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At least 37 records · Page 2Linked to original sources
PubMed1999

Clinical significance of an extensor tendon anomaly to the little finger--a new finding.

A new anatomical variation of extensor digiti minimi (EDM) was discovered during our anatomical studies. The EDM usually gives one tendon to the little finger to extend the metacarpophalangeal joint (MPJ) independently from the other fingers. The EDM in our cadaver had three tendon slips. It supplied the MPJ of the little finger with two tendon slips. Along with the extensor digitorum communis (EDC), the EDM also had an additional slip to the ring finger MPJ extensor hood apparatus. The little finger also received a separate tendon from EDC.

Finger Injuries↗
PubMed1999

External hydrocephalus in primary hypomagnesaemia: a new finding.

This paper reports a new finding in two siblings with primary hypomagnesaemia as a result of renal magnesium wasting, namely, rapidly increasing head size. External hydrocephalus and brain shrinkage in primary hypomagnesaemia seen on computed tomography of the brain with reversibility after magnesium treatment has not been reported previously.

Female↗
PubMed1998

[New findings of Anopheles mosquitoes in artificial containers].

New findings of Anopheles mosquitoes in artificial containers are reported. In one, a plastic container served as a breeding place for Anopheles bellator larvae and, in another, four instar larvae of An. albitarsis s.l. were found in an abandoned toilet basin. Reflections are offered as to the selective pressure represented by the production, of an ever increasing scale, of disposable objects.

Animals↗
PubMed2004

New findings on animal diseases published since 2003. 1. Dogs.

This is the first article of a series of papers reviewing "new findings" on animal diseases. The articles are arranged in order of animal species. This article reviews seven publications on new findings on or directly related to dog diseases. The following seven cases are discussed: Canine sarcocystosis in Central America. Copper accumulation in a Skye terrier: Antemortem diagnosis and cytoprotective bile acid therapy. Keratinocyte culture and use of a cultured epidermal autograft. Line 1 insertion mutation in Factor IX of dogs with hemophilia B. Not previously described localization of the lesions in stifle osteochondritis dissecans. Panniculitis associated with pancreatitis: Antemortem diagnosis. Primary polydipsia associated with (and induced by?) gastrointestinal disease. After a short introduction, the bibliographical data, the abstract of the author(s) and some additional information derived from the article are given.

Animals↗
PubMed1980

Voluntary nystagmus: new findings and clinical implications.

Horizontal eye position was monitored during a variety of tracking tasks in three normal subjects capable of producing voluntary nystagmus. New findings included ability to superimpose voluntary nystagmus saccades on smooth movements during tracking of a target moving with constant acceleration, brief persistence of voluntary nystagmus, and transient occurrence of voluntary nystagmus, and transient occurrence of voluntary nystagmus-like movements and oscillopsia following an intense period of voluntary nystagmus-like movements and oscillopsia during marked convergence. Clinical implications of these new findings are discussed.

Electrophysiology↗
PubMed2002

[New finding: transitory horizontal pendular nystagmus secondary to neonatal abstinence syndrome].

UNLABELLED: New finding: transient horizontal pendular nystagmus as a sequella to post-natal withdrawal syndrome. BACKGROUND: Children born of mothers who abused illegal substances during pregnancy can present with signs and symptoms of a withdrawal syndrome, including irritability, jitteriness, diarrhoea. Usually these symptoms appear from a few hours up to a few days after birth. It is frequently followed by a post-withdrawal period of several weeks duration with crying, excitability, sleep irregularities and feeding difficulties. The purpose is to report the presence of nystagmus in infants born from drug-addicted mothers. METHODS: Five children born from drug-addicted mothers were examined. RESULTS: Three children (case 1 - 3) presented with congenital horizontal pendular nystagmus. Two other children (case 4 - 5) presented with a peculiar transient horizontal nystagmus, lasting 6 months and 7 months respectively. CONCLUSIONS: To our knowledge, transient horizontal pendular nystagmus has never been reported in the literature. It was detected in two children who suffered from a post-natal withdrawal syndrome necessitating substitution therapy, including morphine. This may represent a form of morphine midbrain toxicity.

Child, Preschool↗
PubMed1989

[New findings in the genetics of type II diabetes].

The review of new findings from the sphere of clinical, molecular genetic and physiological investigations is focused on the interpretation of the genetic transmission of type II diabetes, on possibilities of the early identification of relatives of diabetics liable to develop the disease and on the assessment of primary genetic defects. Associations of type II diabetes are sought in particular with polymorphism of the gene for insulin, insulin receptor and glucose transport. The author discusses also the problem of regulating genes and impaired dynamics of insulin secretion. The key problem of effective use of pretentious methods of genetic research is the selection of families of type II diabetics suitable for genealogical studies.

