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At least 19 recordsLinked to original sources
PubMed1979

Auditory evoked potentials and auditory behavior following prenatal and perinatal asphyxia in rhesus monkeys.

Two types of asphyxia were studied in monkeys, total asphyxia during mid-pregnancy (94--98 days gestation) and combined partial and total axphyxia at term (165 days gestation). Auditory evoked potentials and the acquisition of 2 auditory discrimination tasks were studied in asphyxiated animals as well as in group of controls. The brains of all asphyxiates were examined histologically. No auditory discrimination deficit was found in the asphyxiated animals; however, the auditory evoked potentials differentiated between control and asphyxiated animals, especially those with verified inferior colliculus damage.

Animals↗
PubMed2026

Utility of hearing aid use on neurocognitive functions and auditory processing: A systematic review.

PURPOSE: Hearing loss not only affects the peripheral auditory system but also leads to changes in central auditory pathways and neurocognitive skills. The use of hearing aids has shown potential benefits in mitigating the adverse effects of hearing loss. Earlier literature showed various studies assessing the impact of hearing aid use on cognitive functions and auditory processing, a comprehensive review of the existing literature is warranted. Existing literature showed heterogeneous outcomes among studies investigated the effect of Hearing aid use in combating the adverse effects of hearing loss on neurocognitive functions and auditory processing. METHOD: Databases including PubMed, SciELO, Cochrane Library, PsycINFO, Web of Science, and Index Copernicus were searched (2005-2025) using English keywords on hearing aid effects on neurocognition and auditory processing in individuals with hearing loss. Studies on effect of hearing aid use on neurocognition and auditory processing were included, while those involving cochlear implant users or other neurological disorders unrelated to hearing loss were excluded. Titles, authors and publication years were examined, and duplicates were removed. RESULTS: Total of 61 research papers were found on specific area and were included in the present review. Findings of these 61 articles have been analysed and are reported in this article. The outcome of the present study showed usefulness of hearing aid use on neurocognitive functions and auditory processing. CONCLUSION: The present literature review emphasized the importance of early rehabilitation through hearing aid use to alleviate the adverse effects of hearing loss on neurocognitive function and auditory processing.

Humans↗
PubMed1978

Response variability in the mammalian auditory cortex: an objection to feature detection?

Research strategy in the auditory system has tended to parallel that in the visual system, where neurons have been shown to respond selectively to specific stimulus parameters. Auditory neurons have been shown to be sensitive to changes in acoustic parameters, but only rarely have neurons been reported that respond exclusively to only one biologically significant sound. Even at higher levels of the auditory system very few cells have been found that could be described as "vocalization detectors." In addition, variability in responses to artificial sounds have been reported for auditory cortical neurons similar to the response variability that has been reported in the visual system. Recent evidence indicates that the responses of auditory cortical neurons to species-specific vocalizations can also be labile, varying in both strength and selectivity. This is especially true of the secondary auditory cortex. This variability, coupled with the lack of extreme specificity in the secondary auditory cortex, suggests that secondary cortical neurons are not well suited for the role of "vocalization detectors."

Acoustic Stimulation↗
PubMed2026

Polystyrene microplastics induce auditory neurotoxicity in mammals: Integrated multi-omics profiling reveals oxidative damage and synaptic molecular dysregulation.

