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Model-driven interpretation in intelligent vision systems.

With a constructive knowledge-based theory of perception as its foundation, this paper starts with a review and critique of some artificial-intelligence programs that purport to see. It is then argued that these computer programs for scene analysis offer the hope of providing a more adequate account oo the current psychological theories. This thesis has several aspects. The one emphasized here is that those programs have explored a variety of methods of incorporating a priori knowledge of objects through the use of models. After outlining the range of models used, presenting a set of criteria for evaluating the use of model information, and sketching some psychological theories, the various proposals are contrasted. This discussion leads to two new proposals for exploiting model information that involve elaborations of an existing program, POLY.

Humans↗

A feed forward neural network for classification of bull's-eye myocardial perfusion images.

Identification of hypoperfused areas in myocardial perfusion single-photon emission tomography studies can be aided by bull's-eye representation of raw counts, lesion extent and lesion severity, the latter two being produced by comparison of the raw bull's-eye data with a normal data base. An artificial intelligence technique which is presently becoming widely popular and which is particularly suitable for pattern recognition is that of artificial neural network. We have studied the ability of feed forward neural networks to extract patterns from bull's-eye data by assessing their capability to predict lesion presence without direct comparison with a normal data base. Studies were undertaken on both simulation data and on real stress-rest data obtained from 410 male patients undergoing routine thallium-201 myocardial perfusion scintigraphy. The ability of trained neural networks to predict lesion presence was quantified by calculating the areas under receiver operating characteristic curves. Figures as high as 0.96 for non-preclassified patient data were obtained, corresponding to an accuracy of 92%. The results demonstrate that neural networks can accurately classify patterns from bull's-eye myocardial perfusion images and detect the presence of hypoperfused areas without the need for comparison with a normal data base. Preliminary work suggests that this technique could be used to study perfusion patterns in the myocardium and their correlation with clinical parameters.

Computer Simulation↗

Data compression for medical report archiving.

In a hospital environment, where large numbers of reports are compiled, data compression offers a method for substantially reducing the required disk space whilst protecting the confidentiality of patient data. An analysis is given of the most important parameters that influence compression of free-text data, to realize an efficient implementation of an archiving system for medical reports. An overall reduction of the required disk space by more than 50% can be attained, as well as supplementary level of protection. A slight increase in access time is thereby inevitable, but almost insignificant. Such an archiving system constitutes a necessary component for an intelligent information retrieval system. The access to information contained in medical documents (by means of natural language processing and artificial intelligence techniques) is considered to be one of the key issues in the field of medical informatics for the coming decades.

Archives↗

An "intelligent" workstation for computer-aided diagnosis.

Computer-aided diagnosis (CAD) involves a computerized analysis of radiographs that is used as a "second opinion" by the radiologist. The approach presented incorporates computer vision and artificial intelligence techniques and includes schemes for the analysis of lung nodules, interstitial infiltrates, and cardiomegaly seen on chest radiographs; masses and clustered microcalcifications on mammograms; and stenoses and blood flow on angiograms. The demonstration of various CAD schemes in chest radiography and mammography on a six-monitor workstation simulates one possible clinical implementation of CAD in radiology. Whether soft- or hard-copy display media are used, the radiologist can refer to the CAD results and still use the original radiograph for the final diagnosis. Although initial impressions of this simulated "intelligent" workstation are encouraging, CAD is still in a preliminary stage of development. Various methods for effectively and efficiently integrating CAD into a clinical radiology department are being investigated.

Angiography↗

A novel paradigm for telemedicine using the personal bio-monitor.

The foray of solid-state technology in the medical field has yielded an arsenal of sophisticated healthcare tools. Personal, portable computing power coupled with the information superhighway open up the possibility of sophisticated healthcare management that will impact the medical field just as much. The full synergistic potential of three interwoven technologies: (1) compact electronics, (2) World Wide Web, and (3) Artificial Intelligence is yet to be realized. The system presented in this paper integrates these technologies synergistically, providing a new paradigm for healthcare. Our idea is to deploy internet-enabled, intelligent, handheld personal computers for medical diagnosis. The salient features of the 'Personal Bio-Monitor' we envisage are: (1) Utilization of the peripheral signals of the body which may be acquired non-invasively and with ease, for diagnosis of medical conditions; (2) An Artificial Neural Network (ANN) based approach for diagnosis; (3) Configuration of the diagnostic device as a handheld for personal use; (4) Internet connectivity, following the emerging bluetooth protocol, for prompt conveyance of information to a patient's health care provider via the World Wide Web. The proposal is substantiated with an intelligent handheld device developed by the investigators for pediatric cardiac auscultation. This device performed accurate diagnoses of cardiac abnormalities in pediatrics using an artificial neural network to process heart sounds acquired by a low-frequency microphone and transmitted its diagnosis to a desktop PC via infrared. The idea of the personal biomonitor presented here has the potential to streamline healthcare by optimizing two valuable resources: physicians' time and sophisticated equipment time. We show that the elements of such a system are in place, with our prototype. Our novel contribution is the synergistic integration of compact electronics' technology, artificial neural network methodology and the wireless web resulting in a revolutionary new paradigm for healthcare management.

