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Computer graphics in cytologic and pathologic microscopy. Tools for the clinician and researcher.

Computer graphics capabilities are becoming practical economically and ergonometrically for the first time on a widespread basis. The factors that have brought this about and the importance of such graphic interfaces to computer technology in the clinical and research laboratory are discussed. The uses of computer graphics in cytologic and pathologic microscopy are reviewed in terms of objectives, types of display and software and hardware display methods, and examples of various types of displays are presented.

Cell Nucleus↗

Computer graphics and developmental theory: a powerful partnership.

Educating student nurses to successfully use computer technology involves conscientious planning from nursing faculty responsible for curriculum integration. Many computer elements may be considered such as computer literacy, word processing, and computer assisted instruction. Database programs, spreadsheet applications, and statistical packages are also often incorporated into curriculum integration efforts. Computer graphics and desk-top publishing can also be used as an effective teaching strategy. The following describes an attempt to combine a creative teaching approach for developmental theory within a course on human development while expanding on students' computer skills in the field of computer graphics.

Computer Graphics↗

A method for determining reference points in celloidin specimens for computer graphic reconstruction.

For three-dimensional computer graphic reconstruction of histological sections, it is important to determine reference points. We have developed a machine that makes reference points in a celloidin block for this purpose by drilling holes straight into the block. A sliding microtome is placed under the machine, which consists of a worktable, a stand, and a motor-driven unit. The celloidin block is sectioned on a microtome to determine a plane for serial sectioning. Several holes are then drilled in the block vertical to the plane selected. Serially sectioned specimens are next stained with hematoxylin and eosin and are mounted in the usual manner. Three-dimensional reconstructions of the specimens were next done using a PC-9801 computer and CosmoZone-S software. As an example, the reconstruction of a guinea pig stapes is described.

Animals↗

Computer graphics. A tool for decision making in nursing.

The use of computer graphics in nursing has not yet reached its full potential. Graphs or maps can display large amounts of data so that critical elements can be inspected in a minimal amount of time. This article discusses computer graphics in terms of their use in nursing and the need for this electronic modality in nursing curricula.

Computer Graphics↗

High-power graphic computers for visual simulation: a real-time--rendering revolution.

Advances in high-end graphics computers in the past decade have made it possible to render visual scenes of incredible complexity and realism in real time. These new capabilities make it possible to manipulate and investigate the interactions of observers with their visual world in ways once only dreamed of. This paper reviews how these developments have affected two preexisting domains of behavioral research (flight simulation and motion perception) and have created a new domain (virtual environment research) which provides tools and challenges for the perceptual psychologist. Finally, the current limitations of these technologies are considered, with an eye toward how perceptual psychologist might shape future developments.

Aircraft↗

Stereotactic biopsy aided by a computer graphics workstation: experience with 200 consecutive cases.

BACKGROUND: The advent of modern computer technology has made it possible to examine not just the target point, but the entire trajectory in planning for stereotactic biopsies. METHODS: Two hundred consecutive biopsies were performed by one surgeon, utilizing a computer graphics workstation. The target point, entry point, and complete trajectory were carefully scrutinized and adjusted to minimize potential complications. RESULTS: Pathologically abnormal tissue was obtained in 197 cases (98.5%). There was no mortality in this series. Symptomatic hemorrhages occurred in 4 cases (2%). CONCLUSIONS: Computer graphics workstations facilitate safe and effective biopsies in virtually any brain area.

Adolescent↗

The development and extension of hepatohilar bile duct carcinoma. A three-dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system.

Computer-assisted three-dimensional (3D) reconstruction of the biliary tree including extrahepatic and intrahepatic parts was performed from surgical or autopsy materials from 12 patients with hepatohilar bile duct carcinoma in an effort to visualize three-dimensionally the distribution of carcinoma and dysplasia. In each case, material including a hepatic lobe was reduced to serial slices 1 mm thick using a ham slicer, then the tumors, ducts with carcinoma in situ, and those with dysplasia were submitted to reconstruction. In a 3D map of biliary tree reproduced on a display, a dysplastic zone was shown in most cases surrounding a focus of carcinoma, justifying the assumption of a dysplasia-carcinoma sequence. The carcinoma itself proved to form multiple foci along bile ducts in as many as 42% of the patients, in some of whom the foci were independent without any intervening dysplasia. These results suggest that as extensive a surgical measure as possible should be taken in designing a strategy against this tumor.