Microplastics (MPs) are ubiquitous environmental pollutants, yet their neurotoxic effects on the auditory system remain poorly understood. This study develops an integrated multi-level analytical framework combining auditory neurophysiology, behavioral assessment, tissue biochemistry, transcriptomics, and proteomics to investigate polystyrene (PS)-MPs-induced auditory neurotoxicity in rats. PS-MPs infiltrate the auditory system and significantly impair auditory processing, with central dysfunction emerging earlier and more prominently than peripheral alterations. Multi-omics analyses reveal coordinated suppression of glutamatergic synapse and Wnt signaling pathways in the cochlear nucleus. Mechanistically, PS-MPs perturb the crosstalk between glutamatergic synaptic and Wnt signaling, promoting AMPA receptor (AMPAR) internalization and potentially affecting synaptic plasticity-related processes and neuronal responsiveness. In parallel, PS-MPs trigger oxidative stress, apoptosis, and glial activation, reflecting pronounced neuroinflammatory and redox imbalance. In primary cochlear nucleus neurons (PCNNs), these mechanisms were further validated in vitro, where activation of Wnt signaling by Wnt3a significantly alleviated oxidative injury and reduced AMPAR internalization. Collectively, these findings provide comprehensive preclinical evidence for the neurotoxic potential of MPs and reveal a previously unrecognized PS-MPs-induced auditory neurotoxicity, although further studies are needed for human relevance. Results from the rat model further implicate Wnt-mediated signaling as a potential modulatory pathway underlying MPs-induced synaptic molecular alterations and redox dysfunction.

Animals↗
PubMed1979

Connectivity of the auditory forebrain nuclei in the guinea fowl (Numida meleagris).

Injection of tritiated leucine and proline into the nucleus ovoidalis of the Guinea Fowl (Numida meleagris) produces terminal labeling in the palaeostriatum and in three adjacent zones (field L1-L3) of the auditory neostriatum (AN). L2, situated between L1 and L3, receives the main input and corresponds to the former field L of Rose. These neuroanatomically defined zones of the auditory neostriatum are also characterized by differing properties of their neurons. Injection of radioactive material into the auditory neostriatum produces labeling of (i) a palaeostriatal, (ii) a ventral hyperstriatal, and (iii) an additional neostriatal area (Nd). Injection into the hyperstriatum ventrale reveals connections (i) to field L2, (ii) to the palaeostriatum, (iii) to Nd, and (iv) to the archistriatum. After injection into the palaeostriatum, labeling can be observed (i) in the neostriatum dorsale, (ii) in the hyperstriatum ventrale, (iii) in the archistriatum, (iv) in the diencephalic nuclei, nucleus ansae lenticularis and nucleus spiriformis lateralis, and (v) in the mesencephalic nuclei, nucleus tegmenti pedunculo-pontinus and nucleus intercollicularis. These results show that a widespread connectivity exists among primary and presumably higher order auditory areas in the forebrain of birds. Connections also exist between these auditory areas and presumed vocal-motor areas (neostriatum dorsale, archistriatum, nucleus intercollicularis).

Animals↗
PubMed1978

Human auditory sustained potentials. II. Stimulus relationships.

The auditory sustained potential recorded from the human scalp increases in amplitude with increasing stimulus intensity. At rapid rates of stimulus presentation its amplitude decreases but proportionately less so than the amplitude of the transient onset auditory evoked potential. The frequency specificity of this rate effect is complex, suggesting that there may be two underlying components of the scalp-recorded auditory sustained potential. The amplitude of the auditory sustained potential is smaller when the tonal frequency of the stimulus is higher. With prolonged stimulus durations there is some adaptation of the amplitude of the auditory sustained potential. This potential is larger in amplitude when sounds are presented binaurally than monaurally, and has a symmetrical coronal scalp distribution that is unaffected by the ear of stimulation.

Acoustic Stimulation↗
PubMed2026

Effect of intraoperative 40-hz gamma-frequency auditory stimulation on postoperative delirium in older adults undergoing major surgery: a randomized clinical trial protocol.

