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At least 37 records · Page 2Linked to original sources

[Depression and dementia: contribution to the French validation of 2 depression scales: the Cornell Scale for Depression in Dementia and the Dementia Mood Assessment Scale].

This study establishes, in a sample of elderly demented patients, the validity of a french translation of two depression rating scales: Cornell Scale for Depression in Dementia (CSDD, Alexopoulos 1988), Dementia Mood Assessment Scale (DMAS, Sunderland 1988). Cognitive performances of 24 patients (mean age 77.9 +/- 7.4, 7 men 17 women), meeting DSM III-R criteria for dementia, have been evaluated. Four clinicians, blind to the clinical diagnosis of depression established by a psychogeriatrist, have evaluated the sample with the two scales. All patients present middle to severe dementia: MMS = 16.8 +/- 3.45. Eleven patients (45%) present moreover depression. Concurrent validity has been established against Hamilton Depression Rating Scale, test retest reliability, inter-rater reliability and internal consistency are established for each scale. These characteristics are pleading for a good reliability of the french translation of CSDD and DMAS, in the presence of cognitive impairment.

Aged↗

Relative sensitivity of the Montgomery-Asberg Depression Rating Scale, the Hamilton Depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials.

Although early antidepressant clinical trials simply relied on a clinician's judgment as to whether a depressed patient clinically improved or not, the Hamilton Depression (HAM-D) rating scale has become the 'gold standard' to assess the efficacy of new antidepressants. The alternative Montgomery-Asberg Depression Rating Scale (MADRS) has not achieved general acceptance. However, its ease of use warrants evaluation as to whether it is comparable to HAM-D in its sensitivity in detecting antidepressant-placebo differences in antidepressant clinical trials. A retrospective chart review was performed on the records of 208 depressed adult patients that participated in eight randomized, placebo-controlled, double-blind antidepressant clinical trials at the Northwest Clinical Research Center between 1996 and 2000. We compared the effect sizes of the HAM-D, MADRS and Clinical Impressions Rating Scale (CGI-S for severity and CGI-I for improvement) for patients assigned to placebo or an established antidepressant. The effect size (measured as the mean change in rating with antidepressants minus the mean change for placebo divided by the pooled SD of change, adjusted for age, gender and initial scores) was 0.49 with MADRS, 0.53 with HAM-D, 0.55 with CGI-S and 0.59 with CGI-I. The four rating scales had similar effect sizes regardless of the type of antidepressant evaluated. These data suggest that MADRS is as sensitive an instrument as HAM-D for detecting antidepressant efficacy in clinical trials. Thus, MADRS may be a desirable tool in large-scale, pivotal antidepressant clinical trials.

Adolescent↗

Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis.

The present study replicates a previous study in which we found that the less frequently used Montgomery-Asberg Depression Rating Scale (MADRS) is as sensitive an instrument in detecting antidepressant-placebo differences in antidepressant clinical trials as the more widely used Hamilton Depression (HAM-D) rating scale. The Clinical Global Impressions Rating Scale for Severity (CGI-S) was also similar to the other two scales. A retrospective chart review was performed on the records of 139 depressed adult patients who participated in six randomized, placebo-controlled, double-blind antidepressant clinical trials at the North-west Clinical Research Centre between 1996 and 2003. The effect size (measured as the mean change in rating with antidepressants minus the mean change for placebo divided by the pooled SD of change) was 0.68 with MADRS, 0.54 with CGI-S and 0.57 with HAM-D. A correlation analysis also revealed a significant positive relationships between baseline MADRS and HAM-D and final MADRS and HAM-D for the total sample, placebo group, and antidepressant group (P<0.01). Further research is needed to examine which scale is the most appropriate to use for each particular antidepressant clinical trial.

Adolescent↗

[A brief scale for measuring subjective prognosis of gainful employment: findings of a study of 4279 statutory pension insurees concerning reliability (Guttman scaling) and validity of the scale].

The psychometric properties of a 3-item scale for the assessment of subjective vocational disability were tested in 4279 blue-collar workers. Internal consistency of the scale was estimated by Guttman scaling. To evaluate construct validity the scale was compared to other measures of vocational ability, functional capacity, comorbidity, psychic status, and indicators of occupational handicap. The results are highly satisfactory, and the scale can be recommended for further use in rehabilitation research. Ongoing research is discussed.

Activities of Daily Living↗

Swedish translations of the Suicide Probability Scale, Perceived Social Support from Friends and Family Scales, and the Scale for Interpersonal Behavior: a reliability analysis.