Adenoma, Bile Duct↗

Three-dimensional vectorcardiography (3-D VCG) by computer graphics in old myocardial infarction.

By using computer graphics we rotated the vector loop and three coordinate axes to find the viewpoint where the infarctional changes are maximally exposed and demonstrated the advantage of the "3-D VCG" over the conventional VCG by defining the quantitative "MI index." The orthogonal electrocardiogram recorded by the Frank lead system was digitally measured and processed by a microcomputer. The loops and axes were rotated about the X axis (X-rot) and the Y axis (Y-rot). The spatial vector loop and orthogonal coordinates can be presented as viewed from any spheric direction. Eight quadrants were illustrated with four colors and red circles. The subjects consisted of 30 patients with old anterior myocardial infarction (MI) and 15 patients with old inferior MI. We measured the area of "Bite" in anterior MI and superior displacement in inferior MI. The MI index was defined and averaged in 361 directions. In anterior MI, the maximum mean index was obtained when X-rot is +90 degrees and Y-rot -40 degrees, viewed from upward and leftward, whereas in inferior MI it was obtained when X-rot is -50 degrees and Y-rot -80 degrees, viewed from downward and leftward. These values were significantly higher than those in conventional VCG projections, substantiating superior diagnostic sensitivity of 3-D VCG.

Adult↗

Computer graphics with computerized tomography for functional neurosurgery.

A computer graphics technique for computer-assisted stereotactic surgery is presented. The program is designed to aid the surgeon by presenting an on-line graphics display of stereotactic probes and electrodes superimposed on cross sections of the human brain stem. This technique simulates an otherwise blind surgical procedure on a graphics screen for use during surgery. An earlier system based around the DEC MINC-11 BA computer system has been used by the authors for the performance of stereotactic surgery with conventional ventriculography. This system has been upgraded and is now configured about an even more compact microprocessor-based hardware system with expanded graphics capabilities, which also allows its use with computerized tomography.

Brain Diseases↗

Morphogenesis of the brain as studied by 3-D computer graphics simulation.

Morphogenesis of the brain is analysed by 3-D computer graphics simulation. The initial form of the brain, i.e. a neural tube, is created in the computer as a small tubular figure in 3-D Cartesian coordinates which are subsequently transformed into curvilinear coordinates by a set of growth functions. By this method the morphological development of the human brain is simulated. The same computer program can be applied to simulate the development of the brains of mouse, rat and monkey simply by changing the parameters slightly. The result of the analysis reveals that the smaller brains are produced by faster growth of the matrix cell population at the onset of development, coupled with faster rate of retardation of the growth during ontogeny. Thus, smaller brains in smaller animals are produced in a shorter period during their ontogeny.

Animals↗

Computer graphics visions and challenges: a European perspective.

I have briefly described important visions and challenges in computer graphics. They are a personal and therefore subjective selection. But most of these issues have to be addressed and solved--no matter if we call them visions or challenges or something else--if we want to make and further develop computer graphics into a key enabling technology for our IT-based society.

Computer Graphics↗

[Spatial representation of basilar membrane movement with 3D computer graphics].

