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PubMed1994

Evaluation of single-use masks and respirators for protection of health care workers against mycobacterial aerosols.

BACKGROUND: The recent increase in multidrug-resistant tuberculosis has spawned a major controversy concerning the degree of respiratory protection needed by health care workers, particularly during sputum-inducing procedures. The objective of this study was to measure the filtration efficiencies of a single-use submicron surgical mask, two disposable dust/mist respirators, a dust/mist/fume respirator, and a high-efficiency particulate air respirator against aerosolized mycobacteria. Facial fit was not addressed. METHODS: In a specially designed enclosed test apparatus, an aerosol was generated with a Collison nebulizer from a known concentration of Mycobacteria chelonae, used as a surrogate for Mycobacterium tuberculosis. Aerosol concentrations were measured with Anderson samplers upstream and downstream of the test masks and respirators, which were heat sealed to a metal plate. RESULTS: Mean efficiencies ranged from approximately 97% for the surgical mask and a dust/mist respirator to more than 99.99% for the high-efficiency particulate air respirator. Measurements of filter efficiency with an Aerodynamic Particle Sizer for the M. chelonae aerosol and independent challenge tests with latex spheres correlated closely with measurements of M. Chelonae collection efficiency determined with Andersen samplers. CONCLUSIONS: Analysis of variance and Tukey's method for multiple comparisons indicated that the dust/mist/fume respirator and the HEPA respirator collected M. chelonae with significantly greater efficiency than did either the surgical mask or the dust/mist respirator. Even the least efficient mask tested, however, had a filter efficiency of more than 97% against particles averaging less than 1 micron in aerodynamic diameter.

Aerosols↗
PubMed1982

Temporal masking of auditory evoked brainstem responses in human newborns and adults.

Temporal masking effects on brainstem evoked responses (BERs) were studied in normal human newborns and adults. Forward masking prolonged the latencies of the newborn BERs significantly longer than adult BERs. The effect of backward masking on BER latencies for both newborns and adults was small, suggesting that either backward masking effects for these stimuli are mediated by structures rostral to the brainstem or that backward masking does not affect the latency of the BER. Increasing the duration of the forward masker prolonged BER latencies more for newborns than adults. Increasing the intensity of the masker prolonged BER latencies for both newborns and adults, however, there were no significant age-intensity interactions.

Acoustic Stimulation↗
PubMed1984

Frequency threshold curves and simultaneous masking functions in single fibres of the guinea pig auditory nerve.

Tuning curves for simultaneous masking were measured electrophysiologically, in single fibres of the guinea pig auditory nerve. The masking paradigm used was an analogy of that used in the determination of psychophysical tuning curves in man. The resulting tuning curves ran nearly parallel to the corresponding neural frequency threshold curve, over all except the high-frequency portion of the tuning curve. There, the masking functions had a shallower slope than the excitatory frequency threshold curve. The frequency at which the slope became shallower had a close and consistent dependence on fibre characteristic frequency, reaching a value of 1.2 times fibre characteristic frequency in high-frequency fibres. Analysis of firing rates during the threshold determination gave information about the mechanism of the masking, and the results were supported by theoretical analysis. The results give information useful for the interpretation of psychophysical tuning curves, determined by simultaneous masking, in man.

Animals↗
PubMed1984

Noise masking of tone responses and critical ratios in single units of the mouse cochlear nerve and cochlear nucleus.

Responses of single units in the cochlear nerve and cochlear nucleus to tone bursts in a background of continuous white broadband noise were recorded. Tone and noise intensities ranged from threshold to saturation levels. Masking of the tone response by the noise was demonstrated by comparing peristimulus-time histograms and spike rates recorded during the tone and between tone presentations. The response of a unit to masking was found to be predictable based upon the difference in its rate of response to the tone and to the noise when the tone was masked. Several nonlinearities of the masking process are described. The most prominent one is an increase in the difference between tone and noise levels at the threshold of masking with increasing tone levels, i.e. neural critical ratios increase with increasing tone level. On the average, the frequency dependence of single unit effective bandwidths and of critical ratio bandwidths is similar to that of mean behavioral critical ratio bands.

