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PubMed · 974273

Decrease of normotest/thrombotest discrepancy in non-contacted coumarin plasma after glass or ellagic acid activation.

A Girolami·G Patrassi·A Burul
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Abstract

Activation of coumarin plasmas in glass tubes for 60 min resulted in a clear shortening of Thrombotest clotting times. Normotest clotting times were shortened too but to a much lesser extent. As a consequence the Normotest (NT)/Thrombotest (TT) discrepancy which was quite large at 0 time, became progressively smaller. This phenomenon was observed both in undiluted and 6:10 diluted plasma. After ellagic acid activation a similar phenomenon was noted even though a less pronounced shortening of Thrombotest was noted. These data suggest that Thrombotest is very sensitive to contact phase and to factor VII activation and not to any coumarin-induced inhibitors.

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Blood Coagulation TestsCoumarinsEllagic AcidFactor VIIGlassHumansTime FactorsComparative StudyJournal Article

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A Girolami, G Patrassi, A Burul. 1976. Decrease of normotest/thrombotest discrepancy in non-contacted coumarin plasma after glass or ellagic acid activation.. https://doi.org/10.1007/bf01005211

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