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At least 37 records · Page 2Linked to original sources
PubMed2002

Software design for analysis of multichannel intracardial and body surface electrocardiograms.

Analysis of multichannel ECG recordings (body surface maps (BSMs) and intracardial maps) requires special software. We created a software package and a user interface on top of a commercial data analysis package (MATLAB) by a combination of high-level and low-level programming. Our software was created to satisfy the needs of a diverse group of researchers. It can handle a large variety of recording configurations. It allows for interactive usage through a fast and robust user interface, and batch processing for the analysis of large amounts of data. The package is user-extensible, includes routines for both common and experimental data processing tasks, and works on several computer platforms. The source code is made intelligible using software for structured documentation and is available to the users. The package is currently used by more than ten research groups analysing ECG data worldwide.

Algorithms↗
PubMed2007

Web-based primer design software for genome-scale genotyping by pyrosequencing.

Design of locus-specific primers for use during genetic analysis requires combining information from multiple sources and can be a time-consuming process when validating large numbers of assays. Data warehousing of genomic DNA sequences and genetic variations when coupled with software applications for optimizing the generation of locus-specific primers can increase the efficiency of assay development. Selection of oligonucleotide primers for PCR and Pyrosequencing (SOP3) software allows user-directed queries of warehoused data collected from the human and mouse genome sequencing projects. The software automates collection of DNA sequence flanking single-nucleotide polymorphisms (SNPs) as well as the incorporation of locus-associated functional information, such as whether the SNP occurs in an exon, intron, or untranslated region. SOP3 software accepts three types of user-directed input consisting of gene locus symbols, SNP reference sequence numbers, or chromosomal physical location. For human polymorphisms, SOP3 incorporates haplotype, ethnicity, and SNP validation attributes. The output is a list of oligonucleotide primers recommended for Pyrosequencing-based typing of genetic variations. SOP3 is available at the Division of Immunogenetics computational server found at http://imgen.ccbb.pitt.edu.

Animals↗
PubMed2001

[The software design for the molecular biological image processing system].

With the use of Visual Basic 6.0 language and molecular biological technology, we have developed a new molecular biological information processing system to detect the characteristic parameter of molecular biological electrophoresis image. The software can determine the molecular weight of the restriction endonuclease hydrolytic DNA fragment and protein or other macromolecules. The application indicates that the system with its accuracy reliability high efficiency and a large capacity of data to be stored, It is very useful to gene diagnosis and molecular biological researches.

Computer Systems↗
PubMed2003

Learner centered software design to empower physiology education.

Misconceptions in physiology undermine students' knowledge. New uses of technology in education offer interesting alternatives to correct these problems. This poster presents a design strategy based in user-centered design and the result of such process: an interactive program to support learning of respiratory physiology. This is an ongoing project, and future efforts will measure the effectiveness of this design tool in medical education.

Computer-Assisted Instruction↗
PubMed2002

[Application of AOTF in spectral analysis. 1. Hardware and software designs for the self-constructed visible AOTF spectrophotometer].

A self-constructed visible spectrophotometer using an acousto-optic tunable filter(AOTF) as a dispersing element is described. Two different AOTFs (one from The Institute for Silicate (Shanghai, China) and the other from Brimrose(USA)) are tested. The software written with visual C++ and operated on a Window98 platform is an applied program with dual database and multi-windows. Four independent windows, namely scanning, quantitative, calibration and result are incorporated. The Fourier self-deconvolution algorithm is also incorporated to improve the spectral resolution. The wavelengths are calibrated using the polynomial curve fitting method. The spectra and calibration curves of soluble aniline blue and phenol red are presented to show the feasibility of the constructed spectrophotometer.

Acoustics↗
PubMed2005

[The software design of an ultrasonic hyperthermia instrument based on an ARM embedded system].

Development of an ultrasonic hyperthermia instrument's software based on ARM32 microprocessor is here introduced. The system integrates the embedded SOC system, memory system, PWM system, A/D system, JTAG debug system, UART communication system, I/O system and GUI system (include LCD, keyboard) in one PCB board. It effectively completes the control and constance of temperature through the improved PID algorithm, and the instrument miniaturization. Experiments have proved that the system accords with the design requirements.

Algorithms↗
PubMed1987

Computer assisted psychiatric diagnosis: experiments in software design.

The process of psychiatric diagnosis involves the real-time utilization of large amounts of knowledge to maintain and test multiple hypotheses. Therefore, the development of an on-line computerized assistant that can aid a clinician performing psychiatric diagnoses presents challenging problems in data-base organization and retrieval. We have developed the DUNE (Diagnostic Understanding of Natural Events) system architecture that organizes the knowledge around processing structures. The system was designed as a shell for expert-systems that aid diagnoses and assessment tasks in ill-structured domains in general. These domains have previously proven unfeasible for traditional expert-systems such as rule based systems. Currently, DUNE contains sufficient knowledge to aid the diagnosis of anxiety and affective disorders. Among DUNE's advantages: a large degree of tolerance to clinician errors, and flexibility at run time. In this paper, we discuss the general specifications for a program that can aid psychiatric diagnoses, and then describe DUNE and its capabilities.

