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PubMed2001

The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.

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Journal Article↗
PubMed2001

Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky at the ICCB for generously providing resin for the library synthesis. We thank Dr. Helen Blackwell and Lucy Pérez for expert help with library encoding. We are grateful to Prof. Eric Jacobsen and Prof. Scott Denmark for the use of their chiral stationary phase high pressure liquid chromatograph and supercritical fluid chromatograph, respectively. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. R.A.S. is a Research Associate and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University.

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Journal Article↗
PubMed2001

Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this research. We are especially grateful to Dr. Andrew Tyler for expert mass spectroscopy support. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. H.E.B. is supported by a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research (sponsored by Merck & Co.). L.P. is a Research Fellow, and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University.

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Journal Article↗
PubMed2001

cis-3,4-Dichlorocyclobutene as a Versatile Synthon in Organic Synthesis. Rapid Entry into Complex Polycyclic Systems with Remarkably Stereospecific Reactions We thank Drs. D. H. Huang and G. Siuzdak for their assistance with NMR spectroscopy and mass spectrometry, respectively. This work was financially supported by the National Institutes of Health (USA) and The Skaggs Institute for Chemical Biology, a postdoctoral fellowship from the Skaggs Institute for Research (to V.G.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

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Journal Article↗
PubMed2000

The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses.

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Journal Article↗
PubMed2001

Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase We are grateful to Dr. Eugene Seno and the Lilly Research Laboratories for their generous gift of the plasmid pHJL311 and to the National Institutes of Health for grants (GM 35 906 and 54 346). H.-w.L. also thanks the National Institute of General Medical Sciences for a MERIT Award. T.M.H. was a trainee of the National Institute of General Medical Sciences (Biotechnology Training Grant: 2 T32 GM08347).

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Journal Article↗
PubMed2001

Dehydrogenative Dimerization of Tin Hydrides Catalyzed by Ruthenium-Allenylidene Complexes We thank The Skaggs Institute for Chemical Biology at The Scripps Research Institute for support of this work; S.M.M. is a Skaggs Postdoctoral Fellow. We are also grateful to Dr. Michal Sabat (University of Virginia) for X-ray crystallography and Prof. David Goodin (The Scripps Research Institute) for the EPR experiment described in ref. 14.

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Journal Article↗
PubMed2001

Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

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PubMed1999

Institutional Analysis and Ecosystem-Based Management: The Institutional Analysis and Development Framework.

/ Scholars, government practitioners, and environmentalists are increasingly supportive of collaborative, ecosystem-based approaches to natural resource management. However, few researchers have focused their attention on examining the important administrative and institutional challenges surrounding ecosystem-based management. This paper describes how the institutional analysis and development (IAD) framework can be used to better understand the institutional arrangements used to implement ecosystem-based management programs. Some of the observations emanating from previous research on institutional design and performance are also discussed. The paper's central argument is that if this new resource management paradigm is to take hold and flourish, researchers and practitioners must pay closer attention to the questions surrounding institutional design and performance. This should help improve our understanding of the relationship between science and human values in decision making. It should also help researchers avoid making faulty policy recommendations and improve the implementation of ecosystem-based management programs.KEY WORDS: Ecosystem management; Watershed management; Common pool resources; Implementation; Institutional analysis; Evaluation; Policy analysishttp://link.springer-ny.com/link/service/journals/00267/bibs/24n4p449.html</HEA

Journal Article↗
PubMedDate not supplied

The impact of re-engineering a multi-institutional residency program on resident perceptions of the individual institutions.

