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PubMed2000

Central auditory processing in patients with auditory hallucinations.

OBJECTIVE: Data from a full assessment of auditory perception in patients with schizophrenia were used to investigate whether auditory hallucinations are associated with abnormality of central auditory processing. METHOD: Three groups of subjects participated in auditory assessments: 22 patients with psychosis and a recent history of auditory hallucinations, 16 patients with psychosis but no history of auditory hallucinations, and 22 normal subjects. Nine auditory assessments, including auditory brainstem response, monotic and dichotic speech perception tests, and nonspeech perceptual tests, were performed. Statistical analyses for group differences were performed using analysis of variance and Kruskal-Wallis tests. The results of individual patients with test scores in the severely abnormal range (more than three standard deviations from the mean for the normal subjects) were examined for patterns that suggested sites of dysfunction in the central auditory system. RESULTS: The results showed significant individual variability among the subjects in both patient groups. There were no group differences on tests that are sensitive to low brainstem function. Both patient groups performed poorly in tests that are sensitive to cortical or high brainstem function, and hallucinating patients differed from nonhallucinating patients in scores on tests of filtered speech perception and response bias patterns on dichotic speech tests. Six patients in the hallucinating group had scores in the severely abnormal range on more than one test. CONCLUSIONS: Hallucinations may be associated with auditory dysfunction in the right hemisphere or in the interhemispheric pathways. However, comparison of results for the patient groups suggests that the deficits seen in hallucinating patients may represent a greater degree of the same types of deficits seen in nonhallucinating patients.

Adult↗
PubMed1998

Destruction of the auditory thalamus disrupts the production of fear but not the inhibition of fear conditioned to an auditory stimulus.

The auditory thalamus is part of a neural circuit that mediates the expression of fear to auditory stimuli. Bilateral lesions of the auditory thalamus prevent the expression of fear to an auditory stimulus paired with shock. The present study assessed whether bilateral lesions of the auditory thalamus would also disrupt the inhibition of fear to an auditory stimulus paired with the absence of shock. Rats were given bilateral lesions of the auditory thalamus followed by Pavlovian conditioned inhibition training in which a light was paired with shock and a noise and light compound was presented in the absence of shock. Fear and the inhibition of fear were measured with the fear-potentiated startle effect. Lesions of the auditory thalamus did not disrupt the ability of the noise to inhibit the expression of fear to the light. However, these lesions did disrupt the ability of the noise to produce fear-potentiated startle after it had been subsequently paired with shock. These results suggest that although the auditory thalamus is an essential part of a neural circuit that mediates the expression of fear to auditory stimuli, it is not an essential part of the circuit that mediates the inhibition of fear to auditory stimuli.

Acoustic Stimulation↗
PubMed1997

Central auditory information processing in patients with bilateral auditory cortex lesions.

Severe auditory cognitive disorders in 10 patients who had bilateral lesions either to the auditory cortex and/or auditory radiations were studied audiologically with special attention to residual hearing. This auditory cognitive problem is called "auditory agnosia or cortical deafness". Our study revealed that auditory information processing for pure tones, monosyllable discrimination, environmental sound perception, and auditory comprehension is commonly but differently affected by bilateral lesions of auditory cortex or auditory radiation. In summary, these patients can discriminate loudness of pure tones and some environmental sounds but cannot clearly perceive any sounds of monosyllables and sentences. Generally their residual hearing is useful for auditory awareness and is often enhanced by lip reading.

Adult↗
PubMed2004

Middle-latency auditory-evoked magnetic fields in patients with auditory cortex lesions.

OBJECTIVE: To demonstrate the influence of auditory cortex lesions on auditory middle-latency responses (AMLRs) and middle-latency auditory-evoked magnetic fields (MLAEFs) in humans. MATERIAL AND METHODS: A total of 15 normal subjects, 9 patients with left auditory cortex lesions and 1 patient with a right auditory cortex lesion were studied. MLAEFs were recorded from each hemisphere of the brain in a magnetically shielded room using a 37-channel SQUID gradiometer. Simultaneously, AMLRs were recorded from the scalp at the vertex, C3 and C4. Tone bursts were used as auditory stimuli. RESULTS: Pam responses of the MLAEF, which are typically evoked in the latency range of the Pa of the AMLR, and are localized at the auditory cortex as dipoles, were impaired or abolished over the left auditory cortex lesion in the patients with left-hemisphere lesions, but the Pa of the AMLR persisted. CONCLUSION: The main generator of the Pam in MLAEF was demonstrated to be the auditory cortex. The results also show that the Pa of the AMLR is evoked only partly from the auditory cortex.

