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At least 1,135 records · Page 63Linked to original sources
PubMed1995

Microcomputer-based pulse stimulator.

A low-cost PC-based 2-channel stimulator was designed. This device can generate regular current pulses for many neuroscience experiments. It can also generate irregular pulses for nerve stimulation, thus could possibly avoid the problem of sensitization or habituation in the central nervous system. The stimulation frequency (can be < 0.0005 Hz) and pulse duration (5 microseconds to 65 ms) of this device can be programmed by an interactive user interface. Furthermore, the output current (0-10 mA) can be continuously varied and was optically isolated to minimize stimulus artifact. Moreover, features such as low-power consumption (0.2 mA of a 9 V battery) and high-compliance output (> 120 V) could accommodate the stimulator for widespread applications. A trial of nerve stimulation was illustrated besides the electrical specifications of the stimulator.

Electric Stimulation↗
PubMed1985

Microcomputer program for the design of digital filters.

The program presented here is intended to be a design device and learning tool for digital filters. Digital filters designed with the program can be implemented by incorporation within the data analysis programs of the user. The program is written in BASIC for use with the IBM-PC, is intended to be user-friendly, and includes a great deal of filter assistance not found in other programs. An example of program use shows how one filter can be used to remove noise from respiratory waveform data.

Analog-Digital Conversion↗
PubMed1985

A microcomputer-based system for real-time calculation of airway conductance in awake guinea pigs.

Bronchial responsiveness to various drug stimuli is currently studied by constructing cumulative dose-response curves of specific respiratory conductance (SG). Airway conductance can be measured in guinea pigs by the plethysmographic technique, during the rapid transition from expiration to inspiration (TEI). Since the drug action assigns a strict timing to the experiment, conventional methods of measuring SG prove inconvenient and often lack accuracy. A computerized data acquisition system has therefore been developed to recognize TEI and calculate SG in real time. This paper describes the significant features of the program DOREMI, and gives an illustrative example of the system in use.

Airway Resistance↗
PubMed1985

Real-time blood pressure monitoring in physiological experiments using an Apple II microcomputer.

The paper describes a program used for real-time blood pressure monitoring. A simple method allowing interactive control of the decision criteria is used for upstroke detection. The blood pressure signal is characterized by means of 8 parameters, computed for every cycle. The program offers two graphic modes: plotting (a) the original signal and (b) the computed variables. Other useful programs are presented together with the BP/MONITOR to allow use of the Apple II as a digital memory scope in different working modes.

Animals↗
PubMed1986

A C-language program for the computation of power spectra on a laboratory microcomputer.

A computer program is described which performs power-spectral analyses on time-domain data. The program is written in the C language and incorporates an algorithm for the fast Fourier transform translated from BASIC into C. Sequential segments of time-domain data are accessed by the program, transformed to the frequency domain, and ensemble-averaged to generate smoothed spectra. Specific application of the program to the detection of high-frequency oscillations in the phrenic neurogram of the cat is addressed. Thus, 100 successive 512-point fast Fourier transforms were found to accurately reveal the relative strength (power) and frequency position (spectrum) of multiple peaks in this respiratory motor pathway. Because C language programs are very transportable, this program should run on machines other than our LSI 11/23, provided a C-compiler is available.

Animals↗
PubMed1986

MULTI-FORTE, a microcomputer program for modelling and simulation of pharmacokinetic data.

MULTI-FORTE is an expanded version of the MULTI non-linear fitting programs written by Yamaoka et al. The functions of the three original programs (including Gauss-Newton and Simplex fitting algorithms) have been combined and translated into FORTRAN 77 on the Macintosh computer for both speed and convenience. Models can be described in integrated equation form or as a system of differential equations. Bayesian estimation is also available. Improved numerical integration routines have been added including methods suitable for systems of 'stiff' differential equations (Fehlberg's 4/5 Runge-Kutta method and Gear's DIFSUB subroutine). MULTI-FORTE is a user-friendly program taking data from keyboard or disk file to produce output on screen, printer, or disk file in tables or printer-type plots.

Computer Simulation↗
PubMed1986

A microcomputer program for determining turnover rates before and after intervention in a single animal.

A set of three programs to calculate the turnover of biomolecules whose metabolism follows a steady-state precursor-product relationship and follows the open, single-compartment kinetics model has been written in MS-BASIC. The programs comprise a system for determining two values of turnover, before and after an intervention which may alter the turnover rate, in a single animal. The programs have been extensively tested in our laboratory for the determination of norepinephrine turnover under differing physiological and pharmacological conditions. The utility of the programs lies in their ability to readily adapt to turnover determinations for any substance whose metabolic pathway conforms to the model constraints. This includes the biogenic amine neurotransmitters, peptides and proteins, and many small biological molecules or pharmacological agents.

Animals↗
PubMed1987

Buoyant density and molecular weight calculations on an Apple II microcomputer from equilibrium banding experiment on analytical ultracentrifuge.

Buoyant density is one of the non-destructive measurements of viruses, nucleic acids etc. which help in characterizing these entities in terms of their chemical composition and physical conformation. In recent years equilibrium sedimentation in CsCl buoyant density gradient has been proved to be a powerful tool for genome characterization. The method enables one to obtain information such as the absolute and the relative buoyant density of the material and its molecular weight. This communication describes a program in BASIC which calculates these parameters from the raw data obtained directly from the experiment. The program is fully interactive, user-oriented, and written keeping in view biologists and biochemists as the main users. The program has a built-in option to calculate either the absolute or the relative buoyant density and the molecular weight.

