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PubMed1991

The integration of haptically acquired size information in the programming of precision grip.

Recent evidence for the use of visual cues in the programming of the precision grip has been given by Gordon et al. (1991). Visually invoked size-related information influenced the physical forces used to produce a lift, even when it was not consistent with other sensory information. In the present study, blind-folded subjects were required to feel the size of an object by haptic exploration prior to lifting it. Two boxes of equal weight and unequal size were used for the lift objects and were attached to an instrumented (grip) handle. Grip force and load force, their rates, and the vertical movement of the object were measured. Most subjects reported that the small box was heavier, which is consistent with size-weight illusion predictions. However, peak grip force, grip force rate, peak load force, and load force rate were greater for the large box when the boxes were randomly presented, but not when the same boxes were lifted consecutively. If subjects did not feel the box prior to a lift, these parameters were scaled in between those normally employed for the large and small box. Most subjects apparently programmed the parallel increase of the grip and load force during the loading phase as one force rate pulse. This represented a "target strategy" in which an internal neural representation of the objects weight determined the actual target parameter (i.e. just enough force required to overcome gravity). The other subjects exhibited a slower stepwise increase in grip and load force rate. The subjects choosing this "probing strategy" did not scale the force parameters differently for the two boxes.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Parental representation in patients with major depression, anxiety disorder and mixed conditions.

Differences in parental bonding between patients with pure major depression, mixed anxiety-depression and pure anxiety disorders were investigated in 272 consecutive outpatients. A low parental care score seemed to be the best discriminating variable between the mixed group and the 3 other groups. This study supports previous family and twin studies as well as clinical studies emphasizing the mixed group as a special disorder group, possibly with a different etiology. The role of the father in child development seems to be particularly important.

Adult↗
PubMed1992

Merging and emerging realities: simultaneous treatment of parent and child.

The purpose of this paper is to invite dialogue concerning the variety of modalities possible in the spectrum of child treatment. Many issues remain to be discussed, such as the child's need to possess the therapist entirely, and the role of other family members. Countertransference issues for the therapist are complex and involve the risk of dual loyalties. Simultaneous treatment shares these concerns with other modalities in the spectrum of child treatment. In simultaneous treatment, as parent and child come to share an experience of being cared for, the possibility arises for the dissolution of polarities. Representations of the past give way to adaptations to current reality. Both the parent's and the child's feelings of rage are contained within the therapeutic matrix of relationships; boundaries are maintained to permit repair and growth. Both parent and child reach new levels of integration as the therapist reinforces boundaries and does not permit intrusion by either the parent or the child into the others arena of playful construction.

Adult↗
PubMed2003

[Emotion regulatory processes in evoked play narratives].

Evoked play narratives have been demonstrated to provide a novel window towards internal emotion regulation and mental representations. The present study evaluates covariations between emotion themes and mother-child interaction, as well as child behavior problems. An exploratory study in non-referred children in the 3-6 age span utilizing the MacArthur-method was conducted by taking emotional, conflictive and moral themes as indices of emotion-regulatory processes. Emotion themes were linked to external measures of dyadic Emotional Availability, interparental relationship quality, and behavior problems employing the 4/18 version of the Child Behavior Checklist. Mental representations were aggregated using the Person Representation Coding System. Of a principal components analysis with subsequent varimax-rotation for narrative content codes resulted four emotion theme composites: social conflicting, a prosocial aggregate, an antisocial aggregate, and a composite conflict solving/-understanding. The 4-factor solution displayed meaningful correlation patterns with the mental representations of self and parents, as well as with most of the external measures. Although subsequent studies ought to be methodologically improved both in design and sample size, the results of the present investigation give rise to the assumption that future efforts of validating emotion-regulatory processes with more established outside measures are likely to be successful.

Adaptation, Psychological↗
PubMed1992

Psychic change in child analysis.