Acoustic Stimulation↗
PubMed2005

Auditory processing in individuals with auditory neuropathy.

BACKGROUND: Auditory neuropathy is a disorder characterized by no or severely impaired auditory brainstem responses in presence of normal otoacoustic emissions and/or cochlear microphonics. Speech perception abilities in these individuals are disproportionate to their hearing sensitivity and reported to be dependent on cortical evoked potentials and temporal processing abilities. The disproportionate loss of auditory percept in presence of normal cochlear function is suggestive of impairment of auditory neural synchrony. METHODS: We studied the auditory evoked potentials and psychophysical abilities in 14 adults with auditory neuropathy to characterize their perceptual capabilities. Psychophysical tests included measurement of open set speech identification scores, just noticeable difference for transition duration of syllable /da/ and temporal modulation transfer function. Auditory evoked potentials measures were, recording of P1/N1, P2/N2 complex and mismatch negativity (MMN). RESULTS: Results revealed a significant correlation between temporal processing deficits and speech perception abilities. In majority of individuals with auditory neuropathy P1/N1, P2/N2 complex and mismatch negativity could be elicited with normal amplitude and latency. None of the measured evoked potential parameters correlated with the speech perception scores. Many of the subjects with auditory neuropathy showed normal MMN even though they could not discriminate the stimulus contrast behaviorally. CONCLUSION: Conclusions drawn from the study are: 1. Individuals with auditory neuropathy have severely affected temporal processing. 2. The presence of MMN may not be directly linked to presence of behavioral discrimination and to speech perception capabilities at least in adults with auditory neuropathy.

Journal Article↗
PubMed2005

Nonmodularity of the central auditory nervous system: implications for (central) auditory processing disorder.

This response to A. T. Cacace and D. J. McFarland (2005) identifies points of agreement and disagreement regarding the concept of modularity in the diagnosis of (central) auditory processing disorder [(C)APD]. We concur that the evaluation of (C)APD must take into consideration the influence of higher order global or pansensory issues on performance on tests of central auditory function. To accomplish this goal, multidisciplinary (e.g., multimodal) testing is an integral part of differential diagnosis of (C)APD. We also agree that the efficiency of diagnostic tests of (C)APD should not be evaluated by imprecise criteria [e.g., "presumed" or "suspected" (C)APD], which do not provide accurate measures of the true sensitivity and specificity of these tests. Our conceptualization and recommendations for clinical practice in this area diverge, however, from that of Cacace and McFarland in a number of pivotal ways. Based on the current limitations of multimodal assessment relative to issues related to scope of practice and test efficiency, as well as the accumulated basic science and clinical literature that demonstrates the nonmodularity and interactive organization of the brain, we recommend use of the sensitized test battery of the central auditory nervous system (CANS) in combination with multidisciplinary testing to differentially diagnose (C)APD and to guide treatment of the disorder. We assert that sensitivity and specificity measures derived from individuals with well-circumscribed lesions of the CANS provide an important guide to establishing the validity of central auditory diagnostic tests. We note that researchers in the area of auditory science and (C)APD must acknowledge the challenges of the clinical arena, and we encourage their continued help to develop diagnostic tools that are both efficient and practical for the differential diagnosis of (C)APD. We conclude that our approach, which combines multidisciplinary evaluation and specific tests of central auditory function that have demonstrated sensitivity and specificity for disorders of the CANS, allows us to identify (and thus rehabilitate) the auditory deficits present in individuals with (C)APD in its "purest" form. It also permits the identification and rehabilitation of auditory deficits in individuals who exhibit auditory perceptual problems that coexist with other processing problems, while ruling out those who perform poorly on auditory tests because of a global, supramodal problem involving cognition, attention, language, memory, or related skills.

Auditory Diseases, Central↗
PubMed2001

Evidence of peripheral auditory activity modulation by the auditory cortex in humans.