INTRODUCTION: Postoperative delirium (POD) is a common and clinically significant complication among older adults undergoing major surgery under general anesthesia. Gamma-frequency (40-Hz) auditory stimulation has demonstrated potential neuroprotective and cognition-enhancing effects, suggesting a plausible role in perioperative delirium prevention. However, direct clinical evidence supporting intraoperative 40-Hz auditory stimulation in reducing POD remains limited, warranting rigorous evaluation in a randomized trial. PATIENTS AND METHODS: This prospective, parallel-group, randomized controlled trial will enroll 550 older adults scheduled for major noncardiac, nonneurosurgical surgery under general anesthesia. Participants will be randomized in a 1:1 ratio to either the active stimulation group, receiving intraoperative 40-Hz gamma-frequency auditory stimulation delivered via headphones for 2 h following successful anesthesia induction, or the sham stimulation group, wearing headphones without active auditory output. The primary outcome is the incidence of POD on postoperative day 1 though 3, assessed using the Confusion Assessment Method (CAM) or the CAM for the ICU (CAM-ICU). Secondary outcomes include POD severity, sleep quality, pain scores, analgesic consumption, the incidence of postoperative nausea and vomiting (PONV), rescue antiemetic use, duration of post-anesthesia care unit (PACU) stay, length of hospital stay, quality of postoperative recovery, incidence of perioperative adverse events; postoperative morbidity, health-related quality of life, and all-cause 30-day mortality. DISCUSSION: This trial will determine whether intraoperative 40-Hz gamma-frequency auditory stimulation reduces the incidence of POD among older adults undergoing major surgery under general anesthesia. If efficacious, this noninvasive intervention could constitute a feasible perioperative strategy to mitigate delirium risk and enhance postoperative recovery. CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2500115156).

Humans↗
PubMed1977

Correlations between psychophysical magnitude estimates and simultaneously obtained auditory nerve, brain stem and cortical responses to click stimuli in man.

Responses from the auditory nerve, brain stem auditory nuclei and cortex, as well as subjective responses to click stimuli at 10 intensities, were recorded simultaneously in the same human subjects. For various measures of the responses, the power-law exponents of their intensity functions were calculated, along with their statistical significances. The electrophysiological and psycho-physical functions were compared for similarity. On average, the exponents of the intensity functions of amplitudes of the auditory nerve and earlier brain stem responses were highly significant, showing similarity across subjects and similarity with the exponents of the subjective estimates. However, a closer examination proved this similarity to be superficial, since magnitude estimates showed an appreciable intersubject and intersession variability while the auditory nerve and brain stem responses were approximately constant. All other electric response measures either had exponents which were not significant or showed even poorer correlation with the subjective response. It is proposed that the type of electrical activity recorded in this study may not be the proper set of neural parameters which give rise to the loudness estimate.

Acoustic Stimulation↗
PubMed1975

The internal auditory artery: (embryology, anatomy, angiography, pathology).

A review of the literature on the embryology, anatomy and angiography of the internal auditory artery has shown that there may be considerable variation as to the origin and number of internal auditory arteries. The present study, based on serial magnification angiographies of the internal auditory artery, has demonstrated 7 variants of the origin of this artery although in 45.4% of cases the internal auditory artery arose from the anterior inferior cerebellar artery. For the diagnosis of pathological processes in the cerebellopontine angle (tumors, sudden deafness, vascular abnormalities) magnification angiography is of special importance. Acoustic neurinomas in particular can be diagnosed early on the basis of vascular dislocations and possible tumor staining. Magnification angiography is the method of choice for the demonstration of vascular malformations. The etiology of sudden deafness can not be determined by angiographic studies alone, due to the fact that the internal auditory artery can show considerable variations as regards length and caliber. Magnification angiography of this region should be carried out in all cases with the clinical picture of a cerebellopontine angle lesion in order to achieve diagnostic clarification.

Adult↗
PubMed1977

Auditory word discrimination in male children diagnosed as having minimal brain dysfunction.

Investigated auditory word discrimination skill in children diagnosed as having minimal brain dysfunction (MBD), a heretofore unexplored topic in the study of MBD. A lack of auditory discrimination skill seems relevant to learning deficiency in language acquisition, a typical sign of MBD. The present study tested the hypothesis that phonemic aural discriminations would be difficult to make for boys diagnosed as having MBD. Errors and nonresponses made while Ss performed an extended auditory word discrimination task were compared between a group of 26 boys diagnosed as having MBD and a matched normal group. As expected, the MBD group had a significantly higher error rate than the normal group even when Ss were discriminating easy word pairs composed of dissimilar items (e.g., reading, math). These and other results suggested that the MBD group was very susceptible to fatigue even while motivated to perform well and while able to improve with practice. The relatively inferior performance of the MBD group was interpreted as resulting directly from a lack of auditory discrimination skill and indirectly from fatigue and its accompanying attention loss.

