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Vestibular and audiologic functions in gentamicin-treated Menière's disease.

Fifteen patients with disabling Meniere's disease were treated with local intratympanic administration of gentamicin once daily. They had suffered from frequent attacks of vertigo and vomiting, the hearing in the affected ears was decreased permanently, and spontaneous nystagmus was observed. The number of treatment days ranged between 3 and 11. Follow-up time was 1 to 6 years. For evaluation of the treatment, audiologic and vestibular examinations were used, including the broad frequency-band rotatory test (0.4-4.5 Hz). Fourteen patients were free from vertigo after treatment. In 5 patients, there was an increased hearing loss, and in 10 it remained unchanged. Tinnitus and fullness sensations were diminished. After treatment, all ears were unresponsive to caloric stimulation. The clinical examination and rotatory testing in light with sinusoidal stimulation revealed good central compensation of the vestibular loss. However, with pseudorandomized oscillations in darkness, the broad frequency-band rotatory test quantified the loss of peripheral vestibular function and was able to detect the side of the lesion in eight of nine patients.

Administration, Topical↗

Evaluating 3D semicircular canal function by perception of rotation.

OBJECTIVE: We aimed to develop a clinical test of 3D canal dysfunction by perceptual matching of motion stimuli as an alternative to vestibular ocular reflex assessment. STUDY DESIGN: The study was a comparison with age-matched controls. SETTING: The study was performed in a clinical neurophysiology laboratory. PATIENTS: Ten patients with acute unilateral vestibular nerve section and 9 patients in the chronic stage of recovery, 2 acute-stage and 2 chronic-stage patients with posterior canal plugging, and 35 healthy individuals were studied. INTERVENTIONS: Seated on a motorized rotating chair in darkness, subjects were exposed to discrete, raised cosine velocity (60 degrees/s peak) rotations, for random displacements < or = 180 degrees rightward and leftward. They responded by rotating themselves back to the starting position with a joystick control. Horizontal canals were tested with head upright, ipsilateral versus contralateral vertical canal pairs were tested with the head down, face horizontal and co-planar anterior-posterior canal pairs were tested with the head down and turned approximately 45 degrees to the left or right. MAIN OUTCOME MEASURES: These were accuracy and symmetry of responses. RESULTS: Normal responses were approximately accurate returns to start. Nine patients with acute nerve section were hypometric (undershooting start) when displaced toward the lesion but normometric to the intact side. Eight chronic-stage nerve section patients with chronic dysfunction were hypometric to the lesion for vertical canal stimuli, but one third showed normal responses for horizontal canal testing. Patients with posterior canal plugging were hypometric specifically toward the plugged canal. CONCLUSIONS: The method reliably identifies acute and chronic dysfunction of vertical canals and acute dysfunction of horizontal canals. Dysfunction of a single canal can be specified.

Adolescent↗

Physiological bases and a technique for testing the full range of vestibular function.

The vestibulo-ocular reflex (VOR) is most active at higher frequencies (> 2 Hz) during locomotion, in order to stabilize vision. Use of active head movements, monitored by a sensor on a head strap, is a new method of testing the horizontal and vertical VORs which utilizes this natural frequency range, and doesn't require a rotating chair. Specialized computer processing based on Fourier analysis is necessary to analyze head and eye signals, which can be erratic. Higher harmonics of these erratic movements are particularly useful for VOR testing, in the analogous sense that complex sound processing is necessary for speech processing in audition. Use of portable computers with VOR active head analysis can be done at the bedside, as a portable vestibular test. Sophisticated software can effectively substitute for rotating chair hardware, provided that physiological corrections are applied to actively-generated movements at higher frequencies. In summary, the resulting test is brief, comfortable to the patient, portable, and useful for diagnostic screening over the frequency range that is most active during common daily movements.

Eye Movements↗

The evaluation of patients with Eales' disease.

Thirty-two patients with documented Eales' disease who have been followed-up at Johns Hopkins Hospital for periods of as long as 37 years were investigated. The previously reported association of Eales' disease with tuberculoprotein hypersensitivity was confirmed in 10 of 21 patients tested. For the first time, associated vestibuloauditory dysfunction is described. The previously reported association with multiple sclerosis was not confirmed. Eales' disease is a specific vasculopathy that can affect both the retinal and vestibuloauditory circulations. Patients with suspected Eales' disease should also be examined to rule out other diseases such as diabetes, sarcoidosis, and connective tissue diseases including systemic lupus erythematosus. This can be done by obtaining such tests as fasting blood glucose, chest radiograph, erythrocyte sedimentation rate, antinuclear antibody, rheumatoid factor, and LE cell preparation. Tuberculoprotein sensitivity status should be ascertained and active tuberculosis should be ruled out. The patient should be questioned regarding hearing or balance problems, and if a history suggestive of abnormalities is elicited, referral for vestibuloauditory function testing should be made.

Adult↗

[EYE AND VERTIGO].

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Cerebellar Neoplasms↗

Gentamicin - Progressive cochlear toxicity.

Four patients with severe thermal burns showed Gentamicin cochlear toxicity. The hearing loss ranged from moderate to severe and was progressive in the three patients that were followed. These side effects were seen even with only topical application of Gentamicin to large surface burns of the body. All patients had an associated loss of bestibular function. None of the patients during treatment with Gentamicin was in renal failure. These finding are discussed in the light of current knowledge of Gentamicin toxicity, blood levels, and absorption from surface burns of the body.

Administration, Oral↗

Extended caloric tests.

The standard ABB remains the most popular test of vestibular function. The use of air caloric irrigations or the closed loop water system seem to be scientifically sound alternatives to the use of open water irrigation. Although controversy still surrounds the use of monothermal warm calorics as a screening test, several studies have shown its reliability. The Torok monothermal differential caloric test seems to be a good alternative to the ABB, but more studies need to be done showing its results in other hands. Some of the other tests mentioned in this report may be helpful as ancillary tests for use in patients in whom the standard tests produce inconsistent findings.

Air↗

[Evaluating otolith function with subjective visual vertical discrimination].

This report summarizes our experiences with the subjective visual vertical (SVV) as a clinical neuro-otological tool. In the SVV test, patients have to orient a dim light bar in an otherwise dark surrounding earth-vertical, using a remote-control. Normal subjects in an upright position did not deviate more than 2 degrees from true vertical. After vestibular neurectomy, the SVV was consistently tilted by some 12 degrees toward the affected ear. Smaller tilts (approximately 7 degrees) of the SVV occurred in patients with spontaneous peripheral vestibular diseases. This shift in SVV disappeared within weeks to months, similar to the spontaneous nystagmus. After stapes surgery slight deviations of the SVV towards the unoperated ear were seen in about 20% of the patients, indicating a slight irritation of the otolith organs. Assessed in an upright position, the SVV thus may be regarded as reflecting tonic otolithic input differences between the two ears. Asymmetries in the shifts of the SVV induced by roll tilts of the gravito-inertial vector by eccentric rotations of the subject have been proposed as a test for otolithic sensitivity. In our studies such asymmetries in the shifts of the SVV could not be induced by 26 degrees or 90 degrees roll tilts of subjects towards the affected or healthy ears. A simple clinical test to reveal unilateral otolithic sensitivity (comparable to an otolithic "caloric test") thus still has to be found.

Dark Adaptation↗