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PubMed1994

The household structure of second-generation children: an exploratory study of extended family arrangements.

"Using data from the Children of Immigrants Survey, the antecedents of extended family arrangements among [U.S.] immigrant households with children are examined. The incidence and form of such arrangements, especially the presence of grandparents, are analyzed in relation to single parenthood, national origin, cultural assimilation, and socioeconomic variables. The findings serve to underscore the complexity of the correlates of extended family arrangements. While there is a relationship with single parenthood, more research is needed on the economic basis for the presence of relatives in the household. The analysis uncovered the need to also treat presence of grandparents as an independent variable, especially in the cultural assimilation of children of immigrants."

Acculturation↗
PubMed1991

[The use of extended family APGAR index in OPD].

The present study was designed to evaluate the clinical availability of extended family APGAR in OPD. Five hundred and twenty two patients were collected from three different out-patient departments were studied during a 6 month period. All 522 patients were over 12 years of age and asked to completed an extended family function questionnaire. The patient's age, sex, marital status, occupation, education, family role, socioeconomic status and religion were also recorded. The results showed that there were significant difference among the extended scores of patient's marital status and the socioeconomic status. We also found that patients suffering from family problems, psychosomatic problems and multiple problems have significantly lower extended scores. Because only 3 patients were diagnosed as having family problems by a chart reviewed in all 522 patients, we suggest further research on the extended family APGAR before widely using it in OPD.

Adult↗
PubMed2003

Age-related macular degeneration--a genome scan in extended families.

We performed a genomewide scan and genetic linkage analysis, to identify loci associated with age-related macular degeneration (AMD). We collected 70 families, ranging from small nuclear families to extended multigenerational pedigrees and consisting of a total of 344 affected and 217 unaffected members available for genotyping. We performed linkage analyses using parametric and allele-sharing models. We performed the analyses on the complete pedigrees but also subdivided the families into nuclear pedigrees. Finally, to dissect potential genetic factors responsible for differences in disease manifestation, we stratified the sample by two major AMD phenotypes (neovascular AMD and geographic atrophy) and by age of affected family members at the time of our evaluation. We have previously demonstrated linkage between AMD and 1q25-31 in a single large family. In the combined sample, we have detected the following loci with scores exceeding a LOD=2 cutoff under at least one of the models considered: 1q31 (HLOD=2.07 at D1S518), 3p13 (HLOD=2.19 at D3S1304/D3S4545), 4q32 (HLOD=2.66 at D4S2368, for the subset of families with predominantly dry AMD), 9q33 (LODZlr=2.01 at D9S930/D9S934), and 10q26 (HLOD=3.06 at D10S1230). Using correlation analysis, we have found a statistically significant correlation between LOD scores at 3p13 and 10q26, providing evidence for epistatic interactions between the loci and, hence, a complex basis of AMD. Our study has identified new loci that should be considered in future mapping and mutational analyses of AMD and has strengthened the evidence in support of loci suggested by other studies.

Aging↗
PubMed1977

Time-extended family interviewing.

This paper presents a family-therapy technique--time-extended family interviewing--in which the therapist extends the traditional one-hour interview to three to seven hours, by plan, at a particular point in the life of a case and for a particular purpose. Extended sessions promote movement in a case for a variety of reasons. Furthermore, the use of such sessions highlights the dimension of time as an important element of good casework practice.

Adult↗
PubMed1998

Perception of the social support role of the extended family network by some Nigerians with schizophrenia and affective disorders.

Enquiries into patients' perception of psychosocial support from families should help objectively to identify the strengths and needs of families with sick members, in order to enhance management. The aim of this study was to identify the categories of relatives in the extended family whom a sample of Nigerian psychiatric patients perceived as having provided material, social and emotional support, and the factors associated with these perceptions. 123 schizophrenics and 31 patients with major affective disorders attending out-patient clinics were interviewed. Using operational definitions of family member (i.e. tendency to confide in and expect support from a relative), it appears that the size of extended family network that was mostly relied upon for support was five, including parents, full siblings, uncles/aunts, first cousins and in-laws. There were no significant differences in summary scores of family size and social support between the two illness groups. Age and duration of illness were significantly negatively correlated with perception of supports. The size of family network with whom patients interacted was predicted by tendency to confide in members, and emotional support. The findings indicate that the presumed support of the extended family should not negate the need to strengthen the resources of the nuclear family, in order to provide a focus for attraction and deployment of materials needed for the effective care of patients.

Adolescent↗
PubMed1998

The mental health of Muslim mothers in extended families living in Britain: the impact of intergenerational disagreement on anxiety and depression.

