFF-D device provides reliable results for the diagnosis.
A simple optical coherence tomography system has been developed based on a white-light Linnik interferometric microscope with its reference mirror mounted on a piezoelectric translator. The geometrical extension of the optics allows efficient illumination of this device with a low-power (3-W) light bulb, yielding full-field interferometric images at 50 Hz with a fast CCD camera. Owing to the very broad spectral width of the light source and of the camera response, we achieved axial resolutions equal to 1.1 microm in free space and 0.7 microm through a standard microscope cover plate. Tomographic images of an epithelial cell smear and of an hematological sample are shown.