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PubMed1979

IgE synthesis in aging. Enhancement of IgE production in subjects with autoantibodies.

Serum IgE levels were measured in two groups of healthy elderly subjects: a first group of 18 with circulating autoantibodies (sign of a probable deficit of suppressor T lymphocytes) and a second group of 15 without circulating autoantibodies. The IgE levels in the first group (average 1032 U/ml) resulted significantly higher than those in the second group (average 103 U/ml), P less than 0.05. This result can be related to a deficit of suppressor T lymphocytes functionality, present in these subjects, which would cause, besides the appearance of autoantibodies, also an increase of serum IgE levels. Moreover, this phenomenon seems to confirm that in man, too, as in experimental animals, IgE synthesis is under the control of suppressor T lymphocytes specific for IgE. From a clinical viewpoint, the two populations studied do not differentiate and no symptoms of atopy were observed in subjects with high IgE levels.

Aged↗
PubMed1979

Relationship between antigen-specific IgE antibody (RAST) and total serum IgE levels.

Although the total serum IgE level is generally higher in atopic than in non-atopic individuals, high total serum IgE levels and atopic diseases are not invariably associated. In 42 atopic patients with the total serum IgE levels less than 100 U/ml, 27% of RAST against 14 allergens were positive whereas in 45 atopic patients with the total serum IgE levels greater than 500 U/ml, 57% of RAST against 14 allergens were positive. The mean RAST values against four grass antigens expressed as a percentage of antigen-disc bound radioactivities were significantly lower in the group with the lower total serum IgE levels. Low or normal total serum IgE levels are likely to be found in atopic patients who are allergic to a relatively few grass antigens.

Antibody Specificity↗
PubMed1977

Basophil histamine release in patients with hay fever. Results compared with specific IgE and total IgE during immunotherapy.

Histamine release from leucocytes was demonstrated in grass pollen hay fever patients on in vitro challenge with extract of Pleum pratense (timothy). No release was found in persons without a history of grass pollen allergy. During preseasonal hyposensitization the following tendencies were found in cell sensitivity to allergen as well as in specific IgE antibody level of serum: an initial increase at the beginning of the therapy followed by a decrease during the pollen season. This is in contrast to untreated hay fever patients in whom an increase or no change at all of cell sensitivity and specific IgE was observed in the pollen season. Immunotherapy, therefore, can prevent such an increase in the pollen season. The mechanism might be due to a depression of the IgE production. In untreated as well as in treated patients the cell sensitivity was found to be significantly correlated to the grass specific IgE determined by RAST but not to the total serum level of IgE estimated by RIST. It seems likely that the sensitivity would be useful for evaluating the degree of allergy in grass pollen hay fever patients treated or not treated with immunotherapy.

Adult↗
PubMed1977

IgE in experiemental schistosomiasis. I. Serum IgE levels after infection by Schistosoma mansoni in various strains of rats.

Serum IgE levels were measured by radioimmunoassay in four strains of rats, before and after infection by Schistosoma mansoni. Differences were observed in basal IgE levels, depending on the strain considered. Serum IgE rose 10--20 days after infection and the maximum level, between days 30 and 50, ranged from 14 to 60 times the basal level. One of the most characteristic features of IgE production in rat schistosomiasis was the persistence of high IgE levels for a long time after rejection of the worms.

Animals↗
PubMed1978

IgE antibody response to mite antigen in the mouse. Suppression of an established IgE antibody response by chemically modified antigen.

The antibody response to mite antigen in several mouse strains was studied. BALB/c, CBA, C3H/He, and C57B1 strains showed good responses against mite antigen. The AKR strain, on the other hand, showed a relatively poor response. When BALB/c mice were immunized with DNP-mite conjugate in aluminum hydroxide gel (alum), anti-DNP IgE antibody and IgG1 antibody were induced. When these mice were boosted with mite antigen alone in alum, both anti-mite IgE antibody and IgG1 antibody were induced, although these antibodies were not observed after the first immunization. Both IgE antibody responses were high and persistent. Mite antigen was denatured by alkylation and reduction in the presence of 8 M urea. Native antigen remaining in the chemically denatured antigen was removed by an immunoadsorbent method. The modified mite antigen could stimulate the carrier-specific helper cells, at least when it was injected with alum. It was also found that repeated injections of the modified mite antigen resulted in the suppression of an established IgE antibody response against mite antigen. These findings suggest possible clinical application for hyposensitization therapy.

Animals↗
PubMed1979

Serum IgE levels in healthy black American children: a case for environmental influences on IgE.

Serum IgE was determined in 115 healthy, non-atopic black American children, aged 0-16 years, living in Urban Chicago. The mean IgE level varied from 1.48 u/ml at birth to 70 u/ml at adolescence. These values are comparable to those observed in American whites but differ significantly from the IgE levels of both African blacks and European Caucasians. Thus, environmental factors apparently exert a strong influence on IgE production in non-atopic individual.

Adolescent↗
PubMed1977

IgE synthesis in man. I. Development of specific IgE antibodies after immunization with tetanus-diphtheria (Td) toxoids.

Specific IgE and IgG antibodies were measured in 39 adolescent and adult humans preselected to have less than 0.125 antitoxin units (AU) ml to tetanus antitoxin (IgG) irrespective of previous immunization history. Mean antitoxin values (IgG) measured by sheep red cell hemagglutination (SRBC) increased by 2 logs to 1.49 AU/ml sera for tetanus and by 1 log to 0.025 AU/ml sera for diphtheria. Specific tetanus IgE was noted to increase after immunization from a mean 2.0 +/- 0.2% counts bound to 3.1 +/- 0.6% counts bound, but was not statistically significant. Diphtheria-specific IgE rose significantly (p less than 0.05) from a mean 1.5 +/- 0.2% counts bound to a mean 4.0 +/- 1.2% counts bound in atopic individuals and from a mean 1.2 +/- 0.0% counts bound to a mean 2.2 +/- 0.5% counts bound in nonatopics. These data document the development of tetanus and diphtheria IgE antibodies after booster immunization.

Adolescent↗
PubMed1978

[Description of a method for measuring sera with a high level fo IgE: test through the inactivation of anti-IgE covered phages].

The Fab fragment of an anti-IgE serum was conjugated with the bacteriophage T4 through the use of glutaraldehyde. The conjugated phage was inactivated by human sera which contained IgE. The degree of inactivation allowed to make a distinction between the sera of normal individuals and that of those in whom it is known that high levels of Ig E exist, as in patients with allergic diseases. The method is quite sensitive, economical and does not require costly equipment. Besides, the conjugated phage is preserved for prolonged periods of time.

Coliphages↗
PubMed1979

Regulation of IgE antibody production by serum molecules. VI: Preliminary biochemical and immunological characterization of serum molecules active in suppressing IgE antibody production.

Molecules present in the serum and ascites fluids of low IgE responder mice previously inoculated with complete Freund's adjuvant have been analyzed in terms of certain biochemical and immunological characteristics. These studies demonstrate that the active molecules, termed "suppressive factors of allergy" (SFA), are (1) nondialyzable, (2) not associated with low-density or high-density lipoproteins, (3) heat stable, (4) precipitable by ammonium sulfate, and (5) approximately 150,000 daltons in molecular size. Studies with immunoadsorbents prepared from various antisera indicate that the suppressive molecules are (1) not immunoglobulin in nature, (2) not reactive with specific anti-H-2 alloantibodies, but (3) reactive with anti-beta 2m antibodies as well as (4) heterologous antisera raised against CFA-immune mouse serum.

Animals↗