Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Inversion”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed2006

Classification of unilateral vocal fold paralysis by endoscopic digital high-speed recordings and inversion of a biomechanical model.

Hoarseness in unilateral vocal fold paralysis is mainly due to irregular vocal fold vibrations caused by asymmetries within the larynx physiology. By means of a digital high-speed camera vocal fold oscillations can be observed in real-time. It is possible to extract the irregular vocal fold oscillations from the high-speed recordings using appropriate image processing techniques. An inversion procedure is developed which adjusts the parameters of a biomechanical model of the vocal folds to reproduce the irregular vocal fold oscillations. Within the inversion procedure a first parameter approximation is achieved through a knowledge-based algorithm. The final parameter optimization is performed using a genetic algorithm. The performance of the inversion procedure is evaluated using 430 synthetically generated data sets. The evaluation results comprise an error estimation of the inversion procedure and show the reliability of the algorithm. The inversion procedure is applied to 15 healthy voice subjects and 15 subjects suffering from unilateral vocal fold paralysis. The optimized parameter sets allow a classification of pathologic and healthy vocal fold oscillations. The classification may serve as a basis for therapy selection and quantification of therapy outcome in case of unilateral vocal fold paralysis.

Algorithms↗
PubMed2003

Pulse-inversion-based fundamental imaging for contrast detection.

Pulse-inversion-based fundamental imaging was experimentally investigated for the enhancement of contrast detection. The pulse-inversion technique involves two firings with inverted waveforms. When the returning echoes from the two firings are summed, the residue signal is limited to even-order harmonics for tissue. However, when the returning echoes are from microbubbles, the fundamental signal is not completely cancelled because the reaction of the bubbles under compression is different from that under rarefaction. Thus, with the application of pulse-inversion technique, the fundamental signal can be used to enhance the contrast-to-tissue ratio. In this paper, B-mode, pulse-inversion-based fundamental images were constructed with various transmit waveforms. Motion artifacts also were studied. The results indicate that the contrast-to-tissue ratio was significantly enhanced compared to that obtained using either conventional, fundamental imaging or second-harmonic imaging. Longer transmit pulses resulted in a better signal-to-noise ratio, but did not noticeably affect the nonlinear response of the bubbles. In addition, the optimal ratio of the magnitude of the positive pulse to that of the negative pulse was unity, in terms of avoiding the uncancelled, third-order response in the fundamental frequency range. It also was found that the pulse-inversion fundamental technique is highly sensitive to tissue motion because the fundamental tissue signal is not cancelled when motion is present.

Artifacts↗
PubMed2005

Half-thickness inversion layer high-frequency ultrasonic transducers using LiNbO3 single crystal.

Half-thickness inversion layer high-frequency ultrasonic transducers were fabricated using lithium niobate (LiNbO3) single crystal plate. The transducers developed for this study used a 36 degrees rotated Y-cut LiNbO3 thin plate with an active element thickness of 115 microm. The designed center frequency was in the range of 30 to 60 MHz. Half-thickness inversion layer was formed after the sample was annealed at a high temperature, and it is shown that the inversion layer thickness can be controlled by the temperature. Silver powder/epoxy composite and parylene were used as acoustic matching layers. A lossy silver epoxy was used as the backing material. Using an analytical method, the electrical impedance for different inversion layer ratios was determined. The measured resonant frequency was consistent with the modeled data. Even-order higher frequency broadband ultrasonic transducers with a center frequency at 60 MHz was obtained using half-thickness inversion layer of LiNbO3 single crystal.

Journal Article↗
PubMed1999

Feasibility in the inverse protein folding protocol.

Methods for protein structure (3D)-sequence (1D) compatibility evaluation (threading) have been developed during the past decade. The protocol in which a sequence can recognize its compatible structure in the structural library (i.e., the fold recognition or the forward-folding search) is available for the structure prediction of new proteins. However, the reverse protocol, in which a structure recognizes its homologous sequences among a sequence database, named the inverse-folding search, is a more difficult application. In this study, we have investigated the feasibility of the latter approach. A structural library, composed of about 400 well-resolved structures with mutually dissimilar sequences, was prepared, and 163 of them had remote homologs in the library. We examined whether they could correctly seek their homologs by both forward- and inverse-folding searches. The results showed that the inverse-folding protocol is more effective than the forward-folding protocol, once the reference states of the compatibility functions are appropriately adjusted. This adjustment only slightly affects the ability of the forward-folding search. We noticed that the scoring, in which a given sequence is re-mounted onto a structure according to the 3D-1D alignment determined by the dynamic programming method, is only effective in the forward-folding protocol and not in the inverse-folding protocol. Namely, the inverse-folding search works significantly better with the score given by the 3D-1D alignment per se, rather than that obtained by the re-mounting. The implications of these results are discussed.