At the auditory periphery, the medial olivocochlear system is assumed to be involved in complex sound processing and may be influenced by feedback from higher auditory nuclei. Indeed, the descending auditory pathway includes fibers coming from the auditory cortex that are anatomically well positioned to influence the superior olivary complex, and thus the medial efferent system. The aim of the present study was to verify the hypothesis of an implied influence of the auditory cortex on the peripheral auditory system. In three rare cases of patients presenting with intractable temporal lobe epilepsy, Heschl's gyrus (i.e. the temporal superior gyrus) was surgically removed in the right hemisphere in two patients and in the left hemisphere in a third patient, in order to minimize epilepsy attacks, as preoperative stereoencephalography had shown the epileptic focus or tumor to be situated in those locations. In all three cases, several weeks after the operation the medial olivocochlear system was clearly less functional on both sides, but especially on the side contralateral to the resection. In healthy controls, no such pattern was obtained. In four other epileptic patients, who were operated unilaterally at the anterior temporal pole, amygdala and hippocampus with the temporal gyrus partially spared, efferent suppression grew stronger in the ear ipsilateral to surgery. These results revealed that, in humans, the primary and secondary auditory cortex play a role in modulating auditory periphery activity through direct or indirect efferent fibers. In accordance with previous findings, this descending influence may improve the auditory afferent message by adapting the hearing function according to cortical analysis of the ascending input.

Adult↗
PubMed2002

[The status of auditory function in auditory neuropathy].

OBJECTIVE: To study the status of auditory function and the site of lesion in auditory neuropathy. METHOD: The data of 65 patients were analyzed including the clinic signs, pure tone audiometry, auditory brainstem response(ABR), 40 Hz auditory event related potential(40 Hz AERP) and otoacoustic emissions (OAEs). RESULT: The low frequency hearing loss in auditory neuropathy arose from the lesion of retrocochlear auditory afferent and efferent nerve and auditory brainstem, presented at the abnormality of acoustic reflex, efferent suppreSsion, ABR and the unparallel relationship between evoked OAE amplitude and pure tone threshold. To corresponding, the outer hair cells in low frequency region were out of suppression, presented at the strong response of SOAE, TEOAE and DPOAE in low frequency region. The high frequency hearing loss in auditory neuropathy arose from the lesion of cochlear outer hair cells, presented at the parallel relationship between DPOAE amplitude and pure tone threshold in high frequency region. The intermediate frequency hearing loss in auditory neuropathy was damaged gently or close to normal, presented at both pure tone threshold and DPOAE amplitude nearby 2 kHz were close to normal. CONCLUSION: The dysfunction in differ degree lied in the afferent and efferent nervous systems and cochlear level in auditory neuropathy, the main site of lesion was in the cochlear afferent and efferent nerve, up to the brainstem and down to the cochlea.

Adolescent↗
PubMed1990

The Maturation of the Superior Collicular Map of Auditory Space in the Guinea Pig is Disrupted by Developmental Auditory Deprivation.

Guinea pigs, reared from birth in an environment of omnidirectional white noise, fail to develop a map of auditory space in the deeper layers of the superior colliculus. Collicular responses from such noise-reared animals reveal large auditory spatial receptive fields. The representation of auditory space in the colliculus shows no topographic order. Exposing developing animals to the noise environment only for restricted time periods showed that animals reared normally up to 26 days after birth (DAB) and then placed in the noise chamber could not construct spatial maps, whereas animals reared normally to 30 DAB and then placed in the noise chamber until the terminal mapping experiment could construct topographically organized spatial maps with local receptive fields. Limiting the noise exposure to the period between 26 and 30 DAB was sufficient to prevent spatial map formation. The failure to form a map of auditory space did not reflect environmental damage to the cochlea or the functional organization of the primary auditory pathway. The response thresholds of cochlear microphonics and of auditory responses in both the inferior and superior colliculus were normal in noise-reared animals. Similarly normal were the tonotopic organization and frequency tuning characteristics of inferior collicular neurons. The rearing environment thus appears to exert a selective effect upon the maturation of the superior collicular map of auditory space. We attribute this effect to the masking, by the omnidirectional broad-band noise, of discrete localized auditory stimuli. Cues deriving from these latter stimuli would appear to be necessary for the elaboration of the map of auditory space. This auditory experience operates during a 4 day crucial developmental period from 26 to 30 DAB. This is the same developmental time window as that during which visual experience is required for the construction of the map.

Journal Article↗
PubMed2002

Segregated processing of auditory motion and auditory location: an ERP mapping study.