The paper describes a period of analysis of a 5-year-old boy as an illustration of some ideas about psychic change. Psychic change is approached in terms of emotional growth, which is directly associated with the degree of flexibility of the defensive system and its capacity to absorb and re-integrate lost parts of the ego and to be open to new emotional experiences. It is described how, through interpretations, the child's internal objects and relationships changed. In particular, his representation of his bad-analyst, bad-father, bad-self changed from being a gorilla to the Incredible Hulk to the whale and finally to Superman crying. When the analysis was interrupted, the patient was showing clear indications that the basis had been laid for establishing a more stable internalized object capable of containing and transforming his anxieties and feelings of despair into more tolerable ones, which gave him a better chance of being fed by good experiences.

Child, Preschool↗
PubMed2006

Common-sense descriptions of depression as social representations.

BACKGROUND: Major depression is such a prevalent illness worldwide that practically everyone has either direct or indirect experience of it. It is important, then, from both practical and theoretical points of view, to examine this particular experience and related conceptions. AIM: Drawing on the theory of social representations, this research set out to examine the ways in which people define depression in terms of the symptoms they attribute to people they know personally and consider to suffer from depression. METHOD: A group of adult participants (n = 117) were instructed to think of an individual whom they knew personally and considered to suffer from depression, to indicate the age and gender of the person, and to describe his/her symptoms. RESULTS: A great majority of the female participants thought of a female, while the male participants thought of male and female target persons quite evenly. The symptoms attributed to depression with fair unanimity included fatigue and decreased capacity to work, to concentrate, to make decisions and to take part in hobbies. The descriptions of the depressive person were quite unanimously distinguished from the signal symptoms attaching to schizophrenia. The descriptions varied according to the characteristics of the target individuals, and their gender and age in particular, rather than the characteristics of the participants. CONCLUSION: People have perceptive personal experiences of depression, which are guided by socially shared interpretative frameworks.

Adolescent↗
PubMed1988

The dream as religion of the mind.

Dreams are defined as a religion of the mind in the sense that they can re-ligare--i.e. unite in a complex relationship--the components involved in the construction of the mind and its representation. The paper discusses the processes of splitting and projective identification which are manifested in dreams and appear to be essential for the transformation of emotional experiences, the acquisition of knowledge and mental growth. On the basis of clinical findings, a revision of Freud's theory of dreams is proposed: the concept of an internal world dominated by good and bad parent figures suggests a theological function for dreams connected with a state of necessity. Dreams represent a real experience which, in analysis, becomes a representation of the internal organization in its immediate present. For this reason, work on dreams makes it possible to acquire knowledge of one's internal objects and of their relationship with the Self. The work on the internal world offered by dreams is made possible by the recovery of memory, the agency responsible for a fusion between current reality and that of infancy as reactivated in the transference. Finally, some aspects of the processes active in dreams are discussed, which make them similar to poetic texts.

Dreams↗
PubMed1991

Proposed partial beta-structures for lac permease and the Na+/H+ antiporter which use similar transport and H+ coupling mechanisms.

Most antiporters, symporters, and transporters have been represented as containing ten to 14 transmembrane helices, primarily on the basis of hydropathy plots. However, multihelix systems provide no obvious mechanism of transport and no simple way of distinguishing substrates. The models of lac permease and the Na+/H+ antiporter presented here postulate that beta-structures are involved in the transport of substrate, and in following this postulate arrive at readily understandable mechanisms for transport and for substrate specificity. The percentage of beta-structures necessary for these models is low enough that it is not in conflict with prior physical evidence for secondary structures. Immunological data also cannot rule these beta-structure mechanisms invalid. In lac permease the new model is obtained by formal representation of the C-terminal amino acids 243-405 as beta-strands. This formal representation nets two interchangeable beta-barrels which provide a simple mechanism for sugar transport. The alternating barrel system may comprise as little as 1/5 the entire permease. In one configuration the barrel forms a pocket with hydrogen bonding residues oriented to the outside of the cell. In the other configuration the barrel forms an analogous pocket oriented towards the inside. Six particular amino acids participate in the substrate hydrogen bonding schemes of both forms, providing a mechanism to shuttle lactose from the outside to the inside or vice versa. A trigger for change of forms which could couple the beta-barrel to H(+)-transport is easily devised, and it involves the apparently critical His322-Glu325 charge relay system. The Na+/H+ antiporter can be organized similarly with an interchanging beta-barrel-beta-clamshell structure attached to 7-transmembrane helices. Charged amino acid sidechains form the basis of an ionic shuttle which is analogous to the lactose shuttle. In this case, too, coupling of Na+ transport to H+ transport may be accomplished by a histidine-glutamate charge relay system.