OBJECTIVES: The study assessed the impact of intergenerational differences of opinion over child rearing on the mental health of Muslim mothers living in extended families. DESIGN: The study adopted a correlational design in an attempt to identify factors that accounted for mental health problems. METHODS: The child-rearing attitudes of mothers and grandmothers, mothers' mental health, levels of family acculturation and a range of other background and demographic information was collected from 54 extended families living in two Muslim communities in London using Urdu versions of standard questionnaires. RESULTS: Rates of depression and anxiety among the mothers in the study were high. Grandmothers had more traditional attitudes to child rearing than did mothers. Intergenerational discrepancy over child rearing was more marked in more acculturated families. Discrepancy was associated with higher levels of mothers' anxiety and depression. CONCLUSIONS: The unusually high levels of depression and anxiety displayed by Muslim mothers living in extended families can in part be accounted for by patterns of intergenerational discrepancy. These possibly reflect discordant world views within those families that have been assimilated into the dominant British culture.

Acculturation↗
PubMed1990

Extended family living among older people in six Latin American countries.

This study examined and compared demographic and urban/rural residence underpinnings to people 60 and over living in an extended family household in six Latin American countries. Household samples of the World Fertility Survey gathered in the middle 1970s were sued, as was a combination of crosstabular and logit techniques. We found that, in contrast to Western countries, a majority of the elderly population lived in extended family households. This was more likely in the Dominican Republic than in Colombia, Costa Rica, Panama, or Peru, which was, in turn, more likely than in Mexico. However, such differences were most apparent among the married, not the unmarried. In all countries, unmarried people were more likely to live in extended family households than were married people. Among unmarried elderly, the likelihood was greater for women than for men. Contrary to initial expectations, neither urban/rural residence nor age among the elderly themselves tended to be important.

Aged↗
PubMed1996

Genetic counseling in hereditary nonpolyposis colorectal cancer: an extended family with MSH2 mutation.

OBJECTIVES: Molecular genetic advances have increased the demand for DNA testing. We describe DNA based genetic counseling in a hereditary nonpolyposis colorectal cancer (HNPCC) family. METHODS: This extended HNPCC family was found to harbor the MSH2 germline mutation. Family history, medical, and pathology documents enabled us to secure a high degree of verification that the kindred qualified as HNPCC. DNA testing revealed the MSH2 germline mutation that was verified independently in two laboratories. Genetic counseling was provided before DNA testing and disclosure of MSH2 findings. RESULTS: Genetic counseling revealed a variety of findings characterized by emotional stress in MSH2 germline mutation carriers. Concerns centered around reproductive issues, potential transmission of the deleterious gene to their progeny, and discrimination by insurance carriers and employers. More than one-half of the patients found to harbor the MSH2 mutation considered the option of prophylactic subtotal colectomy. CONCLUSION: DNA testing should be restricted to well-verified candidate families in which genetic counseling should be mandatory. HNPCC family members sought genetic risk assessment for their own health and that of their children. Contrasting emotional responses took place when told of their gene testing status and this required a sensitive empathetic listening ear. Patients have many concerns about their lifetime cancer destiny when told that they harbor the culprit MSH2 germline mutation.

Adult↗
PubMed1992

African-American, Anglo-American, and Anglo-Canadian grade 4 children's concepts of old people and of extended family.

A cross-national study of 104 fourth grade children's concepts of old people and extended family was conducted in Canada and the United States, using the Children's Attitudes Toward the Elderly Scale (CATE), and a modified version of the Gilby and Pederson (1982) Family Concept Interview. Both Anglo-American and African-American children were included in the U.S. sample. Results indicated that Anglo-American and Anglo-Canadian children were significantly more similar in their attitudes toward the elderly and their concepts of family than African-American and Anglo-American children. In comparison with the other two cultural groups, Anglo-American children were significantly more likely to include extended family members in their concept of who is family; Anglo-Canadian children had a significantly higher level of age discrimination ability; and African-American children showed a trend toward more positive attitudes toward older people. Overall findings of negative attitudes toward old people were consistent with earlier studies. The implications of children's ageist attitudes for increasingly aging Western societies are noted, particularly given impoverished children's potential need for extrafamilial social supports.

Black or African American↗
PubMed2001

Adrenoleukodystrophy: incidence, new mutation rate, and results of extended family screening.