The Suicide Probability Scale (SPS), the Perceived Social Support (PSS) from Friends (PSS-Fr) and Family (PSS-Fa) scales, and the Scale for Interpersonal Behavior (SIB) were translated into Swedish and their reliability was estimated in a university student sample. The reliability coefficients indicated that both subscales and the total scales of the SPS, PSS, and SIB possess highly adequate reliabilities. The intercorrelations among the subscales and between the subscales and the total scales were found to be highly significant. The results of the study supported the use of SPS, PSS-Fr and PSS-Fa, and the SIB as reliable methods for assessing suicide risk, perceived social support from friends and family, and assertive behavior.

Adult↗

Reliability of the Turkish version of the Perceived Social Support from Friends and Family scales, Scale for Interpersonal Behavior, and Suicide Probability Scale.

This study investigated the reliability of the Turkish version of the Perceived Social Support (PSS) from Friends (PSS-Fr) and Family (PSS-Fa) scales, the Scale for Interpersonal Behavior (SIB), and the Suicide Probability Scale (SPS). Both test-retest and internal consistency reliability estimates were computed. Highly adequate reliability coefficients are recorded for the subscales and the total scales of the PSS, SIB, and SPS. The results of the present study clearly support the use of Turkish versions of the PSS-Fr, PSS-Fa, SIB, and SPS as reliable methods for assessing perceived social support from friends and family, assertiveness, and suicide risk.

Adult↗

Production of human interleukin-8 expressed in Escherichia coli: from a laboratory scale for in vitro tests via a technical scale for animal studies to a process scale for a GMP-compatible production.

An Escherichia coli K 12 strain has been constructed for efficient expression of recombinant biologically active human IL-8 (Interleukin-8). The development of a fermentation and purification process from the laboratory scale (cells from 15 l fermentation broth) to a production scale (cells from 200 l fermentation broth) is described. Material obtained from the laboratory scale was used for initial in vitro studies and for the development of a biological assay. An upscale purification process starting from 80 l fermentation broth resulted in larger amounts of IL-8 needed for preclinical studies. This process includes a fully automated control of the initial affinity chromatography step. Finally, a production process which differed markedly from the small-scale processes was tailor-made for GMP conformity and economic considerations. It consists of a cell disruption step followed by two crossflow diafiltrations with different molecular weight cut offs and filtration rates, one cation exchange chromatography and a final dialysis step. In order to enhance the overall yield of biologically active IL-8, conditions for a resolubilisation of insoluble IL-8 present in the remaining pellet after cell disruption were worked out.

Bioreactors↗

Scales, scales and more scales.

This article examines the nature, uses, and limitations of the large variety of existing, so-called, hypnosis scales; that is, instruments that have been proposed for the assessment of hypnotic behavior. Although the major aim of most of the scales ostensively seems to be to assess several aspects of hypnotic states, they are found generally to say little about these and much more about responses to suggestions. The greatest application of these scales is to be found in research, but they also have a limited place in clinical work.

Humans↗

[A differential description of the SDAT (senile dementia Alzheimer type) patient using 2 behavior observation scales: the BOP (Older Patients Rating Scale) and the GOS-G (Behavior Observation Scale-Geriatrics)].

In this article the BOP (Dutch version of the Stockton Geriatric Rating Scale) and the GOS-G (an adapted version of the BOP) were compared in their capacity to differentiate between a group of SDAT-patients (Senile Dementia Alzheimer Type) and a group of elderly patients with other psycho-organic symptoms. Both scales differentiated between the two groups. A second goal in this study was to test our assumption that the GOS-G would do better than the BOP in describing the SDAT-patient in his differences with the other psycho-organic patients. The reason for our assumption was the fact that the GOS-G was constructed with the intention to overcome some shortcomings of the BOP. The results showed that our assumption was correct. The picture of the differences between both groups given by the BOP was incomplete. Especially the underestimation of the dysfunctioning in activities of daily living and the neglect of disturbing behavior in the picture were seen as a disadvantage of the BOP.

Activities of Daily Living↗

Efficacy of MMPI-2 validity scales and MCMI-II modifier scales for detecting spurious PTSD claims: F, F-K, Fake Bad Scale, ego strength, subtle-obvious subscales, DIS, and DEB.