Adolescent↗

Integration of monitoring for intelligent alarms in anesthesia: neural networks--can they help?

Although there has been a decrease in the number of anesthesia-related critical incidents, there are still opportunities for further improvement. We discuss the potential of integrated monitoring and artificial neural networks as a means of vigilantly watching for patterns in multiple variables to detect incidents and reduce false alarms. We estimate that half the anesthesia-related events could be detected with integrated monitoring using only 5 variables. A review of research using artificial intelligence/expert systems indicates limited potential for success using these tools alone for integrated monitoring in the operating room. We present artificial neural networks as an approach that is more suited to the type of multivariable monitoring and pattern recognition required. Along with rule-based artificial intelligence, these now have the potential to help develop innovative monitoring in the operating room.

Anesthesiology↗

Biochemical recurrence and survival prediction models for the management of clinically localized prostate cancer.

A number of new predictive modeling techniques have emerged in the past several years. These methods, which have been developed in fields such as artificial intelligence research, engineering, and meteorology, are now being applied to problems in medicine with promising results. This review outlines our recent work with use of selected advanced techniques such as artificial neural networks, genetic algorithms, and propensity scoring to develop useful models for estimating the risk of biochemical recurrence and long-term survival in men with clinically localized prostate cancer. In addition, we include a description of our efforts to develop a comprehensive prostate cancer database that, along with these novel modeling techniques, provides a powerful research tool that allows for the stratification of risk for treatment failure and survival by such factors as age, race, and comorbidities. Clinical and pathologic data from 1400 patients were used to develop the biochemical recurrence model. The area under the receiver operating characteristic curve for this model was 0.83, with a sensitivity of 85% and specificity of 74%. For the survival model, data from 6149 men were used. Our analysis indicated that age, income, and comorbidities had a statistically significant impact on survival. The effect of race did not reach statistical significance in this regard. The C index value for the model was 0.69 for overall survival. We conclude that these methods, along with a comprehensive database, allow for the development of models that provide estimates of treatment failure risk and survival probability that are more meaningful and clinically useful than those previously developed.

Aged↗

Robotics and the changing face of the clinical laboratory.

Rapid changes in healthcare coupled with parallel advances in technology have stimulated the evolution of new approaches for laboratory automation. In particular, the emergence of commercially available laboratory robotic systems offers promise for streamlining the clinical laboratory. Increasing cost-containment pressures make the application of this technology extremely attractive, and several organizations have begun to systematically integrate robotic devices into their laboratory automation schemes. Integration of these technologies, however, presents many challenges for software developers, instrument manufacturers, and laboratory workers. Differing needs across laboratories require flexibility and intelligence in robots, instruments, and control systems. Standardization of mechanical and electronic interfaces will be key to making these systems easy to integrate. Systems engineering, aided by simulation modeling and artificial intelligence schemes, will be important to assist in the design of optimal configurations. Software for the overall control of integrated automation will be needed that can be tailored by the laboratorian to fit the requirements of the individual laboratory. Thus, laboratory workers will need to be actively involved in implementing this new wave of laboratory automation, becoming well-versed in computers, electronics, and systems engineering.

Autoanalysis↗

Artificial myocardium with an artificial baroreflex system using nano technology.

Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the heart. At Tohoku University, development research of "the artificial myocardium" has been conducted, using a ball screw type electromagnetic motor. Furthermore, super-miniaturization is being attempted at present. Thus, a system with shape memory alloy is being developed. The cooling speed problem was solved by the application of the Peltier element. A drive at a speed equal to that of a heartbeat was realized by the application of this system. At present, a ventricular assist device is used for patients waiting for a heart transplant in Japan. An air driven type system disturbs a patient's QOL remarkably because it is connected to the drive device. With our concept, energy is provided by using the electromagnetic force from outside of the body by the use of transcutaneous energy transmission system. Magnetic shielding by amorphous fibers was used at Tohoku University to improve the total efficiency. A natural heart can alter the cardiac output corresponding to the demand. Artificial internal organs must participate in the system of the living body, too. Tohoku University has developed a resistance based artificial heart control algorithm, which simulated a baroreflex system to cope with every demand. Nano level sensing equipment is now under development at Tohoku University. At present, development is being conducted aiming at an "intelligent artificial myocardium".

Baroreflex↗

The goal of PACS in Nagoya University Hospital.