Diabetes Mellitus, Type 2↗
PubMed1976

[Trends and new findings in the assessment of the somatic radiation risk (author's transl)].

New findings are described which enable a more precise estimation of the leukemia and cancer risk by radiation. They concern the risk ratio of cancer to leukemia after whole body irradiation, the shape of the dose-risk-relationship and the time factor problem. Finally a balance of the somatic radiation risk from whole body irradiation is set up and the consequences for the establishment of dose limits are discussed.

Dose-Response Relationship, Radiation↗
PubMedDate not supplied

Proteus syndrome: new findings in seven patients.

Seven children with Proteus syndrome (PS) are reported. The majority of clinical findings coincide with what is reported in the literature. New findings were blue sclerae, telecanthus, epiblepharon, endotropy, hemimegaly of the optic nerve, occipital dysmyelination and compression of the corpus callosum, craneosynostosis, decalcification and thinning of the cortical layer of long bones, and talipes equinus. The clinical findings, possible etiology, differential diagnosis, and treatment of PS are discussed.

Child↗
PubMed2005

Implications of the United States census 2000 in analyzing and reporting new findings of disparities in health.

This paper argues that, when analyzing and reporting new findings of disparities in health, two areas from the recent U.S. Census of 2000 should be considered for those findings to be meaningful. The first is to avoid analyzing and reporting findings of disparity with an emphasis on the term "Hispanic" and instead to specify the particular Hispanic group from which such findings were collected, such as Mexican-American versus Cuban communities. The second point is that such findings should also take into consideration combination of two or more races. For example, reporting would allow for multiple groupings for respondents who consider themselves African American and White, or African American, Asian, and White.

Bias↗
PubMed2003

Human intestinal parasites in the past: new findings and a review.

Almost all known human specific parasites have been found in ancient feces. A review of the paleoparasitological helminth and intestinal protozoa findings available in the literature is presented. We also report the new paleoparasitologic findings from the examination performed in samples collected in New and Old World archaeological sites. New finds of ancylostomid, Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Trichostrongylus spp., Diphyllobothrium latum, Hymenolepis nana and Acantocephalan eggs are reported. According to the findings, it is probable that A. lumbricoides was originally a human parasite. Human ancylostomids, A. lumbricoides and T. trichiura, found in the New World in pre-Columbian times, have not been introduced into the Americas by land via Beringia. These parasites could not supported the cold climate of the region. Nomadic prehistoric humans that have crossed the Bering Land Bridge from Asia to the Americas in the last glaciation, probably during generations, would have lost these parasites, which life cycles need warm temperatures in the soil to be transmitted from host to host. Alternative routes are discussed for human parasite introduction into the Americas.

Animals↗
PubMed1989

[New findings on the pathogenesis of rheumatoid arthritis].

In the submitted review the authors present some new findings and approaches pertaining to the pathogenesis of rheumatoid arthritis (RA). First they describe cells participating in the development of the articular inflammation and mediators which transmit signals between these cells and which may lead to their activation. The authors mention the immune complex role of rheumatoid factors and some new theories on their development. They describe effector substances directly responsible for the resulting damage and emphasize their final role in the entire cycle preceding the inflammatory reaction in which lymphocytes, macrophages, polymorphonuclear leucocytes and dendritic cells participate. The possible role of viruses in the aetiology of RA is also mentioned. In the conclusion the authors present the sequence of mechanisms which lead to the development and maintenance of the chronic inflammatory reaction which develops probably on the background of the persisting autologous mixed lymphocytic reaction.

Arthritis, Rheumatoid↗
PubMed1992

Facial expressions of emotion: an old controversy and new findings.

Evidence on universals in facial expression of emotion and renewed controversy about how to interpret that evidence is discussed. New findings on the capability of voluntary facial action to generate changes in both autonomic and central nervous system activity are presented, as well as a discussion of the possible mechanisms relevant to this phenomenon. Finally, new work on the nature of smiling is reviewed which shows that it is possible to distinguish the smile when enjoyment is occurring from other types of smiling. Implications for the differences between voluntary and involuntary expression are considered.

Emotions↗
PubMed2000

D-Amino acid oxidase: new findings.