Algorithms↗
PubMed2005

Identification of factor VIII gene mutations in 101 patients with haemophilia A: mutation analysis by inversion screening and multiplex PCR and CSGE and molecular modelling of 10 novel missense substitutions.

Haemophilia A (HA) is an X-linked bleeding disorder caused by diverse mutations in the human coagulation factor VIII (FVIII) gene. We have analysed DNA from 109 unrelated Indian patients with HA for their FVIII gene defects. Among these patients 89 (82%) had severe (FVIII:C <1%) HA, 11 (10%) had moderate (FVIII:C 1-5%) HA and nine (8%) had mild (FVIII:C 5-30%) HA. These patients were first screened for the common intron 22 and intron 1 inversions. Inversion negative samples were screened for point mutations by a multiplex PCR and conformation sensitive gel electrophoresis strategy. Mutations were identified in 101 of the 109 patients. These included two (2%) intron 1 and 51 (51%) intron 22 inversions, four (4%) gross deletions and 44 (43%) point mutations. Twenty-nine novel causative mutations, including 11 missense, seven frameshift, five nonsense mutations, three splice site defects and three gross deletions were detected. Ten of the novel missense mutations were studied by molecular modelling. Two different (Thr2253Pro and Pro1392fs) mutations were seen in four unrelated families and FVIII gene haplotyping suggested a common founder effect. Seven of these 109 patients had inhibitors. Among them, four had intron 22 inversions, one had a novel gross deletion (delexon 2-9) and one a nonsense mutation (Trp1535Stop). In one of these patients, no mutation could be identified in the FVIII gene. A Thr2253Pro novel mutation and an intron 22 inversion were identified in two female haemophiliacs. The data from this study suggests that the spectrum of gene defects in Indian patients with HA is as heterogeneous as reported in other populations.

Amino Acid Substitution↗
PubMed1990

The Min DNA inversion enzyme of plasmid p15B of Escherichia coli 15T-: a new member of the Din family of site-specific recombinases.

Plasmid p15B is a bacteriophage P1-related resident of Escherichia coli 15T-. Both genomes contain a segment in which DNA inversion occurs, although this part of their genomes is not identical. This DNA segment of p15B was cloned in a multicopy vector plasmid. Like its parent, the resulting plasmid, pAW800, undergoes complex multiple DNA inversions: this DNA inversion system is therefore called Min. The min gene, which codes for the p15B Min DNA invertase, can complement the P1 cin recombinase gene. The Min inversion system is thus a new member of the Din family of site-specific recombinases to which Cin belongs. The DNA sequence of the min gene revealed that Min is most closely related to the Pin recombinase of the e14 defective viral element on the E. coli K12 chromosome. Like other members of the Din family, the min gene contains a recombinational enhancer element which stimulates site-specific DNA inversion 300-fold.

Amino Acid Sequence↗
PubMed2005

Impact of inverse plasma filtration on complement activation in porcine blood.

During extracorporeal circulation, activation of the complement system as a bioincompatibility reaction upon contact with artificial surfaces is well known. This may induce adverse effects for the patient as well as for the bioreactor when using a hybrid liver support system. At present, the achievable clearance rates in hybrid liver support systems are restricted by the limitations of blood flow through the capillaries of the plasma filter. In order to enhance clearance rates it is desirable to develop a high-flow plasma separation unit in which the activation of the complement system is as low as possible. Conventional plasma filters operating in normal and in inverse (blood flow around the capillaries and the capillary lumen serving as plasma compartment) modes were investigated applying an in vitro circuit (n = 4 in each group). For this purpose heparinized porcine blood was used. Complement activation was measured as generation of the soluble membrane attack complex, SC5b-9. With a normal flow mode the maximum achievable filtration rates varied from 25 to 40 mL/min, whereas the maximal filtration rates with an inverse flow mode varied from 40 to 100 mL/min. While these values were significantly higher than those with regularly operating plasma filters, there was no significant difference between normal and inverse mode in the production of SC5b-9. We conclude that the outer surface of the investigated conventional plasma filtration membranes is suitable for an inverse mode and does not lead to an excessive activation of the complement system upon dynamic blood contact. Thus, the inversion of the blood and the plasma compartments may be a possible way forward in the development of a high-flow plasma separation filter.

