Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “systematic analysis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Acoustic distorsion products. A systematic analysis of technical parameters. How to explain the results?].

The aim of this study was to define the most interesting parameters useful for a clinical application of acoustic distortion products (mainly, F1 and F2 primaries frequencies and levels). The most interesting F1 and F2 primaries level in order to separate subjects with a normally-hearing function and patients with a sensorineural hearing loss is 50 dBHL. This result can be explained by some physiological properties of cochlear mechanisms.

Acoustic Stimulation↗
PubMed1990

[Systematic analysis of the state of man exposed to radio wave irradiation for a long time].

A complex examination was made of 72 men--short-wave (3-30 MHz) radio equipment controllers. Two parallel control groups of 70 people all in all were examined. No regular changes in the dynamics of amplitude-frequency characteristics of electroencephalogram, associated with the length of service, were observed. The number of subjective complaints from people in contact with radiofrequencies increased with an increase in the length of service. The role of certain clinico-physiological parameters of the organism in the process of adaptation to electromagnetic radiation was quantitatively assessed with the use of status-metry technique; in particular, a decrease in the functional activity of the right hemisphere brain structures, aggravating with the length of service, was observed.

Adult↗
PubMed1989

The psychiatrist's guide to right and wrong: Part II: A systematic analysis of exculpatory delusions.

Although delusions are prima facie evidence of psychosis, their mere presence is not a sufficient condition for exculpation on the grounds of insanity. In most cases, a determination of insanity will depend on the specific content of the delusions and whether, as a result of these delusions, the defendant was unable to know or appreciate the wrongfulness of his or her act. Delusions may be subdivided into four types, according to their content: 1) delusions of being controlled, 2) delusions of grandiosity, 3) delusions of persecution, and 4) delusions of jealousy. An analysis is undertaken of these delusional subtypes in terms of their exculpatory effect within the jurisdictions which follow each of the three respective standards of wrongfulness (i.e., the illegality standard, the subjective moral standard, and the objective moral standard). The criminal law does not recognize a transcendent constancy in the legal insanity status of psychotic individuals whose offense was the result of their delusional ideation. In most such cases, exculpation is based primarily on the specific content of their delusions and how it comports with the law of the jurisdiction specific content of their delusions and how it comports with the law of the jurisdiction in which the act was committed (the lex loci delicti commissi).

Criminal Law↗
PubMed1988

A systematic analysis of religious variables in The Journal of Family Practice, 1976-1986.

One thousand eighty-six studies were reviewed to determine the prevalence, characteristics, and quality of measures of religion or religiosity in The Journal of Family Practice for the decade ending in 1986. Religious variables occurred at a relatively low rate, even among articles with some psychosocial content. The clear preponderance of religious measures pertained to patients rather than to providers, and religious variables were generally analyzed descriptively, not inferentially. In spite of an encouraging use of some measures of religious beliefs and practices, there remained a significant focus on denominational measures of religious status. These findings suggest that the consideration of religious variables in the family medicine literature has not been commensurate with the emerging picture of the role of religious commitment in health status and mental health status. It is suggested that increased emphasis on developing an original literature of record about religious variables in family medicine will promote the empirical assessment of the beneficial, neutral, and harmful effects of religion among family medicine patients and providers.

Family Practice↗
PubMed1988

[The Principle of causality in psychotherapy and psychotherapeutic methods--an attempt at a systematic analysis based on a technologically oriented psychotherapy concept].

The attempt is made to describe in general psychotherapeutic work and efficacy on the basis of the understanding of psychotherapy as a process of action in the framework of a principle of causality of psychotherapy. Issuing from this usual psychotherapeutic methods and conceptions, which at present are applied in the GDR, are briefly characterized and a systematology of these methods is demonstrated. The description of principles of effect shall facilitate the understanding for psychotherapeutic effects in patients undergoing internal treatment and the broader inclusion of psychotherapy into the therapy of the specialist in internal medicine.

Arousal↗
PubMed1987

Improvement of chemical analysis of antibiotics. XIII. Systematic simultaneous analysis of residual tetracyclines in animal tissues using thin-layer and high-performance liquid chromatography.

A simultaneous analytical system for residual tetracycline antibiotics (TCs) in animal tissues including liver has been developed. This system consists of three methods using Baker 10 C18 clean-up followed by high-performance liquid chromatography (method A), thin-layer chromatography (TLC)-UV densitometry (method B) and TLC with spray reagents (method C). Methods A and B were established for the precise determination of TCs and method C for universal screening. The recoveries from beef liver fortified at the level of 1.0 ppm and their coefficients of variation were 60.5-83.3% and 2.3-3.9% (method A) and 58.1-92.8% and 1.0-3.7% (method B), respectively. The detection limits in animal tissues were 0.01 ppm (method A) and 0.1 ppm (methods B and C). The time required for the analysis of four samples was 2.5-3 h with each method.

Animals↗
PubMed1989

Modern chromatographic procedures in systematic toxicological analysis.