Adolescent↗
PubMed1993

Physician-directed software design: the role of utilization statistics and user input in enhancing HELP results review capabilities.

The M.D. Rounds Report program was developed and implemented in June of 1992 as an adjunct to the HELP System at Rex Hospital. The program facilitates rapid access to information on allergies and current medications, laboratory results, radiology reports and therapist notes for a list of patients without physicians having to make additional menu or submenu selections. In planning for an upgrade of the program, utilization statistics and user feedback provided valuable information in terms of frequency of access, features used and unused, and the value of the program as a reporting tool in comparison to other online results reporting applications. A brief description of the functionality of the M.D. Rounds Report, evaluation of the program audit trail and user feedback, planned enhancements to the program, and a discussion of the prototyping and monitoring experience and the impact on future physician subsystem development will be presented.

Computer Systems↗
PubMed2006

siVirus: web-based antiviral siRNA design software for highly divergent viral sequences.

siVirus (http://siVirus.RNAi.jp/) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

Anti-HIV Agents↗
PubMed1986

Software design for an inexpensive, practical, microcomputer-based DNA cytometry system.

Recent advances in digital electronics have made it possible to put together videophotometry systems capable of practical DNA ploidy measurements at a relatively modest cost. Such a system, based upon the IBM PC microcomputer and other "off-the-shelf" components, is now operational in our laboratory. This paper discusses the design considerations that went into the development of the software for this system. It examines the choices, constraints and tradeoffs involved in such a software engineering project and considers the practical implementation of image processing algorithms and a user-friendly interface. An overview is given of the modular, menu-driven software through which the system is controlled, along with a description of normal operational flow.

Cell Nucleus↗
PubMed1994

Application of existing design software to problems in neuronal modeling.

In this communication, we describe the application of the Valid/Analog Design Tools circuit simulation package called PC Workbench to the problem of modeling the electrical behavior of neural tissue. A nerve cell representation as an equivalent electrical circuit using compartmental models is presented. Several types of nonexcitable and excitable membranes are designed, and simulation results for different types of electrical stimuli are compared to the corresponding analytical data. It is shown that the hardware/software platform and the models developed constitute an accurate, flexible, and powerful way to study neural tissue.

Action Potentials↗
PubMed2005

Automated water analyser computer supported system (AWACSS) Part I: Project objectives, basic technology, immunoassay development, software design and networking.

A novel analytical system AWACSS (automated water analyser computer-supported system) based on immunochemical technology has been developed that can measure several organic pollutants at low nanogram per litre level in a single few-minutes analysis without any prior sample pre-concentration nor pre-treatment steps. Having in mind actual needs of water-sector managers related to the implementation of the Drinking Water Directive (DWD) (98/83/EC, 1998) and Water Framework Directive WFD (2000/60/EC, 2000), drinking, ground, surface, and waste waters were major media used for the evaluation of the system performance. The instrument was equipped with remote control and surveillance facilities. The system's software allows for the internet-based networking between the measurement and control stations, global management, trend analysis, and early-warning applications. The experience of water laboratories has been utilised at the design of the instrument's hardware and software in order to make the system rugged and user-friendly. Several market surveys were conducted during the project to assess the applicability of the final system. A web-based AWACSS database was created for automated evaluation and storage of the obtained data in a format compatible with major databases of environmental organic pollutants in Europe. This first part article gives the reader an overview of the aims and scope of the AWACSS project as well as details about basic technology, immunoassays, software, and networking developed and utilised within the research project. The second part article reports on the system performance, first real sample measurements, and an international collaborative trial (inter-laboratory tests) to compare the biosensor with conventional anayltical methods.

Algorithms↗
PubMed2001

GST-PRIME: a genome-wide primer design software for the generation of gene sequence tags.

The availability of sequenced genomes has generated a need for experimental approaches that allow the simultaneous analysis of large, or even complete, sets of genes. To facilitate such analyses, we have developed GST-PRIME, a software package for retrieving and assembling gene sequences, even from complex genomes, using the NCBI public database, and then designing sets of primer pairs for use in gene amplification. Primers were designed by the program for the direct amplification of gene sequence tags (GSTs) from either genomic DNA or cDNA. Test runs of GST-PRIME on 2000 randomly selected Arabidopsis and Drosophila genes demonstrate that 93 and 88% of resulting GSTs, respectively, fulfilled imposed length criteria. GST-PRIME primer pairs were tested on a set of 1900 Arabidopsis genes coding for chloroplast-targeted proteins: 95% of the primer pairs used in PCRs with genomic DNA generated the correct amplicons. GST-PRIME can thus be reliably used for large-scale or specific amplification of intron-containing genes of multicellular eukaryotes.

Arabidopsis Proteins↗