Animals↗
PubMed2004

QT interval prolongation with global T-wave inversion: a novel ECG finding in acute pulmonary embolism.

OBJECTIVE: The purpose of this study was to report a novel electrocardiographic (ECG) phenomenon in acute pulmonary embolism characterized by QT interval prolongation with global T-wave inversion. METHODS: Among a total of 140 study patients with a confirmed diagnosis of acute pulmonary embolism, patients who fulfilled the inclusion criteria for QT interval prolongation with global T-wave inversion were examined. Each of these patients had undergone a detailed clinical evaluation including testing for myocardial injury and echocardiography. RESULTS: QT interval prolongation with global T-wave inversion was found in five patients (age 51-68 years) with acute pulmonary embolism. Four were women. Acute pulmonary embolism was diagnosed by ventilation-perfusion scan in three patients and by spiral computed tomography in other two patients. None of the patients had any right or left ventricular regional wall motion abnormalities on echocardiography. All patients had changes characteristic of hemodynamically significant pulmonary embolism, including right ventricular stunning or hypokinesis and dilatation in five patients with paradoxical septal motion in four. Acute coronary syndrome was ruled out in each patient by clinical evaluation, serial ECGs and cardiac markers, and lack of regional wall motion abnormalities on echocardiography. Prolongation of QT intervals (QTc 456-521 ms) with global T-wave inversion was noted on presentation. The ECG changes gradually resolved in 1 week in all patients with appropriate treatment of acute pulmonary embolism. One patient died. None of the patients developed torsade de pointes. CONCLUSIONS: Acute pulmonary embolism may occasionally result in reversible QT interval prolongation with deep T-wave inversion, and, thus should be considered among the acquired causes of the long QT syndrome.

Acute Disease↗
PubMed1993

Multiple minima in inverse hyperthermia temperature estimation problems.

Using one-, two-, and three-dimensional numerical simulation models it is shown that multiple minima solutions exist for some inverse hyperthermia temperature estimation problems. This is a new observation that has important implications for all potential applications of these inverse techniques. The general conditions under which these multiple minima occur are shown to be solely due to the existence of symmetries in the bio-heat transfer model used to solve the inverse problem. General rules for determining the number of these global minimum points in the unknown parameter (perfusion) space are obtained for several geometrically symmetric (with respect to the sensor placement and the inverse case blood perfusion model) one-, two-, and three-dimensional problem formulations with multiple perfusion regions when no model mismatch is present. As the amount of this symmetry is successively reduced, all but one of these global minima caused by symmetry become local minima. A general approach for (a) detecting when the inverse algorithm has converged to a local minimum, and (b) for using that knowledge to direct the search algorithm toward the global minimum is presented. A three-dimensional, random perfusion distribution example is given which illustrates the effects of the multiple minima on the performance of a state and parameter estimation algorithm. This algorithm attempts to reconstruct the entire temperature field during simulated hyperthermia treatments based on knowledge of measured temperatures from a limited number of locations.

Algorithms↗
PubMed2006

An alternative proof of Bukhgeim and Kazantsev's inversion formula for attenuated fan-beam projections.

An inversion formula was developed by Bukhgeim and Kazantsev for attenuated fan-beam projections [Russian Academy of Science Siberian Branch: The Sobolev Institute of Mathematics (2002)]. The inversion formula was obtained by relating the attenuated fan-beam projections to unattenuated fan-beam projections and by trickily processing the unattenuated fan-beam projections. We show in this paper that the inversion formula can be readily obtained from Novikov's inversion formula for the two-dimensional (2D) attenuated radon transform. The derivation provides an alternative proof of Bukhgeim and Kazantsev's inversion formula by the use of transformation between parallel-beam coordinates and fan-beam coordinates and thus is quite elementary.

Algorithms↗
PubMed2004

Verification of inverse planning and treatment delivery for segmental IMRT.