This study compared 119 personal injury claimants' scores on MMPI-2 and MCMI-II malingering scales. Data from 55 pseudo-PTSD patients and 64 controls confirm the utility of the scales examined. The following cut-offs were most effective for identifying spurious PTSD: F greater than 62, F-K = greater than -4, Es = greater than 30, FBS = greater than 24 (men), FBS = greater than 26 (women), total obvious minus subtle = greater than 90, DIS = greater than 60, and DEB = greater than 60. Pseudo-PTSD patients were those who (1) claimed to be suffering a psychological injury (2) that was so severe that it was disabling (3) due to an experience that was entirely implausible as a candidate for PTSD criterion A in DSM-III-R and (4) scored T = 65 or higher on both PK and PS, the post-traumatic stress disorder subscales of the MMPI-2.

Adult↗

[Concurrent validation of the suicidal risk assessment scale (R.S.D.) with the Beck's suicidal ideation scale].

The prevention of suicide is a top priority in mental health. The determination of high risk suicidal groups is not sufficient. The expressing suicidal ideas is not a protective factor, but in contrary a risk factor to take into account, or even to search and to quantify: 80% of the subjects who attempt to commit suicide or commit suicide express such ideas months before. Several evaluation instruments try to help the practitioners or the research workers in this reasoning. The suicidal risk assessment scale RSD can be cited in particular. It is composed of eleven sections. The 0 level corresponds to the absence of particular ideas of death or suicide. Levels 1 and 2, the presence of ideas of death. Levels 3-4-5, the presence of suicidal ideas. The difference compared to the majority of the other scales consecrated to the same subject, the passif desire of death, occupies a place totally particular in the RSD (level 6). From the level 7, the risk of acting out seems to become more important. It stops being a simple idea of suicide, but becomes a real will of dying, firstly retained by something or someone (level 7), the fear of causing suffering to dear ones or a religious belief., then determined (level 8). Finally, the patient has elaborated a concrete plan (level 9) or he has already started the preparation of acting out (level 10). It is just necessary to evaluate and to note the highest level of the scale. The inclusion of the suicidal risk assessment scale RSD and of the Suicidal Ideation Scale by Beck in an international multicenters, phase IV, double-blind study, according to two parallel groups, with a fixed dose of fluoxétine or fluvoxamine for six weeks, allowed to search correlations which could exist between the two scales. The ana-lysis before the beginning of the treatment was done on 108 outpatients depressive, male and female, aged 18 or over. It finds a satisfactory concurrent validity between the suicidal risk assessment scale RSD and the Suicidal Ideation Scale by Beck (r=0.69; p<0.0001) as well as between the RSD and the item "suicide" of the Depression scale by Hamilton (r=0.60; p<0.0001). On the other hand, it is less satisfactory between the suicidal risk assessment scale RSD and the Hamilton Depression scale overall score (r=0.35; p=0.0002). During the evolution under the treatment, the suicidal risk assessment scale RSD shows an improvement significantly faster than the Hamilton Depression scale or the Beck's Suicidal Ideation Scale (p<0.0001). This statement of fact arouses some questions about the suicidal risk of which the evolution in the case of a treated depressive episode could be quicker than first thought. All the more so as this difference is affected by the type of the treatment (p=0.015). Moreover, a score of 7 and more on the suicidal risk assessment scale RSD seems to represent a risk level judged particularly significant by the experimenters. In effect, the existence of such a suicidal risk was a criteria of exclusion and no patient with a level superior to 6 on suicidal risk assessment scale RSD was included. In conclusion, the utilisation of the suicidal risk assessment scale RSD could be interesting in the prevention of suicide.

Adolescent↗

Reliability of the Modified Tardieu Scale and the Modified Ashworth Scale in adult patients with severe brain injury: a comparison study.

OBJECTIVE: To assess and to compare the reliability of the Modified Tardieu Scale with the Modified Ashworth Scale in patients with severe brain injury and impaired consciousness. DESIGN: Cross-sectional observational comparison study. SETTING: An early rehabilitation centre for adults with neurological disorders. SUBJECTS: Thirty patients with impaired consciousness due to severe cerebral damage of various aetiologies. MEASUREMENT PROTOCOL: Four experienced physical therapists rated each patient in a randomized order once daily for two consecutive days. Shoulder, elbow, wrist, hip, knee and ankle spasticity were assessed by the use of Modified Tardieu Scale and Modified Ashworth Scale data collection procedures. MAIN OUTCOME MEASURES: Test-retest and inter-rater reliability (kappa = kappa value) of the Modified Tardieu Scale and the Modified Ashworth Scale. RESULTS: The test-retest reliability of the Modified Ashworth Scale was moderate to good (kappa = 0.47-0.62) and of the Modified Tardieu Scale moderate to very good (kappa = 0.52-0.87). Test-retest reliability was significantly higher within the Modified Tardieu Scale in comparison with the Modified Ashworth Scale (Z > 1.96; p < 0.05) except for shoulder extensor and internal rotator muscles (Z < 1.96; p > 0.05). Although inter-rater reliability of both scales was poor to moderate (Modified Ashworth Scale: kappa = 0.16-0.42; Modified Tardieu Scale: kappa = 0.29-0.53), significantly higher K-values were revealed with the Modified Tardieu Scale for all tested muscle groups (Z > 1.96; p < 0.05) except for wrist extensors (Z < 1.96; p > 0.05). CONCLUSION: In patients with severe brain injury and impaired consciousness the Modified Tardieu Scale provides higher test retest and inter-rater reliability compared with the Modified Ashworth Scale and may therefore be a more valid spasticity scale in adults.

