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Vertical gradient in regional vascular resistance and pre to post capillary resistance ratios in the dog lung.

The ratios of pre-capillary (Ra) and post-capillary (Rv) resistances to total vascular resistance (RT) were measured at different vertical distances in the lungs of supine dogs. Capillary pressures were estimated as the algebraic sum of the alveolar absorption pressure for Tyrode's solution and the plasma colloid osmotic pressure. Segmental resistance fractions (Ra/RT, Rv/RT) were calculated using the pressure drops between arterial, capillary, and venous pressures at each vertical distance within the lung. In a second group of animals, total vascular resistance was calculated at each lung level using regional blood flow as measured by radiolabelled microspheres and the corresponding regional vascular pressures. The total vascular resistance was lowest in Zone III portions of the lung, but Ra/RT and Rv/RT were constant throughout this zone (n = 22) averaging .63 +/- .02 (SEM) and .37 +/- .02 (SEM, respectively, resulting in Ra/Rv of 1.70). Total vascular resistance increased markedly in Zone II portions of the lung, but the relative contribution of Ra/RT decreased from .62 +/- .07 (SEM) to .45 +/- .05 (SEM). Thus Ra/Rv decreased from 1.70 to .82 in Zone II. The absolute values of pre- and post-capillary resistances were lowest in Zone III but post-capillary resistance increased to a greater degree than pre-capillary resistance up Zone II.

Animals↗

[Capillary resistance in premature and newborn infants and its relation to hemostatic potential].

Capillary resistance, platelet count, platelet adhesiveness and aggregation and thrombelastogramm (TEG) were studied in 40 healthy newborn infants (term eutrophic, preterm eutrophic and hypotropic). The capillary resistance was normal in all cases. The physiologic decrease of platelet aggregation in newborns and the prolonged clotting time in TEG (hypotrophic infants) were without influence on the capillary resistance. An important factor of the normal capillary resistance in newborns is normal platelet adhesiveness.

Fetal Growth Retardation↗

[A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)].

The effects of procyanidol oligomers on capillary resistance disorders in hypertensive and diabetic patients were studied. The drug was administered in a daily dose of 150 mg. Concordant results were obtained in two investigations as follows: during an open trial in 28 patients, capillary resistance (measured by the technique of Lavollay) rose from 15,4 +/- 1,8 cm Hg to 18,1 +/- 3,2 cm Hg (p less than 0,0005); and during a double blind trial versus placebo (25 patients) capillary resistance rose from 14,6 +/- 0,98 cm Hg to 18 +/- 3,35 cm Hg (p less than 0,005) in the treated group, while no significant variation was observed in the placebo group (15,5 +/- 1,30 cm Hg versus 14,7 +/- 1,3 cm Hg initially). The drug was well tolerated.

Adolescent↗

The clinical significance of the reduced capillary resistance factor in the diabetic patient.

A statistical survey in a group of 235 subjects (174 diabetic patients and 61 nondiabetic control subjects) was conducted to evaluate the incidence of reduced capillary resistance factor in respect to diabetic disease, to its duration, and to the severity of retinopathy. To evaluate the capillary resistance we used a cupping-glass method (Parrot's angiosterrometer test). The incidence of reduced capillary resistance proved to increase in frequency with diabetes, with its duration, and with the severity of retinopathy. Thus, reduced capillary resistance represents a negative prognostic element for retinopathy.

Adolescent↗

Inhibition of prostaglandin synthesis does not alter the decrease in pre-capillary resistance in the human calf in response to small cumulative increases in venous congestion.

The decrease in pre-capillary resistance in the human calf during gradual cumulative increases in venous congestion pressure has been proposed to represent vasodilator signalling between the venous and arterial microcirculations. The present study investigated whether prostaglandins are involved in this local flow regulation by measuring calf blood flow and microvascular filtration capacity using strain gauge plethysmography in young male subjects before (baseline) and after taking either ibuprofen, an inhibitor of prostaglandin synthesis (1600 mg over 2 days), or placebo. At baseline, inflation of a thigh cuff to 50 mmHg in steps of 10 mmHg, each held for 5 min, did not decrease arterial inflow, confirming a reduction of pre-capillary resistance. Ibuprofen reduced resting calf blood flow by 35% (P<0.001), but flow at a Pcuff (cuff pressure) of 50 mmHg was 97% of this value, i.e. pre-capillary resistance had decreased to the same extent as before inhibition of prostaglandin synthesis. Ibuprofen also reduced microvascular filtration capacity (2.98+/-1.20 compared with 3.71+/-0.89 ml.min-1.100 ml-1.mmHg-1x10(-3); P<0.05), probably due to a combination of reduced arterial inflow and lower venous pressure (8.5+/-5.2 compared with 12.6+/-2.8 mmHg; P<0.05) that moderated capillary hydrostatic pressure to override direct effects of inhibition of prostaglandin synthesis on permeability. Placebo was without effect on any measurement. It is unlikely therefore that prostaglandin-mediated vasodilator signals, which have been demonstrated between paired veins and arteries, are important in local vasodilation in response to venous congestion.

Adult↗

[Physiopathological mechanisms of reduced skin capillary resistance in disorders of microcirculation].

Nesteroffs method is a very simple and effective for diagnosis skin capillary resistance, this method is not only effective for diagnosis, but it is very applicable for curing effectiveness control. Women's skim blood vessel conditions were investigated. Only the women of before climacteric period were invavend, all of them had microcirculation which reduced elastins of skin. Reduction of capillary resistance is closely connected with the degree of microcirculation distonia and connected with it skin elastans reduction. We can take into consideration that the changings found are connected with the changings of blood vessel microcirculation. Microcirculation distomia causes the changings of skin elastins.

Adult↗

[Measuring capillary resistance values in atopic dermatitis].

For over 100 years many different methods have been used to determine capillary resistance as a measure of small vessel fragility. There is still no firm agreement as to the most suitable method; the procedure is not standardized and an objective system for measurement is lacking. We have developed a computerized system that makes it possible to count petechiae and determine their area without the results varying with different examiners. Although we tried to keep the conditions for our examinations constant, we found a wide individual spread. In spite of this, the capillary resistance of atopic subjects was significantly lower than that of healthy persons.

Adult↗

Capillary resistance and back pain.

A rapid clinical and epidemiological method of grading Capillary Resistance (CR) based on the appearance of petechiae following negative pressure on the skin of the forearm is described, and the results of testing 469 postmen aged 22 to 63 years are given. CR is shown to be increased in men who have had back pain within 24 hours of testing and no difference was found between men who had had back pain in the past and those who denied ever having had back pain. A separate series of 35 post-laminectomy patients examined at least 10 months after operation and who were shown to have disc disease at operation and/or on myelogram were found to have low CR. This work suggests that the changes involved in disc disease are not limited solely to the discs, but may involve collagen/elastic tissue or ground substance elsewhere as for example in this case when detectable in a test on the forearm. Secondly, it is suggested that CR grading could be a helpful discriminating test for 'disc disease' among those presenting with back pain of undetermined diagnosis.

Adult↗