With intensity-modulated radiotherapy (IMRT), it is important that the inverse planning process yields the most appropriate dose distribution for the patient and that the delivered dose then corresponds to the planned dose. This paper presents methods by which the inverse planning and delivery of segmental (step-and-shoot) IMRT can be verified, and gives results for a typical treatment planning system (Pinnacle3 v6.2b, Philips Radiation Oncology Systems, Milpitas, CA). Inverse planning was assessed by observing the reduction in objective function as fields were successively added to three-field prostate, esophagus, and thyroid plans. The ability of the treatment planning system to calculate dose for a segmented field was examined by creating a stepped field with five successively narrowing segments. The complete planning process was then investigated by using two orthogonal IMRT fields to create a homogeneous dose distribution in a cubic water phantom. Finally, a clinical situation was simulated by creating a five-field segmental IMRT plan for a lung target in an anthropomorphic phantom. A conformal plan was also compared for context. Addition of fields to inverse plans generally resulted in a reduction of objective function, indicating consistency of inverse planning solutions. Planned dose for fields with stepped intensity agreed with ionization chamber measurements to within 5%. For orthogonal fields, planned dose distributions agreed well with dose measured using film and agreed with ionization chamber measurements to within 3%. For the anthropomorphic phantom, the standard deviation of difference between planned and measured dose was 4%. Although no consensus has yet been reached on what constitutes an acceptable IMRT plan, these results indicate that step-and-shoot IMRT can be planned and delivered using the system described with comparable accuracy to a standard conformal treatment.

Algorithms↗
PubMed2001

Optimal focusing by spatio-temporal inverse filter. I. Basic principles.

A focusing technique based on the inversion of the propagation operator relating an array of transducers to a set of control points inside a medium was proposed in previous work [Tanter et al., J. Acoust. Soc. Am. 108, 223-234 (2000)] and is extended here to the time domain. As the inversion of the propagation operator is achieved both in space and time, this technique allows calculation of the set of temporal signals to be emitted by each element of the array in order to optimally focus on a chosen control point. This broadband inversion process takes advantage of the singular-value decomposition of the propagation operator in the Fourier domain. The physical meaning of this decomposition is explained in a homogeneous medium. In particular, a definition of the number of degrees of freedom necessary to define the acoustic field generated by an array of limited aperture in a focal plane of limited extent is given. This number corresponds to the number of independent signals that can be created in the focal area both in space and time. In this paper, this broadband inverse-focusing technique is compared in homogeneous media with the classical focusing achieved by simple geometrical considerations but also with time-reversal focusing. It is shown that, even in a simple medium, slight differences appear between these three focusing strategies. In the companion paper [Aubry et al., J. Acoust. Soc. Am. 110, 48-58 (2001)] the three focusing techniques are compared in heterogeneous, absorbing, or complex media where classical focusing is strongly degraded. The strong improvement achieved by the spatio-temporal inverse-filter technique emphasizes the great potential of multiple-channel systems having the ability to apply completely different signal waveforms on each transducer of the array. The application of this focusing technique could be of great interest in various ultrasonic fields such as medical imaging, nondestructive testing, and underwater acoustics.

Echoencephalography↗
PubMed2003

An iterative implementation of rotated coordinates for inverse problems.

A generalized inversion method is presented that uses a rotated coordinates technique [Collins and Fishman, J. Acoust. Soc. Am. 98, 1637-1644 (1995)] in simulated annealing to invert for both the location of an acoustic source and parameters that describe the ocean seabed. The rotated coordinates technique not only aids in the inversion process but also indicates the coupling of the source and environmental parameters and the relative sensitivities of the cost function to changes in the various parameters. The information obtained from the rotated coordinates provides insights into how the inversion problem can be effectively decoupled. An iterative process consisting of multiple simulated annealing runs that each use a different set of rotated coordinates is demonstrated. This multistep algorithm is called systematic decoupling using rotated coordinates and is especially helpful when inverting for a large number of unknown parameters. The cost function minimized in the inversion algorithm is model-data cross-hydrophone spectra summed coherently over frequency and receiver pairs. The results of applying this inversion method to simulated data are presented in this paper.

Acoustics↗
PubMed2004

Inversion of guided-wave dispersion data with application to borehole acoustics.

The problem of inferring unknown geometry and material parameters of a waveguide model from noisy samples of the associated modal dispersion curves is considered. In a significant reduction of the complexity of a common inversion methodology, the inner of two nested iterations is eliminated: The approach described does not employ explicit fitting of the data to computed dispersion curves. Instead, the unknown parameters are adjusted to minimize a cost function derived directly from the determinant of the boundary condition system matrix. This results in an efficient inversion scheme that, in the case of noise-free data, yields exact results. Multimode data can be simultaneously processed without extra complications. Furthermore, the inversion scheme can accommodate an arbitrary number of unknown parameters, provided that the data have sufficient sensitivity to these parameters. As an important application, we consider the sonic guidance condition for a fluid-filled borehole in an elastic, homogeneous, and isotropic rock formation for numerical forward and inverse dispersion analysis. We investigate numerically the parametric inversion with errors in the model parameters and the influence of bandwidth and noise, and examine the cases of multifrequency and multimode data, using simulated flexural and Stoneley dispersion data.