In Nagoya University Hospital, a Radiology Intelligent Information System (RIIS) is under construction which will be linked with the Hospital Intelligent Information System (HIIS). RIIS is composed of the radiation oncology information system and the diagnostic radiology information system which is named Imaging Diagnosis Intelligent Information System (IDIIS). IDIIS consists of three parts: (a) the Imaging Diagnosis Management System (IDMS); (b) the Picture Archiving and Communication System (PACS); (c) the Report Generation Support System for Imaging Diagnosis (RGSS-ID). Artificial intelligence methodology is applied to RGSS-ID and IDMS which includes the ordering and scheduling system of diagnostic imaging. IDIIS has an important role to improve the quality of patient care and medical education as well as image management and is an essential component for the implementation of HIIS.

Computer Systems↗

Sniffing out the truth: clinical diagnosis using the electronic nose.

Recently the use of smell in clinical diagnosis has been rediscovered due to major advances in odour sensing technology and artificial intelligence (AI). It was well known in the past that a number of infectious or metabolic diseases could liberate specific odours characteristic of the disease stage. Later chromatographic techniques identified an enormous number of volatiles in human clinical specimens that might serve as potential disease markers. "Artificial nose" technology has been employed in several areas of medical diagnosis, including rapid detection of tuberculosis (TB), Helicobacter pylori (HP) and urinary tract infections (UTI). Preliminary results have demonstrated the possibility of identifying and characterising microbial pathogens in clinical specimens. A hybrid intelligent model of four interdependent "tools", odour generation "kits", rapid volatile delivery and recovery systems, consistent low drift sensor performance and a hybrid intelligent system of parallel neural networks (NN) and expert systems, have been applied in gastric, pulmonary and urine diagnosis. Initial clinical tests have shown that it may be possible in the near future to use electronic nose technology not only for the rapid detection of diseases such as peptic ulceration, UTI, and TB but also for the continuous dynamic monitoring of disease stages. Major advances in information and gas sensor technology could enhance the diagnostic power of future bio-electronic noses and facilitate global surveillance models of disease control and management.

Biomarkers↗

Extrapolating a hierarchy of building block systems towards future neural network organisms.

Is it possible to predict future life forms? In this paper it is argued that the answer to this question may well be positive. As a basis for predictions a rationale is used that is derived from historical data, e.g. from a hierarchical classification that ranks all building block systems, that have evolved so far. This classification is based on specific emergent properties that allow stepwise transitions, from low level building blocks to higher level ones. This paper shows how this hierarchy can be used for predicting future life forms. The extrapolations suggest several future neural network organisms. Major aspects of the structures of these organisms are predicted. The results can be considered of fundamental importance for several reasons. Firstly, assuming that the operator hierarchy is a proper basis for predictions, the result yields insight into the structure of future organisms. Secondly, the predictions are not extrapolations of presently observed trends, but are fully integrated with all historical system transitions in evolution. Thirdly, the extrapolations suggest the structures of intelligences that, one day, will possess more powerful brains than human beings. This study ends with a discussion of possibilities for falsification of the present theory, the implications of the present predictions in relation to recent developments in artificial intelligence and the philosophical implications of the role of humanity in evolution with regard to the creation of future neural network organisms.

Animals↗

[Expert systems in gastroenterology].

Expert systems are the software systems developed by the application of the various intelligence, which could successfully compete to peoples-experts, and have the consultant function with the characteristics of the explanations and the advices in some specific domain. These are, in essence, the intelligent information systems, which consists several thousands of the rules from the definite problem field and which are capable to explain their decisions. The knowledge systems are lesser software systems, also developed by means of the technique of the artificial intelligence which are usually less successful in some field of knowledge of the experts. In the paper are presented the basic characteristics three most often applied expert systems in gastroenterology: Quick Medical Reference (QMR), HEPAT, ILIAD.

Diagnosis, Computer-Assisted↗

Pattern classification by adaptive machines.

Man's intelligent behavior is due in part to his ability to select, classify, and abstract significant information reaching him from his environment by way of his senses. This function, pattern recognition, has become a major focus of research by scientists working in the field of artificial intelligence. At the lowest level, pattern recognition reduces to pattern classification, which consists of the separation, into desired classes, of groups of objects, sounds, odors, events, properties, and the like; the separations are based on sets of measurements made on the entities being classified. The pattern classifier is composed of a data filter and a categorizer. The data filter selects the distinguishing features and represents them as sets of real numbers; each set is termed a pattern. The categorizer assigns each pattern to one of several desired classes. Patterns can be represented geometrically as points in an n-dimensional space; the n coordinates of each point are the numerical values of the features selected to represent the pattern. A pattern classification system separates an n-dimensional space into regions, each of which ideally contains points of only one class. One method to effect this separation is by means of ldquo;trainablerdquo; categorizers-major components of adaptive machines. They consist of networks whose internal parameters are varied according to a set of fixed rules during a training cycle. A statistically large sample of known patterns are presented, one at a time, to the networks; internal corrections are made each time a pattern is erroneously classified. Classifica-tion performance tends to improve as the set of known patterns is cycled repetitively through the machine. Finally, the adequacy of adaptation is tested by a separate set of similar patterns which have not been used in the training process. A number of different machine organizations and training rules have been developed and are being applied successfully to numerous classification problems. More difficult recognition problems requiring the aid of logioal tests and analysis, search and association, use the digital computer programmed to supplement the functions of the adaptive classifier.