Recent studies have revealed a distinct cortical network activated during the analysis of sounds' spatial properties. Whether common brain regions in this auditory where pathway are involved in both auditory motion and location processing is unresolved. We investigated this question with multichannel auditory evoked potentials (AEPs) in 11 subjects. Stimuli were binaural 500-ms white noise bursts. Interaural time differences (ITD) created the sensation of moving or stationary sounds within each auditory hemifield, and subjects discriminated either their position or direction of motion in a blocked design. Scalp potential distributions (AEP maps) differentiated electric field configurations across stimulus classes. The initial approximately 250-ms poststimulus yielded common topographies for both stimulus classes and hemifields. After approximately 250-ms, moving and stationary sounds engaged distinct cortical networks at two time periods, again with no differences observed between hemifields. The first ( approximately 250- to 350-ms poststimulus onset) was during stimulus presentation, and the second ( approximately 550- to 900-ms poststimulus onset) occurred after stimulus offset. Distributed linear inverse solutions of the maps over the 250- to 350-ms time period revealed not only bilateral inferior frontal activation for both types of auditory spatial processing, but also strong right inferior parietal activation in the case of auditory motion discrimination. During the later 550-to 900-ms time period, right inferior parietal and bilateral inferior frontal activity was again observed for moving sounds, whereas strong bilateral superior frontal activity was seen in the case of stationary sounds. Collectively, the evidence supports the existence of partly segregated networks within the auditory where pathway for auditory location and auditory motion processing.

Acoustic Stimulation↗
PubMed1995

The spatiotemporal organization of auditory, visual, and auditory-visual evoked potentials in rat cortex.

Four placements of an 8 x 8 channel microelectrode array were used to map auditory, visual, and combined auditory-visual evoked potentials (AEP, VEP, AVEP) from a total of 256 electrode sites over a 7 x 7 mm2 area including most of somatosensory, auditory, and visual cortex in the right hemisphere of the rat. The unimodal AEP and VEP consisted of an archetypal response sequence representing a systematic spatial and temporal activation of primary and secondary sensory cortex. Spatiotemporal analysis of these waveforms indicated that they could be decomposed into a small number of spatial and temporal components; components that are related to patterns of specific and non-specific thalamocortical projections connecting the auditory and visual nuclei of the thalamus with primary and secondary auditory and visual cortex. These data suggest that the AEP and VEP complex are the cortical reflection of asynchronous activation of parallel thalamocortical projection systems. The areal distribution of the AEP and VEP also overlapped, primarily in secondary auditory and visual cortex, indicating that these regions contain populations of cells responding to either modality. Polymodal auditory-visual stimulation resulted in unique activation of two isolated populations of neurons positioned in secondary auditory and secondary visual cortex which were revealed by difference waveforms, computed by subtracting the sum of the AEP and VEP from the AVEP complex. Retrograde labeling of the polymodal zones indicated that they receive parallel thalamocortical projections primarily from non-specific auditory and visual thalamic nuclei including the medial and dorsal divisions of the medial geniculate nucleus (MGm and MGd), the suprageniculate nucleus (SGN), and the lateral posterior nucleus (LP). The polymodal zone in visual cortex also receives specific projections from the dorsal division of the lateral geniculate nucleus (LGd). These data conform to a general model of thalamocortical organization in which specific thalamic nuclei with a high degree of modality specificity make restricted projections to primary sensory cortex and parts of secondary sensory cortex, and association thalamic nuclei with a high degree of sensory convergence make more divergent cortical projections. Primary and secondary sensory cortex, as well as distinct zones of polysensory cortex appear to be activated in tandem via parallel thalamocortical projections. Thus, the cerebral cortex must have simultaneous access to both unimodal and polymodal sensory information.

Animals↗
PubMedDate not supplied

[Stable auditory evoked potentials in the study of two patients with auditory neuropathy].