The fact that the toxicologist in systematic toxicological analysis never knows what he is looking at but has to take into account a vast number of toxicologically relevant substances makes this field a very difficult, yet challenging task. Because of the strong qualitative emphasis gas and thin-layer chromatography are at present the techniques of choice, and can be used with other relevant techniques such as spray reactions on the plate, UV spectrophotometry and mass spectrometry. However, as a single chromatographic technique will never provide unequivocal identification, the techniques have to be used side by side, so that the final identification matches the results from all the techniques applied. This approach requires that the advantages and disadvantages of each technique be well-known so that a combination of techniques can be chosen that provides the optimum identification power. After the unknown substance(s) have been analysed by a number of techniques and their particular behaviour in these techniques has been established, these findings are then matched against a data bank containing the behaviour of reference substances. This data bank should be as large as possible. Moreover, the search process used with the data bank must take into account the identification power of each individual technique, otherwise a well balanced "yes-no" decision about the presence or absence of a given substance is impossible.

Chromatography, Gas↗
PubMed2026

Comparing the efficacy and safety of unilateral versus bilateral spinal anesthesia: a meta-analysis and systematic review.

BACKGROUND: Unilateral spinal anesthesia has gained increasing attention in recent years. Emerging evidence suggests that it provides comparable analgesia to conventional bilateral spinal anesthesia while reducing adverse effects, and its efficacy and safety compared to bilateral spinal anesthesia remains controversial. OBJECTIVE: This systematic review and meta-analysis aims to evaluate and compare the efficacy and safety of unilateral versus bilateral spinal anesthesia. DESIGN: Systematic reviews and meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: A systematic search was conducted across PubMed, EMBASE, and Cochrane Library from inception to December 10, 2024. ELIGIBILITY CRITERIA: Included studies were randomized controlled trials involving adult patients (&#x2265;18&#x2009;years) undergoing surgery under spinal anesthesia, comparing unilateral versus bilateral spinal anesthesia for efficacy and adverse effects. Studies that focused exclusively on either unilateral or bilateral spinal anesthesia were excluded. The comparator group used the same local anesthetic as the experimental group, with no restrictions on adjuncts (e.g. fentanyl, morphine). RESULTS: Nineteen randomized controlled trials including 1191 patients met the inclusion criteria. Compared with bilateral spinal anesthesia, unilateral spinal anesthesia has a longer onset of sensory blockade (MD = 2.58, 95% CI: 0.93 to 4.22, p&#x2009;=&#x2009;0.002), a shorter duration of sensory blockade (MD&#x2009;=&#x2009;-27.83, 95% CI: -39.25 to -16.42, p&#x2009;<&#x2009;0.00001). In addition, unilateral spinal anesthesia significantly reduced the incidence of hypotension (RR = 0.40, 95% CI: 0.31 to 0.52, p&#x2009;<&#x2009;0.0001), nausea and vomiting (RR = 0.20, 95% CI: 0.07 to 0.56, p&#x2009;=&#x2009;0.002), and post-dural puncture headache (RR = 0.44, 95% CI: 0.23 to 0.81, p&#x2009;=&#x2009;0.009). No statistically significant differences were observed in bradycardia and urinary retention. Collectively, these findings support unilateral spinal anesthesia as a strategy that may enhance perioperative safety while maintaining adequate anesthetic efficacy in appropriately selected patients. CONCLUSIONS: Unilateral spinal anesthesia may offer a favorable balance between anesthetic efficacy and safety compared with bilateral spinal anesthesia, although its clinical utility may depend on surgical duration and patient characteristics.

Humans↗
PubMed2026

Socioeconomic differences in the effectiveness of oral health programs for dental caries prevention in Europe: A systematic review and meta-analysis.

AIM: The meta-analysis systematically summarized evidence on how socioeconomic status (SES), access to dental care, and oral health programs (OHP) affect caries prevalence and severity among children and adults in Europe. METHODS: Four electronic databases (PubMed, Scopus, Cochrane Library and Embase) were systematically screened from 1947-2026, supplemented by cross-referencing and manual searches, without language restrictions. Study selection, data extraction and quality assessment were done in duplicate. Methodological quality was assessed using the NHLBI Study Quality Assessment Tools according to study design. Certainty of evidence was graded using GRADE Profiler 3.6. Mean differences (MD) were calculated for changes in DMFT, and odds ratios (OR) for the presence of dental caries in individuals using fixed-or random-effects models. RESULTS: Electronic searching identified 1800 articles; 23 studies were included in the review (>169,000 participants) and 14 in the meta-analyses (>88,000). Nine studies evaluated the effectiveness of OHP stratified by SES, and ten examined OHP in low-SES populations. Among low-SES individuals, participation in OHP was associated with a significantly lower increase in DMFT (MD[95% CI]=-0.63[-0.94;-0.31];very low certainty) and significantly lower odds of having dental caries (OR[95% CI]=0.61[0.52;0.73];very low) compared with non-participation. Among program participants, individuals with low SES showed a significantly greater increase in DMFT than those with high SES (MD[95% CI]=0.79[0.30;1.21];very low) and had significantly higher odds of having dental caries (OR[95% CI]= 2.88[1.97;4.22];very low). CONCLUSION: Participation in OHP may be associated with reducing dental caries in European populations, but benefits are unequally distributed and increase with higher SES. However, this conclusion is based on a limited number of well-conducted trials.