Action Potentials↗
PubMed1987

Evoked response 'forward masking' patterns in chinchillas with temporary hearing loss.

Evoked response "forward masking" data were measured from the inferior colliculus of the chinchilla before and during a temporary threshold shift. The hearing loss was induced by a 2 kHz pure tone of 85 dB SPL presented from 5-8 days. The exposure elevated thresholds by approximately 35 dB at the mid frequencies, but had no effect on low frequency hearing. The exposure also altered the time course of the evoked response forward masking data. Time constants fitting the forward masking data increased by up to a factor of three at the frequency with the greatest loss, but remained within normal limits at the low frequencies where hearing was normal. The increase in the forward masking time constants became most noticeable once the hearing loss exceeded 25 dB. These physiological results are consistent with psychophysical forward masking data from hearing impaired listeners.

Adaptation, Physiological↗
PubMed1993

Forward masking properties of neurons in the dorsal cochlear nucleus: possible role in the process of echo suppression.

The majority of single unit studies in the auditory system have been carried out using stimuli whose temporal and spectral contexts are held constant. Relatively little attention has been given to the influence of context on unit response properties. Indeed, auditory nerve fiber responses are known to be context-dependent due to the property of forward masking, a phenomenon by which the response to one sound results in a reduction in the response to a subsequent sound. Forward masking might be expected to be even more influential at central levels of the auditory pathway where the responses are reshaped by additional synaptic interactions. The purpose of the present study was to characterize the forward masking properties of neurons in the dorsal cochlear nucleus (DCN). A tool was developed for measuring the response to a probe tone as a function of delay following a previous tone-burst. The frequency of the probe was held constant at the unit's characteristic frequency while the frequency of the leading tone (masker) was varied. These measures provided a description of neural masking effects in different temporal and spectral contexts. The data yielded two patterns of suppression. In the first pattern (Type A), the suppression of the probe response became evident immediately following offset of the masker; the suppression bandwidth showed a gradual narrowing as the delay between masker and probe was increased. In the second class (Type B), the suppression of the probe response did not become evident until well after offset of the masker; this pattern appeared more circumscribed in that the suppression bandwidth gradually increased as a function of delay up to a maximum then decreased with further increases in delay. The results imply that mechanisms intrinsic to the DCN contribute to further modification and reshaping of the spectral and temporal context of masking effects beyond those seen in the auditory nerve. It is hypothesized that such properties may be specialized for suppressing the response to echoes thus facilitating communication and localization of sound in enclosed spaces.

Acoustic Stimulation↗
PubMed1994

Neurophysiological model of tinnitus: dependence of the minimal masking level on treatment outcome.

Validity of the neurophysiological model of tinnitus (Jastreboff, 1990), outlined in this paper, was tested on data from multicenter trial of tinnitus masking (Hazell et al., 1985). Minimal masking level, intensity match of tinnitus, and the threshold of hearing have been evaluated on a total of 382 patients before and after 6 months of treatment with maskers, hearing aids, or combination devices. The data has been divided into categories depending on treatment outcome and type of approach used. Results of analysis revealed that: i) the psychoacoustical description of tinnitus does not possess a predictive value for the outcome of the treatment; ii) minimal masking level changed significantly depending on the treatment outcome, decreasing on average by 5.3 dB in patients reporting improvement, and increasing by 4.9 dB in those whose tinnitus remained the same or worsened; iii) 73.9% of patients reporting improvement had their minimal masking level decreased as compared with 50.5% for patients not showing improvement, which is at the level of random change; iv) the type of device used has no significant impact on the treatment outcome and minimal masking level change; v) intensity match and threshold of hearing did not exhibit any significant changes which can be related to treatment outcome. These results are fully consistent with the neurophysiological interpretation of mechanisms involved in the phenomenon of tinnitus and its alleviation.

Acoustic Stimulation↗
PubMed2006

Attention attenuates metacontrast masking.