Brain Injuries↗

Communication Capacity Scale and Agitation Distress Scale to measure the severity of delirium in terminally ill cancer patients: a validation study.

Although valid measurement of the severity of terminal delirium is of great importance in palliative care settings, existing instruments have considerable limitations. In order to quantify patients' communication capacity and agitated behaviour, two new operational observer-rating scales, the Communication Capacity Scale (Communication Scale) and Agitation Distress Scale (Agitation Scale), were validated. Thirty terminally ill cancer patients diagnosed with delirium were evaluated simultaneously by two palliative care physicians blinded to each other's coding using the Communication Scale and Agitation Scale. In addition, the Memorial Delirium Assessment Scale (MDAS), Delirium Rating Scale (DRS) and Sedation Scale were rated by one researcher. Both scales achieved high internal consistency and inter-rater reliability with Cronbach's alpha coefficients of 0.91 and 0.96, and Cohen's kappa values on each item of 0.72-1.00. The principal components analysis resulted in the emergence of only one component for each scale. The total score on the Communication Scale was highly associated with that of the MDAS (rho = 0.78), Sedation Scale (rho = 0.86), and cognitive items from the MDAS and DRS (rho = 0.83). The whole score on the Agitation Scale was significantly correlated with that of the DRS (rho = 0.61) and agitation items from the MDAS and DRS (rho = 0.61). In conclusion, the Communication Scale and Agitation Scale have acceptable reliability and validity to quantify patients' communication capacity and agitation symptoms of terminally ill cancer patients with delirium.

Adult↗

The scale transition: scaling up population dynamics with field data.

Applying the recent developments of scale transition theory, we demonstrate a systematic approach to the problem of scaling up local scale interactions to regional scale dynamics with field data. Dynamics on larger spatial scales differ from the predictions of local dynamics alone because of an interaction between nonlinearity in population dynamics at the local scale and spatial variation in density and environmental factors over the regional population. Our systematic approach to scaling up involves the following five steps. First, define a model for dynamics on the local spatial scale. Second, apply scale transition theory to identify key interactions between nonlinearity and spatial variation that translate local dynamics to the regional scale. Third, measure local-scale model parameters to determine nonlinearities at local scales. Fourth, measure spatial variation. Finally, combine nonlinearity and variation measures to obtain the scale transition. Using field data for the dynamics of grazers and periphyton in a freshwater stream, we show that scale transition terms greatly reduce the growth and equilibrium density of the periphyton population at the stream scale compared to rock scale populations, confirming the importance of spatial mechanisms to stream-scale dynamics.

Ecosystem↗

Validity and reliability of Spanish versions of the Ruminative Responses Scale-Short Form and the Distraction Responses Scale in a sample of Spanish high school and college students.

This study investigated the construct validity and reliability of the Spanish Ruminative Responses Scale-Short From, and the Distraction Responses Scale of the Response Styles Questionnaire for a sample of 727 Spanish high school and college students who responded anonymously and voluntarily to a questionnaire (293 men, 434 women; ages 16 to 29 years, M=18.8, SD=3.0). In addition to the above scales, the questionnaire included the Spanish forms of the Beck Depression Inventory, the Trait Anxiety Scale from the State-Trait Anxiety Scale, the Satisfaction with Life Scale, and the Subjective Happiness Scale. The internal consistency of the scales was satisfactory (Cronbach alpha=.86 for the Ruminative Responses Scale and .78 for the Distraction Responses Scale). As expected, scores on the Spanish Ruminative Responses Scale showed positive correlations with those on the Beck Depression Inventory and the Trait Anxiety Scale and negative associations with the Satisfaction with Life Scale and the Subjective Happiness Scale. Conversely, the Spanish Distraction Responses Scale was negatively correlated with the Beck Depression Inventory and positively associated with the Satisfaction with Life Scale and the Subjective Happiness Scale. These results provide evidence of appropriate reliability for research purposes. Furthermore, the correlational analysis supported prior findings that ruminative response and distraction response styles are differentially associated with reported depressed and positive moods.