Attention↗
PubMed1979

The effects of early auditory deprivation on temporal perceptions: a comparison of hearing and hearing-impaired children on temporal pattern matching tasks.

This study was designed to test the hypothesis that hearing children, but not children deprived of early auditory experiences, would use an auditory frame of reference, or auditory encoding, for temporal perceptions. Two age groups (8 and 11 years of age) of hearing and hearing-impaired children were tested in two sessions; tasks required each child to decide whether two temporal patterns (sequences of lights, sounds or both) were the same or different. Specific trial-types were designed to reveal different patterns of performances (across trial-types) for children who differed in terms of whether an auditory frame of reference was used. The results suggested that all children used similar temporal frames of reference, but that hearing-impaired children demonstrated developmental lags.

Auditory Perception↗
PubMed2026

Transient acoustic stimulation induces time-dependent synaptic remodeling and enhancement of auditory nerve output after threshold recovery.

BACKGROUND: Acoustic stress can alter cochlear function even in the absence of permanent threshold elevation; however, synaptic consequences of transient acoustic stimulation remain incompletely understood. OBJECTIVE: This study aimed to investigate whether transient acoustic stimulation induces changes in the auditory nerve output and cochlear ribbon synapse morphology following hearing threshold recovery. METHODS: Young adult CBA/CaJ mice were exposed to band-limited acoustic stimulation (45-2,000 Hz, 95 dB SPL, 2 h). Auditory brainstem responses (ABRs), hair cell and spiral ganglion neuron survival, and synaptic morphology were evaluated before exposure and up to 2 weeks post-exposure. RESULTS: ABR thresholds were transiently elevated immediately after exposure but largely recovered by 1 day post-exposure. In contrast, ABR wave I amplitudes significantly increased after threshold recovery across multiple test frequencies. Ribbon-associated puncta in both inner and outer hair cell regions exhibited biphasic temporal changes, with an initial decrease immediately after exposure followed by an increase at 1 day post-exposure. The ribbon-associated punctal area also increased after exposure and remained elevated at later post-exposure time points. No significant loss of hair cells or spiral ganglion neurons was observed. Exploratory genomic analysis suggested enrichment of pathways related to metabolic defense and cellular stress responses. CONCLUSIONS: Transient acoustic stimulation induces time-dependent synaptic remodeling and enhancement of peripheral auditory nerve output without overt cellular degeneration. These findings support a model in which early cochlear responses to acoustic perturbation include adaptive synaptic plasticity and gain regulation, extending current concepts of noise-induced cochlear change beyond irreversible synaptic loss.

Animals↗
PubMed1979

Anatomy of the auditory tube and related structures in the rhesus monkey (Macaca mulatta).

The primate nasopharynx-auditory tube-middle ear complex is being used by several researchers to model both normal and pathologic functions of the human auditory tube. An extensive search of the literature has indicated little detailed information on the primate tube/middle ear system. This study was undertaken to define the anatomical characteristic of the system in the rhesus monkey (Macaca mulatta) and to determine the limits on the use of the monkey as a model of human tubal function. Although the direct application of morphologic data to account for the observed function of a system is a tenous one, the data on the rhesus monkey auditory tube appear to be consistent with those published for other mammals. The tensor veli palatini muscle appears to be the only muscle to act directly on the tube and effect tubal dilation. The muscle is attached to the lateral membranous tubal wall along its extrabullar extension. The muscle has an inferior attachment to the posterior hard palate and thus possesses a vector directed inferolaterally; contraction would appear to pull the membranous wall inferiorly and laterally, resulting in tubal dilation. The auditory tube relationships of the salpingopharyngeus, levator veli palatini, and internal pterygoid muscles are described. Their possible role in primate tubal function is minimal at best.

