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PubMed · 9849168

Understanding alpha-hydroxy acids.

J A Kneedler·S S Sky·L R Sexton
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Abstract

This self-study activity has been developed for nurses, estheticians, and other health care professionals whose patients use alpha-hydroxy acid (AHA) products. Skin anatomy and physiology are reviewed and information is presented on the mechanisms of action of AHAs. Cosmetic and therapeutic benefits of AHA-containing products are detailed. Factors that influence the safety and effectiveness of AHA products are explored, including concentration, pH, and the amount of free acid present. A method is detailed for applying AHA-containing chemexfoliating agents, and guidelines are offered for taking a patient history, post-procedure skin care, and applying subsequent peels.

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ChemexfoliationDermatologic AgentsHumansHydroxy AcidsSkinSkin AgingJournal ArticleReview

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J A Kneedler, S S Sky, L R Sexton. 1998. Understanding alpha-hydroxy acids.. https://pubmed.ncbi.nlm.nih.gov/9849168/

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Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest.

BACKGROUND: Salicylic acid, hydroquinone, and glycolic acid have been proved effective in the treatment of photodamaged facial skin. Few reports are available on the treatment of photodamage on the neck and upper chest. OBJECTIVE: This study's purpose was to evaluate the efficacy of a cream containing 4% hydroquinone and 2% glycolic acid (LUSTRA) used alone or with salicylic acid peels in reversing actinic damage on the neck and upper chest. METHODS: Nineteen women with moderate to advanced photodamage on the neck and upper chest applied a cream containing 4% hydroquinone and 2% glycolic acid twice daily on photodamaged areas for 12 weeks. Nine of these subjects had salicylic acid peels every 3 weeks. Improvements were assessed by the investigator, the subjects, and Mexameter readings measuring melanin and erythema levels. RESULTS: The result shows that there was a 33-71% improvement in photodamage, hyperpigmentation, texture, fine lines, dryness, tone, and clarity in both groups. There were no significant differences between the two treatments. CONCLUSION: Hydroquinone 4% cream with 2% glycolic acid is safe and effective in improving photodamage on the neck and upper chest when used alone or in combination with salicylic acid peels.

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