INTRODUCTION: We described the results of the auditory multiple steady state response (MSSR) technique in the assessment of two patients with auditory neuropathy (AN). The aim of this study was to corroborate the correspondence between the MSSR generators elicited by amplitude modulated tones ranging between 80-100 Hz, with the generators of auditory brain stem response (ABR). Moreover, we would also try to demonstrate the validity of the MSSR in the diagnosis of AN in children. MATERIAL AND METHODS: Two children diagnosed of hyperbilirrubinemia, aged, 18 months and 10 years have been studied with MSSR (500, 1000, 2000 and 4000Hz); ABR with clicks; OAE; behavioural audiometry; MRI and acoustic reflexes. RESULTS: A difference between electrophysiological and behavioural audiogram in both cases diagnosed with auditory neuropathy have been found. The auditory thresholds were similar using the two types of evoked potentials (MSSR and ABR). Both techniques showed an increment of auditory threshold congruous with a severe auditory impairment, while behavioural audiometry showed only a mild elevation of auditory threshold. We can also see how the threshold differed between frequencies using behavioral audiometry and MSSR. CONCLUSION: It is concluded that our findings are in agreement with previous studies and they sustain the theory about the coincidence of MSSR at fast rate (80-110 Hz) and ABR generators. Also, we demonstrate the usefulness of the MSSR as an objective [corrected] electroaudiometric tool in patients with auditory neuropathy as ABR. This technique is thus a recommendable test to complete the audiological study in infants with AN, to establish a more precise treatment.

Cerebellopontine Angle↗
PubMed1997

The central auditory system and auditory deprivation: experience with cochlear implants in the congenitally deaf.

In the present paper we briefly review the response of the central auditory system to auditory deprivation and describe recent experimental and clinical experience with cochlear implants. While the central auditory system undergoes marked changes in response to auditory deprivation, it would appear that at least a rudimentary cochleotopic organisation is maintained at the level of the brainstem and auditory cortex in animals deafened from birth. Moreover, recent studies have demonstrated the ability of the central auditory system to undergo functional reorganisation in response to changes in the pattern of afferent activity. Clinical experience has shown that deaf children with little or no prior auditory experience can obtain significant benefit from cochlear implants, provided the device is fitted at a young age. Furthermore, factors predicting successful clinical outcomes with these devices reflect the importance of auditory experience, either prior to an acquired loss or with the use of a cochlear implant. These findings suggest that functional reorganisation within the central auditory pathway can at least partially account for improvements in clinical performance over time.

Adult↗
PubMed2004

SPET assessment of auditory cortex stimulation and tonotopic spatial distribution in auditory brainstem implant.

Activation of the auditory cortex by multifrequency acoustic stimuli has been evaluated using Single Photon Emission Tomography in a case of auditory brainstem implant after activation of 6 and 11 electrodes. Before implantation, no activation of the auditory cortex has been observed after acoustic stimulation. Following auditory brainstem implant, the stimulation of 11 electrodes showed an activation value, in terms of blood flow increase, of the contralateral temporal cortex similar to that obtained with 6 electrodes (47.70 vs. 43.76%), but a significantly stronger activation was present in the contralateral parietal region (29.59 vs. 14.73%), in the homolateral temporal area (22.02 vs. 10.46%) and, especially, in the homolateral parietal zone (16.6 vs. 4.33%). The strongest activation in the contralateral temporal cortex was detected in the sagittal tomogram at 26.25 mm from the midline, that is in the areas where high frequencies are projected, both with 6 and 11 active electrodes. The medio-lateral auditory cortex, where the middle and lower frequencies are projected, showed an overall lower activation which was however significantly lower with 6-electrode stimulation. Stimulation of the surface of cochlear nuclei determines mainly an activation of the high frequency domain, independently of the electrodes number. This finding may explain the better results of cochlear implants in comparison with auditory brainstem implant and could justify the use of needle electrodes in auditory brainstem implant. In conclusion, Single Photon Emission Tomography can be considered useful in evaluating auditory brainstem implant placement and function. It is also able to define the effectiveness of acoustic stimulation, the degree and tonotopic spatial distribution of auditory cortex activation.

Acoustic Stimulation↗
PubMed1993

Multiple brain systems generating the rat auditory evoked potential. II. Dissociation of auditory cortex and non-lemniscal generator systems.