Adolescent↗

The effect of scale manipulations on validity: targetting frequency rating scales for anticipated performance levels.

A common problem with standard five-point frequency rating scales is their inability to differentiate between objects within a relatively narrow band of the rating dimension. Two alternatives for increasing a scale's ability to reflect existing differences are: increasing the number of positions on the rating scale, or packing the rating scale with quantifiers from a particular portion of the frequency dimension. In this study, three types of rating scale - a standard five-point balanced scale, a longer nine-point balanced scale, and a five-point packed scale - were used to rate two videotaped samples of behaviour, one displaying performance levels from 10% to 100% and the other from 70% to 90%. Each subject's ratings were correlated with true performance levels in each sample of behaviour as a measure of validity. Results showed that for ratings of the wide range of behaviour all three types of scales provided average correlations between the ratings and actual frequencies of the event which exceeded 0.90, with the longer nine-point scale yielding a significantly higher mean correlation than the other two scales. For ratings of the narrow performance range, the nine-point scale provided the highest correlation with the actual frequencies, followed by the packed scale and the standard five-point balanced scale. All differences were significant. Findings suggest that increasing the number of scale positions can significantly increase the validity of ratings obtained. Also, though to a lesser degree, validity of ratings may be enhanced in a shorter scale by using quantifiers from the portion of the frequency continuum where performance are anticipated to lie.

Journal Article↗

Avian scale development. XVI. Epidermal commitment to terminal differentiation is prior to definitive scale ridge formation.

Germinative cells of the scutate scale epidermis from 15-day embryos are committed to appendage-specific, beta stratum formation in association with a foreign dermis. Commitment precedes the time (17 days of development) at which beta strata are actually present in their site-specific locations along the outer surface of each scutate scale. This observation suggested the possibility that commitment to beta stratum formation might be occurring as the outer epidermal surface of each scutate scale first becomes established between 12 and 13 days of development. It is at this time that the scale epidermis loses its ability to participate in feather morphogenesis and cell proliferation becomes restricted to a true stratum basale. To examined the ability of the presumptive scutate scale epidermis to generate beta strata in the absence of the inductive scutate scale dermis, scutate scale epidermis from 11-, 12-, and 13-day embryos was recombined with 15-day reticulate scale dermis and grown for 7 or 9 days. The dermis of reticulate scales does not induce beta stratum formation, but it does support differentiation of a beta stratum by the determined 15-day scutate scale epidermis. Using immunohistological and biochemical analyses of beta-keratins, we find that each of these presumptive scutate scale epidermises is competent to generate appendage-specific beta strata in the absence of the scutate scale dermis. This determination is occurring prior to scale ridge morphogenesis and differentiation of the epidermis into the distinct outer and inner epidermal surfaces of the scale ridge. The restricted distribution of beta strata to the apical domes of individual reticulate-like scales demonstrates that the germinative cells of the committed epidermises are responding to patterned cues. This study also suggests that all basal cells of the presumptive scutate scale epidermis are initially endowed with the ability to generate cells that form a beta stratum.

Animals↗

A comparison of small-scale, pilot-scale and large-scale tests for predicting leaching behaviour of landfilled wastes.

Landfills generate emissions over long periods, often longer than a lifetime. The longest lasting emission is leachate. In order to estimate the future requirements for leachate treatment, different kinds of leaching tests may be applied. In this paper, shaking leaching tests (SLT), landfill-simulator leaching tests and a field-cell leaching test performed with ash, municipal solid waste (MSW) and MSW+ash are evaluated. The tests are compared and the factors influencing leaching are identified and discussed. The factors are: liquid to solid (L/S) ratio, water withdrawal, recirculation rate, presence or absence of biological processes, size of particles, duration of experiment, temperature and pre-treatment of the waste. The presence of biological processes has the greatest impact on leaching and is the main reason why SLT is less useful for long-term predictions. The landfill simulator tests were found to be useful for several different kinds of predictions. However, they are not reliable for predicting the L/S required for reaching a certain concentration. The possibilities for reliable long-term predictions would be facilitated by a better knowledge of the influence of various factors on leaching. Such an increased knowledge would make it possible to enhance waste stabilisation in leaching tests as well as in full-scale landfills.

Forecasting↗