PURPOSE: We report on the development of a survey tool used to assess resident perceptions of support and educational quality among multiple institutions in an integrated surgical residency, as well as its use in measuring the impact of re-engineering on that program. METHODS: The University of Connecticut Integrated General Surgical Residency (UCIGSR) is a multisite program that was placed on probation by the Residency Review Committee in Surgery (RRC) in November 1998. This led to a re-evaluation and a re-engineering of the program. In order to better assess the residents' evaluation of the program, we serially examined their attitudes with a survey of 65 questions. A 4-point grading scale (1 = Poor, 4 = Excellent) was used, and each resident was required to complete a survey beginning shortly after RRC probation was announced and at 6-month intervals. Seven global questions in the survey, directed at residency program support and educational quality, were asked for each of the 4 individual adult hospitals, for a total of 28 questions. Statistical analysis of the data was performed using the Jonckhere-Terpstra and the Mann-Whitney U tests. RESULTS: The results demonstrated significant improvement for all 7 questions in all 4 hospitals between November 1998 (S1) and November 1999 (S3). Average scores for all 7 questions, Hospital Support (HS), Departmental Support (DS), Hospital Teaching (HT), Outpatient Teaching (OTC), Operating Room Teaching (ORT), Grand Rounds (GR), and Morbidity and Mortality Conferences (MM), improved in every hospital by 16-28%. In S1, 1 out of 28 questions received an average score greater than or equal to 3, whereas on the most recent survey, 17 of 28 scored greater than or equal to 3 and 78.5% of the questions demonstrated statistically significant improvement (p < 0.05). Three of the 4 hospitals now have a combined overall average score greater than or equal to 3 for all 7 questions. Areas of strength in each hospital had the least amount of improvement yet remained highly rated. CONCLUSIONS: The survey was able to detect weaknesses and variation in program support and educational quality among institutions in our surgical program. Over time, a re-engineering of the process of educating surgical residents demonstrated a positive effect on all of the institutions. While raising the overall satisfaction level of the residents throughout, the greatest improvement occurred in the lowest rated hospitals. Despite barriers of different institutional cultures and geographic locations, a multi-institutional residency program can institute positive change uniformly, and quantitatively monitor that change.

Journal Article↗
PubMed2002

A Canadian experiment: the Institute of Neurosciences, Mental Health and Addiction. How to link up the brain via a virtual institute.

In June 2000, the Canadian government abolished the Medical Research Council of Canada, creating the Canadian Institutes of Health Research (CIHR) and appointing the internationally renowned geneticist Alan Bernstein as its first president. Bernstein and the CIHR Governing Council then elaborated the novel concept of 13 'virtual' CIHR institutes (see http://www.cihr.ca for further information). These institutes are not physical entities, but virtual organizations aiming to support researchers located in universities, hospitals and research centres across Canada. Following an open competition, December 2000 saw the appointment of a scientific director to lead the development of each institute. Rémi Quirion, a neuroscientist and Professor of Psychiatry based at the Douglas Hospital Research Centre of McGill University (Montreal, Canada) is the first Scientific Director of the Institute of Neurosciences, Mental Health and Addiction (INMHA). Here he summarizes the early developments and initiatives undertaken by his institute.

Canada↗
PubMedDate not supplied

Cluster deaths in long-term care institutions: an investigation of excess deaths in two Ontario institutions.

OBJECTIVE: To review clusters of deaths in two Ontario long-term care institutions and to establish whether common etiologic factors could be identified. METHOD: Retrospective review of the health care records of all residents who died to assess the events leading to death and the actions of the institutions and local coroners in response to the deaths. RESULTS: A respiratory infectious outbreak appeared to lead to many of the deaths in both institutions. Several deficiencies were identified with respect to charting practices, coroners' case investigations and institutional responses to the infectious outbreaks. No formal mechanisms were in place to assist in the early detection of cluster deaths in these institutions. CONCLUSIONS: Infectious outbreaks may be an important cause of cluster deaths in long-term care institutions. Standards should be developed for patient charting, coroners' investigations and for the prevention, identification and management of infectious outbreaks in such settings.

Aged↗
PubMed2006

The financial management of research centers and institutes at U.S. medical schools: findings from six institutions.

