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PubMed2003

[The effect of antioxidant on optimation of blood preservation].

In order to optimize the preservation of blood, 3 kinds of antioxidant were selected and each of them can be injected directly into vein, then the optimal dose of these antioxidants was chosen using statistical method; ISMC (injectio salvia miltiorrhizae composita), ginaton and the combination of ISMC and ginaton were added into blood as optimal dose, some references as ATP, EI and so on were observed during blood preservation. The results showed that all of the three kinds of antioxidants increased ATP, EI and decreased FHb during blood preservation. It is concluded that both of ISMC and ginaton can effectively optimize the preservation of blood and combination of ISMC and ginaton can produce additive effect.

Adenosine Triphosphate↗
PubMed1991

[Current methods in blood preservation: recovery of blood components using a multi-bag system].

A new method of blood preparation by use of a multiple plastic bag system is prescribed. Buffy coat free red cell suspensions in additive solution (SAG-M), fresh frozen (recovered) plasma and random platelet concentrates can thus be produced. Apart from the so far clinically not instantaneously available stored platelets the storage time of the red cells is remarkably increased up to 42 to 49 days and the cellular contaminations (red cells and leucocytes in platelet concentrates, thrombocytes and leucocytes in FFP) are markedly diminished leading to a higher quality of these components. The Red Cross Blood Transfusion Service of Upper Austria presents its data obtained by the use of a quadruple plastic bag (RC Transfusion Production Center Eugendorf/Salzburg) with cellular contamination parameters far below the generally accepted limits. Apart from the increased quality of the components a very high level of clinical acceptance concerning especially the stored random platelet concentrates has been experienced. In conclusion the necessity of changing to a multiple bag system is strongly emphasized thus not only better fulfilling the clinical needs for the different blood components but also delivering higher qualities. Red cell preparations containing the buffy coat should therefore not be used any longer.

Blood Coagulation Factors↗
PubMed1997

[Current advance of blood preservation--development and clinical application of additive solutions for preservation of red blood cells and platelets].

The technology for storage of red blood cells and platelets are quite important for the production of safe blood products and their supply. The usage of additive solution rather than plasma can improve the storage condition of red blood cells and allow more plasma recovered for plasma fractionation. Autologous transfusion is increasing extensively in these days, and the interest in a prolonged storage of cells has been growing. The use of synthetic media for platelet storage is expected to increase in the future and research is undergoing extensively worldwide. Further study is required to find the better ways to extend the storage period with high quality of cellular functions.

Blood Component Transfusion↗
PubMed2004

The use of potassium dichromate and ethyl alcohol as blood preservatives for analysis of organochlorine contaminants.

The "gold standard" for preserving and shipping of human tissue samples for analysis of organochlorine contaminants is freezing. This method can be difficult, costly if using heavy dry ice for shipping, and often unfeasible, especially in less developed countries where electricity and dry ice are frequently rare or absent. Therefore, it is essential that more convenient and practical methods for preservation of blood samples are found. As an alternative to freezing, there have been studies employing potassium dichromate as a preservative for human or cow's milk or ethyl alcohol preservation of blood for dioxin analysis. In this study, four methods were compared to investigate the effectiveness of ethyl alcohol and potassium dichromate as blood preservatives for analysis of dioxins, dibenzofuran, and polychlorinated biphenyl (PCB) congeners. Samples of whole blood from a Dallas, Texas hospital were collected and pooled. Freezing, ethyl alcohol in two concentrations (20% and 40% per volume of sample), and potassium dichromate were used for blood preservation. The blood samples containing potassium dichromate or ethyl alcohol were stored and sent to ERGO laboratory for dioxin analysis and comparison with results from the frozen sample, which was kept frozen at all times until analyzed. This study suggests that potassium dichromate is a suitable alternative to freezing for preservation of whole blood for dioxin, dibenzofuran, and PCB measurements when either lipid or wet weight based results are reported. Potassium dichromate tablets were very easy and convenient to use--two 100 mg tablets (with a dichromate content of about 33 mg each) were added to each bottle containing 65 ml of blood. However, ethyl alcohol at 20% and 40% concentration under the conditions of this pilot study and the analytical method employed did not appear to provide satisfactory preservation when lipid based results are given or when the fat content has to be determined (wet or whole weight). Further research with a larger number of samples, inclusion also of other groups of persistent organic pollutants such as organochlorine pesticides or brominated flame retardants, a longer duration of storage time, and at temperatures greater than US or German room temperature is indicated in order to recommend the routine use of potassium dichromate as preservative for whole blood intended for dioxin, dibenzofuran, and PCB analysis.

Blood Preservation↗