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Results for “Benzalkonium Compounds”

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At least 199 records · Page 11Linked to original sources
PubMed1975

Microbiological determination of drug partitioning. IV. Drug-protein interactions.

The protein binding characteristics of chloramphenicol, furazolium chloride, benzalkonium chloride, and phenylmercuric nitrate were described from their partitioning behavior in gelatin-acacia complex coacervate systems. Although the partitioning was determined by two different methods (microbiological and chemical), the microbiological method was more reliable for this type of investigation. Drug-protein parameters were calculated for the four antimicrobials. The advantages of the coacervate systems over other models for protein binding studies of drugs are discussed.

Bacteria↗
PubMed1976

Electron microscope study of effect of benzalkonium chloride and edetate disodium on cell envelope of Pseudomonas aeruginosa.

Electron micrographs of Pseudomonas aeruginosa grown in nutrient broth or broth containing subinhibitory concentrations of benzalkonium chloride indicate that benzalkonium chloride at 50 and 100 mug/ml strips off the outer cell membrane. Cells grown in the presence of edetate disodium, 50-100 mug/ml had convoluted surfaces (wavy in cross section). Cells damaged by growing on nutrient agar containing benzalkonium (200 mug/ml), when subsequently grown for 16 hr in nutrient broth, produced cells with apparently normal outer lavers. Similar cells grown on nutrient agar plus benzalkonium (500 mug/ml) when grown for 16 hr in nutrient broth had normal resistance to edetate disodium lysis, but cells grown overnight in broth plus benzalkonium (500 mug/ml) showed increased sensitivity to edetate disodium lysis. Cells grown on nutrient agar in the presence of benzalkonium (800 mug/ml) grew in broth plus benzalkonium (10 mug/ml) without stripping of their external membrane, but replicate inocula into broth plus benzalkonium (10 mug/ml) and edetate disodium (50 mug/ml) produced cells with structural damage to the outer lavers of the cell envelope.

Benzalkonium Compounds↗
PubMed1978

Differences in antibacterial activity of benzalkonium chloride.

Benzalkonium solutions obtained from different manufacturers were shown to have different activities. This difference in activity was related to the composition of the benzalkonium chloride. The potential seriousness of this situation is emphasized, and a recommendation is made that the official monographs on benzalkonium chloride be amended appropriately, noting the apparently superior antibacterial activity of the tetradecyl (C14) homolog.

Bacteria↗
PubMed1978

Drug resistance studies with topical antiseptics.

Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to povidone-iodine was not encountered. Chlorhexidine resistance was stable after drug-free transfers of Serratia and Pseudomonas but was transitory for Proteus.

Anti-Infective Agents, Local↗
PubMed1980

Determination of benzalkonium chloride by reversed-phase high-pressure liquid chromatography.

A new, specific, and useful approach for the analysis of benzalkonium chloride is presented. Reversed-phase high-pressure liquid chromatography is used to determine benzalkonium chloride in an ophthalmic system at the presevative level of 0.004%. Since the method separates each homolog, it can be extended to determine the homolog composition. These determinations can be made with an analysis time of 13 min/sample.

Benzalkonium Compounds↗
PubMed1982

Influence of benzalkonium chloride on the dissolution rate behavior of several solid-phase preparations of cholesterol in bile acid solutions.

Cholesterol dissolution rate accelerators, such as benzalkonium chloride, function by reducing the interfacial barrier that exists between the negatively-charged bile acid micelle and the negatively-charged cholesterol surface. It has been proposed that this reaction is accomplished by the binding of the positively-charged accelerator to the negatively-charged micelle. An earlier report showed that different solid preparations of cholesterol give different dissolution rates under the same conditions and these differences can be primarily accounted for by variations in the interfacial transport constant (P). By using the rotating disk dissolution apparatus and the Levich theory it has been possible to study the dissolution behavior of different cholesterol solid phases as a function of the benzalkonium chloride concentration. It was shown that the ratios of P values for the different phases are relatively constant over the range of the accelerator concentrations. This suggests that the accelerators act primarily on the micelle to enhance dissolution rate.

Benzalkonium Compounds↗