Journal Article↗
PubMed2005

Optimal nonlocal boundary control of the wide-angle parabolic equation for inversion of a waveguide acoustic field.

This paper applies the concept of optimal boundary control for solving inverse problems in shallow water acoustics. To treat the controllability problem, a continuous analytic adjoint model is derived for the Claerbout wide-angle parabolic equation (PE) using a generalized nonlocal impedance boundary condition at the water-bottom interface. While the potential of adjoint methodology has been recently demonstrated for ocean acoustic tomography, this approach combines the advantages of exact transparent boundary conditions for the wide-angle PE with the concept of adjoint-based optimal control. In contrast to meta-heuristic approaches the inversion procedure itself is directly controlled by the waveguide physics and, in a numerical implementation based on conjugate gradient optimization, many fewer iterations are required for assessment of an environment that is supported by the underlying subbottom model. Furthermore, since regularization schemes are particularly important to enhance the performance of full-field acoustic inversion, special attention is devoted to the application of penalization methods to the adjoint optimization formalism. Regularization incorporates additional information about the desired solution in order to stabilize ill-posed inverse problems and identify useful solutions, a feature that is of particular importance for inversion of field data sampled on a vertical receiver array in the presence of measurement noise and modeling uncertainty. Results with test data show that the acoustic field and the bottom properties embedded in the control parameters can be efficiently retrieved.

Acoustics↗
PubMed2005

Modeling the articulatory space using a hypercube codebook for acoustic-to-articulatory inversion.

Acoustic-to-articulatory inversion is a difficult problem mainly because of the nonlinearity between the articulatory and acoustic spaces and the nonuniqueness of this relationship. To resolve this problem, we have developed an inversion method that provides a complete description of the possible solutions without excessive constraints and retrieves realistic temporal dynamics of the vocal tract shapes. We present an adaptive sampling algorithm to ensure that the acoustical resolution is almost independent of the region in the articulatory space under consideration. This leads to a codebook that is organized in the form of a hierarchy of hypercubes, and ensures that, within each hypercube, the articulatory-to-acoustic mapping can be approximated by means of a linear transform. The inversion procedure retrieves articulatory vectors corresponding to acoustic entries from the hypercube codebook. A nonlinear smoothing algorithm together with a regularization technique is then used to recover the best articulatory trajectory. The inversion ensures that inverse articulatory parameters generate original formant trajectories with high precision and a realistic sequence of the vocal tract shapes.

Algorithms↗
PubMed2006

Data error covariance in matched-field geoacoustic inversion.

Many approaches to geoacoustic inversion are based implicitly on the assumptions that data errors are Gaussian-distributed and spatially uncorrelated (i.e., have a diagonal covariance matrix). However, the latter assumption is often not valid due to theory errors, and can lead to reduced accuracy for geoacoustic parameter estimates and underestimation of parameter uncertainties. This paper examines the effects of data error (residual) covariance in matched-field geoacoustic inversion. An inversion approach is developed based on a nonparametric method of estimating the full covariance matrix (including off-diagonal terms) from the data residuals and explicitly including this covariance in the misfit function. Qualitative and quantitative statistical tests for Gaussianity and for correlations in complex residuals are considered to validate the inversion results. The approach is illustrated for Bayesian geoacoustic inversion of broadband, vertical-array acoustic data measured in the Mediterranean Sea.

Journal Article↗
PubMed1999

The "inverse problem" solved for a three-dimensional model of the cochlea. III. Brushing-up the solution method.

In two earlier papers [de Boer, J. Acoust. Soc. Am. 98, 896-903 and 904-910 (1995)] the inherent problems of the inverse-solution method in cochlear mechanics were described. The present paper shows results obtained with a more universal solution method. With the new method it is possible to construct a three-dimensional model of the cochlea producing a response that accurately simulates a measured mechanical basilar-membrane response. With earlier methods this could not be done. The inverse solution invariably yields that, with low stimulus levels, the model simulating a viable cochlea must be locally active. For the response of a dead animal a passive model is sufficient. Once more the inherent intricacies and problems of the inverse-solution method are discussed. Conservation of fluid volume leads to the concept of the "virtual stapes velocity." For best results, the input signal to the inverse-solution procedure should be acquired in the form of a "composite cross-correlation spectrum." Inverse analysis can, under certain circumstances, produce aberrant results. In this paper it is shown why the resulting impedance function is the most accurate in the region of the response peak. Therefore, it is unlikely that a passive model would exist of which the response simulates the data obtained from a healthy animal.

Acoustic Stimulation↗