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At least 19 recordsLinked to original sources
PubMed2001

Cathodic adsorptive stripping voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil).

A sensitive and simple voltammetric method of analysis is developed for the determination of trace amounts of gallamine triethiode in phosphate media. This method is based on controlled adsorptive preconcentration of the relaxant onto a Hanging Mercury Drop Electrode (HMDE) whereby mercurous iodide salt(s) are formed. The technique used is Cathodic Linear Sweep Stripping Voltammetry (CLSSV). The adsorptive response was evaluated with respect to preconcentration time and potential. As little as 3 x 10(-9) mol dm(-3) i.e. 2.7 ppb flaxedil (proconcentration time 300 seconds) can be determined successfully. The application of this method was tested in the determination of flaxedil in pharmaceutical preparation (ampoules).

Chemistry Techniques, Analytical↗
PubMed1978

[Effects of chronic paralysis of chick embryo by flaxedil on the development of the neuromuscular junction].

Chronic paralysis of Chick embryos by the cholinergic antagonist flaxedil blocks the subsynaptic accumulation of acetylcholinesterase but not the formation of acetylcholine receptor cluster. Flaxedil paralysis also causes an increase of the total muscle content of acetylcholine receptor without altering the half-life of the receptor protein. The spontaneous activity of the embryon therefore "shuts off" the synthesis of extrasynpatic acetylcholine receptor.

Acetylcholinesterase↗
PubMed1976

Changes in multiunit activity and EEG induced by the administration of natural progestins to flaxedil immobilized cats.

The effects of progesterone (P) and 7 of its metabolites on the EEG and multiunit activity (MUA) of various limbic structures were studied in flaxedil immobilized cats. Most progestins inhibited the MUA of the mesencephalic reticular formation, hippocampus and hypothalamus and induced cortical EEG synchronization. MUA changes in the mesencephalic reticular formation frequently preceded EEG synchronization. Progestins reduced in the 5 beta postition (pregnanolone, epipregnanolone and pregnanedion) inhibited neuronal discharge and synchronized EEG activity with shorter latencies and in lower doses than those reduced in the 5 alpha position (allopregnanolone and allopregnanedion). Progestins having the delta 4,3-keto structure (P, 20 alpha-hydroxy pregnenone, 20 beta-hydroxy pregnenone) induced electrophysiological changes with prolonged latencies and in doses significantly higher than ring A reduced progestins. Administration of epipregnanolone to "cerveau isole" preparations depressed neuronal firing in those structures located rostral to the level of the brain stem transection (hypothalamus, hippocampus), but failed to increase the already synchronized cortical activity. These results suggest that: a, ring A reduction increases the capacity of P and other delta 4,3-keto progestins to inhibit neuronal discharge in certain brain areas and b, changes in neuronal firing induced by progestins are not necessarily mediated through the cat brain stem reticular formation.

Animals↗
PubMed1982

Blood glucose profiles in surgically prepared flaxedilized and anesthetized rats.

Blood glucose profiles were monitored over an extended period of time in surgical rat preparations which included femoral artery and vein cannulations, tracheotomy, carotid artery cannulation and a craniotomy to expose the brain. Rats were under pentobarbital anesthesia, urethane anesthesia or Flaxedil neuromuscular blockage and local anesthesia, Fasted and unfasted rats were compared. These profiles are a foundation for studies of the central nervous system control of feeding behavior and metabolic homeostasis and of hypothalamic glucoreceptors, for which knowledge of the baseline blood glucose profile is particularly important. Such studies utilize the surgical preparations examined here. The importance of rapid "on the spot" "moment to moment" monitoring of blood glucose during the course of an experiment and adjustment of the experiment accordingly is demonstrated. Methods for such monitoring are evaluated in comparison with the standard enzymatic fluorometric assay for glucose. The YSI Glucose Analyzer seems to be a suitable one and is feasible for physiological and psychological laboratories without biochemical expertise.

Anesthesia, General↗
PubMed1968

Gallamine (Flaxedil) and synaptic transmission in the spinal cord.

A paralyzing dose of gallamine (Flaxedil) (1 to 2 milligrams per kilogram of body weight) has no effect on synaptic transmission in the cat's spinal cord. In spinal cats ventilated with oxygen, we stimulated a dorsal spinal root and recorded the compound ventral root potential. The reflex potential was not affected by 6.25 milligrams of gallamine per kilogram. Giving 12.5 milligrams of gallamine per kilogram had no significant effect on the monosynaptic spike height, but the polysynaptic response rose briefly to 12 percent above control. Increased magnitude of the polysynaptic response appeared related to a concomitant rise in blood pressure.

Animals↗
PubMed1981

Gallamine triethiodide (flaxedil): tetraethylammonium- and pancuronium-like effects in myelinated nerve fibers.

Gallamine triethiodide (Flaxedil) is commonly used as a neuromuscular blocking agent. Voltage-clamp studies show that gallamine also directly affects amphibian and mammalian myelinated nerve fibers. Externally, gallamine is about five times more potent than tetraethylammonium in blocking potassium conductance, where this is present, but has no effect on the sodium channel. Internal application slows sodium inactivation, which in addition is often incomplete. At positive potentials, gallamine can occlude sodium channels, thereby almost eliminating outward sodium currents.

Animals↗