The influence of attention on perceptual awareness was examined using metacontrast masking. Attention was manipulated with endogenous cues to assess the effects on the temporal and spatial parameters of target visibility. Experiment 1 examined the time course of effective masking when the target and mask set were presented at an attended vs. an unattended location. The valid allocation of attention decreased the magnitude of the masking effect (i.e. increased visibility) for approximately 80 ms. Furthermore, even with spatial displacements of the target and mask and center-to-center separations of 1.5 degrees or 2.7 degrees of visual angle (Experiment 2), target visibility was increased when attention was validly allocated. These results indicate that attention influences low-level visual processes to enhance visual awareness.

Adolescent↗
PubMed2006

No difference between conscious and nonconscious visuomotor control: evidence from perceptual learning in the masked prime task.

Negative compatibility effects (NCEs) in the masked-prime paradigm are usually obtained when primes are masked effectively. With ineffective masks-and primes above the perceptual threshold-positive compatibility effects (PCEs) occur. We investigated whether this pattern reflects a causal relationship between conscious awareness and low-level motor control, or whether it reflects the fact that both are affected in the same way by changes in physical stimulus attributes. In a 5-session perceptual learning task, participants learned to consciously identify masked primes. However, they showed unaltered NCEs that were not different from those produced by participants in a control group without equivalent perceptual learning. A control experiment demonstrated that no NCEs occur when prime identification is made possible by ineffective masking. The results suggest that perceptual awareness and low-level motor control are affected by the same factors, but are fundamentally independent of each other.

Adolescent↗
PubMed2004

Effects of masker component phase on the forward masking produced by complex tones in normally hearing and hearing-impaired subjects.

For normally hearing subjects, harmonic complex tones that give "peaky" waveforms on the basilar membrane (Schroeder-positive phase, sine phase or cosine phase) lead to less forward masking than complex tones that give less peaky waveforms (Schroeder-negative phase or random phase), but have the same power spectrum. This difference has been attributed mainly to the combined effects of peripheral compression and suppression, both of which depend on the operation of the active mechanism in the cochlea. If this explanation is correct, the phase effect should be reduced or absent for subjects with moderate cochlear hearing loss. We measured growth-of-masking functions for forward maskers containing the first 40 harmonics of a 100-Hz fundamental, with components added either in cosine phase or random phase, using both normally hearing subjects and subjects with moderate cochlear hearing loss. The signal frequency was 1 or 2 kHz. For the normally hearing subjects, the mean slopes of the growth-of-masking functions at 1 and 2 kHz, respectively, were 0.53 and 0.44 for the random-phase masker and 0.31 and 0.26 for the cosine-phase masker. For high masker levels, the former produced considerably more masking than the latter. The phase effect was smaller for the hearing-impaired than for the normally hearing subjects, which is consistent with the idea that it is partly caused by peripheral compression and suppression. However, three of the five hearing-impaired subjects showed a significant effect of masker phase for at least one signal frequency. In one case, this occurred when the hearing loss at the signal frequency was 65 dB. The slopes of the growth-of-masking functions were consistently less than one for the hearing-impaired subjects. Further testing suggested that the efferent system was not involved in producing the phase effect.

Acoustic Stimulation↗
PubMed2004

Repositioning accuracy of a commercially available thermoplastic mask system.