Humans↗
PubMed1985

Retrieval of analytical data and substance identification in systematic toxicological analysis by the mean list length approach.

Chromatographic techniques are basic tools in systematic toxicological analysis. Extensive data bases with retention parameters of known drugs to aid in the identification of substances found are available or in preparation. For a search in such a data base the computer is indispenable. The commonly used window search has some disadvantages which can be overcome by a search based on the statistical concept, the mean list length. The latter retrieval system gives for each candidate in the identification process a probability value. It is shown that these probability values are highly influenced by the reproducibility of the retention parameters of the analytical systems used. Explanations for these phenomena are given.

Chromatography, Gas↗
PubMed1988

[Morphometric analysis of systematic colonic biopsies].

Using an automatic image analysis processor we measured the cellular density of the lamina propria and the mean glandular area on biopsies issued from 10 normal patients. The microscopic image was automatically digitalized and filtered. The operator manually traced the perimeter of the mucosal glands. The mean nucleus number for a 32,000 microns2 chorionic area is 177 +/- 24. The mean glandular area is 51.2 +/- 2.9%. This method is fast (2 min by field) and reproducible. It can be proposed for the study of inflammatory conditions on systematic colonic biopsy material.

Biopsy↗
PubMed2026

Test-retest reliability of spatiotemporal, kinematic, and kinetic measures in marker-based 3D gait analysis: A systematic review.

BACKGROUND: Marker-based 3D gait analysis (3DGA) is widely used to quantify impairments and evaluate treatment effects. For longitudinal clinical interpretation, clinicians and researchers need reference values for inter-session measurement error. For this purpose, this systematic review synthesized Standard Error of Measurement (SEM) values for spatiotemporal, kinematic, and kinetic (moments) outcomes obtained from marker-based 3DGA studies. METHODS: PubMed and Scopus were searched (final search: 11 December 2025). Studies reporting inter-session test-retest SEM and/or MDC for steady-state overground or treadmill walking using marker-based motion capture were included. Two authors screened records and appraised methodological/reporting quality using a custom tool informed by COSMIN, GRRAS, and biomechanics-specific items. Due to heterogeneity, results were synthesized descriptively using study-level median SEM values, stratified by joint, plane, population (healthy, pathological, single subgroups), and walking condition. Minimal Detectable Change (MDC) values were computed for all available data. RESULTS: Thirty-four studies (762 participants, 44.2% females) were included, with substantially more evidence for overground than treadmill walking. Overground spatiotemporal outcomes showed low errors (walking speed SEM of 0.06 m/s; timing typically &#x2264;0.03 s; spatial parameters generally &#x2264;0.03 m). For joint kinematics during overground walking, median SEMs were 2.4&#xb0; (sagittal), 1.9&#xb0; (frontal), and 3.3&#xb0; (transverse). The corresponding joint-kinetic SEMs were approximately 0.06, 0.04, and 0.03 Nm/kg, respectively. Treadmill data followed similar patterns. SIGNIFICANCE: Marker-based 3DGA allows for accurate assessment of spatiotemporal, kinematic, and kinetic gait features. We provided detailed SEM/MDC lookup tables to support clinical decision-making. Results further offer a benchmark for validating emerging gait assessment technologies (e.g., markerless systems) against realistic limits of marker-based 3DGA.

Humans↗
PubMed1992

Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry.

Gas chromatographic-mass spectrometric (GC-MS) procedures for the systematic toxicological analysis of several categories of drugs relevant to clinical toxicology, forensic toxicology and doping control are reviewed. Papers from 1981 to 1991 are taken into consideration. They describe the detection of acute or chronic intoxication and the detection of drug abuse. Screening procedures are included for the following categories: barbiturates and other sedative-hypnotics, anticonvulsants, benzodiazepines, antidepressants, phenothiazine and butyrophenone neuroleptics, central stimulants (amphetamines, cocaine), hallucinogens (LSD, phencyclidine, tetrahydrocannabinol), opioid (narcotic) and other potent analgesics, non-opioid analgesics, antihistamines (histamine H1-receptor blockers), antiparkinsonian drugs, beta-blockers (beta-adrenoceptor blockers), antiarrhythmics (class I and IV), diuretics, laxatives and their metabolites. Methods for confirmation of results obtained by screening procedures using immunoassay or chromatographic techniques are also included. GC-MS procedures for the simultaneous detection of several categories of drugs, the so-called "general unknown analysis", are reviewed. The toxicological question to be answered and the consequence for the choice of an adequate method, the sample preparation and the chromatography itself are discussed. The basic information about the biosample assayed, work-up, GC column, mass spectral detection mode, reference data and sensitivity of each procedure are summarized in tables, arranged according to the category of drug. Examples of typical GC-MS applications are presented. Fragment ions that are suitable for mass spectral screening for particular categories of drugs and for general unknown are tabulated.

Gas Chromatography-Mass Spectrometry↗