Antiporters↗
PubMed1996

[Effect of psychological factors in pregnancy on the development of parent-child relations. 2. Transition from prenatal to postnatal phase].

OBJECTIVE: In a longitudinal prospective study on 38 couples and their first child, we examined the influence of prenatally assessed psychological factors of the parents on somatic and psychic aspects of birth, the quality of the newly established parent-child relationship and the early development of the baby. METHODS: Half-standardized psychoanalytic interviews with the couple (pre- and postnatally conducted, video-recorded), the Giessen test for couples, an evaluation of the parents' birth narratives and a parent questionnaire about functional symptoms of the baby were used. RESULTS: We found a high continuity between the pre- and the postnatal measurements of the partnership and the emotional experiences of the parents. Somatic complications of the birth event were not correlated with prenatally assessed psychological factors. But there exists a highly significant correlation between the mental representations and the relationships of the parents and the emotional experiences of birth, the early relationship between the parents and their baby and manifestations of functional disorders of the newborn. CONCLUSIONS: Relevant psychological and psychosocial aspects should be included in the medical care of pregnant women. One should listen to the imaginations and expectations of the parents about the future parentship, including ambivalent feelings. The father should also be seen for psychological assessment.

Female↗
PubMed1976

Idealization and grandiosity: developmental considerations and treatment implications.

Analysis of patients with narcissistic pathology offers an opportunity to study the development of specific distortions of self and object representations. Two cases are presented illustrating the development of idealizations and grandiosity. For one patient these were manifestations of a developmental arrest; for the other, defenses against object-instinctual conflict. Differences in the function of idealizations and grandiosity in the two patients are attributed to the role of aggression and to the degree of separation-individuation attained. Treatment implications with references to the works of Kohut and Kernberg are considered.

Adult↗
PubMed1991

Object relations in childhood and adolescence: the development of working representations.

This article describes two studies based on an integration of theory and research in object relations and developmental social cognition. The following four dimensions were assessed in 2nd and 5th graders and in 9th and 12th graders using Thematic Apperception Test (TAT) responses and Ss' descriptions of meaningful interpersonal episodes: complexity of representations of people, affect-tone of relationship paradigms, capacity for emotional investment in relationships and moral standards, and understanding of social causality. In both studies, developmental differences emerged on all measures except affect-tone, as expected. Results document object-relational development beyond the preoedipal years and suggest the diagnostic importance of distinguishing multiple dimensions of object relations rather than considering object relations as a single or unitary developmental line.

Adolescent↗
PubMed2005

A disturbance of interpreting, of symbolisation and of curiosity in the analyst-analysand relationship (the patient without insight).

The author examines the function of the analyst who may distort the unconscious communication with the patient by means of the expression of his countertransference. He studies a disturbance in curiosity and in symbolisation in a patient with a narcissistic pathology. Both problems were related to this failure in interpreting. The curiosity of the patient, which initially seemed to be non-existent, was found to be directed towards investigating the mind of the analyst, this being his sole purpose. The disturbance in symbolisation was manifested as a constant verbal acting out, which was expressed as verbal communication empty of meaning. A change in the interpretative attitude enabled a modification in the objective of the curiosity, which became focused on investigating his own inner world, and the emptiness of the verbal communication was replaced by representations. This change in communication allowed the analyst to relate the facts of the psychoanalytic relationship both with the patient's phantasy and with the events in his history. An idealised identification with destructive aspects of the mother towards the father was discovered. This idealisation had been sustained by the analyst by means of his errors in interpreting. The author explores disturbances in symbol formation and in the use of symbols, and he considers the different states of emptiness.

Acting Out↗
PubMed2004

Molecular cloning, expression and purification of protein 2A of hepatitis A virus.