The most recent research on D-amino acid oxidases and D-amino acid metabolism has revealed new, intriguing properties of the flavoenzyme and enlighted novel biotechnological uses of this catalyst. Concerning the in vivo function of the enzyme, new findings on the physiological role of D-amino acid oxidase point to a detoxifying function of the enzyme in metabolizing exogenous D-amino acids in animals. A novel role in modulating the level of D-serine in brain has also been proposed for the enzyme. At the molecular level, site-directed mutagenesis studies on the pig kidney D-amino acid oxidase and, more recently, on the enzyme from the yeast Rhodotorula gracilis indicated that the few conserved residues of the active site do not play a role in acid-base catalysis but rather are involved in substrate interactions. The three-dimensional structure of the enzyme was recently determined from two different sources: at 2.5-3.0 A resolution for DAAO from pig kidney and at 1.2-1.8 A resolution for R. gracilis. The active site can be clearly depicted: the striking absence of essential residues acting in acid-base catalysis and the mode of substrate orientation into the active site, taken together with the results of free-energy correlation studies, clearly support a hydrid transfer type of mechanism in which the orbital steering between the substrate and the isoalloxazine atoms plays a crucial role during catalysis.

Amino Acid Sequence↗
PubMed1979

Jerk nystagmus: some new findings.

Eye movements in a subject with jerk nystagmus were recorded during a variety of tracking tasks using a photoelectric method. New findings included ability to reduce nystagmus amplitude and frequency when instructed "to hold the eye steady" rather than "to fixate" in the presence of a visible target, changes in nystagmus characteristics and visual acuity as a function of head position which related to overall retinal-image motion, marked variability of nystagmus especially during reading, and necessity of a prolonged period of visual feedback for generation of nystagmus to approach a "steady-state" level. Clinical implications of these findings are discussed, including use of the "hold" command during ophthalmoscopy in patients with nystagmus.

Adult↗
PubMed2006

[Some new findings in the pathogenesis of myeloproliferative disorders and new insight into more effective treatment].

Advances in molecular biology and genomics enabled more detailed view on the pathogenesis of myeloproliferative disorders, which are considered to be a diseases of hematopoietic stem cell. The autor provides an brief overview of the genetic alterations, leading to the chronic myeloid leukemia, myelodysplastic syndrome and acute myeloid leukemia. In the second part, molecular targeted therapies that have been developed based on these insights are reviewed. These are particularly methods preventing increased proliferation such as inhibition of tyrosinkinases (imatinib, dasatinib), inhibitions of farnesyltransferase (tipifarnib), inhibition of angiogenesis (bevacizumab, vatalanib), induction of diferentiation (hypomethylating agenents) and induction of apoptosis (bortezomib). More detailed information is given on some novel drugs which are currently in clinical trials.

Humans↗
PubMed2006

New findings for in-gel digestion accelerated by high-intensity focused ultrasound for protein identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

New findings in sample treatment based on high-intensity focused ultrasound (HIFU) for protein digestion after polyacrylamide gel electrophoresis separation are presented. The following variables were studied: (i) sample volume; (ii) sonotrode diameter; (iii) previous protein denaturation; (iv) cooling; (v) enzyme concentration; and (vi) protein concentration. Results showed that positive protein identification could be done after protein separation by gel electrophoresis through peptide mass fingerprint (PMF) in a volume as low as 25 microL. The time needed was less than 2 min and no cooling was necessary. The importance of the sonotrode diameter was negligible. On the other hand, protein denaturation before sonication was a trade-off for the success of procedure here described. The protein coverage was raised from 5 to 30%, and the number of peptides matching the proteins was also increased in a percentage ranging 10-100% when the classical overnight treatment is compared with the proposed HIFU procedure. The minimum amount of protein that can be identified using the HIFU sample treatment by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was 0.06 microg. The lower concentration of trypsin successfully used to obtain an adequate protein digestion was 3.6 microg/mL.

Amino Acid Sequence↗
PubMed2004

[The mild encephalitis-hypothesis--new findings and studies].

Causes and pathogenesis of psychiatric disorders is poorly understood. Infections by viruses or other agents may disturb neurotransmitters and elicit behavioral abnormalities, and induce long lasting immune reactions, referred to as mild encephalitis (ME). New findings (pathology, biochemistry, imaging) in schizophrenia and bipolar psychoses are compatible with ME hypothesis. In Chorea Sydenham and PANDAS syndrome autoimmune ME seems to explain anxiety-compulsive-hyperactivity symptoms. Add-on-therapy with Cox-II-blockers or valacyclovir improved acute schizophrenia, CSF filtration some cases of therapy resistant psychoses.

Acyclovir↗