Influence of certain factors on the coating of a medicinal agent on core tablets.
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The adhesion of a polymer film to selected tablet substrates was studied. The effect of tablet surface roughness and film-coating solvent on the adhesion of the film to the tablet was determined. A film-coating solvent having a solubility parameter close to that of the polymer was found to produce a stronger adhesional bond than a solvent having a lower surface tension. An increase in tablet surface roughness also increased film adhesion to the tablet. The adhesion was measured as the force required to peel a section of film from the tablet with a stress-strain analyzer.
The structure of the bark lectin RPbAI (isoform A4) from Robinia pseudoacacia has been determined by protein crystallography both in the free form and complexed with N-acetylgalactosamine. The free form is refined at 1.80 A resolution to an R-factor of 18.9% whereas the complexed structure has an R-factor of 19.7% at 2.05 A resolution. Both structures are compared to each other and to other available legume lectin structures. The polypeptide chains of the two structures exhibit the characteristic legume lectin tertiary fold. The quaternary structure resembles that of the Phaseolus vulgaris lectin, the soybean agglutinin, and the Dolichos biflorus lectin, but displays some unique features leading to the extreme stability of this lectin.
A novel method for the direct analysis of condensed tannin components in bark was developed on the basis of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) combined with a simple solid sampling technique. The MALDI mass spectra obtained from the wood (bark) powder sample clearly showed a series of peaks corresponding to the sodium ion adducts of condensed tannin oligomers up to around m/z 3000. The results indicate that the condensed tannins in the bark sample used in this work mostly consist of combinations of flavan-3-ol units such as profisetinidin (PF), prorobinetinidin (PR) and prodelphinidin (PD), at least up to 10-mers (m/z approximately 3000).
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The three plant exudates gum traganth, gum arabic, and gum karaya and the two seaweed extracts carrageenan and alginate were degraded by five different Bacilli which were isolated from these gums: Bacillus coagulans, B. lentus, B. cereus, B. licheniformis, and B. firmus. After 14 days all the gums have been degraded by these Bacilli to a different extent after addition of trace elements. The fractions of degraded gums by TLC, GLC, and IR-spectroscopy have been examined with the following results: 1. Except the already known monomers of the above mentioned gums no other monosaccharides could be found. 2. The microbial degradation of gum karaya and alginate resulted in products with a high molecularweight. Monomers could not be determined. 3. Carrageenan has been degraded to oligosaccharides with molecularweights of about 500, 3,6-anhydrogalactose has been partly identified. 4. Gum arabic has been partly degraded to rhamnose and arabinose. 5. Gum traganth has been partly degraded to arabinose and xylose and partly to polysaccharides with molecularweights under 3000.