Expression of the protein 2A of Hepatitis A virus (HAV), spanning amino acids 764 through 981 of the viral polyprotein results in a strong inhibition of cap-dependent translation (Maltese et al., 2000). However, the molecular mechanism responsible has remained unclear, in part because the HAV 2A protein was not available in amounts large enough to allow biological or structural studies. To address this issue, a cDNA representation of the sequences encoding HAV 2A was generated by PCR, using primers that introduced an AUG triplet, and a sequence coding for 6 histidine residues at the 5'- and 3'-termini of the genomic sequence, respectively. The cDNA fragment was introduced by cassette exchange in the inducible expression vector pQE-60, and the construct was propagated in bacteria E. coli M15 which constitutively expresses the lac repressor. Upon induction with IPTG (1 mM), HAV 2A was visualized by SDS-PAGE of bacterial lysates as a prominent band M(r) = 21 kDa. The identity of the polypeptide was confirmed by both MALDI-TOF peptide mapping and direct amino acid sequencing. The His-tagged HAV 2A was extracted from bacterial pellets under totally denaturing conditions (6 M urea), subjected to Ni(++)-Sepharose affinity chromatography, allowed to refold while still attached to the matrix, and eluted with 250 mM Imidazole. Contaminant material was partly removed by differential ammonium sulfate precipitation. The protein was further concentrated (Vivaspin centrifugal concentrator), the insoluble material (if present) was discarded, and the homogeneity of the dispersion was ascertained by light scattering. SDS-PAGE revealed that in addition to the main protein (Mr = 21 kDa), a second one of apparent Mr = 14 kDa was always present in variable amounts. The proportion of the latter tended to increase with aging of the preparation. Edman degradation analysis proved that the 14 kDa protein resulted from the cleavage of HAV 2A at a so far undetected scissile bond Gly856/Val857 of the viral polyprotein. A first attempt to crystallize the protein by the hanging drop procedure yielded only small crystals containing exclusively the 14 kDa derivative of HAV 2A. Western blot analysis of HeLa cell extracts that had been incubated with the His-tagged HAV 2A so purified failed to reveal any change in the electrophoretic mobility of the eukaryotic initiation factor (eIF) 4G I.

Amino Acid Sequence↗
PubMed1985

The wish for identification and structural effects in the work of Freud.

The concept of identification is a blurred one. There is no general agreement about the relationships with other concepts. On the other hand, Freud described several forms of identification, opposing each to the other (hysterical and narcissistic, primary and secondary, ego and superego identification). The author points out the fact every identificatory process must be considered as a work of the unconscious. 'To identify oneself with ...' always results from a process in which a representation is identified to an other and thus realizes the fulfillment of a wish. But identification itself becomes a drive goal: the wish for identification. On that point, the importance of drive opposition between primary identification and object relationship must be outlined. The structural effects are then considered. From this point of view, personality agencies can be characterized in the same time as the result of the identificatory process and the source of the wish for identification.

Cathexis↗
PubMed1995

Health care delivery reorganization innovative outcome: universal computerized patient identification.

Twenty-three large employers in the Minneapolis/St. Paul area formed the business health care action coalition group (BHCAC) to obtain medical care for their employees and families. Requirements of BHCAC included: 1) detailed reporting of outcomes of both preventive and standard health care, 2) development and successful implementation of practice guidelines, and 3) development of a functioning automated medical record. The coalition was contracted to meet these requirements. A nonprofit foundation--the Institute for Clinical Systems Integration (ICSI)--was formed and the data standards committee created. To ensure registration information transmitted by network would be attached to the correct patient's computer file; a standardized registration data set was agreed upon to be recorded in a uniform manner. This innovative change has allowed, encouraged, and required that clinical data be transferable electronically among organizations. The following are the ICSI data standard requirements for ICSI member organizations: the Health Level 7 (HL7) is to be used for data transmission [1]. Fields to be used include: 1) Social Security Number (SSN): The SSN was chosen as the patient identifier for the reasons listed in [2]. Record the official SSN assigned by the Social Security Administration; record a pseudo-SSN if a social security number is not available following the Veterans Administration (VA) Hospital algorithm. 2) Name: Use the American National Standards Institute (ANSI) Healthcare Informatics Standards Planning Panel (HISPP) and Message Standards Developers Subcommittee (MSDS) Standard for representation of a person's name [3]; completely record all of the person's legal name (including any punctuation, hyphenated and double last names); nicknames and appellations are to be recorded separately; salutations and suffixes are optional, but must be placed in separate computer fields from other name parts. 3) Gender: Allowable values include FEMALE, MALE, OTHER, UNKNOWN. 4) Date of Birth: Include the day, month, year (including century); permitted is approximate or estimated birth dates provided they are indicated as such. Use the ANSI HISPP MSDS standard for date representation [4]. 5) Address: Record at least one address; multiple addresses desirable identified by type or usage (i.E., home, business, office). Allow two or more lines for street, city, U.S. state or Canadian Province; identify by standard two-letter postal abbreviation--zip code (at least 5-digits, preferably 9) or postal code and country. 6) Home ID or Medical Record Number (MRN): Record if different than Social Security Number.