This study addressed the issue of multiple parallel auditory processing systems and their relationship to the skull-recorded auditory evoked potentials (AEPs) in the unanesthetized, unrestrained rat. In the preceding paper (Brain Res., 602 (1993) 240-250) it has been shown that auditory cortex activity does not contribute significantly to the vertex maximal AEPs recorded from the dorsal skull of the rat. In the present study, mapping of the AEP skull distribution revealed two sets of components: one set maximal at the dorsal skull vertex, and another set at the lateral skull), but not the early (P7-P11, N15) lateral skull components generated in auditory cortex. Bilateral auditory cortex ablation eliminated the lateral skull maximal AEP components, but not the dorsal skull maximal components. These findings support extensive parallel processing of auditory inputs (reflected by the dorsal AEPs) in the absence of primary auditory cortex. Ablation of primary auditory cortex did result in a modulation of the dorsal skull AEPs, indicative of an interaction between the geniculocortical system and the parallel system which generates the dorsal AEPs.

Anesthesia↗
PubMed2003

Auditory event-related potentials in the assessment of auditory processing disorders: a pilot study.

The aim of this pilot study was to investigate whether children with a suspected auditory processing disorder (sAPD) in the presence of normal hearing, differ significantly from normal age-matched controls on particular parameters of auditory event-related potentials. We assessed nine children (mean age 9.5 years) in whom the clinical profile and the results in a screening test for auditory processing disorder (SCAN/SCAN-A) suggested the presence of an auditory processing disorder, and nine age-matched normal control subjects, using auditory event-related potentials (ERP) to phonemes/ba/(standard) and/da/(deviant). Analysis of the auditory ERP recordings revealed an enlarged P85 - 120 and attenuated N1 and P2 in all sAPD children compared to controls. We also found significantly increased N1 peak latency, and a larger peak to peak amplitude of the P85 - 120-N1 and P2-N2 and smaller peak to peak amplitude of the N1-P2 in the sAPD children. Subtraction of the standard auditory ERP from the deviant revealed a mismatch negativity with no significant differences in duration, peak or onset latency between the control subjects and sAPD. Our results indicate that neurophysiological measures may identify a group of children with specific problems suggestive of an auditory processing disorder in the absence of an obvious structural or functional lesion who warrant further study in order to assess whether these findings reflect delayed CNS myelination.

Acoustic Stimulation↗
PubMed2003

[Integrated methods for assessing auditory nerve-auditory pathway integrity].

OBJECTIVE: To evaluate the feasibility and value of integrated methods to assess auditory pathway integrity. METHOD: Twenty-four cases of bilateral profoundly-deafened individuals who were considered as the candidates of cochlear implantation were included in this study. Auditory pathway integrity from these candidates of cochlear implantation were assessed with the integrated methods established by our team, which consist of 5 categories including 1. audiological test; 2. radiological imaging study; 3. ear-canal electric audiometry; 4. response to sound in daily life; and 5. speech development. RESULT: Twenty-three candidates who meet the criteria of auditory nerve-auditory pathway integrity received cochlear implantation with improved hearing and speech development postoperatively. The remainder one of the 24 candidates was diagnosed as bilateral absence of auditory nerve. The fault of cochlear implantation was avoided. CONCLUSION: The integrated methods for assessing auditory pathway integrity is feasible and valuable. Auditory nerve-auditory pathway integrity should be considered and included as one of the most important criteria for cochlear implantation candidate.

Acoustic Stimulation↗
PubMed2004

Auditory scene analysis and sensory memory: the role of the auditory N100m.

We consider the neural dynamics underlying auditory streaming, the perceptual grouping of transient auditory events, by using neural modeling and magnetoencephalographic (MEG) measurements in humans. We demonstrate that spatial variations in the strength of feedback inhibition leads to differential amplitude modulation (AM) tuning resembling that found in animal models. In our model, neurons respond selectively to stimuli presented at different onset-to-onset interstimulus intervals (ISIs), and their summed activity (corresponding to the MEG signal) exhibits both transient and sustained responses (SRs) at fast ISIs. In MEG measurements utilizing 2-s trains of 50-ms stimuli presented at 0-1950 ms ISIs, we observed the transient N100m and SRs predicted by the model, with a prominent SR emerging for discrete stimuli at ISIs below 200 ms. Our results explain why, at fast stimulus rates, the amplitude of the auditory N100m appears to be strongly attenuated even though auditory cortex continues to respond vigorously to the stimuli. The results suggest that the longer and shorter forms of auditory sensory memory may be reflected in the N100m and the SR, respectively. As the emergence of the SR coincides with the stimuli being perceived as auditory streams, our study suggests that auditory sensory memory as indexed by transient and sustained cortical activity might underlie auditory scene analysis.

Acoustic Stimulation↗