BACKGROUND AND PURPOSE: To evaluate the repositioning accuracy of a commercially available thermoplastic mask system for single dose radiosurgery treatments and fractionated treatment courses. PATIENTS AND METHODS: The repositioning accuracy of the Raycast-HP mask system (Orfit Industries, Wijnegem, Belgium) was analyzed. Twenty-two patients that were treated by intensity-modulated radiation therapy (IMRT) or intensity modulated radiosurgery (IMRS) for 43 intracranial lesions, underwent repeated CT imaging during their course of treatment, or as a positional control immediately before radiosurgery. We evaluated multiple anatomical landmark coordinates and their respective shifts in consecutive repeated CT-controls. An iterative optimization algorithm allowed for the calculation of the x, y and z-components of translation of the target isocenter(s) for each repeated CT, as well as rotation in the respective CT data sets. In addition to absolute target isocenter translation, the total magnitude vector (i.e. sum-vector) of isocenter motion was calculated along with patient rotations about the three principle axes. RESULTS: Fifty-five control CT datasets were analyzed for the target isocenter's respective position relative to the original treatment planning CT simulation. Mean target isocenter translation was 0.74+/-0.53, 0.75+/-0.60 and 0.93+/-0.78 mm in x, y and z-directions, respectively. Mean rotation about the x, y and z-axes was 0.67+/-0.66, 0.61+/-0.63 and 0.67+/-0.61 degrees, respectively. The respective median and mean magnitude vectors of isocenter translation were 1.28 and 1.59+/-0.84 mm. Analysis of the accuracy of the first setup control, representative of setup accuracy for radiosurgery treatments, compared with setup accuracy throughout a fractionated radiation treatment course were statistically equivalent (P= 0.15) thus indicating no measurable deterioration of setup accuracy throughout the treatment course. CONCLUSIONS: The analyzed Orfit thermoplastic mask system performed favorably compared with other mask immobilization systems for which peer-reviewed repositioning data exist. While the performance of the system for fractionated treatment courses was considered to be excellent, use of this mask system for radiosurgery immobilization in our clinic is subject to additional quality assurance measures to prohibit the delivery of treatments with target dislocations larger than 2 mm. The measured data in the present study should enable the users of this system to assign appropriate margins for the generation of planning target volumes.

Cranial Irradiation↗
PubMed2004

Attention orienting and the time course of perceptual decisions: response time distributions with masked and unmasked displays.

Mask-dependent cuing effects, like those previously found in yes-no detection, were found in a task in which observers judged the orientations of orthogonally-oriented Gabor patches presented at cued or uncued locations. Attentional cues enhanced sensitivity for masked, but not unmasked, stimuli. Responses were faster to cued than to uncued stimuli, irrespective of masking. The distributions of response times and accuracy were well described by a diffusion process model of decision making. Mask-dependent cuing was explained by an orienting model in which: (a) decisions are based on stable stimulus representations in visual short term memory that determine the rate of evidence accumulation in the diffusion process; (b) inattention delays the entry of stimuli into short term memory, and (c) masks limit the visual persistence of stimuli.

Attention↗
PubMed2004

Spatial frequency selective masking of first-order and second-order motion in the absence of off-frequency 'looking'.

Converging evidence suggests that, at least initially, first-order (luminance defined) and second-order (e.g. contrast defined) motion are processed independently in human vision. However, adaptation studies suggest that second-order motion, like first-order motion, may be encoded by spatial frequency selective mechanisms each operating over a limited range of scales. Nonetheless, the precise properties of these mechanisms are indeterminate since the spatial frequency selectivity of adaptation aftereffects may not necessarily represent the frequency tuning of the underlying units [Vision Research 37 (1997) 2685]. To address this issue we used visual masking to investigate the spatial-frequency tuning of the mechanisms that encode motion. A dual-masking paradigm was employed to derive estimates of the spatial tuning of motion sensors, in the absence of off-frequency 'looking'. Modulation-depth thresholds for identifying the direction of a sinusoidal test pattern were measured over a 4-octave range (0.125-2 c/deg) in both the absence and presence of two counterphasing masks, simultaneously positioned above and below the test frequency. For second-order motion, the resulting masking functions were spatially bandpass in character and remained relatively invariant with changes in test spatial frequency, masking pattern modulation depth and the temporal properties of the noise carrier. As expected, bandpass spatial frequency tuning was also found for first-order motion. This provides compelling evidence that the mechanisms responsible for encoding each variety of motion exhibit spatial frequency selectivity. Thus, although first-order and second-order motion may be encoded independently, they must utilise similar computational principles.

Humans↗
PubMed2002

The effect of 'masking' on picture naming.