Body Constitution↗

Evolution, selection and cognition: from "learning" to parameter setting in biology and in the study of language.

Most biologists and some cognitive scientists have independently reached the conclusion that there is no such thing as learning in the traditional "instructive" sense. This is, admittedly, a somewhat extreme thesis, but I defend it here in the light of data and theories jointly extracted from biology, especially from evolutionary theory and immunology, and from modern generative grammar. I also point out that the general demise of learning is uncontroversial in the biological sciences, while a similar consensus has not yet been reached in psychology and in linguistics at large. Since many arguments presently offered in defense of learning and in defense of "general intelligence" are often based on a distorted picture of human biological evolution, I devote some sections of this paper to a critique of "adaptationism," providing also a sketch of a better evolutionary theory (one based on "exaptation"). Moreover, since certain standard arguments presented today as "knock-down" in psychology, in linguistics and in artificial intelligence are a perfect replica of those once voiced by biologists in favor of instruction and against selection, I capitalize on these errors of the past to draw some lessons for the present and for the future.

Antibody Formation↗

Artificial neural networks for the diagnosis of atrial fibrillation.

Different forms of artificial intelligence have been applied to pattern recognition in medicine. Recently, however, a relatively new technique involving software-based neural networks has become more readily available. Deterministic logic is currently applied to rhythm analysis in computer-assisted ECG interpretation methods developed in the University of Glasgow. The aim of the present study is to compare an artificial neural network with deterministic logic for separating sinus rhythm (SR) with supraventricular extrasystoles (SVEs) and/or ventricular extra-systoles (VEs) from atrial fibrillation (AF) at a particular point in the diagnostic logic of the Glasgow Program. A total of 2363 ECGs with 1495 AF and 868 SR + (SVEs and/or VEs) are used for training and testing a variety of neural networks, and the optimum design is selected. Methods for combining the results of the neural-network classification and the deterministic interpretation are also developed. A further 717 ECGs are used to test the selected network. The results show that the use of an artificial neural network can improve the sensitivity of reporting AF from 88.5% using the deterministic approach to 92%, without sacrificing specificity (92.3%).

Atrial Fibrillation↗

A neural network to analyze fertility data.

OBJECTIVE: To program an artificial intelligence system, a neural network, and use it to predict results of sperm penetration in bovine cervical mucus (Penetrak assay; Serono Laboratories, Norwell, MA) and zona-free hamster egg penetration from the semen analysis. DESIGN: Results of 139 Penetrak assays, 1,416 zona-free hamster egg penetration assays, and the corresponding semen analyses were retrospectively analyzed by an artificial neural network. MAIN OUTCOME MEASURES: Classification errors of the neural network were compared with those of linear and quadratic discriminant function analyses. RESULTS: Data were separated into training and test sets. For the Penetrak result, linear and quadratic discriminant function analysis correctly predicted 58% and 74% of the training set results and only 64.1% and 69.2% of the test data, respectively. The neural network correctly predicted 92% of training set results and 80% of test set results. For the zona-free hamster egg penetration assay outcome, linear and quadratic discriminant function analysis correctly classified 66.3% and 46.0% of the training set and 64.9% and 44.7% of the test set, respectively. The neural network correctly classified 75.7% of the training data and 67.8% of the test data. CONCLUSIONS: Using the semen analysis, the neural network correctly classified 67.8% of zona-free hamster egg penetration assay results and 80% of Penetrak results it had not encountered previously, suggesting that this method of data analysis may be successfully employed to predict fertility potential.

Animals↗

Collective intelligence of the artificial life community on its own successes, failures, and future.

We describe a novel Internet-based method for building consensus and clarifying conflicts in large stakeholder groups facing complex issues, and we use the method to survey and map the scientific and organizational perspectives of the artificial life community during the Seventh International Conference on Artificial Life (summer 2000). The issues addressed in this survey included artificial life's main successes, main failures, main open scientific questions, and main strategies for the future, as well as the benefits and pitfalls of creating a professional society for artificial life. By illuminating the artificial life community's collective perspective on these issues, this survey illustrates the value of such methods of harnessing the collective intelligence of large stakeholder groups.

Artificial Intelligence↗