Female↗
PubMed2006

Perceived parental care and supervision: relations with cognitive representations of future offending in a sample of young offenders.

This article focuses on the relations of two dimensions of perceived child-rearing practices, care and protection, as measured by the Parental Bonding Instrument and on cognitive representations of future offending in a sample of 152 young offenders. The relations of two different models, predictive of juvenile delinquency, are explored. Parental influences are thought to represent distal factors affecting juvenile delinquency, whereas cognitive representations, formulating the decisions of young offenders, are proximally related with juvenile delinquency. The focus of the research is the young offenders'intentions to reoffend, and it was found that intentions to reoffend in the future were predicted by attitudes toward offending and perceived behavioural control of future offending, whereas parental variables were redundant in predicting behavioural intentions of reoffending. Any effects of parental variables on behavioural intentions were mediated by the young offenders' attitudes toward offending.

Adolescent↗
PubMed1999

Tomotherapy.

Tomotherapy is delivery of intensity-modulated, rotational radiation therapy using a fan-beam delivery. The NOMOS (Sewickley, PA) Peacock system is an example of sequential (or serial) tomotherapy that uses a fast-moving, actuator-driven multileaf collimator attached to a conventional C-arm gantry to modulate the beam intensity. In helical tomotherapy, the patient is continuously translated through a ring gantry as the fan beam rotates. The beam delivery geometry is similar to that of helical computed tomography (CT) and requires the use of slip rings to transmit power and data. A ring gantry provides a stable and accurate platform to perform tomographic verification using an unmodulated megavoltage beam. Moreover, megavoltage tomograms have adequate tissue contrast and resolution to provide setup verification. Assuming only translational and rotational offset errors, it is also possible to determine the offsets directly from tomographic projections, avoiding the time-consuming image reconstruction operation. The offsets can be used to modify the leaf delivery pattern to match the beam to the patient's anatomy on each day of a course of treatment. If tomographic representations of the patient are generated, this information can also be used to perform dose reconstruction. In this way, the actual dose distribution delivered can be superimposed onto the tomographic representation of the patient obtained at the time of treatment. The results can be compared with the planned isodose on the planning CT. This comparison may be used as an accurate basis for adaptive radiotherapy whereby the optimized delivery is modified before subsequent fractions. The verification afforded tomotherapy allows more precise conformal therapy. It also enables conformal avoidance radiotherapy, the complement to conformal therapy, for cases in which the tumor volume is ill-defined, but the locations of sensitive structures are adequately determined. A clinical tomotherapy unit is under construction at the University of Wisconsin.

Dose Fractionation, Radiation↗
PubMed1987

Sex differences in prolactin change during mourning.

Fourteen men and 12 women were interviewed eight weeks after conjugal bereavement to discuss the events prior to the spouse's death and the subsequent bereavement period. Prolactin (PRL) was measured at the beginning and end of the interview. Descriptions of the deceased spouse were obtained during the interview and rated for Developmental Level of Object Representation (DLOR), a measure of the cognitive complexity of the description. There were significant correlations between DLOR and PRL change for both men and women but the correlation for women was positive and the correlation for men was negative. These findings extend the literature on the psychological correlates of PRL change and suggest that the physiological changes associated with mourning are different for men and women.

Female↗