It is frequently assumed that because compared to nonliving things, living things are less familiar, have lower name frequency, and are more visually complex, this makes them more difficult to name by patients and normal subjects. This has also been implicitly accepted as an explanation for the greater incidence of living thing disorders. Patient studies do not, however, typically contain any premorbid data and so, we do not know that the same variables would have necessarily predicted their 'normal' performance. To examine this issue, we measured picture-naming latencies in normal subjects presented with unmasked and masked versions of the same line drawings. In accord with other recent studies, living things were named faster than nonliving things. Furthermore, contrary to some theories of category naming, the living thing advantage persisted regardless of whether stimuli were undegraded, degraded or the density of degradation. Finally, multiple simultaneous regression analyses showed that one visual variable (Euclidean Overlap) and one linguistic variable (Age of Acquisition) predicted naming latencies across all masked and unmasked conditions. Other variables either had no predictive value (Contour Overlap; Name Frequency; Category); predicted only high masking (Visual Complexity; Familiarity), or normal and low masking (Number of Phonemes). These findings imply that the more commonly documented deficits for living things do not reflect an exaggeration of the normal profile (be it with masked or unmasked stimuli) or the influence of the same variables that affect normal naming.

Adult↗
PubMed2003

Four-dot masking produces the attentional blink.

When two target stimuli (T1 and T2) are presented sequentially within half a second of each other, identification accuracy is often poor for T2. This phenomenon, known as attentional blink (AB), can be observed generally only if the stimulus terminating the presentation of T2 acts as an interruption mask. Recent evidence suggests that even four small dots surrounding a target item can exert masking effects, provided the target onset occurs at an unattended spatial location. In order to test whether an AB could be observed under conditions of four-dot masking of T2, five rapid serial visual presentation streams of letters were synchronously displayed on each trial of the present experiment. T1 and T2 were digits presented at unpredictable locations and unpredictable temporal intervals. T2 was followed by either a blank field, a letter, or four-dots. No AB was observed when T2 was not masked, but robust and equally sized ABs were observed when T2 was followed by both the letter mask and the four-dots.

Adult↗
PubMed1997

Computing stereo channels from masking data.

The detection of stereoscopic depth in random-dot patterns that have been spatially band-pass filtered is adversely affected by the addition of noise at spatial frequencies in the neighbourhood of the frequencies present in the stereogram. This elevation of threshold is generally termed masking and recent data have been interpreted as evidence for a pair of spatial-frequency-tuned stereo "channels" whose peak spatial frequencies are either at 3 and 5 c/deg or 2.5 and 7 c/deg. This interpretation was re-examined. In particular, we have studied how the characteristics of masking interactions might be affected by taking account of the presence of an initial modulation transfer function (including the optical m.t.f. of the eye) that precedes the stage at which signal and mask interact. Using this approach, we reach the conclusion that the peak of the internal masking function for stereo detection coincides with the signal spatial frequency over the whole range tested (1.7-11.6 c/deg). We conclude that the recent data of Yang and Blake [(1991). Vision Research, 31, 1177-1189] are consistent with a multiple channel model in much the form proposed by Julesz and Miller [(1975). Perception, 4, 125-143]. The analysis presented in this paper has general implications for the interpretation of masking studies in spatial contrast vision.

Depth Perception↗
PubMed1993

Pattern recognition and masking in cochlear implant patients.

Studies of the temporal course of masking using pulsatile electrical stimulation provide a sensitive new technique for the investigation of central pattern recognition. The masked threshold for a single-pulse probe was studied for several different maskers as a function of the time between the probe and the start of the masker. These experiments showed the gradual development of a temporal pattern in the masked thresholds as the number of pulses in the masker was increased. For a 210 msec masker with pulses at 10 msec intervals, both backward and forward masking thresholds showed a well-defined peak at times 10 msec before and after the masker. Probe pulses presented at these times were probably perceived to be part of the masker pattern and therefore were not easily identified as probe pulses. This conclusion was confirmed by using a masker with pulses at 20 msec intervals. Only backward masking was tested, and the results showed a peak approximately 20 msec before the start of the masker, fitting in with the temporal pattern of the masker.

Cochlear Implants↗
PubMed1976

Mask wiggling as a potential cause of wound contamination.

Some operating-theatre staff have a habit of wiggling their surgical masks by moving their facial muscles. The field contamination which can result from this practice was studied. A firmly fitting, moulded, synthetic-fibre mask produced significant bacterial contamination of culture plates held beneath the mask, compared with that found on simultaneously exposed control plates placed nearby. Softer fibreglass masks produced less contamination when moved by facial muscles, and are more suitable for mask wigglers.

Face↗