A mathematical model of the cochlea was implemented on a computer. The basilar membrane motion was computed for single, two, and multi-tone stimuli as well as for musical sounds and vowels. The pattern of the travelling waves were presented in three-dimensional color computer graphics. The high performance 3D graphics system performs local hidden surface removal, 3D geometric transformations and supports local lighting models to generate truly realistic shading for complex 3D objects. An addressable 1280 by 1024 pixel matrix assures crisp, precise resolution of the finest detail in the graphic images. The spatial pattern of basilar membrane motion conveys an impression of the image of acoustic stimuli on the basilar membrane. Firstly, the motion pattern of the travelling wave to a single tone is presented. The superposition of several tones (two-tone, multi-tone) causes a superposition of the travelling waves along the basilar membrane whereby the place principle in the cochlear partition becomes more clearly recognizable. Sounds (flute and violin) and vowels (German "u" and "i") evoke a complex motion pattern on the basilar membrane. The realization of the chronological order of movements on the basilar membrane can be made by computer animation. This enables the analysis of the space-time patterns of complex acoustic stimuli.

Basilar Membrane↗

Facial reconstruction using 3-D computer graphics.

Facial reconstruction using 3-D computer graphics is being used in our institute as a routine procedure in forensic cases as well as for skulls of historical and archaeological interest. Skull and facial data from living subjects is acquired using an optical laser scanning system. For the production of the reconstructed image, we employ facial reconstruction software which is constructed using the TCL/Tk scripting language, the latter making use of the C3D system. The computer image may then be exported to enable the production of a solid model, employing, for example, stereolithography. The image can also be modified within an identikit system which allows the addition of facial features as appropriate.

Cephalometry↗

[Computer graphics of apatite crystals].

Hydroxyapatite was studied by computer graphics. The data of structural coordinates of hydroxyapatite crystal was put into a protein graphics program in A units. The connection of each element, with what comes front and rear, was displayed by the shade-line erasing method, and the solid-image was expressed by the degree of lightness from the light source. The tint of color was drawn by Raster graphics method. A fine picture can be obtained with the program. Rotating the graphics freely in an angle around X, Y or Z axis, gives a view from any direction. Crystal graphics model of fluoridated hydroxyapatite, in which F- ions substituted in part into OH- position, was also drawn.

Computer Graphics↗

The expert teaching system: a new method for learning rhinoplasty using interactive computer graphics.

We have developed software that employs interactive computer graphics to simulate the surgical experience of rhinoplasty by allowing the surgeon to experiment within a model of nasal behavior. For any of three preoperative noses, the surgeon can choose and see the effects of dorsal resection, modification of nasal spine or caudal septum, alar cartilage resection, osteotomy, alar wedge resection, and a variety of nasal grafts. The available choices and views total nearly 3000 images, or approximately 200 different surgical solutions. The surgeon can get textual analysis at any time or see accelerated healing to the projected nasal appearance at 1 year. We believe that the ability to experiment without risk, to safely learn the biological laws governing nasal behavior, should augment the development of surgical judgement in rhinoplasty.

Computer Graphics↗

[Let's study pharmacokinetics related to anesthesiology by using computer graphics: intravenous drugs].

The pharmacokinetics of intravenous drugs used during anesthesia provides us important information for patients' care. The pharmacokinetic data are usually shown in a graphic expression together with numerical values. The numerical values are only convenient for investigators in exchanging their knowledge and information. The graphic data contain, however, whole and real information obtained in a pharmacokinetic study. The authors demonstrated a way to derive information from graphic data, which is practically applicable for patients' care. We also showed a way to calculate numerical values from graphic data by using "graphnote" by Fukutake Pub. Co. We believe that our manual way to calculate numerical values from graphic data, with an aid of computer graphics combined with scientific calculator, helps us to understand the invisible processes performed inside "a black box" or a computer installed with a commercially available soft ware for the pharmacokinetics.

Anesthesia, Intravenous↗

Optimized algorithms for displaying 16-bit gray scale images on 8-bit computer graphic systems.

Most personal computers contain 8-bit graphic display hardware, whereas most medical gray scale images are stored at 16-bit per pixel integers. To display medical gray scale images on such computers, the 16-bit image data must be remapped into 8-bit gray scale images. This report presents the algorithms and computer code that allow very rapid 16-bit to 8-bit image data transformation. These algorithms are helpful in allowing personal computers with at least the performance of a Macintosh II (Apple Computer, Cupertino, CA) computer to function as low-end picture archiving communication systems or personal workstations.

Algorithms↗