PURPOSE: To explore three questions surrounding the financial management of research centers and institutes at U.S. medical schools: How do medical schools allocate institutional funds to centers and institutes? How and by whom are those decisions made? What are the implications of these decision-making models on the future of the academic biomedical research enterprise? METHOD: Using a qualitative research design, the author and associates interviewed over 150 faculty members and administrators at six medical schools and their parent universities in 2004. Interview data were transcribed, coded, and analyzed using a grounded theory approach. This methodology generated rich descriptions and explanations of the six medical schools, which can produce extrapolations to, but not necessarily generalizable findings to, other institutions and settings. RESULTS: An examination of four dimensions of financial decision-making-funding timing, process, structure, and culture-produces two essential models of how medical schools approach the financial management of research centers. In the first, a "charity" model, center directors make hat-in-hand appeals directly to the dean, the result of which may depend on individual negotiation skills and personal relationships. In the second, a "planned-giving" model, the process for obtaining and renewing funds is institutionalized, agreed upon, and monitored. CONCLUSIONS: The ways in which deans, administrators, department chairs, and center directors attend to, decide upon, and carry out financial decisions can influence how people throughout the medical school think about interdisciplinary and collaborative activities marshalled though centers and institutes.

Academies and Institutes↗
PubMed1996

Funding avenues for research in emergency medicine at the National Institutes of Health and the National Heart, Lung, and Blood Institute.

There are opportunities for research in EM at the NIH, which may be appropriate for a variety of Institutes, depending on the topic area. Most NIH-funded research is through investigator-initiated grant applications, and the PHS 398 application packet is a source of more information. RFAs and RFPs, which have set-aside funding, are released for specific topic areas when an Institute identifies an area requiring multiple studies or multicenter research. PAs, which do not have set-aside funding, announce areas of interest for an Institute. The NIH Guide to Grants and Contracts announces RFAs, RFPs, and PAs. It is important to become expert in a field of research to be successful in achieving research funding, whether investigator- or institute-initiated.

Emergency Medicine↗
PubMed2004

[Certification of pathology institutions --a new direction? The view of a certification institute].

A variety of standards for quality-management systems is presently applied in German healthcare institutions, ranging from the international standard ISO 9001:2000 to specific national models like KTQ for hospitals. Pathology institutes currently apply the ISO 9001 in the context of a certification, or alternatively the ISO 17020 as a basis for accreditation. The present article illustrates the different quality-management systems in view of their application in pathology. The focus is placed on the ISO 9001, since this broader system serves the needs of smaller private institutions as well as those of university institutes. For the latter, in addition, ISO 9001 provides the opportunity to include research and teaching activities. Examples of how to conform with the ISO 9001 standard are discussed.

Academies and Institutes↗
PubMedDate not supplied

[The Cancer Registry of the Jules Bordet Institute, a new tool for the institution and its researchers. Description of cases incident in 2000-2001].

A hospital Cancer Registry has recently been initiated at the Jules Bordet Institute. The collected information allows to report pathology items such as incidence date, site, morphology and stage. It permits to describe the therapeutic choices, which, broken down by organ and stage, can be compared to guidelines in a process assessment. The objectives of this registry are institutional (statistical and organisational finalities as well as quality control ones), extra-institutional (participation to the public network of cancer registration), and scientific (providing the researchers a common database that can be queried using multiple criteria to be completed by further detailed data). This paper reports on 3,587 incident cancer cases in 2000 and 2001 which were managed at the Jules Bordet Institute for the primary episode. Cancers in women represent 64.3% of all records, for only 35.7% of men, while in the Belgian National Cancer Registry, the proportion is reversed to 46.7% of women and 53.3% of men. The distribution of cancer by site is also quite different in our hospital registry where breast cancer in women, melanoma in both sexes, lung cancer and head and neck cancers in men are over-represented compared to the general population, while colorectal cancer is underrepresented in both sexes.

Academies and Institutes↗