Animals↗
PubMed1977

Auditory reinforcement in profoundly retarded multiply handicapped children.

Profoundly retarded multiply handicapped children were placed in a situation where auditory stimulation was made contingent on a visually directed level-pulling response. Two experiments were performed. In the first, a technique for establishing an effective reinforcer from a range of possible reinforcing stimuli was evaluated. In the second experiment, a multiple schedule was used to compare the effectiveness of a reinforcer whose efficacy was established in Experiment 1 with a second auditory stimulus. The selection of auditory reinforcers and an evaluation of their relative potency was achieved using these techniques. The results show the feasibility of systematic measurement of operant-conditioning effects with very severely handicapped subjects in a laboratory situation. The information gained concerning the effectiveness of auditory reinforcers has implications for behavior-modification programs with these children.

Acoustic Stimulation↗
PubMed1978

Human magnetic auditory evoked fields.

Magnetoencephalographic (MEG) averaged auditory evoked fields to click stimuli (N = 512) were recorded from four human subjects. The MEG was recorded with an asymmetric second derivative SQUID gradiometer located in an aluminum shielded room. Unlike conventional EEG auditory evoked potentials, which have a widespread distribution, evoked magnetic fields appear to be localized to the general area of the primary auditory cortex and diminish rapidly in amplitude as the gradiometer is moved away in any direction.

Acoustic Stimulation↗
PubMed1976

The scalp topography of potentials associated with missing visual or auditory stimuli.

Averaged potentials time-locked to regularly presented visual and auditory stimuli and to the occasional random deletion of a stimulus were recorded from a scalp electrode array overlying the left hemicranium. The major components of visual and auditory evoked potentials and of the potentials associated with missing stimuli (MSP) were measured and their amplitude distributions depicted in the form of isopotential maps. The N1 components of the VEP and AEP had distributions compatible with sources in and near the respective primary cortical projection areas. The P2 components were more widely distributed and could be attributed in part to generators within modality specific association areas. The MSP comprised two main components, an initial negativity (NMSP) and a later positive wave (PMSP). The NMSP distributions were different in the visual and auditory modalities, and were similar to the respective EP topographies. The NMSP appeared to reflect a more powerful contribution of association areas than did the evoked responses. The PMSP topography was modality unspecific with distributions which were maximal over the parietal region. The possible functional significance of the NMSP and PMSP was considered in the light of their timing and topography.

Adult↗
PubMed1977

The scalp topography of potentials in auditory and visual discrimination tasks.

Averaged event-related cortical potentials (ERPs) were obtained from an array of scalp electrodes overlying the left hemicranium in response to regularly presented visual or auditory stimuli (non-signals)and to infrequent random replacements by different stimuli (signals) in the same modality. A motor response was required to the signals. Non-signal ERPs were subtracted from signal ERPs and the topographic distributions of the negative (N2 delta) and positive (P3 delta) components were plotted as isopotential maps. N2 delta distributions differed for the auditory and visual modalities, whereas P3delta was modality unspecific. These topographic data were compared to those from the previous study of missing stimulus potentials (Simson et al. 1976) using maps representing the contributions from unilateral cerebral sources. The N2 delta and negative missing stimulus potential distributions ascribed to cortical activity within the secondary auditory and visual regions, whereas the late positive component (positive missing stimulus potential or P3 delta) were considered to derive principally from inferior parietal association cortex.

Adult↗
PubMed1978

Human auditory sustained potentials. I. The nature of the response.

In response to a sustained toneburst a negative baseline shift can be recorded from the human fronto-central scalp regions with an onset latency of approximately 150 msec. This auditory sustained potential is distinct both in its scalp distribution and in its stimulus relationships from the transient response occurring at the onset or offset of the toneburst. It differs from the contingent negative variation in that it can occur in the absence of attention or during sleep. Attention to the auditory stimulus can increase the amplitude of the sustained potential, possibly through the addition of an extra negative potential related to auditory expectancy or uncertainty.

Adolescent↗