Algorithms↗
PubMed1987

A simple microcomputer program for predicting the secondary structure of proteins.

An Applesoft BASIC program is presented which applies the Chou-Fasman and Garnier-Osguthorpe-Robson rules for predicting the secondary structure of proteins. This program plots the result of predictions and shows the charge distribution and the consensus prediction. The program is run on an Apple IIe and the results are printed by an Imagewriter printer.

Computers↗
PubMed1989

Microcomputer-aided studies of cry jitter uttered by newborn children based upon high-resolution analysis of fundamental frequencies.

The metrological and computational problems of detecting very weak variations in the frequencies of the fundamental tone are discussed from a signal processing point of view. An appropriate computer method of high-resolution analysis of the fundamental frequency is proposed. When applying high-resolution fundamental frequency analysis to cry signals, a jitter was found to exist in the fundamental frequency curve of both healthy babies and those suffering from cerebral disorders. A method is given to separate the jitter from the fundamental frequency curve. The separated jitter curve depends on the degree of slope of the fundamental frequency curve and shows differences between healthy and ill babies. For an objective evaluation of the jitter abnormities, an integral parameter--the so-called cry-jitter index--is proposed.

Algorithms↗
PubMed1989

A microcomputer program to calculate elemental analysis of peptides.

A BASIC program is presented that calculates the elemental analysis of peptides given their primary sequence. This program is aimed to help synthetic chemists in the characterization of their products. The program runs on any IBM-compatible computer with the MS-DOS operating system, version 2.0 or greater, and the results are printable on any connected printer.

Elements↗
PubMed1990

Microcomputer analysis of three-channel Lissajous' trajectory of auditory brainstem evoked potentials.

A software package for the IBM PC computer is presented to facilitate the analysis of three-channel Lissajous' trajectories (3CLT) of auditory brainstem potentials. The program deals with 4-channel numeric or ASCII files, including three orthogonal X, Y, Z channels and standard vertex-mastoid on the stimulated side. The 3CLT analysis program implements standard measurements of peak latencies, voltage amplitude and curvature plots computed from the three orthogonal channels, interactive three-dimensional rotations of the trajectory and planar segment analysis. Parameter estimates of the best-fit plane are computed for any part of the trajectory limited by two latency cursors. Results are displayed and stored in a table including segment bounds and duration, sight vector orientation, plane equation parameters and adjustment criteria.

Evoked Potentials, Auditory↗
PubMed1991

Measurement systems calibration: microcomputer implementation.

Measurement systems used in the collection and processing of laboratory data must be calibrated periodically to obtain accurate results. Because calibration factors can change over time or may be reset to optimize measurements for specific tests, care must be taken to assure that calibration factors and data are aligned correctly. Users should be able to process current data or re-process older data using appropriate calibration factors. The alignment of calibration factors and data should occur in a simple, automatic and transparent way. This document describes one approach to calibration procedures and computer programs used to collect, process, document, measure and display laboratory data. The examples are from our neurophysiology laboratory, where investigators study the mammalian spinal cord and peripheral neuromuscular system. Typical calibration problems, some workable solutions, and computer programs (described in pseudocode) are presented.

Calibration↗
PubMed1991

A microcomputer system for collecting and processing physiological information about the masticatory system.

A software system has been written for IBM PC, XT, AT and compatible computers to be used for data collection, analysis and display. The system supports the sampling and processing of data for jaw movement tracks, myoelectrical activities of masticatory muscles, the temporomandibular joint (TMJ) and occlusal sounds and bite force, etc. The package includes the following functions: calculating displacement, velocity, curvature, and curvature center of jaw movement trace, analyzing myoelectrical signals in amplitude integration, root mean square and power spectrum, processing TMJ sounds and occlusal sounds and bite force, analysing jaw movement traces and myoelectrical activities during mastication simultaneously, determining the maxillomandibular relations, etc. The program also provides versatile formatting capability for video, printing and plotting of data, and graph creation. The most of the above programs have flexibility and adaptability to other physiological signal processes.

Bite Force↗
PubMed1991

A microcomputer method for continuous system simulation in health care.

A method for continuous system simulation in biomedicine and health care intended for use with personal computers is described. The method is applicable to multistate deterministic models and based on the use of standard spreadsheet programs used with such computers. It includes features such as model implementation, changes of simulation parameters, execution of simulation experiments as well as tabular and graphic presentation of simulation results. The method can be used for simulation of systems in epidemiology, health-care organization and other biomedical fields where deterministic models are suitable tools for studying phenomena connected with live systems.

Communicable Diseases↗
PubMed1991

CANEST: a microcomputer program for estimating cancer in a cohort.

Certain diseases and symptoms carry an overrepresentation of cancer. To be able to measure the strength of such an association it is necessary to be able to predict cancer development in the group being observed. A computer program for computers running under the MS DOS operating system has been developed for this purpose. The program is written in the CLIPPER programming language. The estimates are based on incidence and prevalence data from the Swedish Cancer Registry for the years 1958 to 1986. The program also computes confidence intervals based on the Poisson distribution. The results can be printed out or exported to other programs for further analysis.

Cohort Studies↗