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At least 127 records · Page 7Linked to original sources

[Anticomplementary activity of serums from subjects affected by neoplastic processes].

The Author studied the anticomplementary activity of 46 serums from patients affected by different tumours. The research has been positive on 49% of patients. Negative nearly constantly in mieloid and lymphatic leukemias. The highest percentage of activity was observed in the serums of patients affected by pulmonary cancers, histioleukemias and myelomas. Have been also studied the factors III-IV of the complement.

Adult↗

[Quality control plan for a primary bladder neoplastic process].

OBJECTIVES: Delays in the diagnosis and treatment of bladder cancer may change survival rates (6). We present the application of a plan for quality control in the management of primary bladder cancer, studying delays globally, and for individual indicators, as well as the impact of implemented improvement measures. METHODS: We performed a retrospective chart review to detect problems appeared through the whole clinical management process in a population of patients undergoing surgery for primary bladder cancer in the Hospital Costa del Sol during 2001. Causes were studied and corrective measures established, application of which has been evaluated during the first semester of 2002. Study indicators encompass from delay time for first visit to delay time for radical surgical treatment. RESULTS: Excessive average global delays for radical treatment of bladder tumor (208.3 days), and variability in the time to transurethral resection (one to 73.42 days) and to postoperative revision (54.4 days), were the most significant results. Evaluation of implemented measures shows a descent in global delays (134.2 days) and time to postoperative revision variability (32.4 days). CONCLUSIONS: Application of quality control procedures for clinical management is essential in daily clinical practice, for systematic, continuous, and rigorous evaluation will allow us to offer patients a product that satisfies their personal and social expectations.

Case Management↗

[Connection between the sector structural of the interplanetary magnetic field and hematologic indicators in normal and neoplastic processes].

Interplanetary magnetic field (IMF) sector polarity was compared to hematologic indexes of normal mice and mice after single injection of carcinogen 1,2-Dimethylhydrazine. It has been established that the hemoglobin level and the number of leucocytes in the standard blood volume depend on IMF sector polarity: both indexes are higher at +IMF, than at -IMF. Mice injected with carcinogen have mainly higher hemoglobin level at +IMF and mainly lower one at -IMF than the control mice.

1,2-Dimethylhydrazine↗

[Cytometric analysis of neoplastic processes in the large intestine].

Examinations of macroscopically intact mucosa, of adenomas with various dysplasia degrees, and of adenocarcinoma have helped single out cytometric parameters and a number of morphologic characteristics describing the proliferation processes in the large intestine. Variability of the nuclear shape and size, the mitotic activity of the glandular epithelium, and the volumic fraction of proliferating DNA-synthesizing cells are characteristic of malignant processes.

Adenocarcinoma↗

[Indicators of general and local immunity in chronic and neoplastic processes in the head and neck areas].

Total and secretory immunity was investigated in healthy people, patients with chronic ENT pathologies, and patients with tumors of the oral cavity, larynx and laryngopharynx. It was found that chronic inflammation was followed by a decline of topical defence and a decrease of total immunity. In cancer patients these changes were aggravated. Topical immunity disorders included mainly secretory immunoglobulin A and were most pronounced in patients with tumors localized in the oral cavity.

B-Lymphocytes↗

[Influence of methylcobalamin and cyanocobalamin on the neoplastic process in rats].

The effect of methylcobalamine (5.6-dimethylbenzimidazolyl-Co-methylcobamide, CH3-B12) and cyanocobalamine (5,6-dimethylbenzimidazolyly-Co-cyanocobamide, CN-B12) on the growth of Walker's carcinosarcoma and longevity of white noninbred rats with implanted Zajdela ascites hepatoma was studied. The two agents exerted a similar effect. They 1) reduced the survival of rats with implanted Zajdela ascites hepatoma and Walker's carcinosarcoma; 2) did not increase the cell concentration in ascites; and 3) increased the total volume of ascites.

Animals↗

Comparative analysis of certain metals and tumor markers in bronchopulmonary cancer and colorectal cancers. Metals and tumor markers in the neoplastic process.

Carcinogenic metal levels in serum and tissue samples were measured in patients with bronchopulmonary or colorectal cancer. The cadmium and nickel tissue levels in the patients with lung cancer were significantly higher than in the controls. A statistical correlation was found between chromium and cadmium, as well as between cadmium and nickel in patients with colorectal cancer. In addition, prior to the operation, the tumor markers alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen (Ca 19-9), polypeptide histidio antigen (TPA) and ferritin were analyzed. Their average concentrations were correlated with the existing concentrations of the metals. This was done for both types of cancer. Tumor marker detection showed an increase of CEA and TPA in patients with colorectal cancer. A statistical correlation was observed between AFP and zinc tumor tissue.

Adolescent↗

[Functional morphology of breast APUD cells in dysplasia and neoplastic processes].

Histochemical and immunohistochemical methods were used to examine 29 malignant tumors (18 lobular and 11 invasive carcinomas) and 34 fibroadenomas of the mammary gland (MG). APUD cells containing serotonin, melatonin, and beta-endorphine were shown to be present in the duct epithelium of the normal MG and its pericanalicular fibroadenoma. APUD cells were detected in 21 of the 29 malignant tumours of MG. Hormonal differences of APUD cells were found in poorly and well differentiated carcinomas: the former contained serotonin, melatonin, and beta-endorphine (inhibitors of proliferation), the latter--insulin and adrenocorticotropic hormone (stimulators of cell division). Such differences in the endocrine function of MG malignant tumors are likely to be significant in the clinical course and determination of prognosis for carcinomas of various differentiation.

APUD Cells↗