Utilizing the plasma very long chain fatty acid assay, supplemented by mutation analysis and immunofluorescence assay, we determined the number of X-linked adrenoleukodystrophy (X-ALD) hemizygotes from the United States identified each year in the two laboratories that perform most of the assays in this country: the Kennedy Krieger Institute between 1981 and 1998 and the Mayo Clinic Rochester from 1996 to 1998. The minimum frequency of hemizygotes identified in the United States is estimated to be 1:42,000 and that of hemizygotes plus heterozygotes 1:16,800. Our studies involved 616 pedigrees with a total of 12,787 identified at-risk members. Diagnostic assays were performed in 4,169 at-risk persons (33%) and included members of the extended family. Only 5% of male probands and 1.7% of X-ALD hemizygotes were found to have new mutations. The extended family testing led to the identification of 594 hemizygotes and 1,270 heterozygotes. Two hundred fifty of the newly identified hemizygotes were asymptomatic and represent the group in which therapy has the greatest chance of success. Identification of heterozygotes provides the opportunity for disease prevention through genetic counseling. Diagnostic tests should be offered to all at-risk relatives of X-ALD patients and should include members of the extended family.

Adrenoleukodystrophy↗
PubMed1997

Clinical spectrum of familial Hibernian fever: a 14-year follow-up study of the index case and extended family.

OBJECTIVE: To determine the clinical spectrum and natural history of the disease "familial Hibernian fever" (FHF). DESIGN: We ascertained the disease status in all 54 living members and 9 deceased members of the extended family and conducted a detailed study of those affected. MATERIAL AND METHODS: All family members with FHF were clinically assessed and investigated fully, including human leukocyte antigen (HLA) typing. Medical records were studied for relevant clinical features, drug therapy, and complications. All previously obtained histologic specimens were reviewed. Three typical case histories are presented. RESULTS: The updated family tree confirmed an autosomal dominant mode of inheritance in 16 living members with FHF. In addition to the febrile attacks, abdominal pain and localized myalgias were almost invariably present. Episodic erythematous patches, conjunctivitis, and unilateral periorbital edema were also notable features. Of 10 affected male family members, 8 had inguinal hernias (in comparison with 1 of 21 unaffected male family members). No association with HLA status was noted. Secondary amyloidosis was found in one affected member. CONCLUSION: The characteristic clinical features and natural history of FHF distinguish it from other periodic fever syndromes. The discovery of amyloidosis related to FHF alters the prognosis associated with this condition and emphasizes the need to search for effective treatment strategies. The high prevalence of inguinal herniation may provide clues about its pathogenesis.

Adult↗
PubMed2006

Assessing BRCA carrier probabilities in extended families.

PURPOSE: Carrier prediction models estimate the probability that a person has a BRCA mutation. We evaluated the accuracy of the BOADICEA model and compared its performance with that of other models (BRCAPRO, Myriad I and II, Couch, and Manchester Scoring System). We also studied the effect of extended family information on risk estimation using BOADICEA. METHODS: We compared the area under receiver operating characteristic curves generated from 472 families with one member tested for BRCA mutations. We calculated sensitivity, specificity, and predictive values at an estimated probability of 10% and explored the biases of carrier prediction. RESULTS: BOADICEA performed better than the other models in Ashkenazi Jewish (AJ) families, BRCAPRO performed slightly better in non-AJ families, and Myriad II performed comparably well in both groups. Including extended family information in BOADICEA yielded slightly better performance than did limiting the information to second-degree relatives. Using a 10% cutoff point, BOADICEA and Myriad II were most sensitive in predicting BRCA1/2 mutations in AJ families, and Myriad II was most sensitive in non-AJ families. The Manchester Scoring System was the most sensitive and least specific in a subgroup of non-AJ families. BOADICEA and BRCAPRO tended to underestimate the observed risk at low estimated probabilities and overestimate it at higher probabilities. CONCLUSION: The BOADICEA, BRCAPRO, and Myriad II models performed similarly. Including second-degree relatives slightly improved carrier prediction by BOADICEA. The Myriad II model was the easiest to implement.

Adult↗
PubMed1983

Social and economic forces affecting intergenerational relations in extended families in a Third World country: a cautionary tale from South Asia.

This paper questions the implicit assumption derived from modernization theory that elderly persons in the Third World lead secure and satisfying lives because they still live in extended families. Data from elderly Hindus living in Kathmandu, Nepal, are presented and demonstrate that, although these elderly people do continue to live in extended families, social and economic changes have transformed the nature of intergenerational social relations within these families to the detriment of the elderly family members.

Aged↗
PubMed2002

Screening extended families for genetic hemoglobin disorders in Pakistan.

