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Results for “FLAXEDIL”

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At least 37 records · Page 2Linked to original sources
PubMed2003

Gallamine-tetraphenylborate-modified carbon paste electrode for the potentiometric determination of gallamine triethiodide (flaxedil).

The construction and general performance of a novel modified carbon paste electrode for the determination of gallamine triethiodide have been developed. The electrode shows a stable, potentiometric response for gallamine in the concentration range 1 x 10(-3)-2 x 10(-6) M at 25 degrees C independent of pH in the range 5-8. The electrode passes a near-Nernstian cationic slope of 17.0+/-0.7 mV and lower detection limit of 1 x 10(-6) M with a fast response time of 20-45 s. Selectivity coefficients for gallamine relative to a number of interfering substances were investigated. There is a negligible interference from the studied cations, anions, and pharmaceutical excipients. The determination of gallamine in aqueous solution shows an average recovery of 99.5% and a mean relative standard deviation (RSD) of 1.4% at 100 microg/ml. The direct determination of gallamine in injection solution gave results that compare favorably with those obtained by the British pharmacopoeia method. Potentiometric titration of gallamine with sodium tetraphenylborate and phosphotungstic acid as a titrant has been monitored with the modified carbon paste electrode as an end-point indicator electrode.

Carbon↗
PubMed1970

Gallamine triethiodide (flaxedil) and cat retinal ganglion cell responses.

1. Repeated flashes of diffuse light were presented to the cat's eye over long periods of time (hours) while the mixed ganglion cell response was recorded from single axons in the optic tract. This was done for cats receiving gallamine triethiodide intravenously and for cats who did not receive the drug.2. All responses were transformed into instantaneous pulse density tracings. Such tracings from control and gallamine cells were compared to observe possible effects of gallamine: (a) the shape (time course) did not change during gallamine administration; (b) maximum firing frequency, total number of spikes and latency was measured for both the on- and the off-component on the pulse density tracings and plotted versus time. Statistical methods failed to reveal any difference between the manner in which these response features of control cells and of gallamine cells varied with time.

Action Potentials↗
PubMed1967

Flaxedil (gallamine triethiodide): evidence for a central action.

A central action of gallamine triethiodide has been demonstrated in cats with permanently implanted electrodes that permit direct repetitive stimulation and recording of afterdischarges from cerebral cortex. Systemically administered gallamine produced a consistent and reproducible augmentation of duration of afterdischarge at doses just sufficient to produce skeletal muscle paralysis. Simultaneous examination of expiratory carbon dioxide, blood pressure, body temperature, blood glucose, and direct cortical response to brief single stimuli failed to reveal any consistent peripheral change to which the centrally observed effecte Could be attributed.

Animals↗