BACKGROUND: We have investigated a strategy for identifying and counseling carriers of recessively inherited disorders in developing countries where consanguineous marriage is common. In such communities, gene variants are trapped within extended families, so that an affected child is a marker of a group at high genetic risk. METHODS: Fifteen large Pakistani families, 10 with a history of a hemoglobin disorder and 5 without any such history (controls), were screened for beta-thalassemia and abnormal hemoglobins. All carriers and married couples consisting of two carriers received counseling, and eight families have been followed for two years. RESULTS: In the control families, no carrier was found among 397 members tested. In the 10 families with an index case, 183 of 591 persons tested (31 percent) were carriers; carriers had a 25 percent risk of being in a marriage at risk for producing an affected child, and 17 of 214 married couples (8 percent) consisted of two carriers. No couple at risk was identified among 350 randomly selected pregnant women and their partners. All carriers reported that they have used the information provided in the testing and counseling process: carriers married to carriers with two or more healthy children have avoided further pregnancy, and most such couples with one or no healthy children have used prenatal diagnosis. Seven of eight new marriages and engagements are known not to be at risk. CONCLUSIONS: Testing of extended families is a feasible way of deploying DNA-based genetic screening in communities in which consanguineous marriage is common.

Anemia, Sickle Cell↗
PubMed1996

The probability of finding a suitable related donor for bone marrow transplantation in extended families.

In bone marrow transplantation, the advantages of family donors over unrelated donors are threefold. (1) Family donors are better matched because they share complete haplotypes. (2) The time between the start of the search and the actual transplantation can be much shorter than for unrelated donors. (3) Related bone marrow transplantation is cheaper. We developed a procedure for calculating the probability of finding a suitable donor among cousins and blood-related aunts and uncles (the extended family). The procedure calculates the following probabilities (P): (1) P that any blood-related uncle or aunt is a suitable donor, (2) P that a suitable donor exists in all blood-related uncles/aunts (from [1]), (3) P that any cousin is a suitable donor (as in [1]), (4) P that a suitable donor exists in all cousins (from [3]), (5) P that a suitable donor exists in the entire extended family (from [2] and [4]). Additionally, we discuss the suitability of this procedure in the daily practice of donor procurement. The procedure is also suitable to search for family donors who have a single antigen mismatch with the patient. We also discuss the differences between our method and the one recently described by Kaufman (Bone Marrow Transplant 15:279, 1995).

Algorithms↗
PubMed1989

Echinococcal diseases in an extended family and review of the literature.

Echinococcal disease occurred in an extended family from Athens, Greece. Seven of the 11 family members were noted to be infected with Echinococcus granulosus, and five members have undergone surgical treatment. The potential sources of infection are discussed, although localization was impossible. There is no genetic basis for this disease and no apparent pattern of family member interrelationship or visceral involvement. Although echinococcal infection is frequently diagnosed in large urban centers, its transmission within a family is rare. Review of the literature and the current diagnostic and therapeutic measures are presented.

Adult↗
PubMed1995

Occurrence of Actinobacillus actinomycetemcomitans and anti-leukotoxin antibodies in some members of an extended family affected by Papillon-Lefèvre syndrome.

Eighteen (18) members of an extended family in which numerous individuals have Papillon-Lefèvre syndrome (PLS) were examined. In all, 6 affected members and 12 non-affected members were included. All patients underwent a clinical examination which, in the dentate persons, included plaque index, bleeding on probing, probing depth, and periodontal attachment loss and a set of full mouth periapical x-rays. Subgingival bacterial samples were also collected from 2 teeth in the dentate patients for cultures and identification of Actinobacillus actinomycetemcomitans. Serum samples were collected from all participants and assayed for antileukotoxin antibodies. The results indicate that there is a high prevalence of leukotoxic strains of A. actinomycetemcomitans in persons suffering from PLS, as well as in unaffected family members. The ubiquitous presence of A. actinomycetemcomitans in the family units suggests a close association between A. actinomycetemcomitans and the periodontal disease associated with the syndrome; it also suggests that A. actinomycetemcomitans by itself is not sufficient for the expression of periodontal disease and that other factors, some of which must be genetic, are necessary for lesion development.

Adolescent↗
PubMed1994

Disease, disorder, or deception? Latah as habit in a Malay extended family.

Thirty-seven cases of latah are examined within the author's Malay extended family (N = 115). Based on ethnographic data collected and a literature review, cases are readily divisible into two broad categories: habitual (N = 33) and performance (N = 4). The first form represents an infrequent, culturally conditioned habit that is occasionally used as a learned coping strategy in the form of a cathartic stress response to sudden startle with limited secondary benefits (i.e., exhibiting brief verbal obscenity with impunity). In this sense, it is identical to Western swearing. Performers are engaged in conscious, ritualized social gain through the purported exploitation of a neurophysiological potential. The latter process is essentially irrelevant, akin to sneezing or yawning. It is concluded that latah is a social construction of Western-trained universalist scientists. The concept of malingering and fraud in anthropology is critically discussed.

Adaptation, Psychological↗